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Aliases for PIK3C2A Gene

Aliases for PIK3C2A Gene

  • Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha 2 3 5
  • Phosphoinositide-3-Kinase, Class 2, Alpha Polypeptide 2 3
  • Phosphoinositide 3-Kinase-C2-Alpha 3 4
  • PtdIns-3-Kinase C2 Subunit Alpha 3 4
  • PI3K-C2-Alpha 3 4
  • Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Alpha 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Alpha 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Alpha 2
  • C2-Containing Phosphatidylinositol Kinase 3
  • PI3-K-C2(ALPHA) 3
  • PI3K-C2alpha 3
  • EC 2.7.1.154 4
  • PI3-K-C2A 3
  • CPK 3

External Ids for PIK3C2A Gene

Previous GeneCards Identifiers for PIK3C2A Gene

  • GC11M018181
  • GC11M018055
  • GC11M017147
  • GC11M017075
  • GC11M017064
  • GC11M017067
  • GC11M016791
  • GC11M017099
  • GC11M017083
  • GC11M017084
  • GC11M017089
  • GC11M017102
  • GC11M017106
  • GC11M017110
  • GC11M017114
  • GC11M017115

Summaries for PIK3C2A Gene

Entrez Gene Summary for PIK3C2A Gene

  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIK3C2A Gene

PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha) is a Protein Coding gene. Diseases associated with PIK3C2A include Neuroleptic Malignant Syndrome and Status Asthmaticus. Among its related pathways are mTOR Pathway and MAPK Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot for PIK3C2A Gene

  • Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.

Tocris Summary for PIK3C2A Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3C2A Gene

Additional gene information for PIK3C2A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2A Gene

Genomics for PIK3C2A Gene

GeneHancer (GH) Regulatory Elements for PIK3C2A Gene

Promoters and enhancers for PIK3C2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J017207 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 662.7 -0.6 -642 4.5 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B PIK3C2A NUCB2 GC11P017211 GC11P017210 OR7E14P SAAL1 SNORD14A C11orf58 RPL36AP37 RPS13
GH11J017206 Enhancer 0.2 Ensembl 650.7 +1.9 1895 0.2 PIK3C2A OR7E14P RPS13 SNORD14B RPL29P21
GH11J016381 Enhancer 0.6 ENCODE 4.9 +825.1 825080 2.2 TAL1 DACH1 CBFA2T3 ZMYM3 TCF12 HMBOX1 FOS MLLT1 TAF7 PIK3C2A GC11P016359 GC11M016482 SOX6
GH11J017196 Enhancer 0.8 ENCODE 0.4 +10.4 10430 1.3 ELF3 FOXA2 ARID4B ETS1 SMARCC2 ATF7 CREM MIXL1 RXRA PPARG OR7E14P RPS13 SNORD14B RPL29P21 PIK3C2A
GH11J017161 Enhancer 1 Ensembl ENCODE 0.3 +44.1 44143 4.1 ELF3 PKNOX1 ARID4B THRB RARA ZNF614 IKZF2 RUNX3 RXRA SP5 OR7E14P RPL36AP37 RPL29P21 RPL34P24 PIK3C2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIK3C2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIK3C2A gene promoter:
  • C/EBPbeta
  • Ik-1
  • HNF-1A
  • HNF-1
  • Evi-1
  • FOXF2
  • POU6F1 (c2)
  • c-Rel

Genomic Locations for PIK3C2A Gene

Genomic Locations for PIK3C2A Gene
chr11:17,077,730-17,207,996
(GRCh38/hg38)
Size:
130,267 bases
Orientation:
Minus strand
chr11:17,099,277-17,229,530
(GRCh37/hg19)
Size:
130,254 bases
Orientation:
Minus strand

Genomic View for PIK3C2A Gene

Genes around PIK3C2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3C2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3C2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C2A Gene

Proteins for PIK3C2A Gene

  • Protein details for PIK3C2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00443-P3C2A_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
    Protein Accession:
    O00443
    Secondary Accessions:
    • B0LPH2
    • B4E2G4
    • Q14CQ9

    Protein attributes for PIK3C2A Gene

    Size:
    1686 amino acids
    Molecular mass:
    190680 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Part of a complex with ERBB2 and EGFR. Interacts with clathrin trimers.

