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Aliases for PIK3C2G Gene

Aliases for PIK3C2G Gene

  • Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma 2 3 5
  • Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide 2 3
  • PI3K-C2-Gamma 3 4
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma Polypeptide 3
  • Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Gamma 2
  • Phosphoinositide 3-Kinase-C2-Gamma 4
  • PtdIns-3-Kinase C2 Subunit Gamma 4
  • PTDINS-3-Kinase C2 Gamma 3
  • PI3K-C2GAMMA 3
  • EC 4

External Ids for PIK3C2G Gene

Previous GeneCards Identifiers for PIK3C2G Gene

  • GC12P018154
  • GC12P018559
  • GC12P018314
  • GC12P018305
  • GC12P018414

Summaries for PIK3C2G Gene

Entrez Gene Summary for PIK3C2G Gene

  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for PIK3C2G Gene

PIK3C2G (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma) is a Protein Coding gene. Diseases associated with PIK3C2G include Spermatogenic Failure 17. Among its related pathways are mTOR Pathway and MAPK Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot for PIK3C2G Gene

  • Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).

Tocris Summary for PIK3C2G Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3C2G Gene

Additional gene information for PIK3C2G Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2G Gene

Genomics for PIK3C2G Gene

GeneHancer (GH) Regulatory Elements for PIK3C2G Gene

Promoters and enhancers for PIK3C2G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J018242 Promoter/Enhancer 1.3 EPDnew ENCODE 658.6 -0.2 -214 0.6 ELF3 PKNOX1 FOXA2 MLX RARA YY1 FOS MIXL1 HMG20B RXRA PIK3C2G RERGL PIR48236
GH12J018258 Enhancer 0.9 ENCODE dbSUPER 8.6 +20.7 20732 9.4 NEUROD1 YY1 CTBP1 GATA3 HNF4G FOS SMARCE1 RXRA DPF2 NR2F2 RERGL PIK3C2G GC12M018263
GH12J018140 Enhancer 0.6 ENCODE 10.6 -101.7 -101680 1.2 CTCF NFIB FEZF1 EP300 HIC1 JUND ZNF366 FOS CUX1 HNF4A RERGL PIK3C2G GC12M018127 PIR48236
GH12J018275 Enhancer 0.6 ENCODE dbSUPER 6.8 +32.8 32847 1.3 JUND FOSL2 TCF7L2 PIK3C2G GC12M018263 GC12P018282 RERGL
GH12J018296 Enhancer 0.3 Ensembl 4.8 +53.8 53836 0.4 PRDM1 RERGL PIK3C2G GC12M018287
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIK3C2G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIK3C2G gene promoter:
  • Nkx5-1
  • AREB6
  • POU2F1a
  • POU2F1
  • C/EBPbeta
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4

Genomic Locations for PIK3C2G Gene

Genomic Locations for PIK3C2G Gene
456,696 bases
Plus strand
400,805 bases
Plus strand

Genomic View for PIK3C2G Gene

Genes around PIK3C2G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3C2G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3C2G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C2G Gene

Proteins for PIK3C2G Gene

  • Protein details for PIK3C2G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
    Protein Accession:
    Secondary Accessions:
    • A1L3U0

    Protein attributes for PIK3C2G Gene

    1445 amino acids
    Molecular mass:
    165715 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA03853.1; Type=Erroneous termination; Positions=1446; Note=Translated as stop.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIK3C2G Gene

neXtProt entry for PIK3C2G Gene

Post-translational modifications for PIK3C2G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PIK3C2G Gene

Domains & Families for PIK3C2G Gene

Gene Families for PIK3C2G Gene

Suggested Antigen Peptide Sequences for PIK3C2G Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PI3/PI4-kinase family.
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3C2G: view

Function for PIK3C2G Gene

Molecular function for PIK3C2G Gene

UniProtKB/Swiss-Prot Function:
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
GENATLAS Biochemistry:
phosphatidylinositol 3-kinase class 2,gamma polypeptide,expressed in normal breast,liver,prostate and other tissues

Enzyme Numbers (IUBMB) for PIK3C2G Gene

Phenotypes From GWAS Catalog for PIK3C2G Gene

Gene Ontology (GO) - Molecular Function for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity NAS 9878262
GO:0016307 phosphatidylinositol phosphate kinase activity NAS 9878262
genes like me logo Genes that share ontologies with PIK3C2G: view
genes like me logo Genes that share phenotypes with PIK3C2G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PIK3C2G

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3C2G

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PIK3C2G Gene

Localization for PIK3C2G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2G Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIK3C2G gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
genes like me logo Genes that share ontologies with PIK3C2G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIK3C2G Gene

Pathways & Interactions for PIK3C2G Gene

genes like me logo Genes that share pathways with PIK3C2G: view

Gene Ontology (GO) - Biological Process for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006935 chemotaxis IEA --
GO:0014065 phosphatidylinositol 3-kinase signaling IBA --
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration IBA --
genes like me logo Genes that share ontologies with PIK3C2G: view

No data available for SIGNOR curated interactions for PIK3C2G Gene

Drugs & Compounds for PIK3C2G Gene

(23) Drugs for PIK3C2G Gene - From: DrugBank, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0
Wortmannin Experimental Pharma PI3K inhibitor,selective and irreversible, Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 0
Quercetin Experimental, Investigational Nutra Antitumor agent, Non-selective PI 3-kinase inhibitor 42
SF1126 Investigational Pharma inhibitor Kinase Inhibitors 0

(2) Additional Compounds for PIK3C2G Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
LY 294002 hydrochloride

(5) Tocris Compounds for PIK3C2G Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7
genes like me logo Genes that share compounds with PIK3C2G: view

Transcripts for PIK3C2G Gene

Unigene Clusters for PIK3C2G Gene

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3C2G

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C2G Gene

No ASD Table

Relevant External Links for PIK3C2G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIK3C2G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIK3C2G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIK3C2G Gene

This gene is overexpressed in Stomach (x16.5), Liver (x8.7), Skin - Not Sun Exposed (Suprapubic) (x6.9), Skin - Sun Exposed (Lower leg) (x6.2), and Breast - Mammary Tissue (x4.2).

