TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008] See more...

Aliases for PIP4P2 Gene

Aliases for PIP4P2 Gene

  • Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2 2 3 5
  • Transmembrane Protein 55A 2 3 4
  • Type 2 Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase 3 4
  • Type II PtdIns-4,5-P(2) 4-Phosphatase 2 3
  • Type 2 PtdIns-4,5-P2 4-Ptase 3 4
  • PtdIns-4,5-P2 4-Ptase II 3 4
  • EC 3.1.3.78 4 50
  • TMEM55A 3 4
  • Type II Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2
  • Type II Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase 3
  • PtdIns-4,5-P(2) 4-Phosphatase Type II 3
  • DKFZp762O076 2
  • PIP4P2 5

External Ids for PIP4P2 Gene

Previous HGNC Symbols for PIP4P2 Gene

  • TMEM55A

Summaries for PIP4P2 Gene

Entrez Gene Summary for PIP4P2 Gene

  • TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PIP4P2 Gene

PIP4P2 (Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and 3-phosphoinositide degradation. An important paralog of this gene is PIP4P1.

UniProtKB/Swiss-Prot Summary for PIP4P2 Gene

  • Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIP4P2 Gene

Genomics for PIP4P2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PIP4P2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J091038 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.8 751 4.3 MYC NCOR1 IKZF1 CEBPA NFIC POLR2A CTCF CEBPB SMAD5 ETS1 PIP4P2 OTUD6B-AS1 SLC26A7 LRRC69 ENSG00000254251 RF00100-031 C8orf88
GH08J091068 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.3 -29.0 -29005 3.4 SP1 NCOR1 MYC IKZF1 ZNF580 POLR2A CEBPA ZNF10 ATF3 BRCA1 OTUD6B-AS1 OTUD6B PIP4P2 C8orf88 SLC26A7 ENSG00000246792 LRRC69 lnc-OTUD6B-2
GH08J091033 Enhancer 0.2 FANTOM5 4.6 +7.2 7206 0 PIP4P2 RF00100-031 C8orf88
GH08J091037 Promoter/Enhancer 0.7 Ensembl ENCODE 0.7 +3.3 3295 0.4 CEBPB CEBPG SLC26A7 OTUD6B-AS1 PIP4P2 RF00100-031 C8orf88
GH08J091032 Enhancer 0.6 ENCODE 0.4 +8.7 8668 0.2 CEBPA IRF4 SPI1 HNF4A CEBPG CEBPB IKZF1 NFIL3 HLF IKZF2 OTUD6B-AS1 RF00100-031 PIP4P2 C8orf88
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIP4P2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIP4P2

Genomic Locations for PIP4P2 Gene

Latest Assembly
chr8:90,993,802-91,040,896
(GRCh38/hg38)
Size:
47,095 bases
Orientation:
Minus strand

Previous Assembly
chr8:92,006,030-92,053,087
(GRCh37/hg19 by Entrez Gene)
Size:
47,058 bases
Orientation:
Minus strand

chr8:92,006,024-92,053,292
(GRCh37/hg19 by Ensembl)
Size:
47,269 bases
Orientation:
Minus strand

Genomic View for PIP4P2 Gene

Genes around PIP4P2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP4P2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP4P2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP4P2 Gene

Proteins for PIP4P2 Gene

  • Protein details for PIP4P2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4L2-PP4P2_HUMAN
    Recommended name:
    Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Q8N4L2
    Secondary Accessions:
    • B2R9H4
    • Q68CU2

    Protein attributes for PIP4P2 Gene

    Size:
    257 amino acids
    Molecular mass:
    28081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIP4P2 Gene

Selected DME Specific Peptides for PIP4P2 Gene

Q8N4L2:
  • VCNEATPIK
  • GKKYVRCPCNCLLICK
  • RIINLGP
  • SSVGSALPRRRCC
  • RACYWGAI
  • HQHVVKC
  • ERSPLLS

Post-translational modifications for PIP4P2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP4P2 Gene

Domains & Families for PIP4P2 Gene

Gene Families for PIP4P2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PIP4P2 Gene

InterPro:

Suggested Antigen Peptide Sequences for PIP4P2 Gene

GenScript: Design optimal peptide antigens:
  • Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase (TM55A_HUMAN)
genes like me logo Genes that share domains with PIP4P2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PIP4P2 Gene

Function for PIP4P2 Gene

Molecular function for PIP4P2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:25674, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456; EC=3.1.3.78; Evidence={ECO:0000269|PubMed:16365287};.

