Aliases for PIWIL2 Gene
Aliases for PIWIL2 Gene
External Ids for PIWIL2 Gene
- HGNC: 17644
- Entrez Gene: 55124
- Ensembl: ENSG00000197181
- OMIM: 610312
- UniProtKB: Q8TC59
Previous GeneCards Identifiers for PIWIL2 Gene
- GC08P021891
- GC08P022485
- GC08P021953
- GC08P022154
- GC08P022188
- GC08P022132
- GC08P020675
Summaries for PIWIL2 Gene
-
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PIWIL2 Gene
PIWIL2 (Piwi Like RNA-Mediated Gene Silencing 2) is a Protein Coding gene. Diseases associated with PIWIL2 include Caplan's Syndrome and Acute Cor Pulmonale. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and piRNA binding. An important paralog of this gene is PIWIL1.
UniProtKB/Swiss-Prot for PIWIL2 Gene
-
Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a slicer-competent piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto slicer-incompetent PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660).
Additional gene information for PIWIL2 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIWIL2 Gene
Genomics for PIWIL2 Gene
GeneHancer (GH) Regulatory Elements for PIWIL2 Gene
Promoters and enhancers for PIWIL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PIWIL2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PIWIL2 Gene
Genomic Locations for PIWIL2 Gene
- chr8:22,275,297-22,357,568
- (GRCh38/hg38)
- Size:
- 82,272 bases
- Orientation:
- Plus strand
- chr8:22,132,810-22,215,076
- (GRCh37/hg19)
Genomic View for PIWIL2 Gene
Genes around PIWIL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by Ensembl
- 8p21.3 by Entrez Gene
- 8p21.3 by HGNC
PIWIL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIWIL2 Gene
Proteins for PIWIL2 Gene
-
Protein details for PIWIL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TC59-PIWL2_HUMAN
- Recommended name:
- Piwi-like protein 2
- Protein Accession:
- Q8TC59
- A8K4S3
- A8K8S5
- B0AZN9
- B0AZP2
- B4DR22
- E7ECA4
- Q96SW6
- Q9NW28
Protein attributes for PIWIL2 Gene
- Size:
- 973 amino acids
- Molecular mass:
- 109849 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77. Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes. Interacts (when methylated on arginine residues) with TDRD1 and TDRKH/TDRD2. Interacts with TDRD12. Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs. Interacts with MOV10L1. Interacts with GPAT2. Interacts with TEX19 (By similarity).
- SequenceCaution:
-
- Sequence=BAA91558.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55155.1; Type=Erroneous termination; Positions=421; Note=Translated as Arg.; Evidence={ECO:0000305};
Protein Expression for PIWIL2 Gene
Post-translational modifications for PIWIL2 Gene
- Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PIWIL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PIWIL2 (PIWIL2)
- Novus Biologicals Antibodies for PIWIL2
-
Abcam antibodies for PIWIL2
- Invitrogen Antibodies for PIWIL2
- antibodies-online: Search results for 65 available PIWIL2 Antibodies ranked by validation data
- Compare Top PIWIL2 Antibodies
-
Recommended
- 12 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 44 WB Antibodies (anti-human)
- 22 WB Antibodies (anti-mouse)
- 12 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 44 WB Antibodies (anti-human)
- 22 WB Antibodies (anti-mouse)
- GeneTex PIWIL2 antibody for PIWIL2
-
Custom Antibody ServicesProSci Antibodies for PIWIL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PIWIL2
Protein Products
-
OriGene Purified Proteins for PIWIL2
- Search Origene for MassSpec and Protein Over-expression Lysates for PIWIL2
- Origene Custom Protein Services for PIWIL2
- Novus Biologicals lysates for PIWIL2
- Search GeneTex for Proteins for PIWIL2
-
Abcam proteins for PIWIL2
Assay Products
No data available for DME Specific Peptides for PIWIL2 Gene
Domains & Families for PIWIL2 Gene
Gene Families for PIWIL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PIWIL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PIWIL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TC59- Family:
-
- Belongs to the argonaute family. Piwi subfamily.
