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The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase... See more...
Aliases for PIP4K2B Gene
Aliases for PIP4K2B Gene
- Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta 2 3 5
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta 2 3
- Phosphatidylinositol 5-Phosphate 4-Kinase Type II Beta 3 4
- Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta 3 4
- 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta 3 4
- Diphosphoinositide Kinase 2-Beta 3 4
- PI(5)P 4-Kinase Type II Beta 3 4
- PIP4KII-Beta 3 4
- EC 2.7.1.149 4 51
- PIP5KIIbeta 2 3
External Ids for PIP4K2B Gene
- HGNC: 8998
- NCBI Entrez Gene: 8396
- Ensembl: ENSG00000276293
- OMIM®: 603261
- UniProtKB/Swiss-Prot: P78356
Previous HGNC Symbols for PIP4K2B Gene
- PIP5K2B
Previous GeneCards Identifiers for PIP4K2B Gene
- GC17M034175
- GC17M036921
- GC17M032718
Summaries for PIP4K2B Gene
-
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIP4K2B Gene
PIP4K2B (Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta) is a Protein Coding gene. Diseases associated with PIP4K2B include Lateral Meningocele Syndrome. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP4K2A.
UniProtKB/Swiss-Prot Summary for PIP4K2B Gene
-
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9038203, PubMed:26774281). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
Additional gene information for PIP4K2B Gene
- HGNC (8998)
- NCBI Entrez Gene (8396)
- Ensembl (ENSG00000276293)
- OMIM® (603261)
- UniProtKB/Swiss-Prot (P78356)
- Open Targets Platform(ENSG00000276293)
- Search for PIP4K2B at DataMed
- Search for PIP4K2B at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIP4K2B Gene
Genomics for PIP4K2B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PIP4K2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PIP4K2B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIP4K2B
- Top Transcription factor binding sites by QIAGEN in the PIP4K2B gene promoter:
-
- AML1a
- CP2
- CUTL1
- Egr-4
- NF-E2
- NF-E2 p45
- Nkx2-5
- Pax-5
- Zic3
Genomic Locations for PIP4K2B Gene
Latest Assembly
- chr17:38,765,691-38,800,126
- (GRCh38/hg38)
- Size:
- 34,436 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:36,921,944-36,955,809
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 33,866 bases
- Orientation:
- Minus strand
Genomic View for PIP4K2B Gene
Genes around PIP4K2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
PIP4K2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIP4K2B Gene
Proteins for PIP4K2B Gene
-
Protein details for PIP4K2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78356-PI42B_HUMAN
- Recommended name:
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- Protein Accession:
- P78356
- Q5U0E8
- Q8TBP2
Protein attributes for PIP4K2B Gene
- Size:
- 416 amino acids
- Molecular mass:
- 47378 Da
- Quaternary structure:
-
- Homodimer. Binds TNFRSF1A (PubMed:9038203). Interacts with PIP4K2A; the interaction suppresses ubiquitination by the SPOP/CUL3 complex (PubMed:20583997).
Three dimensional structures from OCA and Proteopedia for PIP4K2B Gene
Protein Expression for PIP4K2B Gene
Selected DME Specific Peptides for PIP4K2B Gene
- P78356:
-
- NHLFNKEN
- KTKKKHFV
- VTRNVFSHRL
- REASDKEK
- IMDYSLL
- VFRNLRERFGI
- QKVKLFRAS
- KEVYFMAIIDILT
- YCPMVFRNLR
- TLLPQFLGMYR
- VKHGAGAEISTV
- RKYDLKGS
- FKFKEYCP
- FLEKLKRDVEFL
- DYSLLVG
- VHRKYDLKGS
- SEDVAEMHNILKKYHQ
Post-translational modifications for PIP4K2B Gene
- Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels.
- Phosphorylated on serine residues.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PIP4K2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- GeneTex Anti-PIP4K2B antibody [N1C1] and Anti-PIP4K2B antibody
-
Custom Antibody ServicesOriGene Antibodies for PIP4K2B
- Novus Biologicals Antibodies for PIP4K2B
-
Abcam antibodies for PIP4K2B
- Invitrogen Antibodies for PIP4K2B (AFLGC-PIP4K2B)
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PIP4K2B
- Origene Custom Protein Services for PIP4K2B
- ProSpec Recombinant Proteins for PIP4K2B
-
Abcam proteins for PIP4K2B
Assay products for research
Domains & Families for PIP4K2B Gene
Gene Families for PIP4K2B Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for PIP4K2B Gene
- InterPro:
- Blocks:
-
- Phosphatidylinositol-4-phosphate 5-kinase
- ProtoNet:
Suggested Antigen Peptide Sequences for PIP4K2B Gene
- GenScript: Design optimal peptide antigens:
-
- PtdIns(5)P-4-kinase isoform 2-beta (PI42B_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PIP4K2B Gene
Function for PIP4K2B Gene
Molecular function for PIP4K2B Gene
- UniProtKB/Swiss-Prot Function:
- Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9038203, PubMed:26774281). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:12280, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.149; Evidence={ECO:0000305|PubMed:26774281};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:55992, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:83423, ChEBI:CHEBI:84968, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:26774281};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+); Xref=Rhea:RHEA:55964, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:83423, ChEBI:CHEBI:84968; Evidence={ECO:0000269|PubMed:26774281};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate {ECO:0000269|PubMed:20583997}; KM=88 uM for ATP {ECO:0000269|PubMed:26774281}; KM=236 uM for GTP {ECO:0000269|PubMed:26774281}; Vmax=0.2 pmol/min/ug enzyme {ECO:0000269|PubMed:20583997}; Vmax=57 umol/min/mg enzyme toward ATP {ECO:0000269|PubMed:26774281}; Vmax=88 umol/min/mg enzyme toward GTP {ECO:0000269|PubMed:26774281};
Enzyme Numbers (IUBMB) for PIP4K2B Gene
Phenotypes From GWAS Catalog for PIP4K2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005524 | ATP binding | IEA,IDA | 26774281 |
| GO:0005525 | GTP binding | IEA,IDA | 26774281 |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for PIP4K2B Gene
- MGI mutant phenotypes for PIP4K2B:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PIP4K2B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased ionizing radiation sensitivity
- Decreased viability
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased shRNA abundance
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased viability with poly (ADP‐ribose)‐polymerase‐1 (PARP) inhibitor
Animal Models for research
-
Taconic Biosciences Mouse Models for PIP4K2B
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PIP4K2B - Starting at $85 >
- * PIP4K2B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PIP4K2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIP4K2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIP4K2B
miRNA for PIP4K2B Gene
- miRTarBase miRNAs that target PIP4K2B
-
- mmu-miR-324-3p (MIRT010972)
- mmu-miR-124-3p (MIRT015781)
- hsa-miR-186-5p (MIRT021118)
- hsa-miR-215-5p (MIRT024431)
- hsa-miR-192-5p (MIRT026451)
- hsa-miR-99b-5p (MIRT044205)
- hsa-miR-320a (MIRT044592)
- hsa-miR-16-5p (MIRT051101)
- hsa-miR-6515-3p (MIRT234292)
- hsa-miR-218-5p (MIRT439968)
- hsa-miR-6881-3p (MIRT655072)
- hsa-miR-877-3p (MIRT655073)
- hsa-miR-5193 (MIRT655074)
- hsa-miR-4667-3p (MIRT655075)
- hsa-miR-6887-3p (MIRT655076)
- hsa-miR-6729-3p (MIRT655077)
- hsa-miR-5690 (MIRT655078)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIP4K2B
- Browse OriGene Inhibitory RNA Products For PIP4K2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIP4K2B
Clone products for research
- Applied Biological Materials (abm): Clones for PIP4K2B - Starting at $45 >
- * PIP4K2B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PIP4K2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIP4K2B
Cell Lines for research
-
Horizon Cell Lines for PIP4K2B
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP4K2B Gene
Localization for PIP4K2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIP4K2B Gene
- Endoplasmic reticulum membrane. Peripheral membrane protein. Cell membrane. Peripheral membrane protein. Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 4 |
| mitochondrion | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 30718367 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005776 | autophagosome | IMP | 25578879 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for PIP4K2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | GAB1 signalosome |
.89
|
|
| 3 | superpathway of inositol phosphate compounds | ||
| 4 | Metabolism |
.40
|
|
| 5 | Regulation of TP53 Activity through Acetylation | ||
Pathways by source for PIP4K2B Gene
4 BioSystems pathways for PIP4K2B Gene
33 Reactome pathways for PIP4K2B Gene
4 KEGG pathways for PIP4K2B Gene
7 Qiagen pathways for PIP4K2B Gene
- Actin-Based Motility by Rho Family GTPases
- Aldosterone Signaling in Epithelial Cells
- Fc-GammaR-Mediated Phagocytosis in Macrophages
- Integrin Pathway
- Rac1 Pathway
1 Cell Signaling Technology pathway for PIP4K2B Gene
Interacting Proteins for PIP4K2B Gene
Selected Interacting proteins:
P78356-PI42B_HUMAN
ENSP00000482548
for PIP4K2B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PIP4K2B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 9038203 |
| GO:0010506 | regulation of autophagy | IEA,ISS | -- |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | TAS | -- |
Drugs & Compounds for PIP4K2B Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
Transcripts for PIP4K2B Gene
mRNA/cDNA for PIP4K2B Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000613767 478 nts (view in UCSC)
- ENST00000617499 547 nts (view in UCSC)
- ENST00000617781 927 nts (view in UCSC)
- ENST00000619039 5383 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PIP4K2B - Starting at $85 >
- * PIP4K2B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PIP4K2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIP4K2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIP4K2B
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIP4K2B
- Browse OriGene Inhibitory RNA Products For PIP4K2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIP4K2B
Clone products for research
- Applied Biological Materials (abm): Clones for PIP4K2B - Starting at $45 >
- * PIP4K2B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PIP4K2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIP4K2B
Relevant External Links for PIP4K2B Gene
- GeneLoc Exon Structure for
- PIP4K2B
Expression for PIP4K2B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
This gene is overexpressed in Fetal Brain (15.9), Brain (9.4), and Frontal cortex (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIP4K2B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIP4K2B
SOURCE GeneReport for Unigene cluster for PIP4K2B Gene:
Hs.260603mRNA Expression by UniProt/SwissProt for PIP4K2B Gene:
P78356-PI42B_HUMAN
Tissue specificity:
Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
Evidence on tissue expression from TISSUES for PIP4K2B Gene
- Nervous system(5)
- Lung(4.4)
- Muscle(2.4)
- Eye(2.1)
- Skin(2.1)
Primer products for research
-
OriGene qPCR primer pairs for PIP4K2B
-
OriGene qPCR primer pairs and template standards for PIP4K2B
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP4K2B Gene
Orthologs for PIP4K2B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PIP4K2B 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | PIP4K2B 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | PIP4K2B 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Pip4k2b 30 17 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Pip4k2b 30 |
|
||
| Chicken (Gallus gallus) |
Aves | PIP4K2B 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pip4k2a 30 |
|
||
| Str.2617 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1824 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pip4k2ab 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG17471 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | ppk-2 30 |
|
- Species where no ortholog for PIP4K2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PIP4K2B Gene
- ENSEMBL:
- Gene Tree for PIP4K2B (if available)
- TreeFam:
- Gene Tree for PIP4K2B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PIP4K2B: view image
Paralogs for PIP4K2B Gene
Variants for PIP4K2B Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2678000 | CNV | deletion | 23128226 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv833438 | CNV | loss | 17160897 |
| nsv833439 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.95;
19.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIP4K2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIP4K2B
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIP4K2B Gene
Disorders for PIP4K2B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lateral meningocele syndrome |
|
|
Search PIP4K2B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PIP4K2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PIP4K2B Gene
Publications for PIP4K2B Gene
- A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. (PMID: 9038203) Castellino AM … Chao MV (The Journal of biological chemistry 1997) 2 3 4 23
- PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. (PMID: 31091439) Wang DG … Cantley LC (Cell reports 2019) 3 4
- The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. (PMID: 26774281) Sumita K … Sasaki AT (Molecular cell 2016) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage. (PMID: 14691457) Luoh SW … Tripathi R (Oncogene 2004) 2 3
ExternalLinks
Products for PIP4K2B Gene
- Custom Antibody ServicesOriGene Antibodies for PIP4K2B
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- Custom Assay Services
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- antibodies-online: Show 16 available PIP4K2B Antibodies ranked by validation data
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- antibodies-online: Show 11 available PIP4K2B Proteins ranked by validation data
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Sources for PIP4K2B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
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- (27) ASD
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- (30) HomoloGene
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- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
- (39) GenAtlas
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- (43) HuGE
- (44) Atlas
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- (60) Sino Biological
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
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- (113) CDC
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
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- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
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- (148) RNAcentral
- (149) LncRNADisease
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- (151) miR2Disease
- (152) DiseaseEnhancer
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- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
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- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (170) snOPY
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- (172) GENCODE
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- (176) snoDB
- (177) MirGeneDB