    Three dimensional structures from OCA and Proteopedia for PIK3C2A Gene

    Alternative splice isoforms for PIK3C2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIK3C2A Gene

Post-translational modifications for PIK3C2A Gene

  • Phosphorylated upon insulin stimulation; which may lead to enzyme activation (By similarity). Phosphorylated on Ser-259 during mitosis and upon UV irradiation; which does not change enzymatic activity but leads to proteasomal degradation. Ser-259 phosphorylation may be mediated by CDK1 or JNK, depending on the physiological state of the cell.
  • Ubiquitination at Lys267 and Lys229
  • Modification sites at PhosphoSitePlus

Other Protein References for PIK3C2A Gene

No data available for DME Specific Peptides for PIK3C2A Gene

Domains & Families for PIK3C2A Gene

Graphical View of Domain Structure for InterPro Entry

O00443

UniProtKB/Swiss-Prot:

P3C2A_HUMAN :
  • Belongs to the PI3/PI4-kinase family.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3C2A: view

Function for PIK3C2A Gene

Molecular function for PIK3C2A Gene

UniProtKB/Swiss-Prot Function:
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by insulin (By similarity). Only slightly inhibited by wortmannin and LY294002. Activated by clathrin.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=122 uM for PtdIns (in the absence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=64 uM for PtdIns (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=25 uM for PtdIns4P (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=15 uM for ATP (with PtdIns as substrate) (in the absence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=32 uM for ATP (with PtdIns as substrate) (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=54 uM for ATP (with PtdIns4P as substrate) (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=990 pmol/min/mg enzyme with PtdIns as substrate (in the absence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=200 pmol/min/mg enzyme with PtdIns as substrate (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=240 pmol/min/mg enzyme with PtdIns4P as substrate (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=6800 pmol/min/mg enzyme toward ATP with PtdIns as substrate (in the absence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=805 pmol/min/mg enzyme toward ATP with PtdIns as substrate (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=880 pmol/min/mg enzyme toward ATP with PtdIns4P as substrate (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Note=In the absence of the carrier phosphatidylserine, enzymatic kinetics toward PtdIns4P are non-linear.;

Enzyme Numbers (IUBMB) for PIK3C2A Gene

Phenotypes From GWAS Catalog for PIK3C2A Gene

Gene Ontology (GO) - Molecular Function for PIK3C2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS 9337861
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PIK3C2A: view
genes like me logo Genes that share phenotypes with PIK3C2A: view

Animal Models for PIK3C2A Gene

MGI Knock Outs for PIK3C2A:
  • Pik3c2a Pik3c2a<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for PIK3C2A

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3C2A Gene

Localization for PIK3C2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2A Gene

Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=Inserts preferentially into membranes containing PtdIns(4,5)P2 (PubMed:17038310). Associated with RNA-containing structures (PubMed:11606566). {ECO:0000269 PubMed:11606566, ECO:0000269 PubMed:17038310}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIK3C2A gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PIK3C2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA,IEA 21081650
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PIK3C2A: view

Pathways & Interactions for PIK3C2A Gene

genes like me logo Genes that share pathways with PIK3C2A: view

SIGNOR curated interactions for PIK3C2A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PIK3C2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006887 exocytosis TAS 17371240
GO:0006897 endocytosis IMP 21081650
GO:0007173 epidermal growth factor receptor signaling pathway TAS 17371240
GO:0008286 insulin receptor signaling pathway TAS 17371240
genes like me logo Genes that share ontologies with PIK3C2A: view

Drugs & Compounds for PIK3C2A Gene

(87) Drugs for PIK3C2A Gene - From: DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
Wortmannin Experimental Pharma PI3K inhibitor,selective and irreversible, Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 0
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0

(165) Additional Compounds for PIK3C2A Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(28:0)
  • pSer(14:0/14:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1W5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(30:0)
  • pSer(14:0/16:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1W7)
  • Phosphatidylserine(30:1)

(5) Tocris Compounds for PIK3C2A Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7
genes like me logo Genes that share compounds with PIK3C2A: view

Transcripts for PIK3C2A Gene

Unigene Clusters for PIK3C2A Gene

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C2A Gene

No ASD Table

Relevant External Links for PIK3C2A Gene

GeneLoc Exon Structure for
PIK3C2A
ECgene alternative splicing isoforms for
PIK3C2A

Expression for PIK3C2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIK3C2A Gene

Protein differential expression in normal tissues from HIPED for PIK3C2A Gene

This gene is overexpressed in Plasma (14.4), Placenta (9.8), and Testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PIK3C2A Gene



Protein tissue co-expression partners for PIK3C2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIK3C2A Gene:

PIK3C2A

SOURCE GeneReport for Unigene cluster for PIK3C2A Gene:

Hs.175343

mRNA Expression by UniProt/SwissProt for PIK3C2A Gene:

O00443-P3C2A_HUMAN
Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans from type 2 diabetes mellitus individuals.

Evidence on tissue expression from TISSUES for PIK3C2A Gene

  • Liver(4.6)
  • Lung(4.5)
  • Heart(3.6)
  • Muscle(3.6)
  • Nervous system(3.2)
  • Blood(3)
  • Kidney(2.9)
  • Thyroid gland(2.4)
  • Skin(2.2)
  • Intestine(2)
  • Urine(2)
genes like me logo Genes that share expression patterns with PIK3C2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3C2A Gene

Orthologs for PIK3C2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIK3C2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIK3C2A 34 33
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3C2A 34 33
  • 92.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PIK3C2A 34 33
  • 91.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3c2a 16 34 33
  • 89.71 (n)
rat
(Rattus norvegicus)
Mammalia Pik3c2a 33
  • 89.42 (n)
oppossum
(Monodelphis domestica)
Mammalia PIK3C2A 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3C2A 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIK3C2A 34 33
  • 75.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIK3C2A 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3c2a 33
  • 65.11 (n)
Str.7067 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14586 33
zebrafish
(Danio rerio)
Actinopterygii pik3c2a 34 33
  • 63.72 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pi3K68D 34 35 33
  • 48.34 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011036 33
  • 46.16 (n)
worm
(Caenorhabditis elegans)
Secernentea piki-1 34 33
  • 44.87 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 34
  • 22 (a)
OneToMany
Species where no ortholog for PIK3C2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIK3C2A Gene

ENSEMBL:
Gene Tree for PIK3C2A (if available)
TreeFam:
Gene Tree for PIK3C2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIK3C2A: view image

Paralogs for PIK3C2A Gene

Paralogs for PIK3C2A Gene

(12) SIMAP similar genes for PIK3C2A Gene using alignment to 5 proteins:

  • P3C2A_HUMAN
  • B4E2G4_HUMAN
  • E9PPP3_HUMAN
  • F5H2B0_HUMAN
  • L7RRS0_HUMAN
genes like me logo Genes that share paralogs with PIK3C2A: view

Variants for PIK3C2A Gene

Sequence variations from dbSNP and Humsavar for PIK3C2A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000018543 -- 17,183,647(-) C/T intron_variant
rs1000035288 -- 17,097,841(-) G/A intron_variant
rs1000045384 -- 17,162,082(-) T/A intron_variant
rs1000089177 -- 17,136,961(-) T/C intron_variant
rs1000109712 -- 17,181,734(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3C2A Gene

Variant ID Type Subtype PubMed ID
esv2677594 CNV deletion 23128226
esv3625466 CNV loss 21293372
nsv467711 CNV gain 19166990
nsv469762 CNV gain 16826518
nsv477831 CNV novel sequence insertion 20440878
nsv553567 CNV gain 21841781
nsv553568 CNV gain 21841781
nsv7691 CNV deletion 18451855
nsv971989 CNV duplication 23825009

Variation tolerance for PIK3C2A Gene

Residual Variation Intolerance Score: 7.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIK3C2A Gene

Human Gene Mutation Database (HGMD)
PIK3C2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIK3C2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2A Gene

Disorders for PIK3C2A Gene

MalaCards: The human disease database

(78) MalaCards diseases for PIK3C2A Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuroleptic malignant syndrome
status asthmaticus
  • asthma with status asthmaticus
leptospirosis
  • fort bragg fever
inferior myocardial infarction
  • inferior wall myocardial infarction
ornithosis
  • psittacosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PIK3C2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PIK3C2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3C2A Gene

Publications for PIK3C2A Gene

  1. Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha. (PMID: 17038310) Stahelin RV … Cho W (The Journal of biological chemistry 2006) 3 4 22 58
  2. Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function. (PMID: 16215232) Gaidarov I … Keen JH (The Journal of biological chemistry 2005) 3 4 22 58
  3. Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles. (PMID: 11606566) Didichenko SA … Thelen M (The Journal of biological chemistry 2001) 3 4 22 58
  4. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PMID: 10805725) Arcaro A … Domin J (Molecular and cellular biology 2000) 3 4 22 58
  5. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. (PMID: 9337861) Domin J … Waterfield MD (The Biochemical journal 1997) 2 3 4 58

Products for PIK3C2A Gene

Sources for PIK3C2A Gene

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