Function for PIWIL2 Gene
Molecular function for PIWIL2 Gene
- UniProtKB/Swiss-Prot Function:
- Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a slicer-competent piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto slicer-incompetent PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660).
Enzyme Numbers (IUBMB) for PIWIL2 Gene
Phenotypes From GWAS Catalog for PIWIL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003729 | mRNA binding | IEA | -- |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004519 | endonuclease activity | IEA | -- |
Phenotypes for PIWIL2 Gene
- MGI mutant phenotypes for PIWIL2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for PIWIL2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIWIL2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PIWIL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIWIL2 gene
- Search ViGene Biosciences for PIWIL2
CRISPR Products
-
OriGene CRISPR knockouts for PIWIL2
- genomics-online: gRNA clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
- Applied Biological Materials CRISPR for PIWIL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIWIL2
- GenScript: Design CRISPR guide RNA sequences for PIWIL2
miRNA for PIWIL2 Gene
- miRTarBase miRNAs that target PIWIL2
-
- hsa-mir-573 (MIRT535215)
- hsa-mir-3616-5p (MIRT535216)
- hsa-mir-4795-5p (MIRT535217)
- hsa-mir-4775 (MIRT535218)
- hsa-mir-93-3p (MIRT535219)
- hsa-mir-153-5p (MIRT535220)
- hsa-mir-1250-3p (MIRT535221)
- hsa-mir-455-5p (MIRT535222)
- hsa-mir-590-3p (MIRT535223)
- hsa-mir-8485 (MIRT607438)
- hsa-mir-520h (MIRT608363)
- hsa-mir-520g-3p (MIRT608364)
- hsa-mir-519e-3p (MIRT608365)
- hsa-mir-515-3p (MIRT608366)
- hsa-mir-33b-3p (MIRT608367)
- hsa-mir-93-5p (MIRT608368)
- hsa-mir-526b-3p (MIRT608369)
- hsa-mir-519d-3p (MIRT608370)
- hsa-mir-20b-5p (MIRT608371)
- hsa-mir-20a-5p (MIRT608372)
- hsa-mir-17-5p (MIRT608373)
- hsa-mir-106b-5p (MIRT608374)
- hsa-mir-106a-5p (MIRT608375)
- hsa-mir-497-3p (MIRT608376)
- hsa-mir-548t-3p (MIRT608377)
- hsa-mir-548ap-3p (MIRT608378)
- hsa-mir-548aa (MIRT608379)
- hsa-mir-6891-3p (MIRT610840)
- hsa-mir-6072 (MIRT610841)
- hsa-mir-6888-3p (MIRT619539)
- hsa-mir-452-3p (MIRT619540)
- hsa-mir-3120-5p (MIRT619541)
miRNA Products
- Search ViGene Biosciences for PIWIL2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PIWIL2
- Browse OriGene Inhibitory RNA Products For PIWIL2
- genomics-online: shRNA clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PIWIL2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PIWIL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIWIL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PIWIL2
- Applied Biological Materials Clones for PIWIL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PIWIL2
-
ViGene Biosciences adenoviral particle packaged cDNA for PIWIL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PIWIL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIWIL2 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIWIL2 Gene
Localization for PIWIL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIWIL2 Gene
- Cytoplasm. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q8CDG1}.
