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The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase... See more...
Aliases for PIP4K2B Gene
Aliases for PIP4K2B Gene
- Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta 2 3 5
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta 2 3
- Phosphatidylinositol 5-Phosphate 4-Kinase Type II Beta 3 4
- Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta 3 4
- 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta 3 4
- PtdIns(5)P-4-Kinase Isoform 2-Beta 3 4
- Diphosphoinositide Kinase 2-Beta 3 4
- PI(5)P 4-Kinase Type II Beta 3 4
- PIP4KII-Beta 3 4
- EC 2.7.1.149 4 51
External Ids for PIP4K2B Gene
- HGNC: 8998
- Entrez Gene: 8396
- Ensembl: ENSG00000276293
- OMIM: 603261
- UniProtKB: P78356
Previous HGNC Symbols for PIP4K2B Gene
- PIP5K2B
Previous GeneCards Identifiers for PIP4K2B Gene
- GC17M034175
- GC17M036921
- GC17M032718
Summaries for PIP4K2B Gene
-
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIP4K2B Gene
PIP4K2B (Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta) is a Protein Coding gene. Diseases associated with PIP4K2B include Lateral Meningocele Syndrome. Among its related pathways are Regulation of TP53 Activity through Acetylation and RET signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP4K2A.
UniProtKB/Swiss-Prot Summary for PIP4K2B Gene
-
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.
Additional gene information for PIP4K2B Gene
- HGNC(8998)
- Entrez Gene(8396)
- Ensembl(ENSG00000276293)
- OMIM(603261)
- UniProtKB(P78356)
- Open Targets Platform(ENSG00000276293)
- Search for PIP4K2B at DataMed
- Search for PIP4K2B at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIP4K2B Gene
Genomics for PIP4K2B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PIP4K2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PIP4K2B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIP4K2B
- Top Transcription factor binding sites by QIAGEN in the PIP4K2B gene promoter:
-
- AML1a
- CP2
- CUTL1
- Egr-4
- NF-E2
- NF-E2 p45
- Nkx2-5
- Pax-5
- Zic3
Genomic Locations for PIP4K2B Gene
Genomic Locations for PIP4K2B Gene
- chr17:38,765,689-38,800,126
- (GRCh38/hg38)
- Size:
- 34,438 bases
- Orientation:
- Minus strand
- chr17:36,921,942-36,956,379
- (GRCh37/hg19)
- Size:
- 34,438 bases
- Orientation:
- Minus strand
Genomic View for PIP4K2B Gene
Genes around PIP4K2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
PIP4K2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIP4K2B Gene
Proteins for PIP4K2B Gene
-
Protein details for PIP4K2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78356-PI42B_HUMAN
- Recommended name:
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- Protein Accession:
- P78356
- Q5U0E8
- Q8TBP2
Protein attributes for PIP4K2B Gene
- Size:
- 416 amino acids
- Molecular mass:
- 47378 Da
- Quaternary structure:
-
- Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex.
