This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutro... See more...

Aliases for PIK3CB Gene

Aliases for PIK3CB Gene

  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta 2 3 5
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform 3 4
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Beta 3 4
  • Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide 2 3
  • PtdIns-3-Kinase Subunit P110-Beta 3 4
  • PtdIns-3-Kinase Subunit Beta 3 4
  • PI3-Kinase Subunit Beta 3 4
  • EC 2.7.1.153 4 51
  • PI3K-Beta 3 4
  • PIK3C1 3 4
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Beta 2
  • PI3-Kinase P110 Subunit Beta 3
  • PtdIns-3-Kinase P110 3
  • P110BETA 3
  • PI3KBETA 3
  • PI3Kbeta 4
  • P110beta 4
  • EC 2.7.1 51
  • PIK3CB 5
  • PI3K 3

External Ids for PIK3CB Gene

Previous HGNC Symbols for PIK3CB Gene

  • PIK3C1

Previous GeneCards Identifiers for PIK3CB Gene

  • GC03M135330
  • GC03M139174
  • GC03M139654
  • GC03M139693
  • GC03M139855
  • GC03M138372
  • GC03M135748

Summaries for PIK3CB Gene

Entrez Gene Summary for PIK3CB Gene

  • This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

GeneCards Summary for PIK3CB Gene

PIK3CB (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PIK3CB include Nk-Cell Enteropathy and Endometrial Cancer. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and GDNF-Family Ligands and Receptor Interactions. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3CD.

UniProtKB/Swiss-Prot Summary for PIK3CB Gene

  • Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.

Tocris Summary for PIK3CB Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3CB Gene

Additional gene information for PIK3CB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIK3CB Gene

Genomics for PIK3CB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PIK3CB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J138831 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 609.7 +0.8 823 4.6 CEBPG CREB1 GATAD2A CTCF HNRNPL PRDM10 REST ZNF629 TFE3 LEF1 PIK3CB lnc-FOXL2-3 lnc-FOXL2NB-10 lnc-FOXL2NB-3 ACTG1P1 FAIM MRAS
GH03J138759 Promoter 0.3 EPDnew 600.2 +75.6 75622 0.1 PIK3CB CEP70 FAIM lnc-CEP70-2 GAPDHP39
GH03J138888 Enhancer 1.2 Ensembl ENCODE dbSUPER 21.5 -59.1 -59073 18.8 ATF7 TFE3 ZNF512 IKZF1 JUND MTA2 PKNOX1 MTA1 IKZF2 ZNF24 PIK3CB FAIM CEP70 A4GNT ATP5MC1P3 lnc-FOXL2-2-001 lnc-FOXL2-2-002 lnc-FOXL2NB-2 RF00017-4132 lnc-FOXL2-5
GH03J138914 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas 11.5 -80.9 -80927 2.5 HNRNPL GATAD2A CTCF PRDM10 ZNF629 LEF1 IKZF1 ZNF692 RCOR2 JUND MN298041 lnc-FOXL2-5 CEP70 PIK3CB FAIM FOXL2 FOXL2NB LINC01391
GH03J138773 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 +59.9 59922 2.3 PRDM10 ZNF629 ZNF692 JUND FOXA1 PRDM1 ZNF600 SCRT2 SOX13 ZBTB44 PIK3CB FAIM GAPDHP39 lnc-CEP70-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIK3CB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIK3CB

Top Transcription factor binding sites by QIAGEN in the PIK3CB gene promoter:
  • E47
  • ER-alpha
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Hand1
  • POU3F1
  • PPAR-alpha
  • Tal-1beta

Genomic Locations for PIK3CB Gene

Genomic Locations for PIK3CB Gene
chr3:138,652,698-138,834,928
(GRCh38/hg38)
Size:
182,231 bases
Orientation:
Minus strand
chr3:138,372,860-138,553,780
(GRCh37/hg19)
Size:
180,921 bases
Orientation:
Minus strand

Genomic View for PIK3CB Gene

Genes around PIK3CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3CB Gene

Proteins for PIK3CB Gene

  • Protein details for PIK3CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42338-PK3CB_HUMAN
    Recommended name:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    Protein Accession:
    P42338
    Secondary Accessions:
    • D3DNF0
    • Q24JU2

