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Aliases for PIN4 Gene

Aliases for PIN4 Gene

  • Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4 2 3 5
  • Peptidyl-Prolyl Cis-Trans Isomerase Pin4 3 4
  • Peptidyl-Prolyl Cis/Trans Isomerase EPVH 3 4
  • Parvulin-14 3 4
  • Parvulin-17 3 4
  • Parvulin 2 3
  • HPar14 3 4
  • HPar17 3 4
  • HEPVH 3 4
  • Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin) 2
  • Protein (Peptidylprolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin) 3
  • Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4 3
  • Peptidylprolyl Cis/Trans Isomerase NIMA-Interacting, 4 2
  • Eukaryotic Parvulin Homolog 3
  • Rotamase PIN4 3
  • Rotamase Pin4 4
  • PPIase PIN4 3
  • PPIase Pin4 4
  • EC 4
  • PAR14 3
  • PAR17 3
  • Par14 4
  • Par17 4
  • EPVH 3

External Ids for PIN4 Gene

Previous GeneCards Identifiers for PIN4 Gene

  • GC0XP067133
  • GC0XP068641
  • GC0XP069634
  • GC0XP070268
  • GC0XP071184
  • GC0XP071318
  • GC0XP071401
  • GC0XP065157

Summaries for PIN4 Gene

Entrez Gene Summary for PIN4 Gene

  • This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

GeneCards Summary for PIN4 Gene

PIN4 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity.

UniProtKB/Swiss-Prot for PIN4 Gene

  • Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.

  • Isoform 2 binds to double-stranded DNA.

Gene Wiki entry for PIN4 Gene

Additional gene information for PIN4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIN4 Gene

Genomics for PIN4 Gene

GeneHancer (GH) Regulatory Elements for PIN4 Gene

Promoters and enhancers for PIN4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ072180 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 654.7 +0.3 251 2.6 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B FOS SP3 NFYC JUNB PIN4 TAF1 ERCC6L RN7SL388P
GH0XJ072238 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 36.3 +57.5 57468 1.6 ATF1 ARID4B SIN3A ZNF48 POLR2B ZNF213 SP3 GTF2B NFYC REST ERCC6L TAF1 PIN4 NONO OGT ZMYM3 ENSG00000229601 RPS26P11 LOC392489 GC0XM072223
GH0XJ072130 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 20.3 -49.5 -49549 1.8 MXI1 ZBTB6 BMI1 KLF14 E2F1 ZFHX2 GLIS2 ZNF213 POLR2A ZNF366 RTL5 PIN4 PIR46676 NHSL2
GH0XJ072271 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15 +93.6 93552 6 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B RPS4X TAF1 NONO LOC100420758 ERCC6L OGT RTL5 LOC392489 ENSG00000229601 TOMM20P4
GH0XJ072120 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -57.2 -57227 7.2 FEZF1 ZNF2 RAD21 RFX5 ZNF335 GLIS2 ZNF143 ZNF654 REST ZNF398 PIN4 FLJ44635 RTL5 NHSL2 PIR46676 PIR32507
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIN4 gene promoter:
  • CUTL1
  • Chx10
  • YY1
  • E4BP4
  • p300
  • Evi-1
  • ISGF-3
  • Meis-1b
  • Meis-1a
  • Meis-1

Genomic Locations for PIN4 Gene

Genomic Locations for PIN4 Gene
121,574 bases
Plus strand
121,574 bases
Plus strand

Genomic View for PIN4 Gene

Genes around PIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIN4 Gene

Proteins for PIN4 Gene

  • Protein details for PIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
    Protein Accession:
    Secondary Accessions:
    • A8E0G6
    • B3KXM0
    • F5H1P5
    • Q0D2H3
    • Q3MHV0
    • Q52M21
    • Q5HYW6
    • Q6IRW4

    Protein attributes for PIN4 Gene

    131 amino acids
    Molecular mass:
    13810 Da
    Quaternary structure:
    • Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes.
    • Sequence=AAH05234.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH70288.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04654.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI11395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG54532.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIN4 Gene

    Alternative splice isoforms for PIN4 Gene


neXtProt entry for PIN4 Gene

Post-translational modifications for PIN4 Gene

  • Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus.
  • Isoform 2 is sumoylated with SUMO2 and SUMO3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PIN4 Gene

Domains & Families for PIN4 Gene

Gene Families for PIN4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PIN4 Gene

Graphical View of Domain Structure for InterPro Entry



  • The PPIase domain enhances mitochondrial targeting.
  • Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
  • The PPIase domain enhances mitochondrial targeting.
  • Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
genes like me logo Genes that share domains with PIN4: view

Function for PIN4 Gene

Molecular function for PIN4 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.
UniProtKB/Swiss-Prot Function:
Isoform 2 binds to double-stranded DNA.
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme Numbers (IUBMB) for PIN4 Gene

Phenotypes From GWAS Catalog for PIN4 Gene

Gene Ontology (GO) - Molecular Function for PIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PIN4: view
genes like me logo Genes that share phenotypes with PIN4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PIN4

miRNA for PIN4 Gene

miRTarBase miRNAs that target PIN4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIN4 Gene

Localization for PIN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIN4 Gene

Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.
Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIN4 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IEA,IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with PIN4: view

Pathways & Interactions for PIN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PIN4: view

No data available for Pathways by source and SIGNOR curated interactions for PIN4 Gene

Drugs & Compounds for PIN4 Gene

No Compound Related Data Available

Transcripts for PIN4 Gene

mRNA/cDNA for PIN4 Gene

Unigene Clusters for PIN4 Gene

Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIN4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -

Relevant External Links for PIN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIN4 Gene

Protein differential expression in normal tissues from HIPED for PIN4 Gene

This gene is overexpressed in Heart (11.6), Skin (9.7), Peripheral blood mononuclear cells (7.8), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIN4 Gene

Protein tissue co-expression partners for PIN4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIN4 Gene:


SOURCE GeneReport for Unigene cluster for PIN4 Gene:


mRNA Expression by UniProt/SwissProt for PIN4 Gene:

Tissue specificity: Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.

Evidence on tissue expression from TISSUES for PIN4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with PIN4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIN4 Gene

Orthologs for PIN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIN4 33
  • 98.94 (n)
(Mus musculus)
Mammalia Pin4 16 34 33
  • 94.4 (n)
(Rattus norvegicus)
Mammalia Pin4 33
  • 93.13 (n)
(Bos Taurus)
Mammalia PIN4 34 33
  • 92.11 (n)
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
LOC100687619 33
  • 90.84 (n)
-- 34
  • 88 (a)
-- 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PIN4 34
  • 88 (a)
(Monodelphis domestica)
Mammalia PIN4 34
  • 82 (a)
(Gallus gallus)
Aves PIN4 34 33
  • 77.27 (n)
(Anolis carolinensis)
Reptilia PIN4 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pin4 33
  • 78.29 (n)
MGC75904 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11342 33
(Danio rerio)
Actinopterygii pin4 34 33
  • 74.14 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6696 33
fruit fly
(Drosophila melanogaster)
Insecta CG11858 34 35 33
  • 65.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013296 33
  • 65.12 (n)
(Caenorhabditis elegans)
Secernentea pinn-4 34
  • 74 (a)
Y48C3A.16 35 33
  • 71.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 77 (a)
Cin.3715 33
bread mold
(Neurospora crassa)
Ascomycetes NCU06433 33
  • 58.16 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3715 33
Species where no ortholog for PIN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIN4 Gene

Gene Tree for PIN4 (if available)
Gene Tree for PIN4 (if available)
Evolutionary constrained regions (ECRs) for PIN4: view image

Paralogs for PIN4 Gene

(1) SIMAP similar genes for PIN4 Gene using alignment to 6 proteins:

  • H0Y4T6_HUMAN
  • H0Y610_HUMAN
  • H0Y8P6_HUMAN
  • J3KMW3_HUMAN Pseudogenes for PIN4 Gene

genes like me logo Genes that share paralogs with PIN4: view

No data available for Paralogs for PIN4 Gene

Variants for PIN4 Gene

Sequence variations from dbSNP and Humsavar for PIN4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1057518449 uncertain-significance, not specified 72,205,955(+) ACTTGGCCTCACTTG/ACTTG genic_downstream_transcript_variant, intron_variant
rs1000086952 -- 72,190,739(+) G/A intron_variant
rs1000098291 -- 72,186,776(+) C/T intron_variant
rs1000307391 -- 72,231,737(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000381258 -- 72,222,482(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PIN4 Gene

Variant ID Type Subtype PubMed ID
esv21569 CNV loss 19812545
esv2673799 CNV deletion 23128226
nsv1125445 OTHER inversion 24896259

Variation tolerance for PIN4 Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIN4 Gene

Disorders for PIN4 Gene

Additional Disease Information for PIN4

No disorders were found for PIN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIN4 Gene

Publications for PIN4 Gene

  1. The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. (PMID: 17875217) Kessler D … Mueller JW (BMC biology 2007) 2 3 4 58
  2. Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation. (PMID: 16522211) Mueller JW … Bayer P (BMC molecular biology 2006) 2 3 4 58
  3. Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14. (PMID: 12860119) Reimer T … Fischer G (Journal of molecular biology 2003) 3 4 22 58
  4. Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14. (PMID: 11162102) Terada T … Uchida T (Journal of molecular biology 2001) 3 4 22 58
  5. Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage. (PMID: 19369196) Fujiyama-Nakamura S … Takahashi N (Molecular & cellular proteomics : MCP 2009) 3 4 58

Products for PIN4 Gene

Sources for PIN4 Gene

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