Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chro... See more...

Aliases for PIK3CG Gene

Aliases for PIK3CG Gene

  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma 2 3 5
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform 3 4
  • Serine/Threonine Protein Kinase PIK3CG 3 4
  • PtdIns-3-Kinase Subunit P110-Gamma 3 4
  • PtdIns-3-Kinase Subunit Gamma 3 4
  • PI3-Kinase Subunit Gamma 3 4
  • EC 2.7.1.153 4 51
  • PI3Kgamma 3 4
  • P110gamma 3 4
  • P120-PI3K 3 4
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Gamma 3
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform 3
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Gamma 4
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Gamma 2
  • Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide 2
  • Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide 4
  • Phosphatidylinositol 3-Kinase Catalytic 110-KD Gamma 3
  • Phosphoinositide-3-Kinase Gamma Catalytic Subunit 3
  • Phosphatidylinositol 3 Kinase Gamma, P110 Gamma 3
  • 1-Phosphatidylinositol 3-Kinase 3
  • EC 2.7.11.1 4
  • PI3K-Gamma 4
  • EC 2.7.1 51
  • PIK3CG 5
  • PI3CG 3
  • PI3K 3
  • PIK3 3

External Ids for PIK3CG Gene

Previous GeneCards Identifiers for PIK3CG Gene

  • GC07P104989
  • GC07P106052
  • GC07P106066
  • GC07P106099
  • GC07P106292
  • GC07P106505
  • GC07P100864

Summaries for PIK3CG Gene

Entrez Gene Summary for PIK3CG Gene

  • Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]

GeneCards Summary for PIK3CG Gene

PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PIK3CG include Tuberous Sclerosis and Sarcoma. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding. An important paralog of this gene is PIK3CB.

UniProtKB/Swiss-Prot Summary for PIK3CG Gene

  • Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Tocris Summary for PIK3CG Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3CG Gene

Additional gene information for PIK3CG Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIK3CG Gene

Genomics for PIK3CG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PIK3CG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J106862 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 600.7 -0.1 -141 5.2 LEF1 IKZF1 JUND ETV6 MTA2 PKNOX1 MTA1 IKZF2 POLR2A BRD9 PIK3CG CBLL1 lnc-CCDC71L-3 CCDC71L
GH07J106772 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -90.7 -90727 4.6 ARHGAP35 HNRNPL TEAD4 ZNF512 RFX1 SIX5 LEF1 IKZF1 JUND DDX20 LINC02577 ATXN7L1 CBLL1 ENSG00000272072 CCDC71L ENSG00000267052 PIK3CG COG5 ENSG00000243797
GH07J106417 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 14.1 -447.0 -446984 2.1 REST GABPA SP1 SOX6 CEBPB CTBP1 FOXA2 NR3C1 CHD2 ATF3 NAMPT PIK3CG CCDC71L ENSG00000286076 piR-56883-179 ENSG00000243797
GH07J106765 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.4 -96.6 -96626 5.7 ATF7 ZNF512 LEF1 JUND RELA ZNF24 IKZF2 ZNF740 KAT8 HDAC1 ENSG00000243797 ENSG00000272072 LINC02577 PIK3CG CCDC71L CBLL1 ENSG00000267052 COG5 HBP1 NAMPT
GH07J106420 Enhancer 1 FANTOM5 ENCODE dbSUPER 15.6 -443.6 -443607 2.1 SP1 FOXJ2 CEBPB ATF3 YY1 JUND ZFHX2 SPI1 RAD21 USF2 NAMPT PIK3CG CCDC71L ENSG00000286076 piR-56883-179 ENSG00000243797
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIK3CG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIK3CG

Top Transcription factor binding sites by QIAGEN in the PIK3CG gene promoter:
  • aMEF-2
  • CREB
  • deltaCREB
  • MEF-2
  • MEF-2A
  • STAT3

Genomic Locations for PIK3CG Gene

Genomic Locations for PIK3CG Gene
chr7:106,865,278-106,908,980
(GRCh38/hg38)
Size:
43,703 bases
Orientation:
Plus strand
chr7:106,505,723-106,547,592
(GRCh37/hg19)
Size:
41,870 bases
Orientation:
Plus strand

Genomic View for PIK3CG Gene

Genes around PIK3CG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3CG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3CG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3CG Gene

Proteins for PIK3CG Gene

  • Protein details for PIK3CG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48736-PK3CG_HUMAN
    Recommended name:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Protein Accession:
    P48736
    Secondary Accessions:
    • A4D0Q6
    • Q8IV23
    • Q9BZC8

