Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protei... See more...

Aliases for PIK3R3 Gene

Aliases for PIK3R3 Gene

  • Phosphoinositide-3-Kinase Regulatory Subunit 3 2 3 5
  • Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma 3 4
  • Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma) 2 3
  • Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma 3 4
  • PtdIns-3-Kinase Regulatory Subunit P55-Gamma 3 4
  • PI3-Kinase Regulatory Subunit Gamma 3 4
  • PI3K Regulatory Subunit Gamma 3 4
  • PI3-Kinase Subunit P55-Gamma 3 4
  • P55PIK 3 4
  • P55 2 3
  • Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma) 3
  • Phosphoinositide-3-Kinase Regulatory Subunit Gamma 2
  • PtdIns-3-Kinase Regulatory Subunit Gamma 4
  • P55-GAMMA 3
  • PIK3R3 5

External Ids for PIK3R3 Gene

Previous GeneCards Identifiers for PIK3R3 Gene

  • GC01M046199
  • GC01M045462
  • GC01M045892
  • GC01M045875
  • GC01M046217
  • GC01M046505
  • GC01M044621

Summaries for PIK3R3 Gene

Entrez Gene Summary for PIK3R3 Gene

  • Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]

GeneCards Summary for PIK3R3 Gene

PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3) is a Protein Coding gene. Diseases associated with PIK3R3 include Asbestos-Related Lung Carcinoma and Cervical Non-Keratinizing Squamous Cell Carcinoma. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and NGF Pathway. Gene Ontology (GO) annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is P3R3URF-PIK3R3.

UniProtKB/Swiss-Prot Summary for PIK3R3 Gene

  • Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Tocris Summary for PIK3R3 Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3R3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIK3R3 Gene

Genomics for PIK3R3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PIK3R3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J046128 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 611.1 +42.8 42848 8.1 BRCA1 RNF2 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 PIK3R3 LOC101929626 TOE1 LRRC41 GPBP1L1 RPL7AP16 MUTYH EFCAB14-AS1 RPS15AP10 MOB3C
GH01J046170 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 +1.6 1573 5 CREB1 ATF7 PRDM10 ZNF629 IKZF1 ZNF692 ZHX2 JUND ZNF300 ZNF776 PIK3R3 TSPAN1 NASP LRRC41 TOE1 NSUN4 MUTYH TEX38 LURAP1 RPL7AP16
GH01J046042 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 611.8 +131.9 131900 3.2 KDM1A RELA TCF12 IKZF2 EED DPF2 RUNX3 GATAD2B NFE2 BCLAF1 PIK3R3 piR-31899 piR-54463 piR-50987 CCDC163 P3R3URF TSPAN1 LURAP1 POMGNT1 MAST2
GH01J046176 Promoter 0.4 EPDnew 600.7 -1.6 -1607 0.1 PRDM10 P3R3URF P3R3URF-PIK3R3 PIK3R3 TSPAN1 lnc-POMGNT1-1 lnc-PIK3R3-3 LURAP1
GH01J046177 Enhancer 0.3 Ensembl 600.7 -1.4 -1400 0.2 PRDM10 P3R3URF P3R3URF-PIK3R3 PIK3R3 TSPAN1 lnc-POMGNT1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIK3R3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIK3R3

Top Transcription factor binding sites by QIAGEN in the PIK3R3 gene promoter:
  • c-Myb
  • Cart-1
  • Hlf
  • Nkx2-5
  • Pax-5

Genomic Locations for PIK3R3 Gene

Genomic Locations for PIK3R3 Gene
chr1:46,040,140-46,174,901
(GRCh38/hg38)
Size:
134,762 bases
Orientation:
Minus strand
chr1:46,505,812-46,642,160
(GRCh37/hg19)
Size:
136,349 bases
Orientation:
Minus strand

Genomic View for PIK3R3 Gene

Genes around PIK3R3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3R3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3R3 Gene

Proteins for PIK3R3 Gene

  • Protein details for PIK3R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92569-P55G_HUMAN
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit gamma
    Protein Accession:
    Q92569
    Secondary Accessions:
    • B2R9C1
    • D3DQ12
    • O60482
    • Q5T4P1
    • Q5T4P2

    Protein attributes for PIK3R3 Gene

    Size:
    461 amino acids
    Molecular mass:
    54448 Da
    Quaternary structure:
    • Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.

