This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008] See more...

Aliases for PITX3 Gene

Aliases for PITX3 Gene

  • Paired Like Homeodomain 3 2 3 5
  • Paired-Like Homeodomain Transcription Factor 3 2 4
  • Homeobox Protein PITX3 3 4
  • Pituitary Homeobox 3 3 4
  • PTX3 3 4
  • Anterior Segment Mesenchymal Dysgenesis 2
  • Paired-Like Homeodomain 3 2
  • CTRCT11 3
  • ASGD1 3
  • CTPP4 3
  • ASOD 3
  • ASMD 3

External Ids for PITX3 Gene

Previous HGNC Symbols for PITX3 Gene

  • ASMD

Previous GeneCards Identifiers for PITX3 Gene

  • GC10M102883
  • GC10M103223
  • GC10M104121
  • GC10M103654
  • GC10M103979
  • GC10M097622

Summaries for PITX3 Gene

Entrez Gene Summary for PITX3 Gene

  • This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008]

GeneCards Summary for PITX3 Gene

PITX3 (Paired Like Homeodomain 3) is a Protein Coding gene. Diseases associated with PITX3 include Cataract 11, Multiple Types and Anterior Segment Dysgenesis 1. Among its related pathways are Dopaminergic Neurogenesis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is PITX2.

UniProtKB/Swiss-Prot Summary for PITX3 Gene

  • Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).

Gene Wiki entry for PITX3 Gene

Additional gene information for PITX3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PITX3 Gene

Genomics for PITX3 Gene

GeneHancer (GH) Regulatory Elements for PITX3 Gene

Promoters and enhancers for PITX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102239 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 509.2 -2.6 -2632 8.5 HNRNPK ZBTB40 ZNF217 EP300 SIN3A TCF12 NRF1 USF1 POLR2G SP1 PITX3 GBF1 PPRC1 LDB1 PSD BORCS7 RPARP-AS1 KCNIP2 WBP1L lnc-ELOVL3-1
GH10J102309 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.8 -70.0 -69989 5 JUND TEAD1 TBX3 FOXA2 MAFF SAP130 NR3C1 MAFK PBX2 GATA3 PITX3 FBXL15 GBF1 ELOVL3 PSD POLL piR-42700-020 RF00017-785 L13705-001
GH10J102341 Enhancer 1 FANTOM5 Ensembl ENCODE 20.1 -101.3 -101289 3.6 FOS TEAD4 YY1 NANOG TCF12 ETS1 FOXA1 ZNF335 ZNF18 GATA2 PITX3 GBF1 ELOVL3 NFKB2 NOLC1 PSD FBXL15 C10orf95 MFSD13A ACTR1A
GH10J102267 Enhancer 0.9 Ensembl ENCODE dbSUPER 20.9 -26.4 -26364 5 GATA3 EZH2 ZFP91 CTCF MAX ZNF24 HNF4A FOS ZNF577 EBF1 PITX3 GBF1 ELOVL3 BORCS7 RF00017-784 lnc-ELOVL3-2 L13705-001
GH10J102393 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8 -154.1 -154050 5.1 RXRA ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 MYC POLR2G SP1 NFKB2 lnc-PSD-2 lnc-NFKB2-1 SFXN2 C10orf95 MFSD13A ELOVL3 PITX3 RPARP-AS1 BORCS7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PITX3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PITX3

Top Transcription factor binding sites by QIAGEN in the PITX3 gene promoter:
  • c-Myb
  • C/EBPbeta
  • Cart-1
  • HOXA5
  • Msx-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • POU3F1

Genomic Locations for PITX3 Gene

Genomic Locations for PITX3 Gene
chr10:102,230,186-102,241,512
(GRCh38/hg38)
Size:
11,327 bases
Orientation:
Minus strand
chr10:103,989,943-104,001,231
(GRCh37/hg19)
Size:
11,289 bases
Orientation:
Minus strand

Genomic View for PITX3 Gene

Genes around PITX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PITX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PITX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PITX3 Gene

Proteins for PITX3 Gene

  • Protein details for PITX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75364-PITX3_HUMAN
    Recommended name:
    Pituitary homeobox 3
    Protein Accession:
    O75364
    Secondary Accessions:
    • Q5VZL2

    Protein attributes for PITX3 Gene

    Size:
    302 amino acids
    Molecular mass:
    31832 Da
    Quaternary structure:
    • Interacts with SFPQ.

neXtProt entry for PITX3 Gene

Post-translational modifications for PITX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PITX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PITX3 Gene

Domains & Families for PITX3 Gene

Gene Families for PITX3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for PITX3 Gene

Blocks:
  • Paired-like homeodomain protein, OAR
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PITX3 Gene

GenScript: Design optimal peptide antigens:
  • Paired-like homeodomain transcription factor 3, isoform CRA_a (D3DR82_HUMAN)
  • Paired-like homeodomain transcription factor 3 (PITX3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75364

UniProtKB/Swiss-Prot:

PITX3_HUMAN :
  • Belongs to the paired homeobox family. Bicoid subfamily.
Family:
  • Belongs to the paired homeobox family. Bicoid subfamily.
genes like me logo Genes that share domains with PITX3: view

Function for PITX3 Gene

Molecular function for PITX3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).
GENATLAS Biochemistry:
paired-like homeo domain transcription factor 3,expressed in lens with later expression extending to the midbrain,tongue,incisors,sternum,vertebrae and limbs

Phenotypes From GWAS Catalog for PITX3 Gene

Gene Ontology (GO) - Molecular Function for PITX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001085 RNA polymerase II transcription factor binding IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with PITX3: view
genes like me logo Genes that share phenotypes with PITX3: view

Human Phenotype Ontology for PITX3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PITX3 Gene

MGI Knock Outs for PITX3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PITX3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PITX3 Gene

Localization for PITX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PITX3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PITX3 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PITX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,ISS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PITX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PITX3 Gene

Pathways & Interactions for PITX3 Gene

PathCards logo

SuperPathways for PITX3 Gene

SuperPathway Contained pathways
1 Dopaminergic Neurogenesis
genes like me logo Genes that share pathways with PITX3: view

Pathways by source for PITX3 Gene

1 BioSystems pathway for PITX3 Gene

SIGNOR curated interactions for PITX3 Gene

Activates:

Gene Ontology (GO) - Biological Process for PITX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002088 lens development in camera-type eye ISS --
GO:0002089 lens morphogenesis in camera-type eye ISS --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with PITX3: view

Drugs & Compounds for PITX3 Gene

(2) Drugs for PITX3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PITX3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PITX3: view

Transcripts for PITX3 Gene

mRNA/cDNA for PITX3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PITX3

Alternative Splicing Database (ASD) splice patterns (SP) for PITX3 Gene

No ASD Table

Relevant External Links for PITX3 Gene

GeneLoc Exon Structure for
PITX3

Expression for PITX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PITX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PITX3 Gene

This gene is overexpressed in Muscle - Skeletal (x33.8) and Brain - Substantia nigra (x6.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PITX3

SOURCE GeneReport for Unigene cluster for PITX3 Gene:

Hs.137568

mRNA Expression by UniProt/SwissProt for PITX3 Gene:

O75364-PITX3_HUMAN
Tissue specificity: Highly expressed in developing eye lens.

Evidence on tissue expression from TISSUES for PITX3 Gene

  • Muscle(4.4)
  • Nervous system(2.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PITX3 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with PITX3: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PITX3 Gene

Orthologs for PITX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PITX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PITX3 31 30
  • 99.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PITX3 31 30
  • 91.72 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PITX3 31
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PITX3 31 30
  • 90.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pitx3 17 31 30
  • 89.74 (n)
rat
(Rattus norvegicus)
Mammalia Pitx3 30
  • 89.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PITX3 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PITX3 31 30
  • 70.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PITX3 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pitx3 30
  • 66.55 (n)
zebrafish
(Danio rerio)
Actinopterygii pitx3 31 30
  • 70.2 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ptx1 31 32
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-30 31
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToMany
Species where no ortholog for PITX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PITX3 Gene

ENSEMBL:
Gene Tree for PITX3 (if available)
TreeFam:
Gene Tree for PITX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PITX3: view image

Paralogs for PITX3 Gene

(4) SIMAP similar genes for PITX3 Gene using alignment to 2 proteins:

  • PITX3_HUMAN
  • D3DR82_HUMAN
genes like me logo Genes that share paralogs with PITX3: view

Variants for PITX3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PITX3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
665913 Uncertain Significance: Cataract 11; Anterior segment mesenchymal dysgenesis 102,230,682(-) C/CGCG INFRAME_INSERTION
671634 Likely Benign: not provided 102,231,624(-) G/T SYNONYMOUS_VARIANT
rs104894175 Pathogenic: Cataract 11. Cataract 11, multiple types (CTRCT11) [MIM:610623] 102,232,043(-) C/Tp.Ser13Asn MISSENSE_VARIANT
rs1057518058 Likely Pathogenic: not provided 102,230,777(-) G/A NONSENSE
rs1411557416 Pathogenic: Cataract 11; Anterior segment mesenchymal dysgenesis; not provided. Uncertain Significance: Cataract 11; Anterior segment mesenchymal dysgenesis 102,230,766(-) G/GCCCAGGCCCTGCA GCCCAGGCCCTGCAGG FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for PITX3 Gene

Variation tolerance for PITX3 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PITX3 Gene

Human Gene Mutation Database (HGMD)
PITX3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PITX3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PITX3 Gene

Disorders for PITX3 Gene

MalaCards: The human disease database

(24) MalaCards diseases for PITX3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cataract 11, multiple types
  • ctrct11
anterior segment dysgenesis 1
  • asgd1
cataract-glaucoma
  • cataract-glaucoma syndrome
early-onset posterior polar cataract
posterior polar cataract
  • cataract, posterior polar
- elite association - COSMIC cancer census association via MalaCards
Search PITX3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PITX3_HUMAN
  • Anterior segment dysgenesis 1 (ASGD1) [MIM:107250]: A form of anterior segment dysgenesis, a group of defects affecting anterior structures of the eye including cornea, iris, lens, trabecular meshwork, and Schlemm canal. Anterior segment dysgeneses result from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to components of the anterior chamber during eye development. Different anterior segment anomalies may exist alone or in combination, including iris hypoplasia, enlarged or reduced corneal diameter, corneal vascularization and opacity, posterior embryotoxon, corectopia, polycoria, abnormal iridocorneal angle, ectopia lentis, and anterior synechiae between the iris and posterior corneal surface. Clinical conditions falling within the phenotypic spectrum of anterior segment dysgeneses include aniridia, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis. {ECO:0000269 PubMed:9620774}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cataract 11, multiple types (CTRCT11) [MIM:610623]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT11 includes posterior polar cataract, among others. Posterior polar cataract is a subcapsular opacity, usually disk-shaped, located at the back of the lens. Some CTRCT11 patients can present a severe phenotype including microphthalmia and neurological dysfunction. {ECO:0000269 PubMed:15286169, ECO:0000269 PubMed:9620774}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PITX3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PITX3: view

No data available for Genatlas for PITX3 Gene

Publications for PITX3 Gene

  1. A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD. (PMID: 9620774) Semina EV … Murray JC (Nature genetics 1998) 2 3 4 23 54
  2. Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease. (PMID: 19345444) Haubenberger D … Zimprich A (Neurobiology of aging 2011) 3 41 54
  3. Transcription factor PITX3 gene in Parkinson's disease. (PMID: 19394114) Le W … Jankovic J (Neurobiology of aging 2011) 3 41 54
  4. Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia. (PMID: 20570600) Bergman O … Eriksson E (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 41 54
  5. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L … Alvarez V (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41 54

Products for PITX3 Gene

Sources for PITX3 Gene