Aliases for PIK3C2B Gene
Aliases for PIK3C2B Gene
External Ids for PIK3C2B Gene
- HGNC: 8972
- Entrez Gene: 5287
- Ensembl: ENSG00000133056
- OMIM: 602838
- UniProtKB: O00750
Previous GeneCards Identifiers for PIK3C2B Gene
- GC01M202118
- GC01M199852
- GC01M200752
- GC01M201569
- GC01M201123
- GC01M202658
- GC01M202538
- GC01M204391
- GC01M175556
Summaries for PIK3C2B Gene
-
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIK3C2B Gene
PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta) is a Protein Coding gene. Among its related pathways are VEGF Signaling Pathway and DNA Damage Response (only ATM dependent). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2A.
UniProtKB/Swiss-Prot for PIK3C2B Gene
-
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
-
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.
Additional gene information for PIK3C2B Gene
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2B Gene
Genomics for PIK3C2B Gene
GeneHancer (GH) Regulatory Elements for PIK3C2B Gene
Promoters and enhancers for PIK3C2B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I204491 | Promoter/Enhancer | 1.7 | Ensembl ENCODE dbSUPER | 550.8 | +1.1 | 1148 | 4.5 | HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF143 | PIK3C2B ZC3H11A MDM4 PPP1R15B | |
| GH01I204488 | Promoter/Enhancer | 0.8 | EPDnew dbSUPER | 550.4 | +6.1 | 6078 | 0.1 | ZNF24 | PIK3C2B PPP1R15B | |
| GH01I204511 | Promoter/Enhancer | 2.8 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 18.3 | -22.3 | -22265 | 11.9 | CLOCK ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 | MDM4 ZC3H11A SNRPE ZBED6 PPP1R15B PIK3C2B NFASC SNRPGP10 SOX13 RBBP5 | |
| GH01I204460 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 24.4 | +30.6 | 30550 | 7.5 | TCF12 ZNF766 ATF7 RUNX3 ZNF592 MEF2D SMARCA4 KDM1A MEIS2 PYGO2 | PIK3C2B PPP1R15B TMCC2 LRRN2 SOX13 ZC3H11A | |
| GH01I204445 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 23.9 | +44.7 | 44722 | 8.2 | HDGF PKNOX1 SIN3A ZNF2 BRCA1 ZNF213 ARID2 ZNF143 ATF7 FOS | PIK3C2B PPP1R15B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PIK3C2B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PIK3C2B Gene
Genomic Locations for PIK3C2B Gene
- chr1:204,422,628-204,494,815
- (GRCh38/hg38)
- Size:
- 72,188 bases
- Orientation:
- Minus strand
- chr1:204,391,756-204,463,852
- (GRCh37/hg19)
Genomic View for PIK3C2B Gene
Genes around PIK3C2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by Ensembl
- 1q32.1 by Entrez Gene
- 1q32.1 by HGNC
PIK3C2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIK3C2B Gene
Proteins for PIK3C2B Gene
-
Protein details for PIK3C2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00750-P3C2B_HUMAN
- Recommended name:
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
- Protein Accession:
- O00750
- O95666
- Q5SW99
Protein attributes for PIK3C2B Gene
- Size:
- 1634 amino acids
- Molecular mass:
- 184768 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1.
