Aliases for PIP4K2C Gene
Aliases for PIP4K2C Gene
External Ids for PIP4K2C Gene
- HGNC: 23786
- Entrez Gene: 79837
- Ensembl: ENSG00000166908
- OMIM: 617104
- UniProtKB: Q8TBX8
Previous HGNC Symbols for PIP4K2C Gene
- PIP5K2C
Previous GeneCards Identifiers for PIP4K2C Gene
- GC12P056272
- GC12P057985
- GC12P055022
Summaries for PIP4K2C Gene
GeneCards Summary for PIP4K2C Gene
PIP4K2C (Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity through Acetylation and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and 1-phosphatidylinositol-5-phosphate 4-kinase activity. An important paralog of this gene is PIP4K2B.
UniProtKB/Swiss-Prot for PIP4K2C Gene
-
May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.
Additional gene information for PIP4K2C Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP4K2C Gene
Genomics for PIP4K2C Gene
GeneHancer (GH) Regulatory Elements for PIP4K2C Gene
Promoters and enhancers for PIP4K2C Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12I057590 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 550.8 | +0.3 | 262 | 1.9 | HDGF SMAD1 FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF766 E2F8 ZNF207 | PIP4K2C ENSG00000224713 NEMP1 SLC26A10 LOC283387 TSPAN31 TSFM EEF1AKMT3 ARHGEF25 CDK4 | |
| GH12I057592 | Enhancer | 0.5 | FANTOM5 ENCODE | 550.8 | +1.6 | 1610 | 0.5 | PIP4K2C KIF5A ARHGEF25 B4GALNT1 DTX3 AGAP2 R3HDM2 | ||
| GH12I057608 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE dbSUPER | 5 | +19.5 | 19481 | 3.7 | HDGF ARID4B SIN3A DMAP1 ZNF48 POLR2B GLIS2 ZNF143 ATF7 SP3 | ARHGEF25 ENSG00000224713 TSFM OS9 EEF1AKMT3 PIP4K2C SLC26A10 DTX3 | |
| GH12I057603 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE dbSUPER | 0.4 | +13.6 | 13617 | 3.2 | ZNF76 SIN3A FEZF1 ZNF2 RFX5 YY1 ZNF335 POLR2B SCRT2 EGR2 | DTX3 ENSG00000224713 ARHGEF25 PIP4K2C |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PIP4K2C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PIP4K2C Gene
Genomic Locations for PIP4K2C Gene
- chr12:57,591,159-57,603,428
- (GRCh38/hg38)
- Size:
- 12,270 bases
- Orientation:
- Plus strand
- chr12:57,984,942-57,997,211
- (GRCh37/hg19)
Genomic View for PIP4K2C Gene
Genes around PIP4K2C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.3 by Ensembl
- 12q13.3 by Entrez Gene
- 12q13.3 by HGNC
PIP4K2C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIP4K2C Gene
Proteins for PIP4K2C Gene
-
Protein details for PIP4K2C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TBX8-PI42C_HUMAN
- Recommended name:
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
- Protein Accession:
- Q8TBX8
- B2RDL3
- B4DM11
- B4DY44
- Q9H6N2
Protein attributes for PIP4K2C Gene
- Size:
- 421 amino acids
- Molecular mass:
- 47300 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB15223.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PIP4K2C Gene
Selected DME Specific Peptides for PIP4K2C Gene
- Q8TBX8:
-
- KTKKKHFV
- KELPTLKDMDFLNK
- REASDKEK
- LKIMDYSLLLGIHD
- IMDYSLL
- KRFLDFI
- APQKEVYFMGLIDILT
- PLGPGEF
- VMRNMFSHRL
- TLLPQFLGMYR
- QQKVKVFRA
- VKHGAGAEISTV
- VGSYGTSPEGI
- RENLPSHFKFK
- RKYDLKGS
- FKFKEYCP
- PVMLLPDDFKA
- MDFLNKNQKVYIGE
- FLEKLKRDVEFL
- DYSLLLG
- VHRKYDLKGS
Post-translational modifications for PIP4K2C Gene
Other Protein References for PIP4K2C Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PIP4K2C
- Novus Biologicals Antibodies for PIP4K2C
-
Abcam antibodies for PIP4K2C
- Invitrogen Antibodies for PIP4K2C
- GeneTex PIP4K2C antibody for PIP4K2C
Protein Products
-
OriGene Purified Proteins for PIP4K2C
- Search Origene for MassSpec and Protein Over-expression Lysates for PIP4K2C
- Origene Custom Protein Services for PIP4K2C
- Search GeneTex for Proteins for PIP4K2C
-
Abcam proteins for PIP4K2C
Assay Products
Domains & Families for PIP4K2C Gene
Gene Families for PIP4K2C Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PIP4K2C Gene
Suggested Antigen Peptide Sequences for PIP4K2C Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA PSEC0253 fis, clone NT2RP3003368, highly similar to Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type II, gamma (PIP5K2C), mRNA (B3KQV3_HUMAN)
- cDNA FLJ60683, highly similar to Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type II, gamma (PIP5K2C), mRNA (B4DM11_HUMAN)
- cDNA FLJ52923, highly similar to Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type II, gamma (PIP5K2C), mRNA (B4DY44_HUMAN)
- Phosphatidylinositol-5-phosphate 4-kinase type II gamma (PI42C_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PIP4K2C Gene
Function for PIP4K2C Gene
Molecular function for PIP4K2C Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
- UniProtKB/Swiss-Prot Function:
- May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.
