Aliases for PITPNB Gene
External Ids for PITPNB Gene
Previous GeneCards Identifiers for PITPNB Gene
This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for PITPNB Gene
PITPNB (Phosphatidylinositol Transfer Protein Beta) is a Protein Coding gene. Diseases associated with PITPNB include Cleft Soft Palate and Cerebellopontine Angle Tumor. Among its related pathways are PI Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is PITPNA.
UniProtKB/Swiss-Prot Summary for PITPNB Gene
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109).