Aliases for PIP4P1 Gene
- Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 1 2 3 5
- Transmembrane Protein 55B 2 3 4
- Type I Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2 3
- Type 1 Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase 3 4
- Type I PtdIns-4,5-P(2) 4-Phosphatase 2 3
- Type 1 PtdIns-4,5-P2 4-Ptase 3 4
- PtdIns-4,5-P2 4-Ptase I 3 4
External Ids for PIP4P1 Gene
Previous HGNC Symbols for PIP4P1 Gene
TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PIP4P1 Gene
PIP4P1 (Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 1) is a Protein Coding gene. Diseases associated with PIP4P1 include Lung Mucoepidermoid Carcinoma and Meniere Disease. Among its related pathways are Glycerophospholipid biosynthesis and Regulation of TP53 Activity through Acetylation. An important paralog of this gene is PIP4P2.
UniProtKB/Swiss-Prot Summary for PIP4P1 Gene
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345).