Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PIM2 Gene

Aliases for PIM2 Gene

  • Pim-2 Proto-Oncogene, Serine/Threonine Kinase 2 3 5
  • Pim-2 Oncogene 2 3
  • EC 2.7.11.1 4 56
  • Pim-2h 3 4
  • Proto-Oncogene Pim-2 (Serine Threonine Kinase) 3
  • Serine/Threonine-Protein Kinase Pim-2 3

External Ids for PIM2 Gene

Previous GeneCards Identifiers for PIM2 Gene

  • GC0XM047573
  • GC0XM047031
  • GC0XM047816
  • GC0XM048526
  • GC0XM048655
  • GC0XM048770
  • GC0XM046426

Summaries for PIM2 Gene

Entrez Gene Summary for PIM2 Gene

  • This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

GeneCards Summary for PIM2 Gene

PIM2 (Pim-2 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PIM2 include Lymphoma and Colorectal Adenocarcinoma. Among its related pathways are Endometrial cancer and Pathways in cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PIM3.

UniProtKB/Swiss-Prot for PIM2 Gene

  • Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

Gene Wiki entry for PIM2 Gene

Additional gene information for PIM2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIM2 Gene

Genomics for PIM2 Gene

GeneHancer (GH) Regulatory Elements for PIM2 Gene

Promoters and enhancers for PIM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI048916 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.6 -0.6 -629 5.6 HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 PIM2 ENSG00000204620 FTSJ1 ENSG00000270012 RBM3 PQBP1 CCDC22 ZNF182 PLP2 OTUD5
GH0XI048954 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 12 -39.6 -39632 8.1 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 IRF4 OTUD5 RNU6-722P GPKOW PIM2 SLC35A2 PCSK1N ENSG00000228343 KCND1 GRIPAP1
GH0XI048933 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -19.4 -19364 9.7 HDGF FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 IRF4 ENSG00000279155 PQBP1 WAS OTUD5 SLC35A2 TIMM17B PIM2 TBC1D25 ENSG00000204620 ENSG00000228343
GH0XI048890 Enhancer 1.1 Ensembl ENCODE 12.8 +27.7 27722 2 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ATF7 SP3 REST GMEB1 GLIS1 SLC35A2 PIM2 ERAS GLOD5 GRIPAP1 PQBP1 PCSK1N
GH0XI048945 Enhancer 0.9 ENCODE dbSUPER 14.3 -26.8 -26802 0.2 CTCF SAP130 ARID4B ZNF2 RAD21 RFX5 FOXK2 SMC3 ZNF143 ZNF600 PIM2 SLC35A2 GLOD5 ENSG00000279155 OTUD5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PIM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIM2 gene promoter:

Genomic Locations for PIM2 Gene

Genomic Locations for PIM2 Gene
chrX:48,913,182-48,919,136
(GRCh38/hg38)
Size:
5,955 bases
Orientation:
Minus strand
chrX:48,770,459-48,776,413
(GRCh37/hg19)

Genomic View for PIM2 Gene

Genes around PIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIM2 Gene

Proteins for PIM2 Gene

  • Protein details for PIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1W9-PIM2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase pim-2
    Protein Accession:
    Q9P1W9
    Secondary Accessions:
    • A8K4G6
    • Q99739

    Protein attributes for PIM2 Gene

    Size:
    311 amino acids
    Molecular mass:
    34190 Da
    Quaternary structure:
    • Interacts with MYC.
    SequenceCaution:
    • Sequence=AAC78506.1; Type=Frameshift; Positions=293; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIM2 Gene

neXtProt entry for PIM2 Gene

Selected DME Specific Peptides for PIM2 Gene

Q9P1W9:
  • HRDIKDEN
  • GVIRLLDWFE
  • LLYDMVCGDIPFE

Post-translational modifications for PIM2 Gene

Other Protein References for PIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PIM2 Gene

Gene Families for PIM2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1W9

UniProtKB/Swiss-Prot:

PIM2_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
genes like me logo Genes that share domains with PIM2: view

Function for PIM2 Gene

Molecular function for PIM2 Gene

GENATLAS Biochemistry:
pim-2 oncogene murine otholog,with a large transcript,expressed in hematopoietic tissues and leukemia and lymphoma cell lines,testis (primary germ cells),small intestine,colon and colorectal adenocarcinoma cells. A short transcript can be detected only in spleen,tissue,small intestine and colon,potentially involved in proliferating cells as well as during meiosis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Enzyme Numbers (IUBMB) for PIM2 Gene

Gene Ontology (GO) - Molecular Function for PIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,TAS 18593906
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PIM2: view
genes like me logo Genes that share phenotypes with PIM2: view

Animal Models for PIM2 Gene

MGI Knock Outs for PIM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIM2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PIM2
  • Addgene plasmids for PIM2

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIM2 Gene

Localization for PIM2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIM2 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PIM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PIM2 Gene

Pathways & Interactions for PIM2 Gene

genes like me logo Genes that share pathways with PIM2: view

Pathways by source for PIM2 Gene

2 KEGG pathways for PIM2 Gene
2 Cell Signaling Technology pathways for PIM2 Gene

SIGNOR curated interactions for PIM2 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 20307683
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007140 male meiotic nuclear division TAS 9804974
genes like me logo Genes that share ontologies with PIM2: view

Drugs & Compounds for PIM2 Gene

(12) Drugs for PIM2 Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ruboxistaurin Investigational Pharma Inhibition, Inhibitor, inhibitor 14
SGI-1776 Investigational Pharma 0
ATP Investigational Nutra Agonist 0
AZD1208 Pharma PIM kinase inhibitor 0
CX-6258 Pharma Pan-Pim kinases Inhibitor 0

(1) Additional Compounds for PIM2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(7) ApexBio Compounds for PIM2 Gene

Compound Action Cas Number
AZD1208 PIM kinase inhibitor 1204144-28-4
CX-6258 Pan-Pim kinases Inhibitor 1202916-90-2
CX-6258 hydrochloride hydrate Pan-Pim kinases Inhibitor 1353858-99-7
SGI-1776 free base Pim kinase inhibitor,ATP-competitive 1025065-69-3
SMI-4a Potent Pim inhibitor 438190-29-5
TCS PIM-1 1 Pim-1 kinase inhibitor,ATP-competitve 491871-58-0
TCS-PIM-1-4a Pim inhibitor 327033-36-3
genes like me logo Genes that share compounds with PIM2: view

Drug Products

Transcripts for PIM2 Gene

mRNA/cDNA for PIM2 Gene

Unigene Clusters for PIM2 Gene

Pim-2 oncogene:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PIM2
  • Addgene plasmids for PIM2

Alternative Splicing Database (ASD) splice patterns (SP) for PIM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - - -

Relevant External Links for PIM2 Gene

GeneLoc Exon Structure for
PIM2
ECgene alternative splicing isoforms for
PIM2

Expression for PIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIM2 Gene

This gene is overexpressed in Whole Blood (x7.3) and Spleen (x7.2).

Protein differential expression in normal tissues from HIPED for PIM2 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIM2 Gene



Protein tissue co-expression partners for PIM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PIM2 Gene:

PIM2

SOURCE GeneReport for Unigene cluster for PIM2 Gene:

Hs.727148

mRNA Expression by UniProt/SwissProt for PIM2 Gene:

Q9P1W9-PIM2_HUMAN
Tissue specificity: Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues.

Evidence on tissue expression from TISSUES for PIM2 Gene

  • Blood(3.9)
  • Nervous system(3.8)
  • Bone marrow(2.4)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PIM2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PIM2 Gene

Orthologs for PIM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIM2 34 33
  • 99.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PIM2 34 33
  • 90.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PIM2 34 33
  • 90.68 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pim2 33
  • 87.25 (n)
mouse
(Mus musculus)
Mammalia Pim2 34 16 33
  • 86.39 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIM2 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIM2 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pim1 33
  • 59.45 (n)
worm
(Caenorhabditis elegans)
Secernentea prk-2 35
  • 42 (a)
prk-1 35
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for PIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIM2 Gene

ENSEMBL:
Gene Tree for PIM2 (if available)
TreeFam:
Gene Tree for PIM2 (if available)

Paralogs for PIM2 Gene

Paralogs for PIM2 Gene

genes like me logo Genes that share paralogs with PIM2: view

Variants for PIM2 Gene

Sequence variations from dbSNP and Humsavar for PIM2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000450660 -- 48,914,426(-) A/C coding_sequence_variant, synonymous_variant
rs1000800400 -- 48,914,101(-) C/T 3_prime_UTR_variant
rs1001402990 -- 48,916,178(-) T/G intron_variant
rs1001850951 -- 48,916,510(-) G/A intron_variant
rs1002810103 -- 48,918,258(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PIM2 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
nsv528292 CNV gain 19592680
nsv6894 CNV insertion 18451855

Variation tolerance for PIM2 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIM2 Gene

Disorders for PIM2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PIM2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
kabuki syndrome 1
  • kms
- elite association - COSMIC cancer census association via MalaCards
Search PIM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PIM2

genes like me logo Genes that share disorders with PIM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIM2 Gene

Publications for PIM2 Gene

  1. The human Pim-2 proto-oncogene and its testicular expression. (PMID: 9804974) Baytel D … Don J (Biochimica et biophysica acta 1998) 2 3 4 22 58
  2. Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell. (PMID: 18675992) Gong J … Shi Y (The Journal of surgical research 2009) 3 4 22 58
  3. Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells. (PMID: 20307683) Wang Z … Magnuson NS (The international journal of biochemistry & cell biology 2010) 3 4 58
  4. Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. (PMID: 19841674) Bullock AN … Knapp S (PloS one 2009) 3 4 58
  5. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PMID: 18593906) Morishita D … Fujita N (Cancer research 2008) 3 4 58

Products for PIM2 Gene

  • Addgene plasmids for PIM2
  • Addgene plasmids for PIM2

Sources for PIM2 Gene

Content
Loading form....