Aliases for PIK3C2G Gene
- Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma 2 3 5
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3 4
- Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide 2 3
- PI3K-C2-Gamma 3 4
- EC 188.8.131.52 4 54
- Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma Polypeptide 3
External Ids for PIK3C2G Gene
Previous GeneCards Identifiers for PIK3C2G Gene
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for PIK3C2G Gene
PIK3C2G (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma) is a Protein Coding gene. Diseases associated with PIK3C2G include Spermatogenic Failure 17. Among its related pathways are PI Metabolism and ICos-ICosL Pathway in T-Helper Cell. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2B.
UniProtKB/Swiss-Prot Summary for PIK3C2G Gene
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.