Aliases for PIK3C2G Gene
- Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma 2 3 5
- Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide 2 3
- PI3K-C2-Gamma 3 4
- EC 188.8.131.52 4 56
- Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma Polypeptide 3
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3
- Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3
External Ids for PIK3C2G Gene
Previous GeneCards Identifiers for PIK3C2G Gene
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for PIK3C2G Gene
PIK3C2G (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma) is a Protein Coding gene. Among its related pathways are DNA Damage Response (only ATM dependent) and VEGF Pathway (Tocris). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2B.
UniProtKB/Swiss-Prot for PIK3C2G Gene
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.