Enzyme Numbers (IUBMB) for PIP4K2C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0016307 | phosphatidylinositol phosphate kinase activity | IEA | -- |
| GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity | EXP | 23758345 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for PIP4K2C Gene
- MGI mutant phenotypes for PIP4K2C:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PIP4K2C:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Decreased viability
- Decreased shRNA abundance
- Increased simian virus 40 (SV40) infection
- Increased cell size
Animal Models for PIP4K2C Gene
- MGI Knock Outs for PIP4K2C:
-
- Pip4k2c tm1b(KOMP)Wtsi
Animal Model Products
-
Taconic Biosciences Mouse Models for PIP4K2C
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIP4K2C
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PIP4K2C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIP4K2C gene
- Search ViGene Biosciences for PIP4K2C
CRISPR Products
-
OriGene CRISPR knockouts for PIP4K2C
- genomics-online: gRNA clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
- Applied Biological Materials CRISPR for PIP4K2C
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIP4K2C
- GenScript: Design CRISPR guide RNA sequences for PIP4K2C
miRNA for PIP4K2C Gene
- miRTarBase miRNAs that target PIP4K2C
-
- hsa-mir-193b-3p (MIRT016341)
- hsa-mir-877-3p (MIRT036860)
- hsa-mir-125b-5p (MIRT045985)
- hsa-mir-101-5p (MIRT066165)
- hsa-mir-142-5p (MIRT066166)
- hsa-mir-374a-3p (MIRT066167)
- hsa-mir-340-5p (MIRT066168)
- hsa-mir-545-3p (MIRT066169)
- hsa-mir-921 (MIRT066171)
- hsa-mir-3174 (MIRT066175)
- hsa-mir-3617-3p (MIRT066177)
- hsa-mir-548at-5p (MIRT066180)
- hsa-mir-5590-5p (MIRT066181)
- hsa-mir-5590-3p (MIRT066182)
- hsa-mir-17-5p (MIRT135705)
- hsa-mir-20a-5p (MIRT135706)
- hsa-mir-93-5p (MIRT135707)
- hsa-mir-106b-5p (MIRT135718)
- hsa-mir-20b-5p (MIRT135724)
- hsa-mir-519d-3p (MIRT135733)
- hsa-mir-6828-5p (MIRT135785)
- hsa-mir-6790-5p (MIRT449851)
- hsa-mir-4658 (MIRT449852)
- hsa-mir-4758-5p (MIRT449853)
- hsa-mir-1238-5p (MIRT449854)
- hsa-mir-526b-5p (MIRT449855)
- hsa-mir-3659 (MIRT449856)
- hsa-mir-574-5p (MIRT449857)
- hsa-mir-20b-3p (MIRT449858)
- hsa-mir-3137 (MIRT449859)
- hsa-mir-361-5p (MIRT555601)
- hsa-mir-561-3p (MIRT555602)
- hsa-mir-1185-5p (MIRT735913)
- hsa-mir-3190-3p (MIRT740962)
- hsa-mir-3679-5p (MIRT742184)
- hsa-mir-451b (MIRT745807)
- hsa-mir-4525 (MIRT745919)
- hsa-mir-4534 (MIRT746056)
- hsa-mir-4668-5p (MIRT746829)
- hsa-mir-4716-3p (MIRT747496)
- hsa-mir-4796-3p (MIRT748972)
- hsa-mir-4802-5p (MIRT749016)
- hsa-mir-5010-5p (MIRT749501)
- hsa-mir-548az-5p (MIRT750651)
- hsa-mir-548t-5p (MIRT750800)
- hsa-mir-6079 (MIRT751742)
- hsa-mir-671-5p (MIRT753709)
- hsa-mir-6794-5p (MIRT756096)
- hsa-mir-6894-5p (MIRT758784)
- hsa-mir-7109-3p (MIRT758933)
- hsa-mir-7154-3p (MIRT759234)
- hsa-mir-765 (MIRT759580)
- hsa-mir-766-5p (MIRT759651)
- hsa-mir-8082 (MIRT760174)
- hsa-mir-1324 (MIRT762548)
- hsa-mir-188-3p (MIRT763219)
- hsa-mir-3120-3p (MIRT764779)
- hsa-mir-5000-5p (MIRT772900)
- hsa-mir-6729-3p (MIRT777943)
miRNA Products
- Search ViGene Biosciences for PIP4K2C
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PIP4K2C
- Browse OriGene Inhibitory RNA Products For PIP4K2C
- genomics-online: shRNA clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for PIP4K2C gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PIP4K2C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIP4K2C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PIP4K2C
- genomics-online: cdna clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
- orf clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
- Applied Biological Materials Clones for PIP4K2C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PIP4K2C
-
ViGene Biosciences adenoviral particle packaged cDNA for PIP4K2C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PIP4K2C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIP4K2C gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIP4K2C Gene
Localization for PIP4K2C Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIP4K2C Gene
- Cytoplasm. Membrane. Note=Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005776 | autophagosome | IMP | 25578879 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA,IDA | 18570454 |
Pathways & Interactions for PIP4K2C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | PI3K/AKT activation |
.89
|
|
| 3 | Inositol phosphate metabolism (KEGG) | ||
| 4 | Regulation of TP53 Activity through Acetylation | ||
| 5 | Regulation of actin cytoskeleton | ||
Pathways by source for PIP4K2C Gene
4 BioSystems pathways for PIP4K2C Gene
33 Reactome pathways for PIP4K2C Gene
3 KEGG pathways for PIP4K2C Gene
Interacting Proteins for PIP4K2C Gene
Selected Interacting proteins:
ENSP00000347032
Q8TBX8-PI42C_HUMAN
for PIP4K2C Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0010506 | regulation of autophagy | IMP | 25578879 |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | TAS | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0046488 | phosphatidylinositol metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for PIP4K2C Gene
