Aliases for PIMREG Gene

Aliases for PIMREG Gene

  • PICALM Interacting Mitotic Regulator 2 3 5
  • Regulator Of Chromosome Segregation Protein 1 2 3 4
  • CALM Interacting Protein Expressed In Thymus And Spleen 2 3
  • CALM-Interactor Expressed In Thymus And Spleen 3 4
  • Family With Sequence Similarity 64 Member A 2 3
  • Protein PIMREG 3 4
  • FAM64A 3 4
  • CATS 3 4
  • RCS1 3 4
  • Family With Sequence Similarity 64, Member A 2
  • Regulator Of Chromosome Segregation 1 3
  • PICALM-Interacting Mitotic Regulator 4
  • Protein FAM64A 3

External Ids for PIMREG Gene

Previous HGNC Symbols for PIMREG Gene

  • FAM64A

Summaries for PIMREG Gene

GeneCards Summary for PIMREG Gene

PIMREG (PICALM Interacting Mitotic Regulator) is a Protein Coding gene. Diseases associated with PIMREG include Suppurative Periapical Periodontitis and Periapical Periodontitis.

UniProtKB/Swiss-Prot Summary for PIMREG Gene

  • During mitosis, may play a role in the control of metaphase-to-anaphase transition.

Additional gene information for PIMREG Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIMREG Gene

Genomics for PIMREG Gene

GeneHancer (GH) Regulatory Elements for PIMREG Gene

Promoters and enhancers for PIMREG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J006443 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 760.6 -0.1 -104 3 SP1 RBPJ POLR2A CREB1 NFYC ELF1 L3MBTL2 DACH1 MNT ZNF280D PIMREG lnc-PITPNM3-1 piR-50437-263 KCTD11 CLEC10A PLSCR3 DERL2 ENSG00000262089
GH17J006445 Promoter 0.3 Ensembl 750.6 +1.7 1695 0.2 HSALNG0114189 PIMREG lnc-PITPNM3-1
GH17J007233 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.4 +794.1 794054 12.1 PPP1R10 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SREBF1 SIX5 ZBTB6 LCORL DVL2 GABARAP PHF23 lnc-GABARAP-2 CNTROB SNORD10 POLR2A WRAP53 SNORA48 EIF4A1
GH17J007010 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 +573.3 573296 14.2 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SREBF1 SIX5 ZBTB6 MLX RNASEK BCL6B C17orf49 ENSG00000267047 MIR195 MIR497 DVL2 POLR2A SNORD10 CNTROB
GH17J007312 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10 +870.3 870340 4 ZNF785 SIN3A ZNF24 ZBTB40 ZBTB6 MLX RBPJ POLR2A ATF1 CREB1 GPS2 NEURL4 DVL2 CNTROB PER1 EIF5A POLR2A EIF4A1 CTC1 ACAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIMREG on UCSC Golden Path with GeneCards custom track

Genomic Locations for PIMREG Gene

Genomic Locations for PIMREG Gene
chr17:6,444,205-6,451,469
(GRCh38/hg38)
Size:
7,265 bases
Orientation:
Plus strand
chr17:6,347,735-6,354,789
(GRCh37/hg19)
Size:
7,055 bases
Orientation:
Plus strand

Genomic View for PIMREG Gene

Genes around PIMREG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIMREG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIMREG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIMREG Gene

Proteins for PIMREG Gene

  • Protein details for PIMREG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSJ6-PIMRE_HUMAN
    Recommended name:
    Protein PIMREG
    Protein Accession:
    Q9BSJ6
    Secondary Accessions:
    • Q96CT4
    • Q9NVV1
    • Q9NWB5

    Protein attributes for PIMREG Gene

    Size:
    248 amino acids
    Molecular mass:
    27480 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 interact with PICALM; this interaction may target PICALM to the nucleus (PubMed:16491119). During mitosis, associates with HDAC2 and MTA2 subunits of the chromatin-remodeling NuRD complex; this association is strongest at prometaphase and decreases as the cell progresses through metaphase and anaphase (PubMed:18757745).

    Alternative splice isoforms for PIMREG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIMREG Gene

Post-translational modifications for PIMREG Gene

  • Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PIMREG Gene

Domains & Families for PIMREG Gene

Gene Families for PIMREG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PIMREG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIMREG Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM64A (FA64A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BSJ6

UniProtKB/Swiss-Prot:

PIMRE_HUMAN :
  • The N-terminal destruction box 2 (D-box 2) is required for APC/C ubiquitination and proteasomal degradation.
Domain:
  • The N-terminal destruction box 2 (D-box 2) is required for APC/C ubiquitination and proteasomal degradation.
genes like me logo Genes that share domains with PIMREG: view

Function for PIMREG Gene

Molecular function for PIMREG Gene

UniProtKB/Swiss-Prot Function:
During mitosis, may play a role in the control of metaphase-to-anaphase transition.

Phenotypes From GWAS Catalog for PIMREG Gene

Gene Ontology (GO) - Molecular Function for PIMREG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16491119
genes like me logo Genes that share ontologies with PIMREG: view
genes like me logo Genes that share phenotypes with PIMREG: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIMREG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PIMREG Gene

Localization for PIMREG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIMREG Gene

Nucleus. Nucleus, nucleolus. Note=Partially localizes to the nucleolus. {ECO:0000269 PubMed:19383357}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIMREG gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PIMREG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IEA,IDA 16491119
genes like me logo Genes that share ontologies with PIMREG: view

Pathways & Interactions for PIMREG Gene

PathCards logo

SuperPathways for PIMREG Gene

No Data Available

SIGNOR curated interactions for PIMREG Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PIMREG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with PIMREG: view

No data available for Pathways by source for PIMREG Gene

Drugs & Compounds for PIMREG Gene

No Compound Related Data Available

Transcripts for PIMREG Gene

mRNA/cDNA for PIMREG Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIMREG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIMREG Gene

No ASD Table

Relevant External Links for PIMREG Gene

GeneLoc Exon Structure for
PIMREG
ECgene alternative splicing isoforms for
PIMREG

Expression for PIMREG Gene

NURSA nuclear receptor signaling pathways regulating expression of PIMREG Gene:

PIMREG

mRNA Expression by UniProt/SwissProt for PIMREG Gene:

Q9BSJ6-PIMRE_HUMAN
Tissue specificity: Expressed in thymus (at protein level). Detected in spleen, colon, ovary and small intestines.

Evidence on tissue expression from TISSUES for PIMREG Gene

  • Lung(4.1)
  • Intestine(4)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with PIMREG: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIMREG Gene

Orthologs for PIMREG Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIMREG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM64A 33 32
  • 98.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM64A 33 32
  • 85.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM64A 33 32
  • 81.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam64a 32
  • 79.15 (n)
mouse
(Mus musculus)
Mammalia Fam64a 33 32
  • 77.54 (n)
OneToOne
Pimreg 17
chicken
(Gallus gallus)
Aves FAM64A 33
  • 22 (a)
OneToOne
Species where no ortholog for PIMREG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIMREG Gene

ENSEMBL:
Gene Tree for PIMREG (if available)
TreeFam:
Gene Tree for PIMREG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIMREG: view image

Paralogs for PIMREG Gene

Pseudogenes.org Pseudogenes for PIMREG Gene

genes like me logo Genes that share paralogs with PIMREG: view

No data available for Paralogs for PIMREG Gene

Variants for PIMREG Gene

Sequence variations from dbSNP and Humsavar for PIMREG Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs142047814 likely-benign, Cone-Rod Dystrophy, Dominant 6,451,797(+) G/A/T downstream_transcript_variant
rs1555549891 uncertain-significance, Cone-Rod Dystrophy, Dominant 6,451,875(+) C/CGC downstream_transcript_variant
rs1555549918 uncertain-significance, Cone-Rod Dystrophy, Dominant 6,451,891(+) CC/CCC downstream_transcript_variant
rs188088185 likely-benign, Cone-Rod Dystrophy, Dominant 6,451,829(+) G/A downstream_transcript_variant
rs200905881 uncertain-significance, Cone-Rod Dystrophy, Dominant 6,451,882(+) /A/AA/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PIMREG Gene

Variant ID Type Subtype PubMed ID
nsv574278 CNV gain 21841781

Variation tolerance for PIMREG Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIMREG Gene

Human Gene Mutation Database (HGMD)
PIMREG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIMREG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIMREG Gene

Disorders for PIMREG Gene

MalaCards: The human disease database

(2) MalaCards diseases for PIMREG Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
suppurative periapical periodontitis
  • apical abscess
periapical periodontitis
  • apical periodontitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PIMREG

genes like me logo Genes that share disorders with PIMREG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIMREG Gene

Publications for PIMREG Gene

  1. The CALM and CALM/AF10 interactor CATS is a marker for proliferation. (PMID: 19383357) Archangelo LF … Bohlander SK (Molecular oncology 2008) 2 3 4 56
  2. The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10. (PMID: 16491119) Archangelo LF … Bohlander SK (Oncogene 2006) 2 3 4 56
  3. The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS). (PMID: 23419774) Archangelo LF … Saad ST (Biochimica et biophysica acta 2013) 3 4 56
  4. RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. (PMID: 18757745) Zhao WM … Fang G (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for PIMREG Gene

Sources for PIMREG Gene