Aliases for PIK3AP1 Gene
External Ids for PIK3AP1 Gene
Previous GeneCards Identifiers for PIK3AP1 Gene
GeneCards Summary for PIK3AP1 Gene
PIK3AP1 (Phosphoinositide-3-Kinase Adaptor Protein 1) is a Protein Coding gene. Diseases associated with PIK3AP1 include Byssinosis and Central Nervous System Tuberculosis. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include identical protein binding and phosphatidylinositol 3-kinase regulatory subunit binding. An important paralog of this gene is BANK1.
UniProtKB/Swiss-Prot Summary for PIK3AP1 Gene
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.