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PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008] See more...
Aliases for PIWIL2 Gene
Aliases for PIWIL2 Gene
External Ids for PIWIL2 Gene
- HGNC: 17644
- Entrez Gene: 55124
- Ensembl: ENSG00000197181
- OMIM: 610312
- UniProtKB: Q8TC59
Previous GeneCards Identifiers for PIWIL2 Gene
- GC08P021891
- GC08P022485
- GC08P021953
- GC08P022154
- GC08P022188
- GC08P022132
- GC08P020675
Summaries for PIWIL2 Gene
-
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PIWIL2 Gene
PIWIL2 (Piwi Like RNA-Mediated Gene Silencing 2) is a Protein Coding gene. Diseases associated with PIWIL2 include Caplan's Syndrome and Cycloplegia. Among its related pathways are Mitotic Prophase and PIWI-interacting RNA (piRNA) biogenesis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and piRNA binding. An important paralog of this gene is PIWIL1.
UniProtKB/Swiss-Prot Summary for PIWIL2 Gene
-
Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660). Represses circadian rhythms by promoting the stability and activity of core clock components ARNTL/BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391).
Additional gene information for PIWIL2 Gene
- HGNC(17644)
- Entrez Gene(55124)
- Ensembl(ENSG00000197181)
- OMIM(610312)
- UniProtKB(Q8TC59)
- Open Targets Platform(ENSG00000197181)
- Search for PIWIL2 at DataMed
- Search for PIWIL2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIWIL2 Gene
Genomics for PIWIL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PIWIL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PIWIL2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIWIL2
- Top Transcription factor binding sites by QIAGEN in the PIWIL2 gene promoter:
-
- AP-4
- Egr-4
- N-Myc
- STAT3
- USF-1
Genomic Locations for PIWIL2 Gene
Genomic Locations for PIWIL2 Gene
- chr8:22,275,314-22,357,568
- (GRCh38/hg38)
- Size:
- 82,255 bases
- Orientation:
- Plus strand
- chr8:22,132,810-22,215,076
- (GRCh37/hg19)
- Size:
- 82,267 bases
- Orientation:
- Plus strand
Genomic View for PIWIL2 Gene
Genes around PIWIL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by HGNC
- 8p21.3 by Entrez Gene
- 8p21.3 by Ensembl
PIWIL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIWIL2 Gene
Proteins for PIWIL2 Gene
-
Protein details for PIWIL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TC59-PIWL2_HUMAN
- Recommended name:
- Piwi-like protein 2
- Protein Accession:
- Q8TC59
- A8K4S3
- A8K8S5
- B0AZN9
- B0AZP2
- B4DR22
- E7ECA4
- Q96SW6
- Q9NW28
Protein attributes for PIWIL2 Gene
- Size:
- 973 amino acids
- Molecular mass:
- 109849 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77 (By similarity). Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes (By similarity). Interacts (when methylated on arginine residues) with TDRD1 and TDRKH/TDRD2 (By similarity). Interacts with TDRD12 (By similarity). Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs (By similarity). Interacts with MOV10L1 (By similarity). Interacts with GPAT2 (By similarity). Interacts with TEX19 (By similarity). Interacts with GSK3B (By similarity). Interacts (via PIWI domain) with ARNTL/BMAL1 and CLOCK (PubMed:28903391).
- SequenceCaution:
-
- Sequence=BAA91558.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB55155.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
Protein Expression for PIWIL2 Gene
Post-translational modifications for PIWIL2 Gene
- Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PIWIL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PIWIL2 Antibody
- Creative Diagnostics Anti-PIWIL2 polyclonal antibody
- Creative Biolabs Mouse Anti-PIWIL2 Recombinant Antibody (11C11)
- Novus Biologicals Antibodies for PIWIL2
-
Abcam antibodies for PIWIL2
- Invitrogen Antibodies for PIWIL2 (AFLGC-Piwil2)
-
Custom Antibody ServicesProSci Antibodies for PIWIL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PIWIL2
- Sino Biological Antibodies for PIWIL2
Protein Products
-
OriGene Purified Proteins for PIWIL2
- Search Origene for MassSpec and Protein Over-expression Lysates for PIWIL2
- Origene Custom Protein Services for PIWIL2
- Novus Biologicals lysates for PIWIL2
-
Abcam proteins for PIWIL2
No data available for DME Specific Peptides for PIWIL2 Gene
Domains & Families for PIWIL2 Gene
Gene Families for PIWIL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PIWIL2 Gene
- InterPro:
- Blocks:
-
- Argonaute and Dicer protein, PAZ
- Stem cell self-renewal protein Piwi
- ProtoNet:
Suggested Antigen Peptide Sequences for PIWIL2 Gene
- GenScript: Design optimal peptide antigens:
-
- Cancer/testis antigen 80 (PIWL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TC59- Family:
-
- Belongs to the argonaute family. Piwi subfamily.
