Aliases for PIP4K2C Gene
External Ids for PIP4K2C Gene
Previous HGNC Symbols for PIP4K2C Gene
Previous GeneCards Identifiers for PIP4K2C Gene
GeneCards Summary for PIP4K2C Gene
PIP4K2C (Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma) is a Protein Coding gene. Diseases associated with PIP4K2C include Parkinson Disease 20, Early-Onset and Macrocephaly/Autism Syndrome. Among its related pathways are RET signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and 1-phosphatidylinositol-5-phosphate 4-kinase activity. An important paralog of this gene is PIP4K2B.
UniProtKB/Swiss-Prot Summary for PIP4K2C Gene
Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).