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The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II ... See more...
Aliases for PIK3C2B Gene
Aliases for PIK3C2B Gene
- Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta 2 3 5
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta 3 4
- Phosphoinositide-3-Kinase, Class 2, Beta Polypeptide 2 3
- Phosphoinositide 3-Kinase-C2-Beta 3 4
- PtdIns-3-Kinase C2 Subunit Beta 3 4
- PI3K-C2-Beta 3 4
External Ids for PIK3C2B Gene
- HGNC: 8972
- Entrez Gene: 5287
- Ensembl: ENSG00000133056
- OMIM: 602838
- UniProtKB: O00750
Previous GeneCards Identifiers for PIK3C2B Gene
- GC01M202118
- GC01M199852
- GC01M200752
- GC01M201569
- GC01M201123
- GC01M202658
- GC01M202538
- GC01M204391
- GC01M175556
Summaries for PIK3C2B Gene
-
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIK3C2B Gene
PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta) is a Protein Coding gene. Among its related pathways are PI Metabolism and ICos-ICosL Pathway in T-Helper Cell. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2A.
UniProtKB/Swiss-Prot Summary for PIK3C2B Gene
-
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
-
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.
Additional gene information for PIK3C2B Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIK3C2B Gene
Genomics for PIK3C2B Gene
GeneHancer (GH) Regulatory Elements for PIK3C2B Gene
Promoters and enhancers for PIK3C2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PIK3C2B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PIK3C2B gene promoter:
-
- aMEF-2
- Elk-1
- MEF-2A
- NF-AT
- NF-AT1
- NF-AT2
- NF-AT3
- NF-AT4
- Pax-4a
- PPAR-alpha
Genomic Locations for PIK3C2B Gene
Genomic Locations for PIK3C2B Gene
- chr1:204,422,628-204,494,815
- (GRCh38/hg38)
- Size:
- 72,188 bases
- Orientation:
- Minus strand
- chr1:204,391,756-204,463,852
- (GRCh37/hg19)
- Size:
- 72,097 bases
- Orientation:
- Minus strand
Genomic View for PIK3C2B Gene
Genes around PIK3C2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by HGNC
- 1q32.1 by Entrez Gene
- 1q32.1 by Ensembl
PIK3C2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIK3C2B Gene
Proteins for PIK3C2B Gene
-
Protein details for PIK3C2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00750-P3C2B_HUMAN
- Recommended name:
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
- Protein Accession:
- O00750
- O95666
- Q5SW99
Protein attributes for PIK3C2B Gene
- Size:
- 1634 amino acids
- Molecular mass:
- 184768 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1.
- SequenceCaution:
-
- Sequence=CAA74194.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PIK3C2B Gene
Selected DME Specific Peptides for PIK3C2B Gene
- O00750:
-
- FTRLIESSLGS
- FVDLCCQAYNLIRK
- CDRHNDNIML
- DRHNDNIM
- KRDRAPF
- EFQELHNKL
- TSDMAYVINGG
- DLRQDML
- QRELQLSVLS
- CVATYVLGI
- GVTGSFKD
Post-translational modifications for PIK3C2B Gene
Other Protein References for PIK3C2B Gene
Antibody Products
- G Biosciences Immunotag™ P3C2B Polyclonal Antibody and Immunotag™ PIK3C2B Antibody
- Atlas Antibodies Anti-PIK3C2B Antibody (HPA030515) and Anti-PIK3C2B Antibody (HPA050360)
-
Custom Antibody ServicesOriGene Antibodies for PIK3C2B
- Novus Biologicals Antibodies for PIK3C2B
-
Abcam antibodies for PIK3C2B
- Invitrogen Antibodies for PIK3C2B (AFLGC-PIK3C2B)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PIK3C2B
Protein Products
- Atlas Antibodies PrEST Antigen PIK3C2B (APrEST76756) and PrEST Antigen PIK3C2B (APrEST91251)
- Search Origene for MassSpec and Protein Over-expression Lysates for PIK3C2B
- Origene Custom Protein Services for PIK3C2B
-
Abcam proteins for PIK3C2B
Domains & Families for PIK3C2B Gene
Gene Families for PIK3C2B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PIK3C2B Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PIK3C2B Gene
- GenScript: Design optimal peptide antigens:
-
- Phosphoinositide-3-kinase, class 2, beta polypeptide, isoform CRA_b (A2RUF7_HUMAN)
- PIK3C2B protein (B7ZM86_HUMAN)
- Phosphoinositide 3-kinase-C2-beta (P3C2B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00750- Family:
-
- Belongs to the PI3/PI4-kinase family.
