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This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
PIGR (Polymeric Immunoglobulin Receptor) is a Protein Coding gene. Diseases associated with PIGR include Protein-Energy Malnutrition and Periampullary Adenocarcinoma. Among its related pathways are IL4-mediated signaling events and Innate Immune System. Gene Ontology (GO) annotations related to this gene include polymeric immunoglobulin receptor activity. An important paralog of this gene is FCAMR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001792 | polymeric immunoglobulin receptor activity | IDA | 22022593 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 24248522 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 2920039 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Allograft rejection | ||
3 | IL4-mediated signaling events | ||
4 | Integrated Breast Cancer Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IDA | 24248522 |
GO:0001895 | retina homeostasis | HEP | 23580065 |
GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor | IDA | 22022593 |
GO:0007173 | epidermal growth factor receptor signaling pathway | IDA | 22022593 |
GO:0038093 | Fc receptor signaling pathway | IDA | 22022593 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PIGR 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PIGR 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PIGR 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pigr 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pigr 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PIGR 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PIGR 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PIGR 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PIGR 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100495453 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3375038 | CNV | insertion | 20981092 |
nsv1010486 | CNV | gain | 25217958 |
nsv468049 | CNV | loss | 19166990 |
nsv549071 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
protein-energy malnutrition |
|
|
periampullary adenocarcinoma |
|
|
immunoglobulin alpha deficiency |
|
|
exudative vitreoretinopathy |
|
|
nasopharyngeal carcinoma |
|