    Protein attributes for PIK3CB Gene

    Size:
    1070 amino acids
    Molecular mass:
    122762 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity).

neXtProt entry for PIK3CB Gene

Selected DME Specific Peptides for PIK3CB Gene

P42338:
  • LDRAIEEFTLSCAGYCVA
  • MDSKMKPLW
  • RERVPFILTYDF
  • QLVQVLKYE
  • VDFLLPTG
  • LFHIDFG
  • SCAGYCV
  • KDIQYLKDSLALGK
  • VLGIGDRH
  • IFKNGDDLRQD
  • HVIQQGKT
  • CDLPRMARLCFA
  • DLRQDML

Post-translational modifications for PIK3CB Gene

  • Phosphorylation at Ser-1070 down-regulates lipid kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PIK3CB Gene

Gene Families for PIK3CB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PIK3CB Gene

InterPro:
Blocks:
  • Phosphatidylinositol 3- and 4-kinase
  • Phosphoinositide 3-kinase, ras-binding domain
  • Phosphatidylinositol 3-kinase, p85-binding
ProtoNet:

Suggested Antigen Peptide Sequences for PIK3CB Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta (PK3CB_HUMAN)
  • PIK3CB protein (Q6PJ60_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42338

UniProtKB/Swiss-Prot:

PK3CB_HUMAN :
  • The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.
  • Belongs to the PI3/PI4-kinase family.
Domain:
  • The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3CB: view

Function for PIK3CB Gene

Molecular function for PIK3CB Gene

UniProtKB/Swiss-Prot Function:
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153;.

Enzyme Numbers (IUBMB) for PIK3CB Gene

Phenotypes From GWAS Catalog for PIK3CB Gene

Gene Ontology (GO) - Molecular Function for PIK3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 19380743
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA,IDA 25327288
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with PIK3CB: view
genes like me logo Genes that share phenotypes with PIK3CB: view

Animal Models for PIK3CB Gene

MGI Knock Outs for PIK3CB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIK3CB

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3CB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3CB Gene

Localization for PIK3CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3CB Gene

Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIK3CB gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Midbody (2)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIK3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PIK3CB: view

Pathways & Interactions for PIK3CB Gene

PathCards logo

SuperPathways for PIK3CB Gene

SuperPathway Contained pathways
1 RET signaling
2 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.42
.38
3 Regulation of lipid metabolism Insulin signaling-generic cascades
.59
.59
.51
.47
.44
.43
.35
4 GAB1 signalosome
5 Endometrial cancer
.44
genes like me logo Genes that share pathways with PIK3CB: view

Pathways by source for PIK3CB Gene

67 GeneGo (Thomson Reuters) pathways for PIK3CB Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Apoptosis and survival BAD phosphorylation
  • Apoptosis and survival NGF signaling pathway
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Cell adhesion PLAU signaling
1 Cell Signaling Technology pathway for PIK3CB Gene
4 GeneTex pathways for PIK3CB Gene

UniProtKB/Swiss-Prot P42338-PK3CB_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

SIGNOR curated interactions for PIK3CB Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PIK3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10570282
GO:0001935 endothelial cell proliferation IMP --
GO:0001952 regulation of cell-matrix adhesion IMP 25139353
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006874 cellular calcium ion homeostasis IMP --
genes like me logo Genes that share ontologies with PIK3CB: view

Drugs & Compounds for PIK3CB Gene

(85) Drugs for PIK3CB Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caffeine Approved Pharma Antagonist, Activator, Target, inhibitor 603
Duvelisib Approved, Investigational Pharma 0
Quercetin Experimental, Investigational Pharma Antitumor agent, Non-selective PI 3-kinase inhibitor 54
Wortmannin Experimental Pharma PI3K inhibitor,selective and irreversible, Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 0
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0

(400) Additional Compounds for PIK3CB Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(32:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1W7)

(5) Tocris Compounds for PIK3CB Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7

(45) ApexBio Compounds for PIK3CB Gene

Compound Action Cas Number
740 Y-P PI 3-kinase activator,cell permeable 1236188-16-1
AS-252424 PI3Kγ inhibitor,novel and potent 900515-16-4
AS-604850 PI3Kγ inhibitor,selective and ATP-competitve 648449-76-7
AZD6482 PI3Kβ inhibitor,potent and selective 1173900-33-8
AZD8186 Potent and selective inhibitor of PI3Kβ and PI3Kδ 1627494-13-6
BAY 80-6946 (Copanlisib) PI3K inhibitor 1032568-63-0
BEZ235 (NVP-BEZ235) PI3K/mTOR inhibitor,ATP-competitve 915019-65-7
BEZ235 Tosylate MTOR/P13K inhibitor 1028385-32-1
BKM120 Inhibitor of pan-Class I PI3K 944396-07-0
CAL-101 (Idelalisib, GS-1101) PI3K inhibitor 870281-82-6
CAL-130 Hydrochloride PI3K inhibitor 1431697-78-7
CAY10505 Potent PI3Kγ inhibitor 1218777-13-9
CH5132799 Class I PI3K inhibitor 1007207-67-1
CZC24832 Selective PI3K-γ inhibitor 1159824-67-5
GDC-0941 PI3K inhibitor,potent and selective 957054-30-7
GDC-0941 dimethanesulfonate PI3K inhibitor 957054-33-0
GDC-0980 (RG7422) Class I PI3K inhibitor for PI3Kα/β/δ/γ 1032754-93-0
GNE-317 1394076-92-6
GSK1059615 PI3K and mTOR inhibitor,potent and reversible 958852-01-2
GSK2126458 PI3K/mTOR inhibitor 1086062-66-9
GSK2636771 PIK3 inhibitor 1372540-25-4
HS-173 1276110-06-5
INK 128 (MLN0128) MTOR(TORC-1/-2) inhibitor,potent and selective 1224844-38-5
LY 294002 Potent PI3K inhibitor 154447-36-6
NVP-BGT226 PI3K/mTOR inhibitor,selective and novel 1245537-68-1
PF-04691502 PI3K/mTOR (FRAP) inhibitor 1013101-36-4
PF-4989216 Selective oral PI3K inhibitor 1276553-09-3
PI 828 942289-87-4
PI-103 Class I PI3K, mTOR and DNA-PK inhibitor 371935-74-9
PI-103 Hydrochloride DNA-PK/PI 3-kinase/mTOR inhibitor 371935-79-4
PIK-293 900185-01-5
PIK-294 900185-02-6
PIK-75 Inhibitor of PI3K isoform p110α 372196-77-5
PIK-90 PI3K inhibitor,potent selective 677338-12-4
PIK-93 PI3Kγ/PI4KIIIβ/PI3Kα inhibitor 593960-11-3
PKI-402 PI3K inhibitor,selective, reversible and ATP-competitive 1173204-81-3
PP121 Dual inhibitor of tyrosine and phosphoinositide kinases 1092788-83-4
Quercetin Antitumor agent 117-39-5
Quercetin dihydrate PLA2 and PI 3-kinase inhibitor 6151-25-3
SAR245409 (XL765) mTOR/PI3K inhibitor 1349796-36-6
TG100713 925705-73-3
TGX-221 PI3Kβ inhibitor,potent,selective and ATP competitive 663619-89-4
VS-5584 (SB2343) MTOR/P13K inhibitor,potent and selective 1246560-33-7
XL147 PI3K inhibitor,selective and reversible 956958-53-5
ZSTK474 Potent PI3K inhibitor 475110-96-4
genes like me logo Genes that share compounds with PIK3CB: view

Drug Products

Transcripts for PIK3CB Gene

mRNA/cDNA for PIK3CB Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3CB

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CB Gene

No ASD Table

Relevant External Links for PIK3CB Gene

GeneLoc Exon Structure for
PIK3CB

Expression for PIK3CB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIK3CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIK3CB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.9) and Lung (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIK3CB Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIK3CB

SOURCE GeneReport for Unigene cluster for PIK3CB Gene:

Hs.239818

mRNA Expression by UniProt/SwissProt for PIK3CB Gene:

P42338-PK3CB_HUMAN
Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for PIK3CB Gene

