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Aliases for PIKFYVE Gene

Aliases for PIKFYVE Gene

  • Phosphoinositide Kinase, FYVE-Type Zinc Finger Containing 2 3 5
  • Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase, Type III 2 3
  • Phosphatidylinositol 3-Phosphate 5-Kinase Type III 3 4
  • Phosphoinositide Kinase, FYVE Finger Containing 2 3
  • Zinc Finger, FYVE Domain Containing 29 2 3
  • Type III PIP Kinase 3 4
  • PIPkin-III 3 4
  • PIP5K3 3 4
  • FYVE Finger-Containing Phosphoinositide Kinase 4
  • 1-Phosphatidylinositol 3-Phosphate 5-Kinase 3
  • Phosphatidylinositol 3-Phosphate 5-Kinase 4
  • Epididymis Luminal Protein 37 3
  • EC 2.7.1.150 4
  • KIAA0981 4
  • ZFYVE29 3
  • PIKfyve 4
  • HEL37 3
  • PIP5K 3
  • FAB1 3
  • CFD 3

External Ids for PIKFYVE Gene

Previous HGNC Symbols for PIKFYVE Gene

  • PIP5K3

Previous GeneCards Identifiers for PIKFYVE Gene

  • GC02P208840
  • GC02P209130
  • GC02P200979

Summaries for PIKFYVE Gene

Entrez Gene Summary for PIKFYVE Gene

  • Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

GeneCards Summary for PIKFYVE Gene

PIKFYVE (Phosphoinositide Kinase, FYVE-Type Zinc Finger Containing) is a Protein Coding gene. Diseases associated with PIKFYVE include Corneal Dystrophy, Fleck and Corneal Dystrophy. Among its related pathways are Metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol phosphate kinase activity and phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity. An important paralog of this gene is ZFYVE16.

UniProtKB/Swiss-Prot for PIKFYVE Gene

  • The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.

Gene Wiki entry for PIKFYVE Gene

Additional gene information for PIKFYVE Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIKFYVE Gene

Genomics for PIKFYVE Gene

GeneHancer (GH) Regulatory Elements for PIKFYVE Gene

Promoters and enhancers for PIKFYVE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J208251 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 666.3 -12.0 -11976 4.8 MLX ZFP64 DMAP1 YY1 ZNF213 ZNF143 ZNF263 SP3 NFYC PPARGC1A PIKFYVE IDH1-AS1 IDH1 CREB1 PTH2R TPT1P2 GC02P208116
GH02J208264 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 659.9 +0.8 804 3.7 HDGF SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 PIKFYVE IDH1 PTH2R MYL6BP1 GC02P208116
GH02J207681 Promoter/Enhancer 1.7 Ensembl ENCODE 32.3 -582.6 -582590 3.9 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 ETS1 YY1 SLC30A9 ZNF121 PPP1R14BP2 PIKFYVE CREB1 CCNYL1 GC02P207688
GH02J207762 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.6 -498.0 -498026 10 CLOCK FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B FZD5 CREB1 PIKFYVE KLF7-IT1 METTL21A PLEKHM3 MIR4775
GH02J207623 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 -640.1 -640069 4.2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 METTL21A CREB1 ENSG00000224342 LOC100533727 LOC100288663 ENSG00000231653 ENSG00000231896 PIKFYVE FASTKD2 CRYGC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIKFYVE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIKFYVE gene promoter:
  • HOXA3
  • MIF-1
  • CHOP-10
  • C/EBPalpha
  • Pax-5
  • STAT5B
  • c-Myb
  • Evi-1
  • ATF6

Genomic Locations for PIKFYVE Gene

Genomic Locations for PIKFYVE Gene
chr2:208,265,753-208,358,751
(GRCh38/hg38)
Size:
92,999 bases
Orientation:
Plus strand
chr2:209,130,991-209,223,475
(GRCh37/hg19)
Size:
92,485 bases
Orientation:
Plus strand

Genomic View for PIKFYVE Gene

Genes around PIKFYVE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIKFYVE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIKFYVE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIKFYVE Gene

Proteins for PIKFYVE Gene

  • Protein details for PIKFYVE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2I7-FYV1_HUMAN
    Recommended name:
    1-phosphatidylinositol 3-phosphate 5-kinase
    Protein Accession:
    Q9Y2I7
    Secondary Accessions:
    • Q08AR7
    • Q08AR8
    • Q53ST3
    • Q53T36
    • Q8N5H0
    • Q8NB67

    Protein attributes for PIKFYVE Gene

    Size:
    2098 amino acids
    Molecular mass:
    237136 Da
    Quaternary structure:
    • Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold.
    SequenceCaution:
    • Sequence=BAC03674.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PIKFYVE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIKFYVE Gene

Post-translational modifications for PIKFYVE Gene

  • Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PIKFYVE Gene

Domains & Families for PIKFYVE Gene

Gene Families for PIKFYVE Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PIKFYVE Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIKFYVE: view

No data available for UniProtKB/Swiss-Prot for PIKFYVE Gene

Function for PIKFYVE Gene

Molecular function for PIKFYVE Gene

UniProtKB/Swiss-Prot Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.