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005844 | polysome | IEA | -- |
| GO:0010370 | perinucleolar chromocenter | IEA | -- |
| GO:0033391 | chromatoid body | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIWIL2 Gene
Pathways & Interactions for PIWIL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Mitotic Prophase | ||
| 3 | PIWI-interacting RNA (piRNA) biogenesis | ||
Pathways by source for PIWIL2 Gene
3 Reactome pathways for PIWIL2 Gene
Interacting Proteins for PIWIL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000966 | RNA 5-end processing | ISS | -- |
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | ISS | -- |
| GO:0010529 | negative regulation of transposition | ISS | -- |
No data available for SIGNOR curated interactions for PIWIL2 Gene
Transcripts for PIWIL2 Gene
mRNA/cDNA for PIWIL2 Gene
- (5) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PIWIL2 Gene
- Piwi-like RNA-mediated gene silencing 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PIWIL2
- genomics-online: gRNA clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
- Applied Biological Materials CRISPR for PIWIL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIWIL2
- GenScript: Design CRISPR guide RNA sequences for PIWIL2
miRNA Products
- Search ViGene Biosciences for PIWIL2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PIWIL2
- Browse OriGene Inhibitory RNA Products For PIWIL2
- genomics-online: shRNA clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PIWIL2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PIWIL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIWIL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PIWIL2
- Applied Biological Materials Clones for PIWIL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PIWIL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- Germ Cells (Reproductive System)
- Gonad
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PIWIL2 Gene
This gene is overexpressed in Testis (x15.7).
This gene is overexpressed in Ovary (43.1) and Testis (19.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIWIL2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PIWIL2 Gene:
PIWIL2SOURCE GeneReport for Unigene cluster for PIWIL2 Gene:
Hs.614809mRNA Expression by UniProt/SwissProt for PIWIL2 Gene:
Q8TC59-PIWL2_HUMAN
Tissue specificity:
Expressed in adult testis and in most tumors.
Evidence on tissue expression from TISSUES for PIWIL2 Gene
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for PIWIL2
-
OriGene qPCR primer pairs and template standards for PIWIL2
- genomics-online: primer clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PIWIL2 Gene
Orthologs for PIWIL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PIWIL2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PIWIL2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PIWIL2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PIWIL2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Piwil2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Piwil2 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PIWIL2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PIWIL2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PIWIL2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | piwil2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | piwil2 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | AGO3 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008862 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | prg-2 34 |
|
ManyToMany | |
| M03D4.6 34 |
|
ManyToMany | |||
| ZK218.8 34 |
|
ManyToMany | |||
| alg-2 34 |
|
ManyToMany | |||
| alg-1 34 |
|
ManyToMany | |||
| hpo-24 34 |
|
ManyToMany | |||
| T22B3.2 34 |
|
ManyToMany | |||
| tag-76 34 |
|
ManyToMany | |||
| ppw-1 34 |
|
ManyToMany | |||
| sago-2 34 |
|
ManyToMany | |||
| C04F12.1 34 |
|
ManyToMany | |||
| sago-1 34 |
|
ManyToMany | |||
| wago-1 34 |
|
ManyToMany | |||
| wago-2 34 |
|
ManyToMany | |||
| C14B1.7 34 |
|
ManyToMany | |||
| wago-10 34 |
|
ManyToMany | |||
| wago-4 34 |
|
ManyToMany | |||
| wago-5 34 |
|
ManyToMany | |||
| csr-1 34 |
|
ManyToMany | |||
| hrde-1 34 |
|
ManyToMany | |||
| nrde-3 34 |
|
ManyToMany | |||
| ppw-2 34 |
|
ManyToMany | |||
| wago-11 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for PIWIL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PIWIL2 Gene
Variants for PIWIL2 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000020345 | -- | 22,273,462(+) | C/T | upstream_transcript_variant | |
| rs1000021462 | -- | 22,307,711(+) | A/G | intron_variant | |
| rs1000046516 | -- | 22,312,859(+) | T/C | intron_variant | |
| rs1000089179 | -- | 22,278,216(+) | T/C | intron_variant | |
| rs1000117142 | -- | 22,326,637(+) | T/C | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv22246 | CNV | loss | 19812545 |