Three dimensional structures from OCA and Proteopedia for PIP4K2B Gene
Protein Expression for PIP4K2B Gene
Selected DME Specific Peptides for PIP4K2B Gene
- P78356:
-
- NHLFNKEN
- KTKKKHFV
- VTRNVFSHRL
- REASDKEK
- IMDYSLL
- VFRNLRERFGI
- QKVKLFRAS
- KEVYFMAIIDILT
- YCPMVFRNLR
- TLLPQFLGMYR
- VKHGAGAEISTV
- RKYDLKGS
- FKFKEYCP
- FLEKLKRDVEFL
- DYSLLVG
- VHRKYDLKGS
- SEDVAEMHNILKKYHQ
Post-translational modifications for PIP4K2B Gene
- Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PIP4K2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-PIP4K2B antibody [N1C1] and Anti-PIP4K2B antibody
-
Custom Antibody ServicesOriGene Antibodies for PIP4K2B
- Novus Biologicals Antibodies for PIP4K2B
-
Abcam antibodies for PIP4K2B
- Invitrogen Antibodies for PIP4K2B (AFLGC-PIP4K2B)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PIP4K2B
- Origene Custom Protein Services for PIP4K2B
- ProSpec Recombinant Proteins for PIP4K2B
-
Abcam proteins for PIP4K2B
Domains & Families for PIP4K2B Gene
Gene Families for PIP4K2B Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for PIP4K2B Gene
- InterPro:
- Blocks:
-
- Phosphatidylinositol-4-phosphate 5-kinase
- ProtoNet:
Suggested Antigen Peptide Sequences for PIP4K2B Gene
- GenScript: Design optimal peptide antigens:
-
- PtdIns(5)P-4-kinase isoform 2-beta (PI42B_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PIP4K2B Gene
Function for PIP4K2B Gene
Molecular function for PIP4K2B Gene
- UniProtKB/Swiss-Prot Function:
- Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:12280, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.149;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate {ECO:0000269|PubMed:20583997}; Vmax=0.2 pmol/min/ug enzyme {ECO:0000269|PubMed:20583997};
Enzyme Numbers (IUBMB) for PIP4K2B Gene
Phenotypes From GWAS Catalog for PIP4K2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0016307 | phosphatidylinositol phosphate kinase activity | IEA | -- |
Phenotypes for PIP4K2B Gene
- MGI mutant phenotypes for PIP4K2B:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PIP4K2B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Decreased viability
- Decreased shRNA abundance
- Increased transferrin (TF) endocytosis
- Decreased ionizing radiation sensitivity
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased human cytomegalovirus (HCMV) strain AD169 replication
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability with poly (ADP‐ribose)‐polymerase‐1 (PARP) inhibitor
Animal Model Products
-
Taconic Biosciences Mouse Models for PIP4K2B
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PIP4K2B - Select products 50% OFF >
- * PIP4K2B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PIP4K2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIP4K2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIP4K2B
miRNA for PIP4K2B Gene
- miRTarBase miRNAs that target PIP4K2B
-
- mmu-miR-324-3p (MIRT010972)
- mmu-miR-124-3p (MIRT015781)
- hsa-miR-186-5p (MIRT021118)
- hsa-miR-215-5p (MIRT024431)
- hsa-miR-192-5p (MIRT026451)
- hsa-miR-99b-5p (MIRT044205)
- hsa-miR-320a (MIRT044592)
- hsa-miR-16-5p (MIRT051101)
- hsa-miR-6515-3p (MIRT234292)
- hsa-miR-218-5p (MIRT439968)
- hsa-miR-6881-3p (MIRT655072)
- hsa-miR-877-3p (MIRT655073)
- hsa-miR-5193 (MIRT655074)
- hsa-miR-4667-3p (MIRT655075)
- hsa-miR-6887-3p (MIRT655076)
- hsa-miR-6729-3p (MIRT655077)
- hsa-miR-5690 (MIRT655078)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIP4K2B
- Browse OriGene Inhibitory RNA Products For PIP4K2B
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Clone Products
- Applied Biological Materials (abm): Clones for PIP4K2B - Select products 50% OFF >
- * PIP4K2B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PIP4K2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIP4K2B
Cell Line Products
-
Horizon Cell Lines for PIP4K2B
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP4K2B Gene
Localization for PIP4K2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIP4K2B Gene
- Endoplasmic reticulum membrane. Peripheral membrane protein. Cell membrane. Peripheral membrane protein. Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 4 |
| cytosol | 4 |
| mitochondrion | 3 |
| endoplasmic reticulum | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005776 | autophagosome | IMP | 25578879 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for PIP4K2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | GAB1 signalosome |
.89
|
|
| 3 | Inositol phosphate metabolism (KEGG) | ||
| 4 | Metabolism |
.40
|
|
| 5 | Regulation of TP53 Activity through Acetylation | ||
Pathways by source for PIP4K2B Gene
4 BioSystems pathways for PIP4K2B Gene
33 Reactome pathways for PIP4K2B Gene
4 KEGG pathways for PIP4K2B Gene
7 Qiagen pathways for PIP4K2B Gene
- Actin-Based Motility by Rho Family GTPases
- Aldosterone Signaling in Epithelial Cells
- Fc-GammaR-Mediated Phagocytosis in Macrophages
- Integrin Pathway
- Rac1 Pathway
1 Cell Signaling Technology pathway for PIP4K2B Gene
Interacting Proteins for PIP4K2B Gene
Selected Interacting proteins:
P78356-PI42B_HUMAN
ENSP00000482548
for PIP4K2B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PIP4K2B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 9038203 |
| GO:0010506 | regulation of autophagy | IMP | 25578879 |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | TAS | -- |