Protein differential expression in normal tissues from HIPED for PIK3C2G Gene

This gene is overexpressed in Plasma (59.2) and Breast (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIK3C2G Gene

Protein tissue co-expression partners for PIK3C2G Gene

NURSA nuclear receptor signaling pathways regulating expression of PIK3C2G Gene:


SOURCE GeneReport for Unigene cluster for PIK3C2G Gene:


mRNA Expression by UniProt/SwissProt for PIK3C2G Gene:

Tissue specificity: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.

Evidence on tissue expression from TISSUES for PIK3C2G Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with PIK3C2G: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3C2G Gene

Orthologs for PIK3C2G Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIK3C2G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIK3C2G 34 33
  • 98.45 (n)
(Canis familiaris)
Mammalia PIK3C2G 34 33
  • 88.94 (n)
(Bos Taurus)
Mammalia PIK3C2G 34 33
  • 87.58 (n)
(Mus musculus)
Mammalia Pik3c2g 16 34 33
  • 79.88 (n)
(Rattus norvegicus)
Mammalia Pik3c2g 33
  • 78.65 (n)
(Gallus gallus)
Aves PIK3C2G 34 33
  • 66.49 (n)
(Danio rerio)
Actinopterygii LOC100330514 33
  • 47.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pi3K68D 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea piki-1 34
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 34
  • 20 (a)
Species where no ortholog for PIK3C2G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIK3C2G Gene

Gene Tree for PIK3C2G (if available)
Gene Tree for PIK3C2G (if available)
Evolutionary constrained regions (ECRs) for PIK3C2G: view image

Paralogs for PIK3C2G Gene

Paralogs for PIK3C2G Gene

(9) SIMAP similar genes for PIK3C2G Gene using alignment to 5 proteins:

  • F5H369_HUMAN
  • F5H7Y7_HUMAN
genes like me logo Genes that share paralogs with PIK3C2G: view

Variants for PIK3C2G Gene

Sequence variations from dbSNP and Humsavar for PIK3C2G Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs757326350 pathogenic, Spermatogenic failure 17 18,688,215(+) T/A/C genic_downstream_transcript_variant, intron_variant
rs373231729 uncertain-significance, not provided 18,314,004(+) A/G/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs375555307 uncertain-significance, not provided 18,538,291(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs387907449 uncertain-significance, not provided 18,491,479(+) T/C/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs387907450 uncertain-significance, not provided 18,563,412(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3C2G Gene

Variant ID Type Subtype PubMed ID
dgv1397n100 CNV gain 25217958
dgv2395n54 CNV loss 21841781
esv1370525 CNV insertion 17803354
esv1542857 CNV deletion 17803354
esv23982 CNV loss 19812545
esv2650294 CNV deletion 19546169
esv2672387 CNV deletion 23128226
esv2674487 CNV deletion 23128226
esv2745610 CNV deletion 23290073
esv2745611 CNV deletion 23290073
esv2745612 CNV deletion 23290073
esv3413119 CNV insertion 20981092
esv3446733 CNV insertion 20981092
esv3580165 CNV loss 25503493
esv3628738 CNV loss 21293372
esv3892152 CNV gain 25118596
esv3892155 CNV loss 25118596
nsv1046263 CNV loss 25217958
nsv1053508 CNV gain 25217958
nsv437727 CNV loss 16327808
nsv437728 CNV loss 16327808
nsv438194 CNV loss 16468122
nsv475890 CNV novel sequence insertion 20440878
nsv520574 CNV loss 19592680
nsv521707 CNV loss 19592680
nsv557667 CNV gain 21841781
nsv557670 CNV loss 21841781
nsv557671 CNV loss 21841781
nsv627 CNV deletion 18451855
nsv628 CNV insertion 18451855
nsv832343 CNV gain 17160897
nsv832344 CNV loss 17160897
nsv8926 CNV loss 18304495

Variation tolerance for PIK3C2G Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.61; 98.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIK3C2G Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2G Gene

Disorders for PIK3C2G Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIK3C2G Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 17
  • spgf17
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PIK3C2G

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PIK3C2G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3C2G Gene

Publications for PIK3C2G Gene

  1. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. (PMID: 9878262) Rozycka M … Fry MJ (Genomics 1998) 2 3 4 22 58
  2. Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. (PMID: 17991425) Daimon M … Kato T (Biochemical and biophysical research communications 2008) 3 4 44 58
  3. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
  4. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) Ruaño G … Hanks S (Clinica chimica acta; international journal of clinical chemistry 2009) 3 44 58
  5. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. (PMID: 17893707) Jungerius BJ … Sinke RJ (Molecular psychiatry 2008) 3 44 58

Products for PIK3C2G Gene

Sources for PIK3C2G Gene

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