Aliases for PIK3AP1 Gene
External Ids for PIK3AP1 Gene
Previous GeneCards Identifiers for PIK3AP1 Gene
GeneCards Summary for PIK3AP1 Gene
PIK3AP1 (Phosphoinositide-3-Kinase Adaptor Protein 1) is a Protein Coding gene. Diseases associated with PIK3AP1 include Byssinosis and Central Nervous System Tuberculosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and GAB1 signalosome. Gene Ontology (GO) annotations related to this gene include identical protein binding and phosphatidylinositol 3-kinase regulatory subunit binding. An important paralog of this gene is BANK1.
UniProtKB/Swiss-Prot Summary for PIK3AP1 Gene
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.