Function for PIK3C2B Gene
Molecular function for PIK3C2B Gene
- UniProtKB/Swiss-Prot Function:
- Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:18373, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57658, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216; EC=2.7.1.154;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by GRB2.
- GENATLAS Biochemistry:
- phosphatidylinositol 3-kinase,class 2,widely expressed
Enzyme Numbers (IUBMB) for PIK3C2B Gene
Phenotypes From GWAS Catalog for PIK3C2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001727 | lipid kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 10805725 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | IBA | 21873635 |
Phenotypes for PIK3C2B Gene
- MGI mutant phenotypes for PIK3C2B:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PIK3C2B:
-
- Decreased telomerase activity
- Decreased viability after gemcitabine stimulation
- Increased cilium length after serum starvation
- Decreased viability
- Increased cell migration
- Decreased cell migration
- Increased cell viability after pRB stimulation
- Increased viability with tamoxifen
- no effect
- Increased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
Animal Models for PIK3C2B Gene
- MGI Knock Outs for PIK3C2B:
-
- Pik3c2b Pik3c2b<tm1.1Pkha>
Animal Model Products
-
Taconic Biosciences Mouse Models for PIK3C2B
CRISPR Products
-
OriGene CRISPR knockouts for PIK3C2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIK3C2B
- genomics-online: gRNA clones - Search for available PIK3C2B gRNA products
- Overview of 80 available PIK3C2B gene related products
- Applied Biological Materials (abm): CRISPR Clones for PIK3C2B - Select products 50% OFF >
- * PIK3C2B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PIK3C2B CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIK3C2B
miRNA for PIK3C2B Gene
- miRTarBase miRNAs that target PIK3C2B
-
- hsa-mir-335-5p (MIRT018449)
- hsa-mir-128-3p (MIRT022049)
- hsa-mir-15b-5p (MIRT046415)
- hsa-mir-4469 (MIRT183625)
- hsa-mir-218-5p (MIRT439974)
- hsa-mir-4314 (MIRT471074)
- hsa-mir-4753-3p (MIRT471075)
- hsa-mir-4672 (MIRT471076)
- hsa-mir-30e-5p (MIRT471077)
- hsa-mir-30d-5p (MIRT471078)
- hsa-mir-30c-5p (MIRT471079)
- hsa-mir-30b-5p (MIRT471080)
- hsa-mir-30a-5p (MIRT471081)
- hsa-mir-5196-5p (MIRT471082)
- hsa-mir-4747-5p (MIRT471083)
- hsa-mir-4795-5p (MIRT471084)
- hsa-mir-4320 (MIRT471085)
- hsa-mir-548ax (MIRT471086)
- hsa-mir-548ao-5p (MIRT471087)
- hsa-mir-302d-5p (MIRT471088)
- hsa-mir-6506-5p (MIRT471089)
- hsa-mir-302b-5p (MIRT471090)
- hsa-mir-619-5p (MIRT471091)
- hsa-mir-4646-5p (MIRT471092)
- hsa-mir-3192-5p (MIRT471093)
- hsa-mir-204-3p (MIRT471094)
- hsa-mir-130b-5p (MIRT471095)
- hsa-mir-4459 (MIRT471096)
- hsa-mir-4433a-3p (MIRT471097)
- hsa-mir-6768-5p (MIRT471098)
- hsa-mir-551b-5p (MIRT471099)
- hsa-mir-101-3p (MIRT471100)
- hsa-mir-4667-3p (MIRT625975)
- hsa-mir-1470 (MIRT625976)
- hsa-mir-520h (MIRT625977)
- hsa-mir-520g-3p (MIRT625978)
- hsa-mir-3973 (MIRT625979)
- hsa-mir-2114-5p (MIRT625980)
- hsa-mir-6507-3p (MIRT625981)
- hsa-mir-4774-5p (MIRT625982)
- hsa-mir-4490 (MIRT625983)
- hsa-mir-3613-3p (MIRT625984)
- hsa-mir-7151-5p (MIRT625985)
- hsa-mir-4668-3p (MIRT625986)
- hsa-mir-548c-3p (MIRT625987)
- hsa-mir-3679-3p (MIRT646110)
- hsa-mir-1236-3p (MIRT646111)
- hsa-mir-877-3p (MIRT646112)
- hsa-mir-4286 (MIRT646113)
- hsa-mir-483-3p (MIRT646114)
- hsa-mir-362-5p (MIRT735308)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PIK3C2B
- Browse OriGene Inhibitory RNA Products For PIK3C2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3C2B
- genomics-online: shRNA clones - Search for available PIK3C2B shRNA products
- Overview of 80 available PIK3C2B gene related products
Clone Products
- Sino Biological Human cDNA Clone for PIK3C2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIK3C2B
- Applied Biological Materials (abm): Clones for PIK3C2B - Select products 50% OFF >
- * PIK3C2B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PIK3C2B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for PIK3C2B
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3C2B Gene
Localization for PIK3C2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2B Gene
- Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| endoplasmic reticulum | 3 |
| endosome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
Pathways & Interactions for PIK3C2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | superpathway of inositol phosphate compounds | ||
| 2 | Metabolism |
.40
|
|
| 3 | Apoptosis Pathway |
.39
|
|
| 4 | mTOR Pathway |
.38
.38
|
.32
|
| 5 | VEGF Pathway (Tocris) |
.36
|
|
Pathways by source for PIK3C2B Gene
8 BioSystems pathways for PIK3C2B Gene
5 Reactome pathways for PIK3C2B Gene
4 PharmGKB pathways for PIK3C2B Gene
3 KEGG pathways for PIK3C2B Gene
1 R&D Systems pathway for PIK3C2B Gene
9 Tocris pathways for PIK3C2B Gene
3 Qiagen pathways for PIK3C2B Gene
- CD28 Signaling in T-Helper Cell
- ICos-ICosL Pathway in T-Helper Cell
- PI3K Signaling in B-Lymphocyte
1 GeneTex pathway for PIK3C2B Gene
Interacting Proteins for PIK3C2B Gene
Selected Interacting proteins:
O00750-P3C2B_HUMAN
ENSP00000356155
for PIK3C2B Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PIK3C2B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0009267 | cellular response to starvation | IEA | -- |
| GO:0014065 | phosphatidylinositol 3-kinase signaling | IBA | 21873635 |
| GO:0016236 | macroautophagy | IEA | -- |
Drugs & Compounds for PIK3C2B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| Calcium | Approved | Nutra | 7773 | |||
| Manganese | Approved | Nutra | 48 | |||
| 3-Methyladenine | Experimental | Pharma | Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| LY 294002 hydrochloride |
|
934389-88-5 |
|
|
(5) Tocris Compounds for PIK3C2B Gene
| Compound | Action | Cas Number |
|---|---|---|
| 3-Methyladenine | Class III PI 3-kinase inhibitor; also inhibits autophagy | 5142-23-4 |
| LY 294002 hydrochloride | Prototypical PI 3-kinase inhibitor; also inhibits other kinases | 934389-88-5 |
| PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | 371935-79-4 |
| Quercetin | Non-selective PI 3-kinase inhibitor | 117-39-5 |
| Wortmannin | Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 | 19545-26-7 |
Drug Products
- Atlas Antibodies PrEST Antigen PIK3C2B (APrEST76756) and PrEST Antigen PIK3C2B (APrEST91251)
Transcripts for PIK3C2B Gene
mRNA/cDNA for PIK3C2B Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (87) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367187 7686 bps (ENST00000367187.7)
- ENST00000462752 526 bps (ENST00000462752.1)
- ENST00000479079 402 bps (ENST00000479079.1)
- ENST00000496872 651 bps (ENST00000496872.1)
- ENST00000367184 830 bps (ENST00000367184.2)
CRISPR Products
-
OriGene CRISPR knockouts for PIK3C2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIK3C2B
- genomics-online: gRNA clones - Search for available PIK3C2B gRNA products
- Overview of 80 available PIK3C2B gene related products
- Applied Biological Materials (abm): CRISPR Clones for PIK3C2B - Select products 50% OFF >
- * PIK3C2B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PIK3C2B CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIK3C2B
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PIK3C2B
- Browse OriGene Inhibitory RNA Products For PIK3C2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3C2B
- genomics-online: shRNA clones - Search for available PIK3C2B shRNA products
- Overview of 80 available PIK3C2B gene related products
Clone Products
- Sino Biological Human cDNA Clone for PIK3C2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIK3C2B
- Applied Biological Materials (abm): Clones for PIK3C2B - Select products 50% OFF >
- * PIK3C2B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PIK3C2B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for PIK3C2B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
This gene is overexpressed in Serum (24.8), Plasma (16.3), and Testis (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIK3C2B Gene
NURSA nuclear receptor signaling pathways regulating expression of PIK3C2B Gene:
PIK3C2BSOURCE GeneReport for Unigene cluster for PIK3C2B Gene:
Hs.497487mRNA Expression by UniProt/SwissProt for PIK3C2B Gene:
O00750-P3C2B_HUMAN
Tissue specificity:
Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.
