Aliases for PIGR Gene
External Ids for PIGR Gene
Previous GeneCards Identifiers for PIGR Gene
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
GeneCards Summary for PIGR Gene
PIGR (Polymeric Immunoglobulin Receptor) is a Protein Coding gene. Diseases associated with PIGR include Protein-Energy Malnutrition and Periampullary Adenocarcinoma. Among its related pathways are IL4-mediated signaling events and Allograft rejection. Gene Ontology (GO) annotations related to this gene include polymeric immunoglobulin receptor activity. An important paralog of this gene is FCAMR.
UniProtKB/Swiss-Prot Summary for PIGR Gene
[Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
[Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).