Aliases for PILRA Gene
External Ids for PILRA Gene
Previous GeneCards Identifiers for PILRA Gene
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
GeneCards Summary for PILRA Gene
PILRA (Paired Immunoglobin Like Type 2 Receptor Alpha) is a Protein Coding gene. Diseases associated with PILRA include Herpes Simplex and Asymptomatic Neurosyphilis. Among its related pathways are Herpes simplex virus 1 infection. An important paralog of this gene is PILRB.
UniProtKB/Swiss-Prot Summary for PILRA Gene
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.
(Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.