Aliases for PIK3C2B Gene
- Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta 2 3 5
- C2-PI3K 2 3 4
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta 3 4
- Phosphoinositide-3-Kinase, Class 2, Beta Polypeptide 2 3
- Phosphoinositide 3-Kinase-C2-Beta 3 4
- PtdIns-3-Kinase C2 Subunit Beta 3 4
- PI3K-C2-Beta 3 4
External Ids for PIK3C2B Gene
Previous GeneCards Identifiers for PIK3C2B Gene
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIK3C2B Gene
PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta) is a Protein Coding gene. Diseases associated with PIK3C2B include Myopathy, Centronuclear, X-Linked. Among its related pathways are mTOR Pathway and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2A.
UniProtKB/Swiss-Prot Summary for PIK3C2B Gene
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725).
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.