    Alternative splice isoforms for PIK3R3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIK3R3 Gene

Post-translational modifications for PIK3R3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PIK3R3 Gene

Domains & Families for PIK3R3 Gene

Gene Families for PIK3R3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for PIK3R3 Gene

InterPro:
Blocks:
  • SH2 domain signature
  • PI3 kinase P85 regulatory subunit signature
ProtoNet:

Suggested Antigen Peptide Sequences for PIK3R3 Gene

GenScript: Design optimal peptide antigens:
  • p55PIK (P55G_HUMAN)
  • PIK3R3 protein (Q05DQ0_HUMAN)
  • Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) (Q8N381_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92569

UniProtKB/Swiss-Prot:

P55G_HUMAN :
  • Belongs to the PI3K p85 subunit family.
Family:
  • Belongs to the PI3K p85 subunit family.
genes like me logo Genes that share domains with PIK3R3: view

Function for PIK3R3 Gene

Molecular function for PIK3R3 Gene

UniProtKB/Swiss-Prot Function:
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Phenotypes From GWAS Catalog for PIK3R3 Gene

Gene Ontology (GO) - Molecular Function for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IPI 20624904
GO:0005515 protein binding IPI 16273093
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS 9524259
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA 21873635
genes like me logo Genes that share ontologies with PIK3R3: view
genes like me logo Genes that share phenotypes with PIK3R3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3R3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIK3R3 Gene

Localization for PIK3R3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIK3R3 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 3
plasma membrane 2
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005942 phosphatidylinositol 3-kinase complex IBA 21873635
genes like me logo Genes that share ontologies with PIK3R3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PIK3R3 Gene

Pathways & Interactions for PIK3R3 Gene

PathCards logo

SuperPathways for PIK3R3 Gene

SuperPathway Contained pathways
1 RET signaling
2 IL-2 Pathway
.59
.59
.54
.51
.49
.49
.48
.47
.43
.36
.35
.34
3 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.42
.38
.36
4 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.66
.65
.64
.60
5 Regulation of lipid metabolism Insulin signaling-generic cascades
.59
.59
.51
.47
.44
.43
.35
genes like me logo Genes that share pathways with PIK3R3: view

Pathways by source for PIK3R3 Gene

51 GeneGo (Thomson Reuters) pathways for PIK3R3 Gene
  • Apoptosis and survival BAD phosphorylation
  • Apoptosis and survival NGF signaling pathway
  • Cell adhesion PLAU signaling
  • Cell adhesion_Plasmin signaling
  • Cytoskeleton remodeling FAK signaling
132 Qiagen pathways for PIK3R3 Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • Activation of PKC through GPCR
  • Akt Signaling
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for PIK3R3 Gene

SIGNOR curated interactions for PIK3R3 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 28341552
GO:0002042 cell migration involved in sprouting angiogenesis IGI 28341552
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0008286 insulin receptor signaling pathway TAS,IBA 21873635
GO:0010628 positive regulation of gene expression IMP 28341552
genes like me logo Genes that share ontologies with PIK3R3: view

Drugs & Compounds for PIK3R3 Gene

(27) Drugs for PIK3R3 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoproterenol Approved, Investigational Pharma Agonist, Full agonist, Target, agonist 31
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0
Quercetin Experimental, Investigational Pharma Antitumor agent, Non-selective PI 3-kinase inhibitor 54
Wortmannin Experimental Pharma PI3K inhibitor,selective and irreversible, Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 0
SF1126 Investigational Pharma Target, inhibitor Kinase Inhibitors 0

(3) Additional Compounds for PIK3R3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LY 294002 hydrochloride
934389-88-5

(5) Tocris Compounds for PIK3R3 Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7
genes like me logo Genes that share compounds with PIK3R3: view