    Protein attributes for PIK3CG Gene

    Size:
    1102 amino acids
    Molecular mass:
    126454 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with GRK2 through the PIK helical domain. Interaction with GRK2 is required for targeting to agonist-occupied receptor. Interacts with PDE3B (By similarity). Interacts with TPM2. Interacts with EPHA8; regulates integrin-mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity).
    Miscellaneous:
    • Candidate target in therapy for inflammatory diseases. Selective inhibitors and protein ablation are anti-inflammatory in multiple disease models such as asthma, rheumatoid arthritis, allergy, systemic lupus erythematosus, airway inflammation, lung injury and pancreatitis (PubMed:18278175).

    Three dimensional structures from OCA and Proteopedia for PIK3CG Gene

neXtProt entry for PIK3CG Gene

Selected DME Specific Peptides for PIK3CG Gene

P48736:
  • LFHIDFG
  • IGHFLFW
  • NVRAIAV
  • PYGCISTGD
  • SCAGYCV
  • VLGIGDRH
  • PFVLTPDF
  • DRHNDNIM
  • DLRQDML
  • IVAKTYQ

Post-translational modifications for PIK3CG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for PIK3CG Gene

Gene Families for PIK3CG Gene

Protein Domains for PIK3CG Gene

Suggested Antigen Peptide Sequences for PIK3CG Gene

GenScript: Design optimal peptide antigens:
  • Phosphoinositide-3-kinase, catalytic, gamma polypeptide, isoform CRA_a (A4D0Q6_HUMAN)
  • p120-PI3K (PK3CG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48736

UniProtKB/Swiss-Prot:

PK3CG_HUMAN :
  • Belongs to the PI3/PI4-kinase family.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3CG: view

Function for PIK3CG Gene

Molecular function for PIK3CG Gene

UniProtKB/Swiss-Prot Function:
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by both the alpha and the beta-gamma G proteins following stimulation of G protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6) leading to the translocation from the cytosol to the plasma membrane and to kinase activation. Inhibited by AS-604850 and AS-605240.

Enzyme Numbers (IUBMB) for PIK3CG Gene

Phenotypes From GWAS Catalog for PIK3CG Gene

Gene Ontology (GO) - Molecular Function for PIK3CG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS 19376709
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 12507995
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PIK3CG: view

Phenotypes for PIK3CG Gene

genes like me logo Genes that share phenotypes with PIK3CG: view

Animal Models for PIK3CG Gene

MGI Knock Outs for PIK3CG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3CG

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3CG Gene

Localization for PIK3CG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3CG Gene

Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIK3CG gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 3
nucleus 3
lysosome 3
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIK3CG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IBA,IDA 12507995
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA,IDA --
GO:0005942 phosphatidylinositol 3-kinase complex IBA 21873635
genes like me logo Genes that share ontologies with PIK3CG: view

Pathways & Interactions for PIK3CG Gene

genes like me logo Genes that share pathways with PIK3CG: view

Pathways by source for PIK3CG Gene

5 Qiagen pathways for PIK3CG Gene
  • Akt Signaling
  • CCR3 Pathway in Eosinophils
  • EphrinA-EphR Signaling
  • Ephrin-Eph Signaling
  • Molecular Mechanisms of Cancer
1 Cell Signaling Technology pathway for PIK3CG Gene
4 GeneTex pathways for PIK3CG Gene

UniProtKB/Swiss-Prot P48736-PK3CG_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

SIGNOR curated interactions for PIK3CG Gene

Gene Ontology (GO) - Biological Process for PIK3CG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001816 cytokine production TAS 19075988
GO:0001932 regulation of protein phosphorylation IEA --
GO:0002250 adaptive immune response TAS 17290298
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with PIK3CG: view

Drugs & Compounds for PIK3CG Gene

(150) Drugs for PIK3CG Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Duvelisib Approved, Investigational Pharma Target, inhibitor 0
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Quercetin Experimental, Investigational Pharma Target Antitumor agent, Non-selective PI 3-kinase inhibitor 54
Wortmannin Experimental Pharma Target PI3K inhibitor,selective and irreversible, Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 0
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0

(439) Additional Compounds for PIK3CG Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(32:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1W7)

(5) Tocris Compounds for PIK3CG Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7