- SequenceCaution:
-
- Sequence=CAA74194.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PIK3C2B Gene
Selected DME Specific Peptides for PIK3C2B Gene
- O00750:
-
- FTRLIESSLGS
- FVDLCCQAYNLIRK
- CDRHNDNIML
- DRHNDNIM
- KRDRAPF
- EFQELHNKL
- TSDMAYVINGG
- DLRQDML
- QRELQLSVLS
- CVATYVLGI
- GVTGSFKD
Post-translational modifications for PIK3C2B Gene
- Ubiquitination at isoforms=22, isoforms=70, isoforms=201, Lys241, isoforms=267, isoforms=752, Lys1027, Lys1047, and isoforms=1152
Other Protein References for PIK3C2B Gene
Antibody Products
- R&D Systems Antibodies for PIK3C2B (PI 3-Kinase C2 beta)
-
Custom Antibody ServicesOriGene Antibodies for PIK3C2B
- Novus Biologicals Antibodies for PIK3C2B
-
Abcam antibodies for PIK3C2B
- Invitrogen Antibodies for PIK3C2B
- Search GeneTex for Antibodies for PIK3C2B
-
Santa Cruz Biotechnology (SCBT) Antibodies for PIK3C2B
Protein Products
-
OriGene Purified Proteins for PIK3C2B
- Search Origene for MassSpec and Protein Over-expression Lysates for PIK3C2B
- Origene Custom Protein Services for PIK3C2B
- Search GeneTex for Proteins for PIK3C2B
-
Abcam proteins for PIK3C2B
Assay Products
Domains & Families for PIK3C2B Gene
Gene Families for PIK3C2B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PIK3C2B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PIK3C2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00750- Family:
-
- Belongs to the PI3/PI4-kinase family.
Function for PIK3C2B Gene
Molecular function for PIK3C2B Gene
- GENATLAS Biochemistry:
- phosphatidylinositol 3-kinase,class 2,widely expressed
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by GRB2.
- UniProtKB/Swiss-Prot Function:
- Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
Enzyme Numbers (IUBMB) for PIK3C2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001727 | lipid kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 10805725 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | IBA | -- |
Phenotypes for PIK3C2B Gene
- MGI mutant phenotypes for PIK3C2B:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PIK3C2B:
-
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased cell migration
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased viability with tamoxifen
- Increased cell viability after pRB stimulation
- Increased cell migration
- Increased cilium length after serum starvation
- Decreased viability after gemcitabine stimulation
- Decreased telomerase activity
Animal Models for PIK3C2B Gene
- MGI Knock Outs for PIK3C2B:
-
- Pik3c2b tm1.1Pkha
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIK3C2B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PIK3C2B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIK3C2B gene
- Search ViGene Biosciences for PIK3C2B
CRISPR Products
-
OriGene CRISPR knockouts for PIK3C2B
- genomics-online: gRNA clones - Search results for 75 available PIK3C2B gene related products
- Overview of 75 available PIK3C2B gene related products
- Applied Biological Materials CRISPR for PIK3C2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIK3C2B
- GenScript: Design CRISPR guide RNA sequences for PIK3C2B
miRNA for PIK3C2B Gene
- miRTarBase miRNAs that target PIK3C2B
-
- hsa-mir-335-5p (MIRT018449)
- hsa-mir-128-3p (MIRT022049)
- hsa-mir-15b-5p (MIRT046415)
- hsa-mir-4469 (MIRT183625)
- hsa-mir-218-5p (MIRT439974)
- hsa-mir-4314 (MIRT471074)
- hsa-mir-4753-3p (MIRT471075)
- hsa-mir-4672 (MIRT471076)
- hsa-mir-30e-5p (MIRT471077)
- hsa-mir-30d-5p (MIRT471078)
- hsa-mir-30c-5p (MIRT471079)
- hsa-mir-30b-5p (MIRT471080)
- hsa-mir-30a-5p (MIRT471081)
- hsa-mir-5196-5p (MIRT471082)
- hsa-mir-4747-5p (MIRT471083)
- hsa-mir-4795-5p (MIRT471084)
- hsa-mir-4320 (MIRT471085)
- hsa-mir-548ax (MIRT471086)
- hsa-mir-548ao-5p (MIRT471087)
- hsa-mir-302d-5p (MIRT471088)
- hsa-mir-6506-5p (MIRT471089)
- hsa-mir-302b-5p (MIRT471090)
- hsa-mir-619-5p (MIRT471091)
- hsa-mir-4646-5p (MIRT471092)
- hsa-mir-3192-5p (MIRT471093)
- hsa-mir-204-3p (MIRT471094)
- hsa-mir-130b-5p (MIRT471095)
- hsa-mir-4459 (MIRT471096)
- hsa-mir-4433a-3p (MIRT471097)
- hsa-mir-6768-5p (MIRT471098)
- hsa-mir-551b-5p (MIRT471099)
- hsa-mir-101-3p (MIRT471100)
- hsa-mir-4667-3p (MIRT625975)
- hsa-mir-1470 (MIRT625976)
- hsa-mir-520h (MIRT625977)
- hsa-mir-520g-3p (MIRT625978)
- hsa-mir-3973 (MIRT625979)
- hsa-mir-2114-5p (MIRT625980)
- hsa-mir-6507-3p (MIRT625981)
- hsa-mir-4774-5p (MIRT625982)
