The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selecti... See more...

Aliases for PIM1 Gene

Aliases for PIM1 Gene

  • Pim-1 Proto-Oncogene, Serine/Threonine Kinase 2 3 5
  • Serine/Threonine-Protein Kinase Pim-1 3 4
  • EC 2.7.11.1 4 50
  • Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1 3
  • Pim-1 Oncogene (Proviral Integration Site 1) 3
  • Pim-1 Oncogene 2
  • Oncogene PIM1 3
  • PIM1 5
  • PIM 3

External Ids for PIM1 Gene

Previous HGNC Symbols for PIM1 Gene

  • PIM

Previous GeneCards Identifiers for PIM1 Gene

  • GC06P037140
  • GC06P037184
  • GC06P037245
  • GC06P036856
  • GC06P037137
  • GC06P037189
  • GC06P037818
  • GC06P042836
  • GC06P043184
  • GC06P043376
  • GC06P046065
  • GC06P037822
  • GC06P038426
  • GC06P039016
  • GC06P039604
  • GC06P040165
  • GC06P041245
  • GC06P041922
  • GC06P042564
  • GC06P047471
  • GC06P049529

Summaries for PIM1 Gene

Entrez Gene Summary for PIM1 Gene

  • The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

CIViC Summary for PIM1 Gene

GeneCards Summary for PIM1 Gene

PIM1 (Pim-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PIM1 include Primary Central Nervous System Lymphoma and Polyploidy. Among its related pathways are Validated targets of C-MYC transcriptional activation and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PIM3.

UniProtKB/Swiss-Prot Summary for PIM1 Gene

  • Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (PubMed:18056989). Promotes brown adipocyte differentiation (By similarity).

Tocris Summary for PIM1 Gene

  • Pim kinases are constitutively active serine/threonine kinases that promote growth factor-independent proliferation by phosphorylating, and thus inhibiting, a range of cellular proteins. They are serine/threonine kinases that control cell growth, differentiation and apoptosis.

Gene Wiki entry for PIM1 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIM1 Gene

Genomics for PIM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PIM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIM1

Top Transcription factor binding sites by QIAGEN in the PIM1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • E47
  • Lmo2
  • Max1
  • MAZR
  • SRF
  • SRF (504 AA)

Genomic Locations for PIM1 Gene

Latest Assembly
chr6:37,170,152-37,175,428
(GRCh38/hg38)
Size:
5,277 bases
Orientation:
Plus strand

Previous Assembly
chr6:37,137,928-37,143,204
(GRCh37/hg19 by Entrez Gene)
Size:
5,277 bases
Orientation:
Plus strand

chr6:37,137,979-37,143,202
(GRCh37/hg19 by Ensembl)
Size:
5,224 bases
Orientation:
Plus strand

Genomic View for PIM1 Gene

Genes around PIM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIM1 Gene

Proteins for PIM1 Gene

  • Protein details for PIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11309-PIM1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase pim-1
    Protein Accession:
    P11309
    Secondary Accessions:
    • Q38RT9
    • Q5T7H7
    • Q96RG3

    Protein attributes for PIM1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35686 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Isoform 1 is isolated as a monomer whereas isoform 2 complexes with other proteins (By similarity). Binds to RP9 (By similarity). Isoform 2, but not isoform 1, binds BMX (PubMed:16186805). Isoform 1 interacts with CDKN1B and FOXO3 (PubMed:18593906). Interacts with BAD (By similarity). Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination and proteasomal degradation (PubMed:12473674). Interacts with HSP90AA1, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation (PubMed:15798097). Interacts with CDKN1A (PubMed:12431783). Interacts with CDC25C (PubMed:16356754). Interacts (via N-terminal 96 residues) with CDC25A (By similarity). Interacts with MAP3K5 (PubMed:19749799). Interacts with MYC (By similarity). Interacts with CBX3 (PubMed:10664448).
    Miscellaneous:
    • [Isoform 2]: Initiates from CTG codon.

