Aliases for PIP4P2 Gene
External Ids for PIP4P2 Gene
Previous HGNC Symbols for PIP4P2 Gene
TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PIP4P2 Gene
PIP4P2 (Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and 3-phosphoinositide degradation. An important paralog of this gene is PIP4P1.
UniProtKB/Swiss-Prot Summary for PIP4P2 Gene
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity).