Aliases for PIK3R2 Gene
- Phosphoinositide-3-Kinase Regulatory Subunit 2 2 3 5
- Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Beta 3 4
- Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta) 2 3
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta 3 4
- Phosphoinositide-3-Kinase Regulatory Subunit Beta 2 3
- PtdIns-3-Kinase Regulatory Subunit P85-Beta 3 4
- PI3K Regulatory Subunit Beta 3 4
- PI3-Kinase Subunit P85-Beta 3 4
External Ids for PIK3R2 Gene
Previous GeneCards Identifiers for PIK3R2 Gene
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Apr 2019]
GeneCards Summary for PIK3R2 Gene
PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2) is a Protein Coding gene. Diseases associated with PIK3R2 include Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 and Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome. Among its related pathways are MAPK-Erk Pathway and RANK Signaling in Osteoclasts. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and receptor tyrosine kinase binding. An important paralog of this gene is ENSG00000268173.
UniProtKB/Swiss-Prot Summary for PIK3R2 Gene
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.