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Aliases for PIK3R3 Gene

Aliases for PIK3R3 Gene

  • Phosphoinositide-3-Kinase Regulatory Subunit 3 2 3 5
  • Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma 3 4
  • Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma) 2 3
  • PtdIns-3-Kinase Regulatory Subunit P55-Gamma 3 4
  • PI3-Kinase Regulatory Subunit Gamma 3 4
  • PI3K Regulatory Subunit Gamma 3 4
  • PI3-Kinase Subunit P55-Gamma 3 4
  • P55PIK 3 4
  • Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma) 3
  • Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma 3
  • Phosphoinositide-3-Kinase Regulatory Subunit Gamma 2
  • PtdIns-3-Kinase Regulatory Subunit Gamma 4
  • P55-GAMMA 3
  • P55 3

External Ids for PIK3R3 Gene

Previous GeneCards Identifiers for PIK3R3 Gene

  • GC01M046199
  • GC01M045462
  • GC01M045892
  • GC01M045875
  • GC01M046217
  • GC01M046505
  • GC01M044621

Summaries for PIK3R3 Gene

Entrez Gene Summary for PIK3R3 Gene

  • Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]

GeneCards Summary for PIK3R3 Gene

PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3) is a Protein Coding gene. Diseases associated with PIK3R3 include Asbestos-Related Lung Carcinoma and Intravenous Leiomyomatosis. Among its related pathways are ERK Signaling and mTOR Pathway. Gene Ontology (GO) annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is LOC110117498-PIK3R3.

UniProtKB/Swiss-Prot for PIK3R3 Gene

  • Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Tocris Summary for PIK3R3 Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3R3 Gene

Additional gene information for PIK3R3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3R3 Gene

Genomics for PIK3R3 Gene

GeneHancer (GH) Regulatory Elements for PIK3R3 Gene

Promoters and enhancers for PIK3R3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J046129 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661.1 +43.5 43542 6.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PIK3R3 LOC101929626 TOE1 GPBP1L1 LRRC41 RPL7AP16 EFCAB14-AS1 RPS15AP10 TMEM69 MOB3C
GH01J046043 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 661.7 +132.8 132752 1.1 STAT5A EBF1 IRF4 RELA ZNF121 POLR2A EED ATF7 BCLAF1 IKZF2 PIK3R3 PIR44986 PIR32898 LOC110117498 TSPAN1 LURAP1 POMGNT1 ENSG00000226957 LOC110117498-PIK3R3
GH01J046176 Promoter 0.6 EPDnew 650.7 0.0 -13 0.1 PRDM10 TSPAN1 PIK3R3 LOC110117498 LOC110117498-PIK3R3 LURAP1
GH01J046196 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.4 -21.8 -21751 2.8 HDGF ARNT SIN3A DMAP1 ZNF48 YY1 TCF12 POLR2B ZNF143 ATF7 POMGNT1 LURAP1 TOE1 GPBP1L1 LRRC41 TSPAN1 PIK3R3 LOC110117498 RAD54L RPL7AP16
GH01J046338 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -165.1 -165053 5.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC NSUN4 LRRC41 GPBP1L1 LURAP1 RPL7AP16 EFCAB14-AS1 UQCRH RPS15AP10 MOB3C PIK3R3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIK3R3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIK3R3 gene promoter:
  • Nkx2-5
  • Pax-5
  • c-Myb
  • Hlf
  • Cart-1

Genomic Locations for PIK3R3 Gene

Genomic Locations for PIK3R3 Gene
136,356 bases
Minus strand
136,349 bases
Minus strand

Genomic View for PIK3R3 Gene

Genes around PIK3R3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3R3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3R3 Gene

Proteins for PIK3R3 Gene

  • Protein details for PIK3R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B2R9C1
    • D3DQ12
    • O60482
    • Q5T4P1
    • Q5T4P2

    Protein attributes for PIK3R3 Gene

    461 amino acids
    Molecular mass:
    54448 Da
    Quaternary structure:
    • Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.

    Alternative splice isoforms for PIK3R3 Gene


neXtProt entry for PIK3R3 Gene

Post-translational modifications for PIK3R3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for PIK3R3 (PI 3-Kinase p55 gamma)

No data available for DME Specific Peptides for PIK3R3 Gene

Domains & Families for PIK3R3 Gene

Gene Families for PIK3R3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PIK3R3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PI3K p85 subunit family.
  • Belongs to the PI3K p85 subunit family.
genes like me logo Genes that share domains with PIK3R3: view

Function for PIK3R3 Gene

Molecular function for PIK3R3 Gene

UniProtKB/Swiss-Prot Function:
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Phenotypes From GWAS Catalog for PIK3R3 Gene

Gene Ontology (GO) - Molecular Function for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IPI 20624904
GO:0005515 protein binding IPI 16273093
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS 9524259
GO:0035014 phosphatidylinositol 3-kinase regulator activity IEA --
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA --
genes like me logo Genes that share ontologies with PIK3R3: view
genes like me logo Genes that share phenotypes with PIK3R3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3R3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIK3R3 Gene

Localization for PIK3R3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIK3R3 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
genes like me logo Genes that share ontologies with PIK3R3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PIK3R3 Gene

Pathways & Interactions for PIK3R3 Gene

SuperPathways for PIK3R3 Gene

SuperPathway Contained pathways
1 RET signaling
2 IL-2 Pathway
3 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
4 Apoptotic Pathways in Synovial Fibroblasts
5 Regulation of lipid metabolism Insulin signaling-generic cascades
genes like me logo Genes that share pathways with PIK3R3: view