Enzyme Numbers (IUBMB) for PIP4P2 Gene

Phenotypes From GWAS Catalog for PIP4P2 Gene

Gene Ontology (GO) - Molecular Function for PIP4P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0016787 hydrolase activity IEA --
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA,IDA 16365287
genes like me logo Genes that share ontologies with PIP4P2: view

Phenotypes for PIP4P2 Gene

genes like me logo Genes that share phenotypes with PIP4P2: view

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP4P2 Gene

Localization for PIP4P2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP4P2 Gene

Late endosome membrane. Multi-pass membrane protein. Lysosome membrane. Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIP4P2 gene
Compartment Confidence
plasma membrane 5
endosome 5
lysosome 5
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PIP4P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 16365287
GO:0005768 endosome IEA --
GO:0005886 plasma membrane ISS --
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with PIP4P2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIP4P2 Gene

Pathways & Interactions for PIP4P2 Gene

genes like me logo Genes that share pathways with PIP4P2: view

Pathways by source for PIP4P2 Gene

Gene Ontology (GO) - Biological Process for PIP4P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046856 phosphatidylinositol dephosphorylation IEA,IDA 16365287
GO:0050765 negative regulation of phagocytosis IEA,ISS --
genes like me logo Genes that share ontologies with PIP4P2: view

No data available for SIGNOR curated interactions for PIP4P2 Gene

Drugs & Compounds for PIP4P2 Gene

(2) Drugs for PIP4P2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0

(379) Additional Compounds for PIP4P2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphoric acid
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(32:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1W7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phospho-D-myo-inositol
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
182509-29-1
genes like me logo Genes that share compounds with PIP4P2: view

Transcripts for PIP4P2 Gene

mRNA/cDNA for PIP4P2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PIP4P2 Gene

No ASD Table

Relevant External Links for PIP4P2 Gene

GeneLoc Exon Structure for
PIP4P2

Expression for PIP4P2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIP4P2

mRNA Expression by UniProt/SwissProt for PIP4P2 Gene:

Q8N4L2-PP4P2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PIP4P2 Gene

  • Nervous system(4.6)
  • Kidney(4.2)
  • Liver(4.1)

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP4P2 Gene

Orthologs for PIP4P2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIP4P2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM55A 29 30
  • 99.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM55A 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM55A 29 30
  • 91.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM55A 29 30
  • 91.44 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem55a 29 30
  • 90.53 (n)
OneToOne
Pip4p2 16
Rat
(Rattus norvegicus)
Mammalia Tmem55a 29
  • 89.49 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM55A 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM55A 29 30
  • 85.99 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM55A 30
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem55a 29
  • 79.95 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmem55a 29 30
  • 75.88 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6707 30
  • 42 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 30
  • 36 (a)
OneToMany
Species where no ortholog for PIP4P2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PIP4P2 Gene

ENSEMBL:
Gene Tree for PIP4P2 (if available)
TreeFam:
Gene Tree for PIP4P2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIP4P2: view image
Alliance of Genome Resources:
Additional Orthologs for PIP4P2

Paralogs for PIP4P2 Gene

Paralogs for PIP4P2 Gene

genes like me logo Genes that share paralogs with PIP4P2: view

Variants for PIP4P2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PIP4P2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PIP4P2 Gene

Variant ID Type Subtype PubMed ID
esv2443764 CNV deletion 19546169
esv2759629 CNV loss 17122850
esv3618011 CNV loss 21293372
nsv1028201 CNV loss 25217958
nsv475564 CNV novel sequence insertion 20440878
nsv6300 CNV insertion 18451855
nsv831390 CNV gain 17160897

Variation tolerance for PIP4P2 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIP4P2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIP4P2
Leiden Open Variation Database (LOVD)
PIP4P2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIP4P2 Gene

Disorders for PIP4P2 Gene

Additional Disease Information for PIP4P2

No disorders were found for PIP4P2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP4P2 Gene

Publications for PIP4P2 Gene

  1. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A … Majerus PW (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair. (PMID: 31900314) Chen Z … Chen J (Molecular & cellular proteomics : MCP 2020) 3
  5. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. (PMID: 30471916) Lum KK … Cristea IM (Cell systems 2018) 3

Products for PIP4P2 Gene

Sources for PIP4P2 Gene