Aliases for PITRM1 Gene
External Ids for PITRM1 Gene
Previous GeneCards Identifiers for PITRM1 Gene
The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016]
GeneCards Summary for PITRM1 Gene
PITRM1 (Pitrilysin Metallopeptidase 1) is a Protein Coding gene. Diseases associated with PITRM1 include Alzheimer Disease. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and enzyme activator activity.
UniProtKB/Swiss-Prot for PITRM1 Gene
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.