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The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
PIP4K2B (Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta) is a Protein Coding gene. Diseases associated with PIP4K2B include Lateral Meningocele Syndrome. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP4K2A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0005524 | ATP binding | IEA,IDA | 26774281 |
GO:0005525 | GTP binding | IEA,IDA | 26774281 |
GO:0016301 | kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 30718367 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005776 | autophagosome | IMP | 25578879 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | GAB1 signalosome |
.89
|
|
3 | superpathway of inositol phosphate compounds | ||
4 | Metabolism |
.40
|
|
5 | Regulation of TP53 Activity through Acetylation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006644 | phospholipid metabolic process | TAS | -- |
GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
GO:0007166 | cell surface receptor signaling pathway | TAS | 9038203 |
GO:0010506 | regulation of autophagy | IEA,ISS | -- |
GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PIP4K2B 30 |
|
||
Cow (Bos Taurus) |
Mammalia | PIP4K2B 30 |
|
||
Dog (Canis familiaris) |
Mammalia | PIP4K2B 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Pip4k2b 30 17 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Pip4k2b 30 |
|
||
Chicken (Gallus gallus) |
Aves | PIP4K2B 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pip4k2a 30 |
|
||
Str.2617 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1824 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pip4k2ab 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17471 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ppk-2 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2678000 | CNV | deletion | 23128226 |
nsv1146669 | OTHER | inversion | 26484159 |
nsv833438 | CNV | loss | 17160897 |
nsv833439 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lateral meningocele syndrome |
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|