Transcripts for PIK3R3 Gene

mRNA/cDNA for PIK3R3 Gene

11 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3R3

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:
SP10:

ExUns: 13b ^ 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PIK3R3 Gene

GeneLoc Exon Structure for
PIK3R3

Expression for PIK3R3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIK3R3 Gene

Protein differential expression in normal tissues from HIPED for PIK3R3 Gene

This gene is overexpressed in Testis (56.2) and Spleen (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIK3R3 Gene



Protein tissue co-expression partners for PIK3R3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIK3R3

SOURCE GeneReport for Unigene cluster for PIK3R3 Gene:

Hs.655387

mRNA Expression by UniProt/SwissProt for PIK3R3 Gene:

Q92569-P55G_HUMAN
Tissue specificity: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for PIK3R3 Gene

  • Nervous system(4.8)
  • Muscle(2.6)
  • Heart(2.5)
  • Kidney(2.3)
  • Blood(2.3)
  • Lymph node(2.2)
  • Lung(2.2)
  • Spleen(2.2)
  • Pancreas(2.2)
  • Intestine(2.1)
  • Liver(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with PIK3R3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3R3 Gene

Orthologs for PIK3R3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3R3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PIK3R3 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PIK3R3 30 31
  • 94.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PIK3R3 30 31
  • 93.78 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pik3r3 30 17 31
  • 91.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pik3r3 30
  • 90.89 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PIK3R3 31
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PIK3R3 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PIK3R3 30 31
  • 83.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PIK3R3 31
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pik3r3 30
  • 80.55 (n)
Str.7110 30
Zebrafish
(Danio rerio)
Actinopterygii pik3r3b 30 31
  • 75.05 (n)
OneToOne
zgc55564 30
Fruit Fly
(Drosophila melanogaster)
Insecta Pi3K21B 31
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea aap-1 31
  • 24 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 2 (a)
OneToMany
Species where no ortholog for PIK3R3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PIK3R3 Gene

ENSEMBL:
Gene Tree for PIK3R3 (if available)
TreeFam:
Gene Tree for PIK3R3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIK3R3: view image

Paralogs for PIK3R3 Gene

Paralogs for PIK3R3 Gene

(5) SIMAP similar genes for PIK3R3 Gene using alignment to 6 proteins:

  • P55G_HUMAN
  • E7EMU8_HUMAN
  • F6TDL0_HUMAN
  • Q05DQ0_HUMAN
  • Q5T4P3_HUMAN
  • Q8N381_HUMAN
genes like me logo Genes that share paralogs with PIK3R3: view

Variants for PIK3R3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIK3R3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs765790132 Uncertain Significance: Familial cancer of breast 46,055,939(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs785467 - p.Asn283Lys

Additional dbSNP identifiers (rs#s) for PIK3R3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PIK3R3 Gene

Variant ID Type Subtype PubMed ID
dgv19e214 CNV gain 21293372
dgv31e212 CNV gain 25503493
esv2761743 CNV gain 21179565
esv3577805 CNV gain 25503493
esv3585925 CNV gain 21293372
esv3893512 CNV gain 25118596
nsv1007750 CNV gain 25217958
nsv1009527 CNV gain 25217958
nsv475809 CNV novel sequence insertion 20440878
nsv508012 OTHER sequence alteration 20534489
nsv829737 CNV gain 17160897

Variation tolerance for PIK3R3 Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIK3R3 Gene

Human Gene Mutation Database (HGMD)
PIK3R3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIK3R3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3R3 Gene

Disorders for PIK3R3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for PIK3R3 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PIK3R3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PIK3R3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3R3 Gene

Publications for PIK3R3 Gene

  1. Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. (PMID: 9524259) Dey BR … Nissley SP (Gene 1998) 2 3 4
  2. Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. (PMID: 20197460) Koutros S … Berndt SI (Cancer research 2010) 3 41
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. (PMID: 17360667) Soroceanu L … Phillips HS (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for PIK3R3 Gene

Sources for PIK3R3 Gene