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PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
PIWIL2 (Piwi Like RNA-Mediated Gene Silencing 2) is a Protein Coding gene. Diseases associated with PIWIL2 include Caplan's Syndrome and Cycloplegia. Among its related pathways are Mitotic Prophase and PIWI-interacting RNA (piRNA) biogenesis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and piRNA binding. An important paralog of this gene is PIWIL1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA | -- |
GO:0003729 | mRNA binding | IEA | -- |
GO:0004518 | nuclease activity | IEA | -- |
GO:0004519 | endonuclease activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 28025795 |
GO:0005737 | cytoplasm | ISS | -- |
GO:0010370 | perinucleolar chromocenter | IEA | -- |
GO:0033391 | chromatoid body | ISS | -- |
GO:0043186 | P granule | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | Mitotic Prophase | ||
3 | PIWI-interacting RNA (piRNA) biogenesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000966 | RNA 5'-end processing | ISS | -- |
GO:0006417 | regulation of translation | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007283 | spermatogenesis | ISS | -- |
GO:0010529 | negative regulation of transposition | ISS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PIWIL2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PIWIL2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PIWIL2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PIWIL2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Piwil2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Piwil2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PIWIL2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PIWIL2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PIWIL2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | piwil2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | piwil2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | AGO3 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008862 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | prg-2 31 |
|
ManyToMany | |
ZK218.8 31 |
|
ManyToMany | |||
M03D4.6 31 |
|
ManyToMany | |||
alg-2 31 |
|
ManyToMany | |||
hpo-24 31 |
|
ManyToMany | |||
alg-1 31 |
|
ManyToMany | |||
tag-76 31 |
|
ManyToMany | |||
T22B3.2 31 |
|
ManyToMany | |||
sago-2 31 |
|
ManyToMany | |||
ppw-1 31 |
|
ManyToMany | |||
C04F12.1 31 |
|
ManyToMany | |||
wago-2 31 |
|
ManyToMany | |||
sago-1 31 |
|
ManyToMany | |||
wago-1 31 |
|
ManyToMany | |||
wago-10 31 |
|
ManyToMany | |||
C14B1.7 31 |
|
ManyToMany | |||
wago-5 31 |
|
ManyToMany | |||
wago-4 31 |
|
ManyToMany | |||
ppw-2 31 |
|
ManyToMany | |||
csr-1 31 |
|
ManyToMany | |||
wago-11 31 |
|
ManyToMany | |||
nrde-3 31 |
|
ManyToMany | |||
hrde-1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv22246 | CNV | loss | 19812545 |
esv2669515 | CNV | deletion | 23128226 |
esv2759604 | CNV | loss | 17122850 |
esv2764071 | CNV | gain | 21179565 |
esv3409921 | CNV | insertion | 20981092 |
esv3543210 | CNV | deletion | 23714750 |
esv3616606 | CNV | loss | 21293372 |
esv3616607 | CNV | loss | 21293372 |
nsv518646 | CNV | gain | 19592680 |
nsv6115 | CNV | insertion | 18451855 |
nsv831264 | CNV | gain+loss | 17160897 |
nsv831265 | CNV | loss | 17160897 |
nsv831266 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
caplan's syndrome |
|
|
cycloplegia |
|
|
acute cor pulmonale |
|
|
acute pulmonary heart disease |
|
|
male infertility |
|
|