  • Nervous system(3.9)
  • Muscle(2.8)
  • Blood(2.8)
  • Kidney(2.8)
  • Heart(2.8)
  • Liver(2.8)
  • Skin(2.7)
  • Intestine(2.7)
  • Spleen(2.6)
  • Thyroid gland(2.6)
  • Lung(2.5)
  • Lymph node(2.5)
  • Bone marrow(2.5)
  • Pancreas(2.4)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with PIK3CB: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3CB Gene

Orthologs for PIK3CB Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3CB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PIK3CB 30 31
  • 99.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PIK3CB 30 31
  • 93.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PIK3CB 30 31
  • 93.18 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PIK3CB 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PIK3CB 31
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pik3cb 30
  • 88.69 (n)
Mouse
(Mus musculus)
Mammalia Pik3cb 30 17 31
  • 88.44 (n)
OneToOne
Chicken
(Gallus gallus)
Aves PIK3CB 30 31
  • 80.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PIK3CB 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pik3cb 30
  • 71.98 (n)
Zebrafish
(Danio rerio)
Actinopterygii pik3cb 30 31
  • 66.82 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Pi3K92E 31 32
  • 37 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToMany
Species where no ortholog for PIK3CB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PIK3CB Gene

ENSEMBL:
Gene Tree for PIK3CB (if available)
TreeFam:
Gene Tree for PIK3CB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIK3CB: view image

Paralogs for PIK3CB Gene

Paralogs for PIK3CB Gene

(11) SIMAP similar genes for PIK3CB Gene using alignment to 10 proteins:

  • PK3CB_HUMAN
  • C9J345_HUMAN
  • C9JNF6_HUMAN
  • C9JYX0_HUMAN
  • F8WDJ8_HUMAN
  • H0Y871_HUMAN
  • H7C527_HUMAN
  • H7C565_HUMAN
  • H7C5C3_HUMAN
  • Q6PJ60_HUMAN
genes like me logo Genes that share paralogs with PIK3CB: view

Variants for PIK3CB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIK3CB Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
638630 Likely Pathogenic: NK-cell enteropathy 138,656,256(-) C/A MISSENSE_VARIANT
709670 Benign: not provided 138,694,824(-) G/A SYNONYMOUS_VARIANT
717285 Likely Benign: not provided 138,691,056(-) T/C SYNONYMOUS_VARIANT
717584 Likely Benign: not provided 138,684,790(-) T/C MISSENSE_VARIANT
722053 Benign: not provided 138,682,038(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PIK3CB Gene

Structural Variations from Database of Genomic Variants (DGV) for PIK3CB Gene

Variant ID Type Subtype PubMed ID
dgv4908n100 CNV gain 25217958
esv2571713 CNV deletion 19546169
esv3413413 CNV insertion 20981092
esv3426153 CNV insertion 20981092
nsv1000927 CNV gain 25217958
nsv428422 CNV gain+loss 18775914
nsv591854 CNV gain 21841781
nsv967070 CNV duplication 23825009

Variation tolerance for PIK3CB Gene

Residual Variation Intolerance Score: 2.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIK3CB Gene

Human Gene Mutation Database (HGMD)
PIK3CB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIK3CB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3CB Gene

Disorders for PIK3CB Gene

MalaCards: The human disease database

(15) MalaCards diseases for PIK3CB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nk-cell enteropathy
endometrial cancer
  • endometrial cancer, familial
breast cancer
  • breast lobular carcinoma
cowden syndrome 1
  • cws1
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PIK3CB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PIK3CB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3CB Gene

Publications for PIK3CB Gene

  1. Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle. (PMID: 20107106) Ribel-Madsen R … Vaag A (Diabetes 2010) 3 23 41
  2. PTEN-deficient cancers depend on PIK3CB. (PMID: 18755892) Wee S … Lengauer C (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23
  3. Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus. (PMID: 16380997) Phillips WA … Campbell IG (International journal of cancer 2006) 3 23 41
  4. Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes. (PMID: 11016459) Kossila M … Laakso M (Diabetes 2000) 4 23 41
  5. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. (PMID: 8246984) Hu P … Schlessinger J (Molecular and cellular biology 1993) 2 3 4

Products for PIK3CB Gene

Sources for PIK3CB Gene