- hsa-mir-4490 (MIRT625983)
- hsa-mir-3613-3p (MIRT625984)
- hsa-mir-7151-5p (MIRT625985)
- hsa-mir-4668-3p (MIRT625986)
- hsa-mir-548c-3p (MIRT625987)
- hsa-mir-3679-3p (MIRT646110)
- hsa-mir-1236-3p (MIRT646111)
- hsa-mir-877-3p (MIRT646112)
- hsa-mir-4286 (MIRT646113)
- hsa-mir-483-3p (MIRT646114)
- hsa-mir-362-5p (MIRT735308)
miRNA Products
- Search ViGene Biosciences for PIK3C2B
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIK3C2B
- Browse OriGene Inhibitory RNA Products For PIK3C2B
- genomics-online: shRNA clones - Search results for 75 available PIK3C2B gene related products
- Overview of 75 available PIK3C2B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PIK3C2B gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PIK3C2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIK3C2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PIK3C2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PIK3C2B
-
ViGene Biosciences adenoviral particle packaged cDNA for PIK3C2B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PIK3C2B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIK3C2B gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3C2B Gene
Localization for PIK3C2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2B Gene
- Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 3 |
| endosome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for PIK3C2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Inositol phosphate metabolism (KEGG) | ||
| 2 | Metabolism |
.37
|
|
| 3 | Apoptosis Pathway |
.39
|
|
| 4 | mTOR Pathway |
.38
.38
|
.32
|
| 5 | VEGF Pathway (Tocris) |
.36
|
|
Pathways by source for PIK3C2B Gene
1 GeneTex pathway for PIK3C2B Gene
8 BioSystems pathways for PIK3C2B Gene
5 Reactome pathways for PIK3C2B Gene
3 PharmGKB pathways for PIK3C2B Gene
3 KEGG pathways for PIK3C2B Gene
1 R&D Systems pathway for PIK3C2B Gene
9 Tocris pathways for PIK3C2B Gene
3 Qiagen pathways for PIK3C2B Gene
Interacting Proteins for PIK3C2B Gene
Selected Interacting proteins:
ENSP00000356155
O00750-P3C2B_HUMAN
for PIK3C2B Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0009267 | cellular response to starvation | IEA | -- |
| GO:0014065 | phosphatidylinositol 3-kinase signaling | IBA | -- |
| GO:0016236 | macroautophagy | IEA | -- |
Drugs & Compounds for PIK3C2B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 | |||
| Magnesium | Approved | Nutra | 0 | |||
| Manganese | Approved | Nutra | 37 | |||
| 3-Methyladenine | Experimental | Pharma | Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy | 0 | ||
| SF1126 | Investigational | Pharma | inhibitor | Kinase Inhibitors | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| LY 294002 hydrochloride |
|
934389-88-5 |
|
|
(5) Tocris Compounds for PIK3C2B Gene
| Compound | Action | Cas Number |
|---|---|---|
| 3-Methyladenine | Class III PI 3-kinase inhibitor; also inhibits autophagy | 5142-23-4 |
| LY 294002 hydrochloride | Prototypical PI 3-kinase inhibitor; also inhibits other kinases | 934389-88-5 |
| PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | 371935-79-4 |
| Quercetin | Non-selective PI 3-kinase inhibitor | 117-39-5 |
| Wortmannin | Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 | 19545-26-7 |
Transcripts for PIK3C2B Gene
mRNA/cDNA for PIK3C2B Gene
- (9) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (87) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PIK3C2B Gene
CRISPR Products
-
OriGene CRISPR knockouts for PIK3C2B
- genomics-online: gRNA clones - Search results for 75 available PIK3C2B gene related products
- Overview of 75 available PIK3C2B gene related products
- Applied Biological Materials CRISPR for PIK3C2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIK3C2B
- GenScript: Design CRISPR guide RNA sequences for PIK3C2B
miRNA Products
- Search ViGene Biosciences for PIK3C2B
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIK3C2B
- Browse OriGene Inhibitory RNA Products For PIK3C2B
- genomics-online: shRNA clones - Search results for 75 available PIK3C2B gene related products
- Overview of 75 available PIK3C2B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PIK3C2B gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PIK3C2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIK3C2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PIK3C2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PIK3C2B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Eye (Sensory Organs)