    Three dimensional structures from OCA and Proteopedia for PIM1 Gene

    Alternative splice isoforms for PIM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIM1 Gene

Selected DME Specific Peptides for PIM1 Gene

P11309:
  • QVLEAVRHC
  • RYHRYHGRSA
  • HRDIKDEN
  • DLFDFITE
  • AVRHCHNCGV
  • GVIRLLDWFE
  • GQVFFRQ
  • VSSECQHLI
  • GGFGSVY
  • LLYDMVCGDIPFE

Post-translational modifications for PIM1 Gene

  • Autophosphorylated on both serine/threonine and tyrosine residues. Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.
  • Ubiquitinated, leading to proteasomal degradation.
  • Ubiquitination at Lys5
  • Modification sites at PhosphoSitePlus

Other Protein References for PIM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for PIM1

Domains & Families for PIM1 Gene

Gene Families for PIM1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PIM1 Gene

GenScript: Design optimal peptide antigens:
  • Proto-oncogene serine/threonine-protein kinase pim-1 (PIM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11309

UniProtKB/Swiss-Prot:

PIM1_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
genes like me logo Genes that share domains with PIM1: view

Function for PIM1 Gene

Molecular function for PIM1 Gene

UniProtKB/Swiss-Prot Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (PubMed:18056989). Promotes brown adipocyte differentiation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:15525646, ECO:0000269|PubMed:15657054, ECO:0000269|PubMed:15808862};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:15525646, ECO:0000269|PubMed:15657054, ECO:0000269|PubMed:15808862};.
UniProtKB/Swiss-Prot Induction:
Strongly induced in leukocytes by the JAK/STAT pathway in response to cytokines. Induced by different cellular stresses, heat shock and cytotoxic agents.
GENATLAS Biochemistry:
pim-1 oncogene

Enzyme Numbers (IUBMB) for PIM1 Gene

Phenotypes From GWAS Catalog for PIM1 Gene

Gene Ontology (GO) - Molecular Function for PIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 1825810
GO:0005515 protein binding IPI 16186805
GO:0005524 ATP binding IDA 1825810
genes like me logo Genes that share ontologies with PIM1: view
genes like me logo Genes that share phenotypes with PIM1: view

Animal Models for PIM1 Gene

MGI Knock Outs for PIM1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIM1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIM1 Gene

Localization for PIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIM1 Gene

[Isoform 1]: Cytoplasm. Nucleus.
[Isoform 2]: Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIM1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21474815
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA,IDA 1825810
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PIM1: view

Pathways & Interactions for PIM1 Gene

genes like me logo Genes that share pathways with PIM1: view

Pathways by source for PIM1 Gene

3 Qiagen pathways for PIM1 Gene
  • IL-10 Pathway
  • IL-6 Pathway
  • STAT3 Pathway
2 Cell Signaling Technology pathways for PIM1 Gene
1 GeneTex pathway for PIM1 Gene

SIGNOR curated interactions for PIM1 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 1825810
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development TAS 2682662
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PIM1: view

Drugs & Compounds for PIM1 Gene

(47) Drugs for PIM1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Manganese Approved Nutra 65
Imidazole Experimental, Investigational Pharma Target 66
(2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile Experimental Pharma Target 0
(3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Experimental Pharma Target 0

(3) Additional Compounds for PIM1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
TCS PIM-1 4a
438190-29-5

(4) Tocris Compounds for PIM1 Gene

Compound Action Cas Number
PIM-1 Inhibitor 2 Pim-1 kinase inhibitor 477845-12-8
R8-T198wt Pim-1 kinase inhibitor
TCS PIM-1 1 Selective, ATP-competitive Pim-1 kinase inhibitor 491871-58-0
TCS PIM-1 4a Selective, ATP-competitive Pim kinase inhibitor 438190-29-5

(9) ApexBio Compounds for PIM1 Gene

Compound Action Cas Number
AZD1208 PIM kinase inhibitor 1204144-28-4
CX-6258 Pan-Pim kinases Inhibitor 1202916-90-2
LKB1 (AAK1 dual inhibitor) Pim-1 kinase inhibitor 1093222-27-5
PIM-1 Inhibitor 2 Potent Pim-1 kinase inhibitor 477845-12-8
R8-T198wt Pim-1 kinase inhibitor
SGI-1776 free base Pim kinase inhibitor,ATP-competitive 1025065-69-3
SMI-4a Potent Pim inhibitor 438190-29-5
TCS PIM-1 1 Pim-1 kinase inhibitor,ATP-competitve 491871-58-0
TCS-PIM-1-4a Pim inhibitor 327033-36-3
genes like me logo Genes that share compounds with PIM1: view

Drug products for research

Transcripts for PIM1 Gene

mRNA/cDNA for PIM1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIM1

Alternative Splicing Database (ASD) splice patterns (SP) for PIM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: -
SP3:
SP4: -
SP5: - -

Relevant External Links for PIM1 Gene

GeneLoc Exon Structure for
PIM1

Expression for PIM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIM1 Gene

This gene is overexpressed in Whole Blood (x6.3) and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for PIM1 Gene

This gene is overexpressed in Lung (62.0) and Vitreous humor (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIM1 Gene



Protein tissue co-expression partners for PIM1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIM1

SOURCE GeneReport for Unigene cluster for PIM1 Gene:

Hs.81170

mRNA Expression by UniProt/SwissProt for PIM1 Gene:

P11309-PIM1_HUMAN
Tissue specificity: Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.