(51) ApexBio Compounds for PIK3CG Gene

Compound Action Cas Number
3-Methyladenine Class III PI3K inhibitor 5142-23-4
740 Y-P PI 3-kinase activator,cell permeable 1236188-16-1
AS-252424 PI3Kγ inhibitor,novel and potent 900515-16-4
AS-604850 PI3Kγ inhibitor,selective and ATP-competitve 648449-76-7
AS-605240 Potent and selective PI 3-Kγ inhibitor 648450-29-7
AZD6482 PI3Kβ inhibitor,potent and selective 1173900-33-8
BAY 80-6946 (Copanlisib) PI3K inhibitor 1032568-63-0
BEZ235 (NVP-BEZ235) PI3K/mTOR inhibitor,ATP-competitve 915019-65-7
BEZ235 Tosylate MTOR/P13K inhibitor 1028385-32-1
BKM120 Inhibitor of pan-Class I PI3K 944396-07-0
CAL-101 (Idelalisib, GS-1101) PI3K inhibitor 870281-82-6
CAL-130 Hydrochloride PI3K inhibitor 1431697-78-7
CAY10505 Potent PI3Kγ inhibitor 1218777-13-9
CH5132799 Class I PI3K inhibitor 1007207-67-1
CZC24832 Selective PI3K-γ inhibitor 1159824-67-5
GDC-0941 PI3K inhibitor,potent and selective 957054-30-7
GDC-0941 dimethanesulfonate PI3K inhibitor 957054-33-0
GDC-0980 (RG7422) Class I PI3K inhibitor for PI3Kα/β/δ/γ 1032754-93-0
GNE-317 1394076-92-6
GSK1059615 PI3K and mTOR inhibitor,potent and reversible 958852-01-2
GSK2126458 PI3K/mTOR inhibitor 1086062-66-9
GSK2636771 PIK3 inhibitor 1372540-25-4
HS-173 1276110-06-5
INK 128 (MLN0128) MTOR(TORC-1/-2) inhibitor,potent and selective 1224844-38-5
IPI-145 (INK1197) PI3K-δ/PI3K-γ inhibitor 1201438-56-3
LY 294002 Potent PI3K inhibitor 154447-36-6
NVP-BGT226 PI3K/mTOR inhibitor,selective and novel 1245537-68-1
PF-04691502 PI3K/mTOR (FRAP) inhibitor 1013101-36-4
PF-05212384 (PKI-587) PI3Kα, PI3Kγ and mTOR inhibitor 1197160-78-3
PF-4989216 Selective oral PI3K inhibitor 1276553-09-3
PI 828 942289-87-4
PI-103 Class I PI3K, mTOR and DNA-PK inhibitor 371935-74-9
PI-103 Hydrochloride DNA-PK/PI 3-kinase/mTOR inhibitor 371935-79-4
PIK-293 900185-01-5
PIK-294 900185-02-6
PIK-75 Inhibitor of PI3K isoform p110α 372196-77-5
PIK-90 PI3K inhibitor,potent selective 677338-12-4
PIK-93 PI3Kγ/PI4KIIIβ/PI3Kα inhibitor 593960-11-3
PKI-402 PI3K inhibitor,selective, reversible and ATP-competitive 1173204-81-3
PP121 Dual inhibitor of tyrosine and phosphoinositide kinases 1092788-83-4
Quercetin Antitumor agent 117-39-5
Quercetin dihydrate PLA2 and PI 3-kinase inhibitor 6151-25-3
SAR245409 (XL765) mTOR/PI3K inhibitor 1349796-36-6
TG100-115 PI3Kγ/PI3Kδ inhibitor 677297-51-7
TG100713 925705-73-3
TGX-221 PI3Kβ inhibitor,potent,selective and ATP competitive 663619-89-4
VS-5584 (SB2343) MTOR/P13K inhibitor,potent and selective 1246560-33-7
Wortmannin PI3K inhibitor,selective and irreversible 19545-26-7
XL147 PI3K inhibitor,selective and reversible 956958-53-5
ZSTK474 Potent PI3K inhibitor 475110-96-4
α-mangostin PI3K/AKT inhibitor 6147-11-1
genes like me logo Genes that share compounds with PIK3CG: view

Drug Products

Transcripts for PIK3CG Gene

mRNA/cDNA for PIK3CG Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3CG

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: -
SP2: - -
SP3:

Relevant External Links for PIK3CG Gene

GeneLoc Exon Structure for
PIK3CG

Expression for PIK3CG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIK3CG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIK3CG Gene

This gene is overexpressed in Whole Blood (x20.2).