Pathways by source for PIK3R3 Gene

SIGNOR curated interactions for PIK3R3 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0008286 insulin receptor signaling pathway TAS,IBA --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA --
GO:0043551 regulation of phosphatidylinositol 3-kinase activity IBA --
GO:0046854 phosphatidylinositol phosphorylation IBA --
genes like me logo Genes that share ontologies with PIK3R3: view

Drugs & Compounds for PIK3R3 Gene

(27) Drugs for PIK3R3 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoproterenol Approved, Investigational Pharma Full agonist, Agonist, Target, agonist 24
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0
Wortmannin Experimental Pharma PI3K inhibitor,selective and irreversible, Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 0
Quercetin Experimental, Investigational Nutra Antitumor agent, Non-selective PI 3-kinase inhibitor 42
SF1126 Investigational Pharma inhibitor, Target Kinase Inhibitors 0

(3) Additional Compounds for PIK3R3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LY 294002 hydrochloride

(5) Tocris Compounds for PIK3R3 Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7
genes like me logo Genes that share compounds with PIK3R3: view

Transcripts for PIK3R3 Gene

Unigene Clusters for PIK3R3 Gene

Phosphoinositide-3-kinase, regulatory subunit 3 (gamma):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3R3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -

ExUns: 13b ^ 14a · 14b · 14c

Relevant External Links for PIK3R3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIK3R3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIK3R3 Gene

Protein differential expression in normal tissues from HIPED for PIK3R3 Gene

This gene is overexpressed in Testis (56.2) and Spleen (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIK3R3 Gene

Protein tissue co-expression partners for PIK3R3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIK3R3 Gene:


SOURCE GeneReport for Unigene cluster for PIK3R3 Gene:


mRNA Expression by UniProt/SwissProt for PIK3R3 Gene:

Tissue specificity: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for PIK3R3 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with PIK3R3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3R3 Gene

Orthologs for PIK3R3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3R3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIK3R3 34 33
  • 99.78 (n)
(Canis familiaris)
Mammalia PIK3R3 34 33
  • 94.96 (n)
(Bos Taurus)
Mammalia PIK3R3 34 33
  • 93.78 (n)
(Mus musculus)
Mammalia Pik3r3 16 34 33
  • 91.83 (n)
(Rattus norvegicus)
Mammalia Pik3r3 33
  • 90.89 (n)
(Ornithorhynchus anatinus)
Mammalia PIK3R3 34
  • 89 (a)
(Monodelphis domestica)
Mammalia PIK3R3 34
  • 71 (a)
(Gallus gallus)
Aves PIK3R3 34 33
  • 83.61 (n)
(Anolis carolinensis)
Reptilia PIK3R3 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3r3 33
  • 80.55 (n)
Str.7110 33
(Danio rerio)
Actinopterygii pik3r3b 34 33
  • 75.05 (n)
zgc55564 33
fruit fly
(Drosophila melanogaster)
Insecta Pi3K21B 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea aap-1 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 2 (a)
Species where no ortholog for PIK3R3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIK3R3 Gene

Gene Tree for PIK3R3 (if available)
Gene Tree for PIK3R3 (if available)
Evolutionary constrained regions (ECRs) for PIK3R3: view image

Paralogs for PIK3R3 Gene

Paralogs for PIK3R3 Gene

(5) SIMAP similar genes for PIK3R3 Gene using alignment to 6 proteins:

  • P55G_HUMAN
  • Q05DQ0_HUMAN
  • Q5T4P3_HUMAN
  • Q8N381_HUMAN
genes like me logo Genes that share paralogs with PIK3R3: view

Variants for PIK3R3 Gene

Sequence variations from dbSNP and Humsavar for PIK3R3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs765790132 uncertain-significance, Familial cancer of breast 46,055,939(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs1000001784 -- 46,064,396(-) C/G/T intron_variant
rs1000011558 -- 46,127,768(-) C/A intron_variant
rs1000014672 -- 46,131,119(-) T/G intron_variant
rs1000050297 -- 46,062,929(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3R3 Gene

Variant ID Type Subtype PubMed ID
dgv19e214 CNV gain 21293372
dgv31e212 CNV gain 25503493
esv2761743 CNV gain 21179565
esv3577805 CNV gain 25503493
esv3585925 CNV gain 21293372
esv3893512 CNV gain 25118596
nsv1007750 CNV gain 25217958
nsv1009527 CNV gain 25217958
nsv475809 CNV novel sequence insertion 20440878
nsv508012 OTHER sequence alteration 20534489
nsv829737 CNV gain 17160897

Variation tolerance for PIK3R3 Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIK3R3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3R3 Gene

Disorders for PIK3R3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PIK3R3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
asbestos-related lung carcinoma
intravenous leiomyomatosis
  • leiomyomatosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PIK3R3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PIK3R3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3R3 Gene

Publications for PIK3R3 Gene

  1. Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. (PMID: 9524259) Dey BR … Nissley SP (Gene 1998) 2 3 4 58
  2. Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. (PMID: 20197460) Koutros S … Berndt SI (Cancer research 2010) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. (PMID: 17360667) Soroceanu L … Phillips HS (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PIK3R3 Gene

Sources for PIK3R3 Gene

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