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Aliases for PIP4K2B Gene

Aliases for PIP4K2B Gene

  • Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta 2 3 5
  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta 2 3
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type II Beta 3 4
  • 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta 3 4
  • PtdIns(5)P-4-Kinase Isoform 2-Beta 3 4
  • Diphosphoinositide Kinase 2-Beta 3 4
  • PI(5)P 4-Kinase Type II Beta 3 4
  • PIP4KII-Beta 3 4
  • PIP5K2B 3 4
  • Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta 2
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta 3
  • 1-Phosphatidylinositol-4-Phosphate Kinase 3
  • PTDINS(4)P-5-Kinase 3
  • EC 4
  • PIP5KIIbeta 3
  • PIP5KIIB 3
  • PIP5P4KB 3
  • PI5P4KB 3

External Ids for PIP4K2B Gene

Previous HGNC Symbols for PIP4K2B Gene

  • PIP5K2B

Previous GeneCards Identifiers for PIP4K2B Gene

  • GC17M034175
  • GC17M036921
  • GC17M032718

Summaries for PIP4K2B Gene

Entrez Gene Summary for PIP4K2B Gene

  • The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIP4K2B Gene

PIP4K2B (Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta) is a Protein Coding gene. Among its related pathways are Gene Expression and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP4K2A.

UniProtKB/Swiss-Prot for PIP4K2B Gene

  • Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.

Gene Wiki entry for PIP4K2B Gene

Additional gene information for PIP4K2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP4K2B Gene

Genomics for PIP4K2B Gene

GeneHancer (GH) Regulatory Elements for PIP4K2B Gene

Promoters and enhancers for PIP4K2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J038795 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.4 +1.8 1812 5 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PIP4K2B GC17M038796 LOC105371762 CWC25 LASP1 GC17M038766
GH17J038823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.3 -24.8 -24812 3 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CWC25 MIR4727 MED1 CDK12 SNORA21 LOC105371762 STARD3 RPL23 RPL19 PIP4K2B
GH17J038673 Promoter/Enhancer 1.5 Ensembl ENCODE 16.2 +125.4 125404 1.7 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 GC17M038673 EPOP PCGF2 PIP4K2B MLLT6 CISD3 PSMB3 CWC25
GH17J038925 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.7 -126.0 -125961 2.1 HDAC1 PKNOX1 ARNT TCF12 ZNF766 ZFP91 ETV6 ATF7 IKZF2 RUNX3 LINC00672 ENSG00000266588 MED1 FBXO47 C17orf98 SNORA21 CDK12 PIP4K2B CWC25 LOC105371762
GH17J038740 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +57.6 57571 3.6 KLF1 PKNOX1 FOXA2 NFIB ZSCAN4 BMI1 ZIC2 ZNF48 ZNF121 GLIS2 C17orf98 PCGF2 MLLT6 FBXO47 PIP4K2B SOCS7 PSMB3 CISD3 LOC100287808 RNA5SP440
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIP4K2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIP4K2B gene promoter:
  • Nkx2-5
  • Egr-4
  • Zic3
  • AML1a
  • CP2
  • CUTL1
  • Pax-5
  • NF-E2 p45
  • NF-E2

Genomic Locations for PIP4K2B Gene

Genomic Locations for PIP4K2B Gene
34,438 bases
Minus strand
34,438 bases
Minus strand

Genomic View for PIP4K2B Gene

Genes around PIP4K2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP4K2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP4K2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP4K2B Gene

Proteins for PIP4K2B Gene

  • Protein details for PIP4K2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
    Protein Accession:
    Secondary Accessions:
    • Q5U0E8
    • Q8TBP2

    Protein attributes for PIP4K2B Gene

    416 amino acids
    Molecular mass:
    47378 Da
    Quaternary structure:
    • Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex.

    Three dimensional structures from OCA and Proteopedia for PIP4K2B Gene

    Alternative splice isoforms for PIP4K2B Gene


neXtProt entry for PIP4K2B Gene

Post-translational modifications for PIP4K2B Gene

  • Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP4K2B Gene

No data available for DME Specific Peptides for PIP4K2B Gene

Domains & Families for PIP4K2B Gene

Gene Families for PIP4K2B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PIP4K2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIP4K2B: view

No data available for UniProtKB/Swiss-Prot for PIP4K2B Gene

Function for PIP4K2B Gene

Molecular function for PIP4K2B Gene

UniProtKB/Swiss-Prot Function:
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate {ECO:0000269 PubMed:20583997}; Vmax=0.2 pmol/min/ug enzyme {ECO:0000269 PubMed:20583997};