Protein differential expression in normal tissues from HIPED for PIK3CG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (50.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIK3CG Gene



Protein tissue co-expression partners for PIK3CG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIK3CG

SOURCE GeneReport for Unigene cluster for PIK3CG Gene:

Hs.32942

mRNA Expression by UniProt/SwissProt for PIK3CG Gene:

P48736-PK3CG_HUMAN
Tissue specificity: Pancreas, skeletal muscle, liver and heart.

Evidence on tissue expression from TISSUES for PIK3CG Gene

  • Pancreas(4.5)
  • Blood(3.2)
  • Lung(3.1)
  • Intestine(3)
  • Heart(3)
  • Bone marrow(2.9)
  • Lymph node(2.8)
  • Spleen(2.8)
  • Nervous system(2.7)
  • Kidney(2.6)
  • Liver(2.5)
  • Muscle(2.4)
  • Skin(2.4)
  • Eye(2.3)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with PIK3CG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3CG Gene

Orthologs for PIK3CG Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3CG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PIK3CG 30 31
  • 99.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PIK3CG 30 31
  • 89.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PIK3CG 30 31
  • 88.32 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PIK3CG 31
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Pik3cg 30 17 31
  • 86.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pik3cg 30
  • 86.6 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PIK3CG 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PIK3CG 30 31
  • 75.59 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PIK3CG 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pik3cg 30
  • 71.72 (n)
Str.8580 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.34757 30
Zebrafish
(Danio rerio)
Actinopterygii pik3cg 30 31
  • 54.55 (n)
OneToOne
wufb15d07 30
Worm
(Caenorhabditis elegans)
Secernentea age-1 31
  • 24 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5268 30
Species where no ortholog for PIK3CG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PIK3CG Gene

ENSEMBL:
Gene Tree for PIK3CG (if available)
TreeFam:
Gene Tree for PIK3CG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIK3CG: view image

Paralogs for PIK3CG Gene

Paralogs for PIK3CG Gene

(7) SIMAP similar genes for PIK3CG Gene using alignment to 3 proteins:

  • PK3CG_HUMAN
  • E9PDN7_HUMAN
  • L0R522_HUMAN
genes like me logo Genes that share paralogs with PIK3CG: view

Variants for PIK3CG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIK3CG Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
714354 Likely Benign: not provided 106,874,781(+) G/T MISSENSE_VARIANT
715611 Benign: not provided 106,868,550(+) C/T MISSENSE_VARIANT
733484 Benign: not provided 106,867,951(+) G/C SYNONYMOUS_VARIANT
738973 Likely Benign: not provided 106,867,579(+) T/C SYNONYMOUS_VARIANT
740172 Likely Benign: not provided 106,868,860(+) C/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PIK3CG Gene

Structural Variations from Database of Genomic Variants (DGV) for PIK3CG Gene

Variant ID Type Subtype PubMed ID
nsv472277 CNV novel sequence insertion 20440878
nsv507407 OTHER sequence alteration 20534489
nsv949926 CNV duplication 24416366

Variation tolerance for PIK3CG Gene

Residual Variation Intolerance Score: 8.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.97; 84.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIK3CG Gene

Human Gene Mutation Database (HGMD)
PIK3CG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIK3CG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3CG Gene

Disorders for PIK3CG Gene

MalaCards: The human disease database

(36) MalaCards diseases for PIK3CG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis
  • tuberous sclerosis 1
sarcoma
  • connective and soft tissue neoplasm
arthritis
  • inflammatory disorder of joint
breast cancer
  • breast lobular carcinoma
endometrial cancer
  • endometrial cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PIK3CG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PIK3CG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3CG Gene

Publications for PIK3CG Gene

  1. Cardiac regulation by phosphoinositide 3-kinases and PTEN. (PMID: 19147653) Oudit GY … Penninger JM (Cardiovascular research 2009) 3 4 23
  2. Targeting phosphoinositide 3-kinase gamma to fight inflammation and more. (PMID: 18278175) Barberis L … Hirsch E (Thrombosis and haemostasis 2008) 3 4 23
  3. p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. (PMID: 15797027) Suire S … Stephens L (Current biology : CB 2005) 3 4 23
  4. Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. (PMID: 16094730) Naga Prasad SV … Rockman HA (Nature cell biology 2005) 3 4 23
  5. A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. (PMID: 21393242) Wilson LS … Maurice DH (The Journal of biological chemistry 2011) 3 4

Products for PIK3CG Gene

Sources for PIK3CG Gene