Aliases for PIK3R3 Gene
- Phosphoinositide-3-Kinase Regulatory Subunit 3 2 3 5
- Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma 3 4
- Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma) 2 3
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma 3 4
- PtdIns-3-Kinase Regulatory Subunit P55-Gamma 3 4
- PI3-Kinase Regulatory Subunit Gamma 3 4
- PI3K Regulatory Subunit Gamma 3 4
External Ids for PIK3R3 Gene
Previous GeneCards Identifiers for PIK3R3 Gene
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
GeneCards Summary for PIK3R3 Gene
PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3) is a Protein Coding gene. Diseases associated with PIK3R3 include Asbestos-Related Lung Carcinoma and Cervical Non-Keratinizing Squamous Cell Carcinoma. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and NGF Pathway. Gene Ontology (GO) annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is P3R3URF-PIK3R3.
UniProtKB/Swiss-Prot Summary for PIK3R3 Gene
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.