Enzyme Numbers (IUBMB) for PIP4K2B Gene

Phenotypes From GWAS Catalog for PIP4K2B Gene

Gene Ontology (GO) - Molecular Function for PIP4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 obsolete signal transducer activity, downstream of receptor TAS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity IEA --
genes like me logo Genes that share ontologies with PIP4K2B: view
genes like me logo Genes that share phenotypes with PIP4K2B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PIP4K2B

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP4K2B Gene

Localization for PIP4K2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP4K2B Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIP4K2B gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
mitochondrion 3
endoplasmic reticulum 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PIP4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005776 autophagosome IMP 25578879
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PIP4K2B: view

Pathways & Interactions for PIP4K2B Gene

genes like me logo Genes that share pathways with PIP4K2B: view

Interacting Proteins for PIP4K2B Gene

SIGNOR curated interactions for PIP4K2B Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PIP4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007166 cell surface receptor signaling pathway TAS 9038203
GO:0010506 regulation of autophagy IMP 25578879
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS --
genes like me logo Genes that share ontologies with PIP4K2B: view

Drugs & Compounds for PIP4K2B Gene

(2) Drugs for PIP4K2B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for PIP4K2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with PIP4K2B: view

Transcripts for PIP4K2B Gene

Unigene Clusters for PIP4K2B Gene

Phosphatidylinositol-5-phosphate 4-kinase, type II, beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP4K2B Gene

No ASD Table

Relevant External Links for PIP4K2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIP4K2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIP4K2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIP4K2B Gene

This gene is overexpressed in Fetal Brain (15.9), Brain (9.4), and Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIP4K2B Gene

Protein tissue co-expression partners for PIP4K2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIP4K2B Gene:


SOURCE GeneReport for Unigene cluster for PIP4K2B Gene:


mRNA Expression by UniProt/SwissProt for PIP4K2B Gene:

Tissue specificity: Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.

Evidence on tissue expression from TISSUES for PIP4K2B Gene

  • Nervous system(5)
  • Lung(4.4)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with PIP4K2B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP4K2B Gene

Orthologs for PIP4K2B Gene

This gene was present in the common ancestor of animals.

Orthologs for PIP4K2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIP4K2B 33
  • 99.36 (n)
(Bos Taurus)
Mammalia PIP4K2B 33
  • 94.31 (n)
(Canis familiaris)
Mammalia PIP4K2B 33
  • 93.59 (n)
(Mus musculus)
Mammalia Pip4k2b 16 33
  • 91.75 (n)
(Rattus norvegicus)
Mammalia Pip4k2b 33
  • 91.19 (n)
(Gallus gallus)
Aves PIP4K2B 33
  • 85.4 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia pip4k2a 33
  • 80.55 (n)
Str.2617 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1824 33
(Danio rerio)
Actinopterygii pip4k2ab 33
  • 73.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17471 33
  • 58.24 (n)
(Caenorhabditis elegans)
Secernentea ppk-2 33
  • 55.29 (n)
Species where no ortholog for PIP4K2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP4K2B Gene

Gene Tree for PIP4K2B (if available)
Gene Tree for PIP4K2B (if available)
Evolutionary constrained regions (ECRs) for PIP4K2B: view image

Paralogs for PIP4K2B Gene

Paralogs for PIP4K2B Gene

(6) SIMAP similar genes for PIP4K2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIP4K2B: view

Variants for PIP4K2B Gene

Sequence variations from dbSNP and Humsavar for PIP4K2B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000012019 -- 38,798,098(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000116442 -- 38,776,095(-) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000219380 -- 38,771,487(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000272441 -- 38,769,536(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000296123 -- 38,771,783(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PIP4K2B Gene

Variant ID Type Subtype PubMed ID
esv2678000 CNV deletion 23128226
nsv1146669 OTHER inversion 26484159
nsv833438 CNV loss 17160897
nsv833439 CNV loss 17160897

Variation tolerance for PIP4K2B Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIP4K2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP4K2B Gene

Disorders for PIP4K2B Gene

Additional Disease Information for PIP4K2B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PIP4K2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP4K2B Gene

Publications for PIP4K2B Gene

  1. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. (PMID: 9038203) Castellino AM … Chao MV (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage. (PMID: 14691457) Luoh SW … Tripathi R (Oncogene 2004) 2 3 58
  4. Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. (PMID: 9753329) Rao VD … Hurley JH (Cell 1998) 3 4 58
  5. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. (PMID: 9367159) Rameh LE … Cantley LC (Nature 1997) 2 3 58

Products for PIP4K2B Gene

Sources for PIP4K2B Gene

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