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Aliases for PIK3C2B Gene

Aliases for PIK3C2B Gene

  • Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta 2 3 5
  • Phosphoinositide-3-Kinase, Class 2, Beta Polypeptide 2 3
  • Phosphoinositide 3-Kinase-C2-Beta 3 4
  • PtdIns-3-Kinase C2 Subunit Beta 3 4
  • PI3K-C2-Beta 3 4
  • C2-PI3K 3 4
  • Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Beta 2
  • Phosphatidylinositol 3-Kinase C2 Domain-Containing Beta Polypeptide 3
  • PTDINS-3-Kinase C2 Beta 3
  • EC 4
  • PI3K-C2beta 3

External Ids for PIK3C2B Gene

Previous GeneCards Identifiers for PIK3C2B Gene

  • GC01M202118
  • GC01M199852
  • GC01M200752
  • GC01M201569
  • GC01M201123
  • GC01M202658
  • GC01M202538
  • GC01M204391
  • GC01M175556

Summaries for PIK3C2B Gene

Entrez Gene Summary for PIK3C2B Gene

  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIK3C2B Gene

PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta) is a Protein Coding gene. Among its related pathways are mTOR Pathway and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2A.

UniProtKB/Swiss-Prot for PIK3C2B Gene

  • Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

Tocris Summary for PIK3C2B Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3C2B Gene

Additional gene information for PIK3C2B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2B Gene

Genomics for PIK3C2B Gene

GeneHancer (GH) Regulatory Elements for PIK3C2B Gene

Promoters and enhancers for PIK3C2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J204491 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.1 1148 4.5 HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF143 PIK3C2B ZC3H11A MDM4 SNRPE PPP1R15B
GH01J204511 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.3 -22.3 -22265 11.9 CLOCK ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 MDM4 ZC3H11A SNRPE ZBED6 PPP1R15B PIK3C2B LOC101929459 ENSG00000236108 NFASC SOX13
GH01J204460 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 24.4 +30.6 30550 7.5 BATF YY1 TCF12 ZNF766 EGR1 ETV6 ATF7 IKZF2 RUNX3 EGR2 PIK3C2B PPP1R15B TMCC2 LRRN2 SOX13 ZC3H11A
GH01J204445 Enhancer 1.3 Ensembl ENCODE dbSUPER 23.9 +44.7 44722 8.2 HDGF PKNOX1 SIN3A ZNF2 BRCA1 ZNF213 ARID2 ZNF143 ATF7 FOS PIK3C2B PPP1R15B
GH01J204431 Enhancer 1.3 Ensembl ENCODE dbSUPER 23.3 +59.1 59120 9.3 CLOCK FOXA2 ARID4B BRCA1 RAD21 RFX5 YY1 TCF12 SCRT2 ZNF143 PIK3C2B PPP1R15B ENSG00000226330
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIK3C2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIK3C2B gene promoter:
  • PPAR-alpha
  • Elk-1
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • Pax-4a
  • MEF-2A
  • aMEF-2

Genomic Locations for PIK3C2B Gene

Genomic Locations for PIK3C2B Gene
72,188 bases
Minus strand
72,097 bases
Minus strand

Genomic View for PIK3C2B Gene

Genes around PIK3C2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3C2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3C2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C2B Gene

Proteins for PIK3C2B Gene

  • Protein details for PIK3C2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
    Protein Accession:
    Secondary Accessions:
    • O95666
    • Q5SW99

    Protein attributes for PIK3C2B Gene

    1634 amino acids
    Molecular mass:
    184768 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1.
    • Sequence=CAA74194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PIK3C2B Gene

Post-translational modifications for PIK3C2B Gene

  • Ubiquitination at isoforms=1152, Lys1047, isoforms=1027, isoforms=752, Lys267, Lys241, isoforms=201, isoforms=70, and Lys22
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PIK3C2B Gene

Domains & Families for PIK3C2B Gene

Gene Families for PIK3C2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PI3/PI4-kinase family.
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3C2B: view

Function for PIK3C2B Gene

Molecular function for PIK3C2B Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by GRB2.
GENATLAS Biochemistry:
phosphatidylinositol 3-kinase,class 2,widely expressed

Enzyme Numbers (IUBMB) for PIK3C2B Gene

Gene Ontology (GO) - Molecular Function for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001727 lipid kinase activity IEA --
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 10805725
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with PIK3C2B: view
genes like me logo Genes that share phenotypes with PIK3C2B: view

Animal Models for PIK3C2B Gene

MGI Knock Outs for PIK3C2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIK3C2B

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3C2B Gene

Localization for PIK3C2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2B Gene

Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIK3C2B gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endoplasmic reticulum 3
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PIK3C2B: view

Pathways & Interactions for PIK3C2B Gene

genes like me logo Genes that share pathways with PIK3C2B: view

SIGNOR curated interactions for PIK3C2B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0009267 cellular response to starvation IEA --
GO:0014065 phosphatidylinositol 3-kinase signaling IBA --
GO:0016236 macroautophagy IEA --
genes like me logo Genes that share ontologies with PIK3C2B: view

Drugs & Compounds for PIK3C2B Gene

(26) Drugs for PIK3C2B Gene - From: DrugBank, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0

(5) Additional Compounds for PIK3C2B Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
LY 294002 hydrochloride

(5) Tocris Compounds for PIK3C2B Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7
genes like me logo Genes that share compounds with PIK3C2B: view

Transcripts for PIK3C2B Gene

Unigene Clusters for PIK3C2B Gene

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C2B Gene

No ASD Table

Relevant External Links for PIK3C2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIK3C2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIK3C2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIK3C2B Gene

This gene is overexpressed in Serum (24.8), Plasma (16.3), and Testis (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIK3C2B Gene

NURSA nuclear receptor signaling pathways regulating expression of PIK3C2B Gene:


SOURCE GeneReport for Unigene cluster for PIK3C2B Gene:


mRNA Expression by UniProt/SwissProt for PIK3C2B Gene:

Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.

Evidence on tissue expression from TISSUES for PIK3C2B Gene

  • Blood(4.3)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with PIK3C2B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3C2B Gene

Orthologs for PIK3C2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIK3C2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIK3C2B 34 33
  • 98.35 (n)
(Canis familiaris)
Mammalia PIK3C2B 34 33
  • 91.15 (n)
(Bos Taurus)
Mammalia PIK3C2B 34 33
  • 90.43 (n)
(Monodelphis domestica)
Mammalia PIK3C2B 34
  • 90 (a)
(Mus musculus)
Mammalia Pik3c2b 16 34 33
  • 88.83 (n)
(Rattus norvegicus)
Mammalia Pik3c2b 33
  • 88.44 (n)
(Ornithorhynchus anatinus)
Mammalia PIK3C2B 34
  • 82 (a)
(Gallus gallus)
Aves PIK3C2B 34 33
  • 79.01 (n)
(Anolis carolinensis)
Reptilia PIK3C2B 34
  • 82 (a)
(Danio rerio)
Actinopterygii pik3c2b 34 33
  • 65.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pi3K68D 34 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea piki-1 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 34
  • 21 (a)
Species where no ortholog for PIK3C2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIK3C2B Gene

Gene Tree for PIK3C2B (if available)
Gene Tree for PIK3C2B (if available)
Evolutionary constrained regions (ECRs) for PIK3C2B: view image

Paralogs for PIK3C2B Gene

Paralogs for PIK3C2B Gene

(16) SIMAP similar genes for PIK3C2B Gene using alignment to 7 proteins:

  • B7ZM86_HUMAN
  • Q5SW97_HUMAN
  • Q5SW98_HUMAN
genes like me logo Genes that share paralogs with PIK3C2B: view

Variants for PIK3C2B Gene

Sequence variations from dbSNP and Humsavar for PIK3C2B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000028000 -- 204,474,553(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000096765 -- 204,481,457(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000098724 -- 204,434,902(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000201628 -- 204,457,999(-) G/A intron_variant
rs1000227326 -- 204,478,487(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3C2B Gene

Variant ID Type Subtype PubMed ID
esv1350665 CNV deletion 17803354
esv2721851 CNV deletion 23290073
esv2721862 CNV deletion 23290073
esv2721873 CNV deletion 23290073
esv2721884 CNV deletion 23290073
esv2721895 CNV deletion 23290073
nsv516276 CNV loss 19592680

Variation tolerance for PIK3C2B Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIK3C2B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2B Gene

Disorders for PIK3C2B Gene

Additional Disease Information for PIK3C2B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PIK3C2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIK3C2B Gene

Publications for PIK3C2B Gene

  1. Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. (PMID: 11533253) Wheeler M … Domin J (Molecular and cellular biology 2001) 3 4 22 58
  2. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PMID: 10805725) Arcaro A … Domin J (Molecular and cellular biology 2000) 3 4 22 58
  3. Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. (PMID: 9830063) Arcaro A … Waterfield MD (The Journal of biological chemistry 1998) 2 3 4 58
  4. Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. (PMID: 9144573) Brown RA … Fry MJ (Biochemical and biophysical research communications 1997) 2 3 4 58
  5. Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. (PMID: 20197460) Koutros S … Berndt SI (Cancer research 2010) 3 44 58

Products for PIK3C2B Gene

Sources for PIK3C2B Gene

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