Function for PIWIL2 Gene
Molecular function for PIWIL2 Gene
- UniProtKB/Swiss-Prot Function:
- Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660). Represses circadian rhythms by promoting the stability and activity of core clock components ARNTL/BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391).
Enzyme Numbers (IUBMB) for PIWIL2 Gene
Phenotypes From GWAS Catalog for PIWIL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003729 | mRNA binding | IEA | -- |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004519 | endonuclease activity | IEA | -- |
Phenotypes for PIWIL2 Gene
- MGI mutant phenotypes for PIWIL2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for PIWIL2:
Animal Models for PIWIL2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PIWIL2 - Select products 50% OFF >
- * PIWIL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PIWIL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIWIL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIWIL2
miRNA for PIWIL2 Gene
- miRTarBase miRNAs that target PIWIL2
-
- hsa-miR-573 (MIRT535215)
- hsa-miR-3616-5p (MIRT535216)
- hsa-miR-4795-5p (MIRT535217)
- hsa-miR-4775 (MIRT535218)
- hsa-miR-93-3p (MIRT535219)
- hsa-miR-153-5p (MIRT535220)
- hsa-miR-1250-3p (MIRT535221)
- hsa-miR-455-5p (MIRT535222)
- hsa-miR-590-3p (MIRT535223)
- mmu-miR-467g (MIRT581838)
- mmu-miR-466d-3p (MIRT581839)
- mmu-miR-466e-3p (MIRT581840)
- mmu-miR-297b-3p (MIRT581841)
- mmu-miR-466a-3p (MIRT581842)
- mmu-miR-1b-5p (MIRT581843)
- mmu-miR-466b-3p (MIRT581844)
- mmu-miR-466p-3p (MIRT581845)
- mmu-miR-466c-3p (MIRT581846)
- mmu-miR-466m-3p (MIRT581847)
- mmu-miR-466o-3p (MIRT581848)
- mmu-miR-466f-3p (MIRT581849)
- mmu-miR-466l-3p (MIRT581850)
- hsa-miR-8485 (MIRT607438)
- hsa-miR-520h (MIRT608363)
- hsa-miR-520g-3p (MIRT608364)
- hsa-miR-519e-3p (MIRT608365)
- hsa-miR-515-3p (MIRT608366)
- hsa-miR-33b-3p (MIRT608367)
- hsa-miR-93-5p (MIRT608368)
- hsa-miR-526b-3p (MIRT608369)
- hsa-miR-519d-3p (MIRT608370)
- hsa-miR-20b-5p (MIRT608371)
- hsa-miR-20a-5p (MIRT608372)
- hsa-miR-17-5p (MIRT608373)
- hsa-miR-106b-5p (MIRT608374)
- hsa-miR-106a-5p (MIRT608375)
- hsa-miR-497-3p (MIRT608376)
- hsa-miR-548t-3p (MIRT608377)
- hsa-miR-548ap-3p (MIRT608378)
- hsa-miR-548aa (MIRT608379)
- hsa-miR-6891-3p (MIRT610840)
- hsa-miR-6072 (MIRT610841)
- hsa-miR-6888-3p (MIRT619539)
- hsa-miR-452-3p (MIRT619540)
- hsa-miR-3120-5p (MIRT619541)
- mmu-miR-17-5p (MIRT734894)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIWIL2
- Browse OriGene Inhibitory RNA Products For PIWIL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIWIL2
Clone Products
- Applied Biological Materials (abm): Clones for PIWIL2 - Select products 50% OFF >
- * PIWIL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223877
- MR223877
- MR223877L3
- MR223877L4
- RC205464
- RC205464L1
- RC205464L2
- RC205464L3
- RC205464L4
- RC227303
- RC227303L1
- RC227303L2
- RC227303L3
- RC227303L4
- RG205464
- RG227303
- RR207242
- RR207242L3
- RR207242L4
- MR223877L3V
- MR223877L4V
- RC205464L1V
- RC205464L2V
- RC205464L3V
- RC205464L4V
- RC227303L1V
- RC227303L2V
- RC227303L3V
- RC227303L4V
- RR207242L3V
- RR207242L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PIWIL2
- Addgene plasmids for PIWIL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIWIL2
Cell Line Products
-
Horizon Cell Lines for PIWIL2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIWIL2 Gene
Localization for PIWIL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIWIL2 Gene
- Cytoplasm. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q8CDG1}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 28025795 |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0010370 | perinucleolar chromocenter | IEA | -- |
| GO:0033391 | chromatoid body | ISS | -- |
| GO:0043186 | P granule | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIWIL2 Gene
Pathways & Interactions for PIWIL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Mitotic Prophase | ||
| 3 | PIWI-interacting RNA (piRNA) biogenesis | ||
Pathways by source for PIWIL2 Gene
3 Reactome pathways for PIWIL2 Gene
Interacting Proteins for PIWIL2 Gene
GPS-Prot Interaction Network for PIWIL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000966 | RNA 5'-end processing | ISS | -- |
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | ISS | -- |
| GO:0010529 | negative regulation of transposition | ISS | -- |
No data available for SIGNOR curated interactions for PIWIL2 Gene
Transcripts for PIWIL2 Gene
mRNA/cDNA for PIWIL2 Gene
- 3 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356766 5114 nts (view in UCSC)
- ENST00000454009 3442 nts (view in UCSC)
- ENST00000519884 1262 nts (view in UCSC)
- ENST00000521356 3488 nts (view in UCSC)
- ENST00000611073 2864 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PIWIL2 - Select products 50% OFF >
- * PIWIL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PIWIL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIWIL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIWIL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIWIL2
- Browse OriGene Inhibitory RNA Products For PIWIL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIWIL2
Clone Products
- Applied Biological Materials (abm): Clones for PIWIL2 - Select products 50% OFF >
- * PIWIL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223877
- MR223877
- MR223877L3
- MR223877L4
- RC205464
- RC205464L1
- RC205464L2
- RC205464L3
- RC205464L4
- RC227303
- RC227303L1
- RC227303L2
- RC227303L3
- RC227303L4
- RG205464
- RG227303
- RR207242
- RR207242L3
- RR207242L4
- MR223877L3V
- MR223877L4V
- RC205464L1V
- RC205464L2V
- RC205464L3V
- RC205464L4V
- RC227303L1V
- RC227303L2V
- RC227303L3V
- RC227303L4V
- RR207242L3V
- RR207242L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PIWIL2
- Addgene plasmids for PIWIL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIWIL2
Relevant External Links for PIWIL2 Gene
- GeneLoc Exon Structure for
- PIWIL2
Expression for PIWIL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- Germ Cells (Reproductive System)
- Gonad
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PIWIL2 Gene
This gene is overexpressed in Testis (x15.7).
This gene is overexpressed in Ovary (43.1) and Testis (19.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIWIL2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIWIL2
SOURCE GeneReport for Unigene cluster for PIWIL2 Gene:
Hs.614809mRNA Expression by UniProt/SwissProt for PIWIL2 Gene:
Q8TC59-PIWL2_HUMAN
Tissue specificity:
Expressed in adult testis and in most tumors.
