This locus is a transcribed pseudogene with similarity to two adjacent chromosome 1 loci: phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (PIP5K1A, GeneID 8394) and proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (PSMD4, GeneID 5710). The pseudogene is believed to have occurred from L1 retrotransposition into chromosome 10 of a read-through transcript betwee... See more...

Aliases for PIPSL Gene

Aliases for PIPSL Gene

  • PIP5K1A And PSMD4 Like (Pseudogene) 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4, Pseudogene 2 2 3
  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type I-Like 1 2 3
  • Putative PIP5K1A And PSMD4-Like Protein 3 4
  • PIP5K1A-PSMD4 3 4
  • PSMD4P2 3 4
  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, Alpha Pseudogene 3
  • Proteasome 26S Non-ATPase Subunit 4 Pseudogene 3
  • PIP5K1A And PSMD4-Like, Pseudogene 2
  • PIP5K1A And PSMD4-Like 2
  • EC 2.7.1.68 52
  • BA429H9.1 3
  • PIP5K1P3 3
  • PIP5K1L1 3
  • EC 2.7.1 52

External Ids for PIPSL Gene

Previous HGNC Symbols for PIPSL Gene

  • PSMD4P2
  • PIP5K1L1

Previous GeneCards Identifiers for PIPSL Gene

  • GC10M095707
  • GC10M089344

Summaries for PIPSL Gene

Entrez Gene Summary for PIPSL Gene

  • This locus is a transcribed pseudogene with similarity to two adjacent chromosome 1 loci: phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (PIP5K1A, GeneID 8394) and proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (PSMD4, GeneID 5710). The pseudogene is believed to have occurred from L1 retrotransposition into chromosome 10 of a read-through transcript between the two adjacent loci. Evidence of transcription has been found (PubMed IDs: 16344562 and 17623810), but the latter publication found no evidence that the predicted protein is translated. The NCBI RefSeq Project therefore continues to treat this as a transcribed pseudogene. [provided by RefSeq, Jan 2009]

GeneCards Summary for PIPSL Gene

PIPSL (PIP5K1A And PSMD4 Like (Pseudogene)) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol phosphate kinase activity.

UniProtKB/Swiss-Prot Summary for PIPSL Gene

  • Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins.

Additional gene information for PIPSL Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIPSL Gene

Genomics for PIPSL Gene

GeneHancer (GH) Regulatory Elements for PIPSL Gene

Promoters and enhancers for PIPSL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J093945 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 0.4 +14.9 14925 2.8 USF1 POLR2A NR3C1 MITF BHLHE40 ESR1 L3MBTL2 ZNF449 USF2 SLC35G1 PLCE1 PIPSL piR-44707
GH10J093955 Enhancer 0.6 Ensembl ENCODE 0.4 +7.2 7200 1.4 FOS FOSL2 NR3C1 FOXA1 CEBPB PLCE1 PIPSL piR-44707 SLC35G1
GH10J093968 Enhancer 0.4 Ensembl ENCODE 0.4 -6.6 -6617 0.9 POLR2A piR-43583-052 piR-56022-050 PLCE1 PIPSL
GH10J093940 Enhancer 0.4 Ensembl ENCODE 0.4 +20.4 20444 1.9 YY1 SLC35G1 PIPSL piR-44707
GH10J093916 Enhancer 0.5 ENCODE 0.3 +44.7 44673 1.1 CTCF USF1 RAD21 SMC3 GATA3 ZNF654 EZH2 TRIM22 YY1 SLC35G1 piR-44707 PIPSL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIPSL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIPSL gene promoter:
  • AML1a
  • c-Ets-1
  • CUTL1
  • GR
  • GR-alpha
  • GR-beta
  • HSF2
  • Sp1
  • STAT1

Genomic Locations for PIPSL Gene

Genomic Locations for PIPSL Gene
chr10:93,958,140-93,961,915
(GRCh38/hg38)
Size:
3,776 bases
Orientation:
Minus strand
chr10:95,717,897-95,721,672
(GRCh37/hg19)
Size:
3,776 bases
Orientation:
Minus strand

Genomic View for PIPSL Gene

Genes around PIPSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIPSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIPSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIPSL Gene

Proteins for PIPSL Gene

  • Protein details for PIPSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2A3N6-PIPSL_HUMAN
    Recommended name:
    Putative PIP5K1A and PSMD4-like protein
    Protein Accession:
    A2A3N6
    Secondary Accessions:
    • Q6NUK8

    Protein attributes for PIPSL Gene

    Size:
    862 amino acids
    Molecular mass:
    95048 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • PIPSL gene appeared in hominoids by L1-mediated retrotransposition in a hominoid ancestor of a readthrough, intergenically spliced transcript between the PIP5K1A and PSMD4 genes.

neXtProt entry for PIPSL Gene

Selected DME Specific Peptides for PIPSL Gene

A2A3N6:
  • GIIDILQ
  • IMDYSLL
  • PTFKDLDFLQD
  • QKALYSTA
  • NIRIVVMNN
  • DGDTVSVHRP
  • PSEGSNLTPAHH
  • LYSTAMESIQG
  • KTLQRDC

Post-translational modifications for PIPSL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PIPSL Gene

Suggested Antigen Peptide Sequences for PIPSL Gene

GenScript: Design optimal peptide antigens:
  • Putative PIP5K1A and PSMD4-like protein (PIPSL_HUMAN)
genes like me logo Genes that share domains with PIPSL: view

No data available for Gene Families , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PIPSL Gene

Function for PIPSL Gene

Molecular function for PIPSL Gene

UniProtKB/Swiss-Prot Function:
Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins.

Enzyme Numbers (IUBMB) for PIPSL Gene

Phenotypes From GWAS Catalog for PIPSL Gene

Gene Ontology (GO) - Molecular Function for PIPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016307 phosphatidylinositol phosphate kinase activity IEA --
genes like me logo Genes that share ontologies with PIPSL: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PIPSL Gene

Localization for PIPSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIPSL Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for PIPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PIPSL: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PIPSL Gene

Pathways & Interactions for PIPSL Gene

PathCards logo

SuperPathways for PIPSL Gene

No Data Available

Interacting Proteins for PIPSL Gene

Selected Interacting proteins: A2A3N6-PIPSL_HUMAN for PIPSL Gene via IID

;

Gene Ontology (GO) - Biological Process for PIPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046854 phosphatidylinositol phosphorylation IEA --
genes like me logo Genes that share ontologies with PIPSL: view

No data available for Pathways by source and SIGNOR curated interactions for PIPSL Gene

Drugs & Compounds for PIPSL Gene

(2) Drugs for PIPSL Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PIPSL: view

Transcripts for PIPSL Gene

mRNA/cDNA for PIPSL Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIPSL Gene

No ASD Table

Relevant External Links for PIPSL Gene

GeneLoc Exon Structure for
PIPSL

Expression for PIPSL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIPSL Gene

mRNA differential expression in normal tissues according to GTEx for PIPSL Gene

This gene is overexpressed in Testis (x13.1).

Protein differential expression in normal tissues from HIPED for PIPSL Gene

This gene is overexpressed in Lung (38.3) and Peripheral blood mononuclear cells (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIPSL Gene



Protein tissue co-expression partners for PIPSL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIPSL

SOURCE GeneReport for Unigene cluster for PIPSL Gene:

Hs.149255

mRNA Expression by UniProt/SwissProt for PIPSL Gene:

A2A3N6-PIPSL_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with PIPSL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIPSL Gene

Orthologs for PIPSL Gene

Evolution for PIPSL Gene

ENSEMBL:
Gene Tree for PIPSL (if available)
TreeFam:
Gene Tree for PIPSL (if available)

No data available for Orthologs for PIPSL Gene

Paralogs for PIPSL Gene

(8) SIMAP similar genes for PIPSL Gene using alignment to 1 proteins:

  • PIPSL_HUMAN
genes like me logo Genes that share paralogs with PIPSL: view

No data available for Paralogs for PIPSL Gene

Variants for PIPSL Gene

Structural Variations from Database of Genomic Variants (DGV) for PIPSL Gene

Variant ID Type Subtype PubMed ID
nsv7495 CNV insertion 18451855
nsv948143 CNV duplication 23825009

Additional Variant Information for PIPSL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIPSL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for PIPSL Gene

Disorders for PIPSL Gene

Additional Disease Information for PIPSL

No disorders were found for PIPSL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIPSL Gene

Publications for PIPSL Gene

  1. A novel testis ubiquitin-binding protein gene arose by exon shuffling in hominoids. (PMID: 17623810) Babushok DV … Kazazian HH (Genome research 2007) 3 4 54
  2. Transcription-mediated gene fusion in the human genome. (PMID: 16344562) Akiva P … Sorek R (Genome research 2006) 2 3 54
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

Products for PIPSL Gene

Sources for PIPSL Gene