Aliases for PIPOX Gene

Aliases for PIPOX Gene

  • Pipecolic Acid And Sarcosine Oxidase 2 3 5
  • L-Pipecolic Acid Oxidase 2 3 4
  • LPIPOX 2 3 4
  • Peroxisomal Sarcosine Oxidase 3 4
  • Pipecolic Acid Oxidase 2 3
  • L-Pipecolate Oxidase 3 4
  • PSO 3 4
  • EC 4
  • EC 4
  • PIPOX 5

External Ids for PIPOX Gene

Previous GeneCards Identifiers for PIPOX Gene

  • GC17U990195
  • GC17P029269
  • GC17P027221
  • GC17P027515
  • GC17P024394
  • GC17P027369
  • GC17P023579
  • GC17P027277

Summaries for PIPOX Gene

GeneCards Summary for PIPOX Gene

PIPOX (Pipecolic Acid And Sarcosine Oxidase) is a Protein Coding gene. Diseases associated with PIPOX include Inflammatory Bowel Disease 15 and Zellweger Syndrome. Among its related pathways are Lysine degradation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and sarcosine oxidase activity.

UniProtKB/Swiss-Prot Summary for PIPOX Gene

Additional gene information for PIPOX Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIPOX Gene

Genomics for PIPOX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PIPOX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIPOX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIPOX

Top Transcription factor binding sites by QIAGEN in the PIPOX gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • Pax-4a
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for PIPOX Gene

Genomic Locations for PIPOX Gene
106,715 bases
Plus strand
106,706 bases
Plus strand

Genomic View for PIPOX Gene

Genes around PIPOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIPOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIPOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIPOX Gene

Proteins for PIPOX Gene

  • Protein details for PIPOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peroxisomal sarcosine oxidase
    Protein Accession:
    Secondary Accessions:
    • B3KNH0
    • Q96H28
    • Q9C070

    Protein attributes for PIPOX Gene

    390 amino acids
    Molecular mass:
    44066 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer.

neXtProt entry for PIPOX Gene

Post-translational modifications for PIPOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIPOX Gene

Antibody Products

No data available for DME Specific Peptides for PIPOX Gene

Domains & Families for PIPOX Gene

Gene Families for PIPOX Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PIPOX Gene

Suggested Antigen Peptide Sequences for PIPOX Gene

GenScript: Design optimal peptide antigens:
  • PIPOX protein (Q6IAJ9_HUMAN)
  • Pipecolic acid oxidase (Q8N6Z6_HUMAN)
  • L-pipecolic acid oxidase (SOX_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MSOX/MTOX family.
  • Belongs to the MSOX/MTOX family.
genes like me logo Genes that share domains with PIPOX: view

Function for PIPOX Gene

Molecular function for PIPOX Gene

UniProtKB/Swiss-Prot Function:
Metabolizes sarcosine, L-pipecolic acid and L-proline.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O2 + sarcosine = formaldehyde + glycine + H2O2; Xref=Rhea:RHEA:13313, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:57305, ChEBI:CHEBI:57433; EC=;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate; Xref=Rhea:RHEA:11992, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58769, ChEBI:CHEBI:61185; EC=;.

Enzyme Numbers (IUBMB) for PIPOX Gene

Phenotypes From GWAS Catalog for PIPOX Gene

Gene Ontology (GO) - Molecular Function for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0008115 sarcosine oxidase activity IBA,IDA 10642506
GO:0016491 oxidoreductase activity IEA --
GO:0050031 L-pipecolate oxidase activity TAS --
genes like me logo Genes that share ontologies with PIPOX: view
genes like me logo Genes that share phenotypes with PIPOX: view

Animal Models for PIPOX Gene

MGI Knock Outs for PIPOX:
  • Pipox Pipox<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for PIPOX Gene

miRTarBase miRNAs that target PIPOX

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIPOX

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIPOX Gene

Localization for PIPOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIPOX Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIPOX gene
Compartment Confidence
peroxisome 5
cytosol 4
plasma membrane 2
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IBA,IDA 10642506
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PIPOX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIPOX Gene

Pathways & Interactions for PIPOX Gene

genes like me logo Genes that share pathways with PIPOX: view

Gene Ontology (GO) - Biological Process for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006554 lysine catabolic process TAS --
GO:0006625 protein targeting to peroxisome TAS --
GO:0033514 L-lysine catabolic process to acetyl-CoA via L-pipecolate IBA,IDA 10642506
GO:0046653 tetrahydrofolate metabolic process IEA --
GO:0055114 oxidation-reduction process IEA,IDA 10642506
genes like me logo Genes that share ontologies with PIPOX: view

No data available for SIGNOR curated interactions for PIPOX Gene

Drugs & Compounds for PIPOX Gene

(8) Drugs for PIPOX Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Agonist, Full agonist, Target, product of 196
FAD Approved Pharma 0
Formaldehyde Approved, Vet_approved Pharma 142
Hydrogen peroxide Approved, Vet_approved Pharma 115
Oxygen Approved, Vet_approved Pharma 0

(4) Additional Compounds for PIPOX Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pipecolic acid
  • 2-Piperidinecarboxylic acid
  • Homoproline
  • Pipecolinic acid
  • 2-Piperidinecarboxylate
  • Pipecolate
  • (S)-2,3,4,5-Tetrahydropyridine-2-carboxylic acid
  • delta1-Piperideine-6-L-carboxylate
  • Delta(1)-Piperideine-6-L-carboxylic acid
  • (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
  • (S)-1-Piperideine-6-carboxylate
D-1-Piperideine-2-carboxylic acid
  • 1,2-Didehydropiperidine-2-carboxylate
  • Delta(1)-Piperidine-2-carboxylic acid
  • 1,2-Didehydropiperidine-2-carboxylic acid
  • D-1-Piperideine-2-carboxylate
  • delta(1)-Piperidine-2-carboxylate
L-Pipecolic acid
  • (S)-(-)-Pipecolic acid
  • (S)-Pipecolic acid
  • (S)-Piperidine-2-carboxylic acid
  • 2-Piperidinecarboxylic acid
  • L-(-)-Pipecolic acid
genes like me logo Genes that share compounds with PIPOX: view

Transcripts for PIPOX Gene

mRNA/cDNA for PIPOX Gene

8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIPOX

Alternative Splicing Database (ASD) splice patterns (SP) for PIPOX Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - -
SP6: - - - - - -

Relevant External Links for PIPOX Gene

GeneLoc Exon Structure for

Expression for PIPOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIPOX Gene

mRNA differential expression in normal tissues according to GTEx for PIPOX Gene

This gene is overexpressed in Liver (x31.3) and Kidney - Cortex (x7.0).

Protein differential expression in normal tissues from HIPED for PIPOX Gene

This gene is overexpressed in Gallbladder (34.3), Liver, secretome (19.1), Liver (8.1), and Kidney (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIPOX Gene

Protein tissue co-expression partners for PIPOX Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIPOX

SOURCE GeneReport for Unigene cluster for PIPOX Gene:


Evidence on tissue expression from TISSUES for PIPOX Gene

  • Liver(4.7)
  • Muscle(4.4)
  • Adrenal gland(4.3)
  • Nervous system(3.6)
  • Kidney(3.1)
  • Skin(2.6)
  • Heart(2.2)
  • Blood(2.1)
  • Intestine(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with PIPOX: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIPOX Gene

Orthologs for PIPOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIPOX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIPOX 30 31
  • 99.66 (n)
(Bos Taurus)
Mammalia PIPOX 30 31
  • 87.61 (n)
(Canis familiaris)
Mammalia PIPOX 30 31
  • 86.75 (n)
(Rattus norvegicus)
Mammalia Pipox 30
  • 82.31 (n)
(Mus musculus)
Mammalia Pipox 30 17 31
  • 81.79 (n)
(Ornithorhynchus anatinus)
Mammalia PIPOX 31
  • 68 (a)
(Monodelphis domestica)
Mammalia PIPOX 31
  • 68 (a)
(Gallus gallus)
Aves PIPOX 30 31
  • 62.69 (n)
(Anolis carolinensis)
Reptilia PIPOX 31
  • 58 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pipox 30
  • 62.32 (n)
(Danio rerio)
Actinopterygii pipox 30 31
  • 59.76 (n)
(Caenorhabditis elegans)
Secernentea C15B12.1 30 31 32
  • 46.54 (n)
C15B12.8 31 32
  • 31 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G24580 30
  • 48.05 (n)
(Oryza sativa)
Liliopsida Os01g0316100 30
  • 48.68 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
Bread mold
(Neurospora crassa)
Ascomycetes NCU04771 30
  • 41.72 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fap1 30
  • 40.52 (n)
Species where no ortholog for PIPOX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PIPOX Gene

Gene Tree for PIPOX (if available)
Gene Tree for PIPOX (if available)
Evolutionary constrained regions (ECRs) for PIPOX: view image

Paralogs for PIPOX Gene

No data available for Paralogs for PIPOX Gene

Variants for PIPOX Gene

Additional dbSNP identifiers (rs#s) for PIPOX Gene

Structural Variations from Database of Genomic Variants (DGV) for PIPOX Gene

Variant ID Type Subtype PubMed ID
esv2672779 CNV deletion 23128226
nsv833408 CNV loss 17160897

Variation tolerance for PIPOX Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIPOX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIPOX Gene

Disorders for PIPOX Gene

MalaCards: The human disease database

(8) MalaCards diseases for PIPOX Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
inflammatory bowel disease 15
  • ibd15
zellweger syndrome
  • zs
peroxisome biogenesis disorder 1b
  • pbd1b
functional colonic disease
  • colonic diseases, functional
  • inflammation of tendon sheath
- elite association - COSMIC cancer census association via MalaCards
Search PIPOX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PIPOX

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PIPOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIPOX Gene

Publications for PIPOX Gene

  1. Molecular cloning and expression of human L-pipecolate oxidase. (PMID: 10772957) IJlst L … Wanders RJ (Biochemical and biophysical research communications 2000) 2 3 4 23
  2. L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases. (PMID: 10642506) Dodt G … Mihalik SJ (The Biochemical journal 2000) 2 3 4 23
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PIPOX Gene

Sources for PIPOX Gene