Evidence on tissue expression from TISSUES for PIWIL2 Gene
- Liver(3)
- Nervous system(2.1)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for PIWIL2
-
OriGene qPCR primer pairs and template standards for PIWIL2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PIWIL2 Gene
Orthologs for PIWIL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PIWIL2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PIWIL2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PIWIL2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PIWIL2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Piwil2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Piwil2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PIWIL2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PIWIL2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PIWIL2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | piwil2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | piwil2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | AGO3 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008862 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | prg-2 31 |
|
ManyToMany | |
| ZK218.8 31 |
|
ManyToMany | |||
| M03D4.6 31 |
|
ManyToMany | |||
| alg-2 31 |
|
ManyToMany | |||
| hpo-24 31 |
|
ManyToMany | |||
| alg-1 31 |
|
ManyToMany | |||
| tag-76 31 |
|
ManyToMany | |||
| T22B3.2 31 |
|
ManyToMany | |||
| sago-2 31 |
|
ManyToMany | |||
| ppw-1 31 |
|
ManyToMany | |||
| C04F12.1 31 |
|
ManyToMany | |||
| wago-2 31 |
|
ManyToMany | |||
| sago-1 31 |
|
ManyToMany | |||
| wago-1 31 |
|
ManyToMany | |||
| wago-10 31 |
|
ManyToMany | |||
| C14B1.7 31 |
|
ManyToMany | |||
| wago-5 31 |
|
ManyToMany | |||
| wago-4 31 |
|
ManyToMany | |||
| ppw-2 31 |
|
ManyToMany | |||
| csr-1 31 |
|
ManyToMany | |||
| wago-11 31 |
|
ManyToMany | |||
| nrde-3 31 |
|
ManyToMany | |||
| hrde-1 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for PIWIL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PIWIL2 Gene
- ENSEMBL:
- Gene Tree for PIWIL2 (if available)
- TreeFam:
- Gene Tree for PIWIL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PIWIL2: view image
Paralogs for PIWIL2 Gene
Variants for PIWIL2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv22246 | CNV | loss | 19812545 |
| esv2669515 | CNV | deletion | 23128226 |
| esv2759604 | CNV | loss | 17122850 |
| esv2764071 | CNV | gain | 21179565 |
| esv3409921 | CNV | insertion | 20981092 |
| esv3543210 | CNV | deletion | 23714750 |
| esv3616606 | CNV | loss | 21293372 |
| esv3616607 | CNV | loss | 21293372 |
| nsv518646 | CNV | gain | 19592680 |
| nsv6115 | CNV | insertion | 18451855 |
| nsv831264 | CNV | gain+loss | 17160897 |
| nsv831265 | CNV | loss | 17160897 |
| nsv831266 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.63;
56.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIWIL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIWIL2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIWIL2 Gene
Disorders for PIWIL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| caplan's syndrome |
|
|
| cycloplegia |
|
|
| acute cor pulmonale |
|
|
| acute pulmonary heart disease |
|
|
| male infertility |
|
|
Search PIWIL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PIWIL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PIWIL2 Gene
Publications for PIWIL2 Gene
- Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T … Shimizu N (Genomics 2003) 2 3 4
- Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. (PMID: 28903391) Lu Y … Ma Y (Oncotarget 2017) 3 4
- Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. (PMID: 21193640) Tian Y … Patel DJ (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4
- Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. (PMID: 20940137) Gu A … Wang X (Human reproduction (Oxford, England) 2010) 3 41
- Absence of PIWIL2 (HILI) expression in human bladder cancer cell lines and tissues. (PMID: 19683485) Nikpour P … Mowla SJ (Cancer epidemiology 2009) 3 23
ExternalLinks
Products for PIWIL2 Gene
- Custom Antibody Services
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- MG223877
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- RR207242
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- RC227303L1V
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- RR207242L3V
- RR207242L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for PIWIL2
- antibodies-online: Show 22 available PIWIL2 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for PIWIL2
- Search Santa Cruz Biotechnology (SCBT) for PIWIL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PIWIL2
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIWIL2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIWIL2
Sources for PIWIL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (30) HomoloGene
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- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (43) HuGE
- (44) Atlas
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (77) ESI-BIO
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- (84) COMPARTMENTS
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- (90) CYP
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- (104) diseasecard
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- (154) Biorbyt
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- (156) Mastermind
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- (178) MirGeneDB