Drugs & Compounds for PIP4K2B Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-Phosphatidyl-D-myo-inositol |
|
|
||||
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for PIP4K2B Gene
mRNA/cDNA for PIP4K2B Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000613767 478 nts (view in UCSC)
- ENST00000617499 547 nts (view in UCSC)
- ENST00000617781 927 nts (view in UCSC)
- ENST00000619039 5734 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PIP4K2B - Select products 50% OFF >
- * PIP4K2B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PIP4K2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIP4K2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIP4K2B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIP4K2B
- Browse OriGene Inhibitory RNA Products For PIP4K2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIP4K2B
Clone Products
- Applied Biological Materials (abm): Clones for PIP4K2B - Select products 50% OFF >
- * PIP4K2B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PIP4K2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIP4K2B
Relevant External Links for PIP4K2B Gene
- GeneLoc Exon Structure for
- PIP4K2B
Expression for PIP4K2B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
This gene is overexpressed in Fetal Brain (15.9), Brain (9.4), and Frontal cortex (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIP4K2B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIP4K2B
SOURCE GeneReport for Unigene cluster for PIP4K2B Gene:
Hs.260603mRNA Expression by UniProt/SwissProt for PIP4K2B Gene:
P78356-PI42B_HUMAN
Tissue specificity:
Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
Evidence on tissue expression from TISSUES for PIP4K2B Gene
- Nervous system(5)
- Lung(4.4)
- Muscle(2.4)
- Skin(2.2)
- Eye(2.1)
Primer Products
-
OriGene qPCR primer pairs for PIP4K2B
-
OriGene qPCR primer pairs and template standards for PIP4K2B
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP4K2B Gene
Orthologs for PIP4K2B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PIP4K2B 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | PIP4K2B 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | PIP4K2B 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Pip4k2b 30 17 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Pip4k2b 30 |
|
||
| Chicken (Gallus gallus) |
Aves | PIP4K2B 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pip4k2a 30 |
|
||
| Str.2617 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1824 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pip4k2ab 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG17471 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | ppk-2 30 |
|
- Species where no ortholog for PIP4K2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PIP4K2B Gene
- ENSEMBL:
- Gene Tree for PIP4K2B (if available)
- TreeFam:
- Gene Tree for PIP4K2B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PIP4K2B: view image
Paralogs for PIP4K2B Gene
Variants for PIP4K2B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2678000 | CNV | deletion | 23128226 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv833438 | CNV | loss | 17160897 |
| nsv833439 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.95;
19.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIP4K2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIP4K2B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIP4K2B Gene
Disorders for PIP4K2B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lateral meningocele syndrome |
|
|
Search PIP4K2B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PIP4K2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PIP4K2B Gene
Publications for PIP4K2B Gene
- A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. (PMID: 9038203) Castellino AM … Chao MV (The Journal of biological chemistry 1997) 2 3 4 23
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage. (PMID: 14691457) Luoh SW … Tripathi R (Oncogene 2004) 2 3
- Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. (PMID: 9753329) Rao VD … Hurley JH (Cell 1998) 3 4
- A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. (PMID: 9367159) Rameh LE … Cantley LC (Nature 1997) 2 3
ExternalLinks
Products for PIP4K2B Gene
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- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for PIP4K2B
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- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
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- VectorBuilder Custom and pre-made DNA vectors for PIP4K2B (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 16 available PIP4K2B Antibodies ranked by validation data
- Compare Top PIP4K2B Antibodies
- antibodies-online: Search results for available PIP4K2B related products ranked by validation data
- antibodies-online: Show 11 available PIP4K2B Proteins ranked by validation data
- Compare Top PIP4K2B Proteins
- Horizon Cell Lines for PIP4K2B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIP4K2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIP4K2B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PIP4K2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIP4K2B
Sources for PIP4K2B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB