This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by Ref... See more...

Aliases for PIGR Gene

Aliases for PIGR Gene

  • Polymeric Immunoglobulin Receptor 2 3 4 5
  • Poly-Ig Receptor 3 4
  • Hepatocellular Carcinoma Associated Protein TB6 3
  • Hepatocellular Carcinoma-Associated Protein TB6 4
  • PIGR 5
  • PIgR 4

External Ids for PIGR Gene

Previous GeneCards Identifiers for PIGR Gene

  • GC01M205761
  • GC01M202813
  • GC01M203745
  • GC01M204185
  • GC01M203335
  • GC01M205168
  • GC01M207101
  • GC01M177799

Summaries for PIGR Gene

Entrez Gene Summary for PIGR Gene

  • This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for PIGR Gene

PIGR (Polymeric Immunoglobulin Receptor) is a Protein Coding gene. Diseases associated with PIGR include Protein-Energy Malnutrition and Periampullary Adenocarcinoma. Among its related pathways are IL4-mediated signaling events and Allograft rejection. Gene Ontology (GO) annotations related to this gene include polymeric immunoglobulin receptor activity. An important paralog of this gene is FCAMR.

UniProtKB/Swiss-Prot Summary for PIGR Gene

  • [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
  • [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).

Gene Wiki entry for PIGR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIGR Gene

Genomics for PIGR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PIGR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206944 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 258.6 +0.3 304 2.7 IKZF1 RXRA USF2 ZFP91 TAL1 RAD51 HNF4A RAD21 NR2F6 ATF2 PIGR ENSG00000271680 PFKFB2 IL19 FCAMR lnc-FCMR-4 HSALNG0010061 FCMR
GH01J206947 Enhancer 0.2 dbSUPER 250.7 -1.9 -1925 0.9 PIGR lnc-PIGR-2 FCAMR HSALNG0010061
GH01J207017 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -80.2 -80202 18.4 IKZF1 MYC NCOR1 JUND ZNF592 ATF2 CEBPA BRCA1 POLR2A NFIC C1orf116 HSALNG0010068 EIF2D C4BPA CDCA4P4 C4BPB FCAMR PIGR FCMR RPL7AP20
GH01J206917 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.9 +23.4 23395 12 BCLAF1 SP1 ZNF207 IKZF1 POLR2A ZSCAN16 BCL11A REST CEBPB ZNF592 FCMR HSALNG0010058 lnc-FCMR-1 lnc-PIGR-3 CDCA4P4 MAPKAPK2 EIF2D ENSG00000271680 PIGR FCAMR
GH01J206907 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 12.3 +37.2 37219 2.5 ZNF600 NFIC ZIC2 ZBTB10 REST ZNF341 KLF7 MAX ZNF217 CTBP1 ENSG00000226945 RPL13AP8 piR-46238-001 ENSG00000271680 CDCA4P4 PIGR IL20 FCAMR EIF2D IL19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PIGR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIGR

Top Transcription factor binding sites by QIAGEN in the PIGR gene promoter:
  • ATF6
  • Bach1
  • Bach2
  • HNF-1
  • HNF-1A
  • IRF-7A
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for PIGR Gene

Latest Assembly
chr1:206,928,522-206,946,466
(GRCh38/hg38)
Size:
17,945 bases
Orientation:
Minus strand

Previous Assembly
chr1:207,101,867-207,119,811
(GRCh37/hg19 by Entrez Gene)
Size:
17,945 bases
Orientation:
Minus strand

chr1:207,101,863-207,119,811
(GRCh37/hg19 by Ensembl)
Size:
17,949 bases
Orientation:
Minus strand

Genomic View for PIGR Gene

Genes around PIGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGR Gene

Proteins for PIGR Gene

  • Protein details for PIGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01833-PIGR_HUMAN
    Recommended name:
    Polymeric immunoglobulin receptor
    Protein Accession:
    P01833
    Secondary Accessions:
    • Q68D81
    • Q8IZY7

    Protein attributes for PIGR Gene

    Size:
    764 amino acids
    Molecular mass:
    83284 Da
    Quaternary structure:
    • Interacts (mainly via CDR1-like domain) with dimeric IgA (PubMed:15530357). Interacts (mainly via CDR2-like domain) with pentameric IgM (PubMed:10229845).
    • [Secretory component]: Either free or part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR) (PubMed:8292260, PubMed:19079336, PubMed:32029686, PubMed:16543244). Free secretory component interacts with bacterial antigens toxA of C. difficile and eae of E. coli (PubMed:16543244).

    Three dimensional structures from OCA and Proteopedia for PIGR Gene

neXtProt entry for PIGR Gene

Post-translational modifications for PIGR Gene

  • N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding.
  • Glycosylation at Asn83, Asn90, Asn135, Asn186, Asn421, Asn469, Asn499, Thr614, Ser621, Ser624, Ser627, and Ser630
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PIGR_HUMAN (550)

Other Protein References for PIGR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIGR Gene

Domains & Families for PIGR Gene

Gene Families for PIGR Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for PIGR Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin subtype

Suggested Antigen Peptide Sequences for PIGR Gene

GenScript: Design optimal peptide antigens:
  • Hepatocellular carcinoma-associated protein TB6 (PIGR_HUMAN)
  • Polymeric immunoglobulin receptor (Q8TE27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01833

UniProtKB/Swiss-Prot:

PIGR_HUMAN :
  • The Ig-like V-type 1/D1 domain contains three complementarity determining region-like loops CDR1-3, which mediate interaction with IgA and IgM.
Domain:
  • The Ig-like V-type 1/D1 domain contains three complementarity determining region-like loops CDR1-3, which mediate interaction with IgA and IgM.
genes like me logo Genes that share domains with PIGR: view

Function for PIGR Gene

Molecular function for PIGR Gene

UniProtKB/Swiss-Prot Function:
[Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
UniProtKB/Swiss-Prot Function:
[Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).
GENATLAS Biochemistry:
immunoglobulin polymeric (poly-Ig) receptor,transmembrane secretory complement

Phenotypes From GWAS Catalog for PIGR Gene

Gene Ontology (GO) - Molecular Function for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001792 polymeric immunoglobulin receptor activity IDA 22022593
GO:0004888 transmembrane signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with PIGR: view
genes like me logo Genes that share phenotypes with PIGR: view

Animal Models for PIGR Gene

MGI Knock Outs for PIGR:

miRNA for PIGR Gene

miRTarBase miRNAs that target PIGR

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIGR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIGR Gene

Localization for PIGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGR Gene

[Polymeric immunoglobulin receptor]: Cell membrane. Single-pass type I membrane protein.
[Secretory component]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIGR gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 4
nucleus 3
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
mitochondrion 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 24248522
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2920039
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PIGR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIGR Gene

Pathways & Interactions for PIGR Gene

genes like me logo Genes that share pathways with PIGR: view

Pathways by source for PIGR Gene

Gene Ontology (GO) - Biological Process for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0001895 retina homeostasis HEP 23580065
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IBA,IDA 9379029
GO:0007173 epidermal growth factor receptor signaling pathway IDA 22022593
GO:0038093 Fc receptor signaling pathway IDA 22022593
genes like me logo Genes that share ontologies with PIGR: view

No data available for SIGNOR curated interactions for PIGR Gene

Drugs & Compounds for PIGR Gene

(11) Drugs for PIGR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for PIGR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIGR: view

Transcripts for PIGR Gene

mRNA/cDNA for PIGR Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIGR

Alternative Splicing Database (ASD) splice patterns (SP) for PIGR Gene

No ASD Table

Relevant External Links for PIGR Gene

GeneLoc Exon Structure for
PIGR

Expression for PIGR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIGR Gene

This gene is overexpressed in Colon - Transverse (x26.3), Minor Salivary Gland (x10.5), and Small Intestine - Terminal Ileum (x5.5).

Protein differential expression in normal tissues from HIPED for PIGR Gene

This gene is overexpressed in Milk (25.3), Pancreatic juice (15.6), and Lavage (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIGR Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIGR

SOURCE GeneReport for Unigene cluster for PIGR Gene:

Hs.497589

Evidence on tissue expression from TISSUES for PIGR Gene

  • Intestine(5)
  • Liver(4.5)
  • Bone marrow(4.4)
  • Saliva(4.4)
  • Lung(4.3)
  • Stomach(3.4)
  • Kidney(3.3)
  • Muscle(2.5)
  • Gall bladder(2.5)
  • Blood(2.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PIGR: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIGR Gene

Orthologs for PIGR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIGR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PIGR 29 30
  • 99.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PIGR 29 30
  • 79.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PIGR 29 30
  • 76.68 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pigr 29 16 30
  • 75.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pigr 29
  • 75.81 (n)
Oppossum
(Monodelphis domestica)
Mammalia PIGR 30
  • 51 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PIGR 30
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PIGR 29 30
  • 53.47 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PIGR 30
  • 36 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100495453 29
  • 46.77 (n)
Species where no ortholog for PIGR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PIGR Gene

ENSEMBL:
Gene Tree for PIGR (if available)
TreeFam:
Gene Tree for PIGR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PIGR: view image
Alliance of Genome Resources:
Additional Orthologs for PIGR

Paralogs for PIGR Gene

genes like me logo Genes that share paralogs with PIGR: view

Variants for PIGR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIGR Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs291102 Uncertain Significance: Berger disease 206,933,133(-) G/Ap.Ala580Val
NM_002644.4(PIGR):c.1739C>T (p.Ala580Val)
MISSENSE
rs2275531 -- p.Gly365Ser
rs7542760 -- p.Thr555Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PIGR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PIGR Gene

Variant ID Type Subtype PubMed ID
esv3375038 CNV insertion 20981092
nsv1010486 CNV gain 25217958
nsv468049 CNV loss 19166990
nsv549071 CNV loss 21841781

Variation tolerance for PIGR Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.31; 88.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIGR Gene

Human Gene Mutation Database (HGMD)
PIGR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIGR
Leiden Open Variation Database (LOVD)
PIGR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGR Gene

Disorders for PIGR Gene

MalaCards: The human disease database

(9) MalaCards diseases for PIGR Gene - From: COP and GCD

Disorder Aliases PubMed IDs
protein-energy malnutrition
  • pem
periampullary adenocarcinoma
iga glomerulonephritis
  • berger's iga or igg nephropathy
immunoglobulin alpha deficiency
  • gamma-a-globulin deficiency
nasopharyngeal carcinoma
  • npca
- elite association - COSMIC cancer census association via MalaCards
Search PIGR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PIGR

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PIGR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIGR Gene

Publications for PIGR Gene

  1. [Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]. (PMID: 16086865) Fan Q … Zeng YX (Ai zheng = Aizheng = Chinese journal of cancer 2005) 3 22 40
  2. Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. (PMID: 15530357) Hamburger AE … Bjorkman PJ (Structure (London, England : 1993) 2004) 3 4 22
  3. Association of gene polymorphism of polymeric immunoglobulin receptor and IgA nephropathy. (PMID: 11579946) Narita I … Gejyo F (Internal medicine (Tokyo, Japan) 2001) 3 22 40
  4. Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interaction. (PMID: 10229845) Røe M … Johansen FE (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4 22
  5. Mechanism for enhanced external transfer of dimeric IgA over pentameric IgM: studies of diffusion, binding to the human polymeric Ig receptor, and epithelial transcytosis. (PMID: 9379029) Natvig IB … Brandtzaeg P (Journal of immunology (Baltimore, Md. : 1950) 1997) 3 4 22

Products for PIGR Gene

Sources for PIGR Gene