Enzyme Numbers (IUBMB) for PIKFYVE Gene

Phenotypes From GWAS Catalog for PIKFYVE Gene

Gene Ontology (GO) - Molecular Function for PIKFYVE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity IBA,IEA --
GO:0005515 protein binding IPI 15046600
GO:0005524 ATP binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PIKFYVE: view
genes like me logo Genes that share phenotypes with PIKFYVE: view

Human Phenotype Ontology for PIKFYVE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PIKFYVE Gene

MGI Knock Outs for PIKFYVE:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIKFYVE

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for PIKFYVE Gene

Localization for PIKFYVE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIKFYVE Gene

Endosome membrane. Note=Mainly associated with membranes of the late endocytic pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIKFYVE gene
Compartment Confidence
golgi apparatus 5
endosome 5
cytosol 4
nucleus 3
plasma membrane 2
lysosome 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIKFYVE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IBA --
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with PIKFYVE: view

Pathways & Interactions for PIKFYVE Gene

genes like me logo Genes that share pathways with PIKFYVE: view

Pathways by source for PIKFYVE Gene

SIGNOR curated interactions for PIKFYVE Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PIKFYVE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006458 NOT de novo protein folding IBA --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006898 NOT receptor-mediated endocytosis IMP 14551253
GO:0007005 mitochondrion organization IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PIKFYVE: view

Drugs & Compounds for PIKFYVE Gene

(9) Drugs for PIKFYVE Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
YM201636 Pharma PIKfyve inhibitor,potent and selective 0

(13) Additional Compounds for PIKFYVE Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with PIKFYVE: view

Transcripts for PIKFYVE Gene

Unigene Clusters for PIKFYVE Gene

Phosphoinositide kinase, FYVE finger containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIKFYVE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2: - -
SP3: - -
SP4: - -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
SP1:
SP2:
SP3:
SP4:

Relevant External Links for PIKFYVE Gene

GeneLoc Exon Structure for
PIKFYVE
ECgene alternative splicing isoforms for
PIKFYVE

Expression for PIKFYVE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIKFYVE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIKFYVE Gene

This gene is overexpressed in Breast (15.8), Plasma (11.9), Saliva (9.5), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIKFYVE Gene



NURSA nuclear receptor signaling pathways regulating expression of PIKFYVE Gene:

PIKFYVE

SOURCE GeneReport for Unigene cluster for PIKFYVE Gene:

Hs.744997

Evidence on tissue expression from TISSUES for PIKFYVE Gene

  • Nervous system(4.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PIKFYVE Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • eye
  • head
genes like me logo Genes that share expression patterns with PIKFYVE: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PIKFYVE Gene

Orthologs for PIKFYVE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIKFYVE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIKFYVE 34 33
  • 99.76 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PIKFYVE 34 33
  • 91.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PIKFYVE 34 33
  • 91.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pikfyve 33
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia PIKFYVE 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pikfyve 16 34 33
  • 85.94 (n)
chicken
(Gallus gallus)
Aves PIKFYVE 34 33
  • 77.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIKFYVE 34
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pikfyve 34 33
  • 67.92 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fab1 34 33
  • 49.13 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005216 33
  • 47.18 (n)
worm
(Caenorhabditis elegans)
Secernentea ppk-3 34
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAB1 36 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2672 34
  • 35 (a)
OneToOne
Species where no ortholog for PIKFYVE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIKFYVE Gene

ENSEMBL:
Gene Tree for PIKFYVE (if available)
TreeFam:
Gene Tree for PIKFYVE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIKFYVE: view image

Paralogs for PIKFYVE Gene

Paralogs for PIKFYVE Gene

genes like me logo Genes that share paralogs with PIKFYVE: view

Variants for PIKFYVE Gene

Sequence variations from dbSNP and Humsavar for PIKFYVE Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000968617 uncertain-significance, Fleck corneal dystrophy 208,355,857(+) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs10208191 benign, Fleck corneal dystrophy 208,355,433(+) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs10208295 benign, Fleck corneal dystrophy 208,355,514(+) G/C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs10622340 benign, Fleck corneal dystrophy 208,358,400(+) TTTTTTTTTT/TTTTTTTTTTT/TTTTTTTTTTTT/TTTTTTTTTTTTT/TTTTTTTTTTTTTT 3_prime_UTR_variant, genic_downstream_transcript_variant
rs10932258 benign, Fleck corneal dystrophy 208,320,256(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for PIKFYVE Gene

Variant ID Type Subtype PubMed ID
nsv3137 CNV insertion 18451855
nsv437315 CNV loss 16327808
nsv460055 CNV loss 19166990
nsv478606 CNV novel sequence insertion 20440878
nsv584297 CNV gain 21841781
nsv584302 CNV loss 21841781
nsv819526 CNV loss 19587683
nsv834517 CNV loss 17160897

Variation tolerance for PIKFYVE Gene

Residual Variation Intolerance Score: 0.693% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIKFYVE Gene

Human Gene Mutation Database (HGMD)
PIKFYVE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIKFYVE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIKFYVE Gene

Disorders for PIKFYVE Gene

MalaCards: The human disease database

(6) MalaCards diseases for PIKFYVE Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

FYV1_HUMAN
  • Corneal dystrophy, fleck (CFD) [MIM:121850]: A form of stromal corneal dystrophy characterized by numerous small white flecks scattered in all levels of the stroma, with configurations varying from semicircular to wreath-like, curvilinear, or punctate. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision. {ECO:0000269 PubMed:15902656}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PIKFYVE

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PIKFYVE: view

No data available for Genatlas for PIKFYVE Gene

Publications for PIKFYVE Gene

  1. ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. (PMID: 18950639) Sbrissa D … Shisheva A (Journal of molecular biology 2008) 3 4 22 58
  2. Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. (PMID: 17556371) Sbrissa D … Shisheva A (The Journal of biological chemistry 2007) 3 4 22 58
  3. Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization. (PMID: 11706043) Sbrissa D … Shisheva A (The Journal of biological chemistry 2002) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin. (PMID: 19056739) Ikonomov OC … Shisheva A (The Journal of biological chemistry 2009) 3 22 58

Products for PIKFYVE Gene

Sources for PIKFYVE Gene

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