| esv2669515 | CNV | deletion | 23128226 |
| esv2759604 | CNV | loss | 17122850 |
| esv2764071 | CNV | gain | 21179565 |
| esv3409921 | CNV | insertion | 20981092 |
| esv3543210 | CNV | deletion | 23714750 |
| esv3616606 | CNV | loss | 21293372 |
| esv3616607 | CNV | loss | 21293372 |
| nsv518646 | CNV | gain | 19592680 |
| nsv6115 | CNV | insertion | 18451855 |
| nsv831264 | CNV | gain+loss | 17160897 |
| nsv831265 | CNV | loss | 17160897 |
| nsv831266 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.63;
56.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIWIL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIWIL2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIWIL2 Gene
Disorders for PIWIL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| caplan's syndrome |
|
|
| acute cor pulmonale |
|
|
| acute pulmonary heart disease |
|
|
Search PIWIL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PIWIL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PIWIL2 Gene
Publications for PIWIL2 Gene
- Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T … Shimizu N (Genomics 2003) 2 3 4 58
- Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. (PMID: 21193640) Tian Y … Patel DJ (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
- Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. (PMID: 20940137) Gu A … Wang X (Human reproduction (Oxford, England) 2010) 3 44 58
- Absence of PIWIL2 (HILI) expression in human bladder cancer cell lines and tissues. (PMID: 19683485) Nikpour P … Mowla SJ (Cancer epidemiology 2009) 3 22 58
- Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. (PMID: 16377660) Lee JH … Nayernia K (Human molecular genetics 2006) 3 4 58
Products for PIWIL2 Gene
- R&D Systems Antibodies for PIWIL2 (PIWIL2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PIWIL2
- Search Origene for MassSpec and Protein Over-expression Lysates for PIWIL2
- Origene Custom Protein Services for PIWIL2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIWIL2
- Browse OriGene Inhibitory RNA Products For PIWIL2
- OriGene qPCR primer pairs and template standards for PIWIL2
- OriGene qPCR primer pairs for PIWIL2
- OriGene CRISPR knockouts for PIWIL2
- OriGene ORF clones in human for PIWIL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PIWIL2
- GenScript: Next-day shipping of latest version cDNA ORF clones for PIWIL2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PIWIL2
- GenScript Custom Assay Services for PIWIL2
- GenScript Custom overexpressing Cell Line Services for PIWIL2
- GenScript: Design CRISPR guide RNA sequences for PIWIL2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PIWIL2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PIWIL2
- Novus Biologicals lysates for PIWIL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PIWIL2
- Abcam proteins for PIWIL2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIWIL2
- VectorBuilder custom plasmid, inducible vectors for PIWIL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIWIL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PIWIL2
- antibodies-online: Search results for 65 available PIWIL2 Antibodies ranked by validation data
- Compare Top PIWIL2 Antibodies
- Recommended
- 22 WB Antibodies (anti-mouse)
- 44 WB Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 12 WB Antibodies (anti-rat)
- 22 WB Antibodies (anti-mouse)
- 44 WB Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 12 WB Antibodies (anti-rat)
- antibodies-online: Search results for available PIWIL2 related products ranked by validation data
- antibodies-online: Search results for available PIWIL2 related products ranked by validation data
- GeneTex PIWIL2 antibody for PIWIL2
- Search GeneTex for Proteins for PIWIL2
- ViGene Biosciences adenoviral particle packaged cDNA for PIWIL2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PIWIL2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PIWIL2 gene
- Search ViGene Biosciences for PIWIL2
- Santa Cruz Biotechnology (SCBT) Antibodies for PIWIL2
- Search Santa Cruz Biotechnology (SCBT) for PIWIL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PIWIL2
- Custom Antibody ServicesProSci Antibodies for PIWIL2
- Search for PIWIL2 Proteins at ProSci
- Horizon Cell Lines for PIWIL2
- genomics-online: cdna clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
- orf clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
- genomics-online: gRNA clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
- genomics-online: primer clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
- genomics-online: shRNA clones - Search results for 72 available PIWIL2 gene related products
- Overview of 72 available PIWIL2 gene related products
Sources for PIWIL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems