PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009] See more...

Aliases for PIP5KL1 Gene

Aliases for PIP5KL1 Gene

  • Phosphatidylinositol-4-Phosphate 5-Kinase Like 1 2 3 5
  • Phosphatidylinositol 4-Phosphate 5-Kinase-Like Protein 1 3 4
  • PtdIns(4)P-5-Kinase-Like Protein 1 3 4
  • PI(4)P 5-Kinase-Like Protein 1 3 4
  • Phosphatidylinositol-4-Phosphate 5-Kinase-Like 1 2
  • Phosphatidylinositol Phosphate Kinase Homolog 3
  • EC 2.7.1.68 4
  • BA203J24.5 2
  • MGC46424 2
  • PIP5KL1 5
  • PIPKH 3

External Ids for PIP5KL1 Gene

Previous GeneCards Identifiers for PIP5KL1 Gene

  • GC09M126060
  • GC09M127763
  • GC09M129723
  • GC09M130683
  • GC09M100300

Summaries for PIP5KL1 Gene

Entrez Gene Summary for PIP5KL1 Gene

  • PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]

GeneCards Summary for PIP5KL1 Gene

PIP5KL1 (Phosphatidylinositol-4-Phosphate 5-Kinase Like 1) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol phosphate kinase activity and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP5K1C.

UniProtKB/Swiss-Prot Summary for PIP5KL1 Gene

  • May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIP5KL1 Gene

Genomics for PIP5KL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PIP5KL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J127929 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 274 +0.8 767 2.6 SP1 NCOR1 ZNF600 IKZF1 ZMYM3 ATF2 CEBPA ZNF10 POLR2A ZIC2 PIP5KL1 CDK9 CIZ1 SPOUT1 ODF2 lnc-DPM2-2 ST6GALNAC4 RF00017-7346
GH09J127926 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 270.7 +4.4 4395 2 MYC POLR2A MNT SIN3A NKRF SMARCA4 ZEB2 TAF1 ZBTB33 NRF1 PIP5KL1 lnc-DPM2-2 lnc-ST6GALNAC4-1 ST6GALNAC4 RF00017-7346
GH09J127932 Enhancer 0.4 dbSUPER 250.7 -1.2 -1164 0.7 ZNF341 SUPT5H POLR2A KLF8 ENSG00000227218 PIP5KL1 CIZ1 DPM2 RF00017-7346
GH09J127935 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 28.4 -5.4 -5385 4.3 NCOR1 IKZF1 MYC SIX5 ZNF580 POLR2A CHD4 YY1 MXD4 SIN3A DPM2 lnc-DPM2-1 PIP5KL1 SNORA65 ZNF79 NAIF1 ST6GALNAC6 AK1 FAM102A ENSG00000230848
GH09J127962 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 27.9 -41.4 -41390 22.2 BCLAF1 SP1 NCOR1 ZNF600 MYC IKZF1 SSRP1 JUND ZNF592 ATF2 ENSG00000228510 PIP5KL1 DPM2 NAIF1 ENSG00000227218 SNORA65 SLC25A25 FPGS LOC102723566 ZNF79
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIP5KL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIP5KL1

Top Transcription factor binding sites by QIAGEN in the PIP5KL1 gene promoter:
  • aMEF-2
  • MEF-2
  • MEF-2A
  • Pax-4a

Genomic Locations for PIP5KL1 Gene

Latest Assembly
chr9:127,920,881-127,931,958
(GRCh38/hg38)
Size:
11,078 bases
Orientation:
Minus strand

Previous Assembly
chr9:130,683,160-130,693,056
(GRCh37/hg19 by Entrez Gene)
Size:
9,897 bases
Orientation:
Minus strand

chr9:130,683,158-130,693,076
(GRCh37/hg19 by Ensembl)
Size:
9,919 bases
Orientation:
Minus strand

Genomic View for PIP5KL1 Gene

Genes around PIP5KL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP5KL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP5KL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP5KL1 Gene

Proteins for PIP5KL1 Gene

  • Protein details for PIP5KL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9C9-PI5L1_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
    Protein Accession:
    Q5T9C9
    Secondary Accessions:
    • Q8IVS3

    Protein attributes for PIP5KL1 Gene

    Size:
    394 amino acids
    Molecular mass:
    44572 Da
    Quaternary structure:
    • Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase.

    Alternative splice isoforms for PIP5KL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP5KL1 Gene

Post-translational modifications for PIP5KL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP5KL1 Gene

No data available for DME Specific Peptides for PIP5KL1 Gene

Domains & Families for PIP5KL1 Gene

Gene Families for PIP5KL1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PIP5KL1 Gene

InterPro:
Blocks:
  • Phosphatidylinositol-4-phosphate 5-kinase

Suggested Antigen Peptide Sequences for PIP5KL1 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylinositol-4-phosphate 5-kinase-like protein 1 (PI5L1_HUMAN)
genes like me logo Genes that share domains with PIP5KL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PIP5KL1 Gene

Function for PIP5KL1 Gene

Molecular function for PIP5KL1 Gene

UniProtKB/Swiss-Prot Function:
May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68;.

Enzyme Numbers (IUBMB) for PIP5KL1 Gene

Phenotypes From GWAS Catalog for PIP5KL1 Gene

Gene Ontology (GO) - Molecular Function for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity IEA --
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA --
genes like me logo Genes that share ontologies with PIP5KL1: view
genes like me logo Genes that share phenotypes with PIP5KL1: view

miRNA for PIP5KL1 Gene

miRTarBase miRNAs that target PIP5KL1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIP5KL1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP5KL1 Gene

Localization for PIP5KL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP5KL1 Gene

Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIP5KL1 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with PIP5KL1: view

Pathways & Interactions for PIP5KL1 Gene

genes like me logo Genes that share pathways with PIP5KL1: view

Pathways by source for PIP5KL1 Gene

Gene Ontology (GO) - Biological Process for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 19680787
GO:0010917 negative regulation of mitochondrial membrane potential IDA 16751333
GO:0016310 phosphorylation IEA --
GO:0030336 negative regulation of cell migration IMP 19680787
GO:0043065 positive regulation of apoptotic process IDA 16751333
genes like me logo Genes that share ontologies with PIP5KL1: view

No data available for SIGNOR curated interactions for PIP5KL1 Gene

Drugs & Compounds for PIP5KL1 Gene

(2) Drugs for PIP5KL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for PIP5KL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIP5KL1: view

Transcripts for PIP5KL1 Gene

mRNA/cDNA for PIP5KL1 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIP5KL1

Alternative Splicing Database (ASD) splice patterns (SP) for PIP5KL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for PIP5KL1 Gene

GeneLoc Exon Structure for
PIP5KL1

Expression for PIP5KL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIP5KL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIP5KL1 Gene

This gene is overexpressed in Monocytes (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIP5KL1 Gene



Protein tissue co-expression partners for PIP5KL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIP5KL1

SOURCE GeneReport for Unigene cluster for PIP5KL1 Gene:

Hs.734928

Evidence on tissue expression from TISSUES for PIP5KL1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with PIP5KL1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP5KL1 Gene

Orthologs for PIP5KL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIP5KL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PIP5KL1 29 30
  • 99.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PIP5KL1 29 30
  • 90.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PIP5KL1 29 30
  • 88.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pip5kl1 29
  • 81.18 (n)
Mouse
(Mus musculus)
Mammalia Pip5kl1 29 16 30
  • 78.8 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PIP5KL1 30
  • 64 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PIP5KL1 30
  • 52 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii pip5kl1 30
  • 48 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSS4 30
  • 13 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8691 30
  • 32 (a)
OneToOne
Species where no ortholog for PIP5KL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PIP5KL1 Gene

ENSEMBL:
Gene Tree for PIP5KL1 (if available)
TreeFam:
Gene Tree for PIP5KL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIP5KL1: view image
Alliance of Genome Resources:
Additional Orthologs for PIP5KL1

Paralogs for PIP5KL1 Gene

Paralogs for PIP5KL1 Gene

genes like me logo Genes that share paralogs with PIP5KL1: view

Variants for PIP5KL1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PIP5KL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PIP5KL1 Gene

Variant ID Type Subtype PubMed ID
esv3621797 CNV gain 21293372
nsv466577 CNV loss 19166990
nsv615381 CNV loss 21841781
nsv6722 CNV insertion 18451855
nsv831727 CNV loss 17160897

Variation tolerance for PIP5KL1 Gene

Gene Damage Index Score: 1.16; 23.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIP5KL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIP5KL1
Leiden Open Variation Database (LOVD)
PIP5KL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIP5KL1 Gene

Disorders for PIP5KL1 Gene

Additional Disease Information for PIP5KL1

No disorders were found for PIP5KL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP5KL1 Gene

Publications for PIP5KL1 Gene

  1. Identification and characterization of a phosphoinositide phosphate kinase homolog. (PMID: 14701839) Chang JD … Cantley LC (The Journal of biological chemistry 2004) 3 22
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P2 distribution and the localization of small G-proteins. (PMID: 31616009) Yang Y … Fairn GD (Scientific reports 2019) 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. Phosphoinositide 3-kinase signaling in the vertebrate retina. (PMID: 19638643) Rajala RV (Journal of lipid research 2010) 22

Products for PIP5KL1 Gene

  • Biorbyt antibodies for PIP5KL1

Sources for PIP5KL1 Gene