Evidence on tissue expression from TISSUES for PIK3C2B Gene
- Blood(4.3)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for PIK3C2B
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3C2B Gene
Orthologs for PIK3C2B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PIK3C2B 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PIK3C2B 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PIK3C2B 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PIK3C2B 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pik3c2b 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pik3c2b 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PIK3C2B 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PIK3C2B 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PIK3C2B 33 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | pik3c2b 33 32 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Pi3K68D 33 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | piki-1 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS34 33 |
|
OneToMany |
- Species where no ortholog for PIK3C2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for PIK3C2B Gene
- ENSEMBL:
- Gene Tree for PIK3C2B (if available)
- TreeFam:
- Gene Tree for PIK3C2B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PIK3C2B: view image
Paralogs for PIK3C2B Gene
Paralogs for PIK3C2B Gene
(16) SIMAP similar genes for PIK3C2B Gene using alignment to 7 proteins:
- P3C2B_HUMAN
- A2RUF7_HUMAN
- B7ZM86_HUMAN
- F5GWN5_HUMAN
- Q5SW97_HUMAN
- Q5SW98_HUMAN
- Q5SWA0_HUMAN
Variants for PIK3C2B Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000028000 | -- | 204,474,553(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000096765 | -- | 204,481,457(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000098724 | -- | 204,434,902(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000201628 | -- | 204,457,999(-) | G/A | intron_variant | |
| rs1000227326 | -- | 204,478,487(-) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1350665 | CNV | deletion | 17803354 |
| esv2721851 | CNV | deletion | 23290073 |
| esv2721862 | CNV | deletion | 23290073 |
| esv2721873 | CNV | deletion | 23290073 |
| esv2721884 | CNV | deletion | 23290073 |
| esv2721895 | CNV | deletion | 23290073 |
| nsv516276 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.69;
66.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIK3C2B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2B Gene
Disorders for PIK3C2B Gene
Additional Disease Information for PIK3C2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PIK3C2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIK3C2B Gene
Publications for PIK3C2B Gene
- Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. (PMID: 11533253) Wheeler M … Domin J (Molecular and cellular biology 2001) 3 4 23 56
- Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PMID: 10805725) Arcaro A … Domin J (Molecular and cellular biology 2000) 3 4 23 56
- Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. (PMID: 9830063) Arcaro A … Waterfield MD (The Journal of biological chemistry 1998) 2 3 4 56
- Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. (PMID: 9144573) Brown RA … Fry MJ (Biochemical and biophysical research communications 1997) 2 3 4 56
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
ExternalLinks
Products for PIK3C2B Gene
- Custom Antibody ServicesOriGene Antibodies for PIK3C2B
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for PIK3C2B
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- Taconic Biosciences Mouse Models for PIK3C2B
- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for PIK3C2B (AFLGC-PIK3C2B)
- antibodies-online: Show 17 available PIK3C2B Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for PIK3C2B
- Search Santa Cruz Biotechnology (SCBT) for PIK3C2B siRNA/shRNA
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- Horizon Cell Lines for PIK3C2B
- genomics-online: cdna clones - Search for available PIK3C2B CDNA products
- Overview of 80 available PIK3C2B gene related products
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- Overview of 80 available PIK3C2B gene related products
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- Overview of 80 available PIK3C2B gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIK3C2B
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for PIK3C2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIK3C2B
Sources for PIK3C2B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
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- (118) NCBI Bookshelf
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- (120) Gene Damage Index
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- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
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- (172) Modomics
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- (176) snOPY
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- (178) GENCODE
- (179) TarBase
- (180) MyBioSource