Evidence on tissue expression from TISSUES for PIM1 Gene

  • Kidney(4.5)
  • Skin(3.2)
  • Bone marrow(2.8)
  • Spleen(2.7)
  • Heart(2.6)
  • Nervous system(2.6)
  • Liver(2.5)
  • Muscle(2.5)
  • Intestine(2.4)
  • Lung(2.4)
  • Blood(2.4)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with PIM1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PIM1 Gene

Orthologs for PIM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PIM1 29 30
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PIM1 29 30
  • 95.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PIM1 29 30
  • 94.78 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PIM1 30
  • 93 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pim1 29
  • 89.99 (n)
Mouse
(Mus musculus)
Mammalia Pim1 29 16 30
  • 89.88 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 56 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves PIM1 29 30
  • 78.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PIM1 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pim1 29
  • 68.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia pim1-A-prov 29
Zebrafish
(Danio rerio)
Actinopterygii pim1 30
  • 70 (a)
OneToOne
zgc:153997 29
  • 69.4 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2507 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG3105 31
  • 32 (a)
Worm
(Caenorhabditis elegans)
Secernentea prk-2 29 31
  • 52.31 (n)
prk-1 31
  • 36 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 53 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5685 29
Species where no ortholog for PIM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PIM1 Gene

ENSEMBL:
Gene Tree for PIM1 (if available)
TreeFam:
Gene Tree for PIM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIM1: view image
Alliance of Genome Resources:
Additional Orthologs for PIM1

Paralogs for PIM1 Gene

Paralogs for PIM1 Gene

(2) SIMAP similar genes for PIM1 Gene using alignment to 1 proteins:

  • PIM1_HUMAN
genes like me logo Genes that share paralogs with PIM1: view

Variants for PIM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIM1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs262937 Benign: not provided 37,170,529(+) G/A
NM_002648.4(PIM1):c.-47G>A
MISSENSE_VARIANT,FIVE_PRIME_UTR
rs56213408 Benign: not provided 37,173,123(+) C/T
NM_002648.4(PIM1):c.735C>T (p.Asp245=)
SYNONYMOUS
VAR_041004 A colorectal adenocarcinoma sample p.Tyr53His
rs200523275 -- p.Glu135Lys
rs33989191 -- p.Glu142Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PIM1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PIM1 Gene

Variant ID Type Subtype PubMed ID
nsv1015689 CNV gain 25217958
nsv1073549 CNV deletion 25765185
nsv1145098 CNV deletion 24896259
nsv5264 CNV insertion 18451855

Variation tolerance for PIM1 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIM1
Leiden Open Variation Database (LOVD)
PIM1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIM1 Gene

Disorders for PIM1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PIM1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
primary central nervous system lymphoma
  • pcnsl
polyploidy
prostate cancer
  • prostate cancer, somatic
myeloid leukemia
  • leukaemia myelogenous
plasma protein metabolism disease
- elite association - COSMIC cancer census association via MalaCards
Search PIM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PIM1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PIM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIM1 Gene

Publications for PIM1 Gene

  1. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PMID: 18593906) Morishita D … Fujita N (Cancer research 2008) 3 4 22
  2. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. (PMID: 16356754) Bachmann M … Möröy T (The international journal of biochemistry & cell biology 2006) 3 4 22
  3. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. (PMID: 16186805) Xie Y … Qiu Y (Oncogene 2006) 3 4 22
  4. Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. (PMID: 15525646) Qian KC … Farmer B (The Journal of biological chemistry 2005) 3 4 22
  5. Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway. (PMID: 15798097) Shay KP … Magnuson NS (Molecular cancer research : MCR 2005) 3 4 22

Products for PIM1 Gene

  • Addgene plasmids for PIM1

Sources for PIM1 Gene