- Neural Tube (Nervous System)
- Brain (Nervous System)
This gene is overexpressed in Serum (24.8), Plasma (16.3), and Testis (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIK3C2B Gene
NURSA nuclear receptor signaling pathways regulating expression of PIK3C2B Gene:
PIK3C2BSOURCE GeneReport for Unigene cluster for PIK3C2B Gene:
Hs.497487mRNA Expression by UniProt/SwissProt for PIK3C2B Gene:
O00750-P3C2B_HUMAN
Tissue specificity:
Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.
Evidence on tissue expression from TISSUES for PIK3C2B Gene
- Blood(4.3)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for PIK3C2B
- genomics-online: primer clones - Search results for 75 available PIK3C2B gene related products
- Overview of 75 available PIK3C2B gene related products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3C2B Gene
Orthologs for PIK3C2B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PIK3C2B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PIK3C2B 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PIK3C2B 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PIK3C2B 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pik3c2b 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pik3c2b 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PIK3C2B 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PIK3C2B 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PIK3C2B 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | pik3c2b 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Pi3K68D 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | piki-1 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS34 34 |
|
OneToMany |
- Species where no ortholog for PIK3C2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for PIK3C2B Gene
(16) SIMAP similar genes for PIK3C2B Gene using alignment to 7 proteins:
Variants for PIK3C2B Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000028000 | -- | 204,474,553(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000096765 | -- | 204,481,457(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000098724 | -- | 204,434,902(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000201628 | -- | 204,457,999(-) | G/A | intron_variant | |
| rs1000227326 | -- | 204,478,487(-) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv516276 | CNV | loss | 19592680 |
| esv2721895 | CNV | deletion | 23290073 |
| esv2721884 | CNV | deletion | 23290073 |
| esv2721873 | CNV | deletion | 23290073 |
| esv2721862 | CNV | deletion | 23290073 |
| esv2721851 | CNV | deletion | 23290073 |
| esv1350665 | CNV | deletion | 17803354 |
Residual Variation Intolerance Score:
12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.69;
66.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIK3C2B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2B Gene
Disorders for PIK3C2B Gene
Additional Disease Information for PIK3C2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PIK3C2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIK3C2B Gene
Publications for PIK3C2B Gene
- Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. (PMID: 11533253) Wheeler M … Domin J (Molecular and cellular biology 2001) 3 4 22 58
- Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PMID: 10805725) Arcaro A … Domin J (Molecular and cellular biology 2000) 3 4 22 58
- Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. (PMID: 9830063) Arcaro A … Waterfield MD (The Journal of biological chemistry 1998) 2 3 4 58
- Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. (PMID: 9144573) Brown RA … Fry MJ (Biochemical and biophysical research communications 1997) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
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- Invitrogen Antibodies for PIK3C2B
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- Mammalian expression: PiggyBac
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Sources for PIK3C2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (125) NCBI Bookshelf
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- (133) ENCODE
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- (139) VectorBuilder
- (140) SNPedia
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
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- (148) abm
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew