Aliases for PIK3R4 Gene
External Ids for PIK3R4 Gene
Previous GeneCards Identifiers for PIK3R4 Gene
GeneCards Summary for PIK3R4 Gene
PIK3R4 (Phosphoinositide-3-Kinase Regulatory Subunit 4) is a Protein Coding gene. Diseases associated with PIK3R4 include Danon Disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding.
UniProtKB/Swiss-Prot for PIK3R4 Gene
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.