Drugs & Compounds for PIP4K2C Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-Phosphatidyl-D-myo-inositol |
|
|
||||
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for PIP4K2C Gene
mRNA/cDNA for PIP4K2C Gene
- (7) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (94) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PIP4K2C Gene
CRISPR Products
-
OriGene CRISPR knockouts for PIP4K2C
- genomics-online: gRNA clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
- Applied Biological Materials CRISPR for PIP4K2C
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIP4K2C
- GenScript: Design CRISPR guide RNA sequences for PIP4K2C
miRNA Products
- Search ViGene Biosciences for PIP4K2C
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PIP4K2C
- Browse OriGene Inhibitory RNA Products For PIP4K2C
- genomics-online: shRNA clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for PIP4K2C gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PIP4K2C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIP4K2C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PIP4K2C
- genomics-online: cdna clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
- orf clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
- Applied Biological Materials Clones for PIP4K2C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||
| SP6: | - | - |
Expression for PIP4K2C Gene
This gene is overexpressed in Cervix (10.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIP4K2C Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PIP4K2C Gene:
PIP4K2CSOURCE GeneReport for Unigene cluster for PIP4K2C Gene:
Hs.745011Evidence on tissue expression from TISSUES for PIP4K2C Gene
- Nervous system(2.9)
Primer Products
-
OriGene qPCR primer pairs for PIP4K2C
-
OriGene qPCR primer pairs and template standards for PIP4K2C
- genomics-online: primer clones - Search results for 104 available PIP4K2C gene related products
- Overview of 104 available PIP4K2C gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP4K2C Gene
Orthologs for PIP4K2C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PIP4K2C 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PIP4K2C 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PIP4K2C 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PIP4K2C 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pip4k2c 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pip4k2c 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PIP4K2C 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PIP4K2C 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pip4k2c 33 |
|
||
| Str.3445 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | pip5k2 33 34 |
|
||
| LOC100535634 33 |
|
||||
| PIP4K2C (2 of 2) 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17471 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ppk-2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7002 34 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10982 33 |
|
- Species where no ortholog for PIP4K2C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PIP4K2C Gene
(7) SIMAP similar genes for PIP4K2C Gene using alignment to 5 proteins:
Variants for PIP4K2C Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000692519 | -- | 57,597,227(+) | C/T | intron_variant | |
| rs1000854418 | -- | 57,600,543(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000929405 | -- | 57,600,131(+) | G/C | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000953778 | -- | 57,597,477(+) | A/G | intron_variant | |
| rs1001090524 | -- | 57,593,572(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.76;
57.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIP4K2C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIP4K2C
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP4K2C Gene
Disorders for PIP4K2C Gene
Additional Disease Information for PIP4K2C
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PIP4K2C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP4K2C Gene
Publications for PIP4K2C Gene
- Genetic variants in the prediction of rheumatoid arthritis. (PMID: 20439292) van der Helm-van Mil AH … Huizinga TW (Annals of the rheumatic diseases 2010) 3 44 58
- Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis. (PMID: 19644859) van der Linden MP … van der Helm-Van Mil AH (Arthritis and rheumatism 2009) 3 44 58
- Common variants at CD40 and other loci confer risk of rheumatoid arthritis. (PMID: 18794853) Raychaudhuri S … Plenge RM (Nature genetics 2008) 3 44 58
- A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. (PMID: 9367159) Rameh LE … Cantley LC (Nature 1997) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for PIP4K2C Gene
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- Taconic Biosciences Mouse Models for PIP4K2C
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- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 20 available PIP4K2C Antibodies ranked by validation data
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- genomics-online: cdna clones - Search results for 104 available PIP4K2C gene related products
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Sources for PIP4K2C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
