Aliases for PIK3R5 Gene
External Ids for PIK3R5 Gene
Previous GeneCards Identifiers for PIK3R5 Gene
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
GeneCards Summary for PIK3R5 Gene
PIK3R5 (Phosphoinositide-3-Kinase Regulatory Subunit 5) is a Protein Coding gene. Diseases associated with PIK3R5 include Ataxia-Oculomotor Apraxia 3 and Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include G-protein beta/gamma-subunit complex binding and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is PIK3R6.
UniProtKB/Swiss-Prot Summary for PIK3R5 Gene
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.