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This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by Ref... See more...
Aliases for PIGR Gene
Aliases for PIGR Gene
External Ids for PIGR Gene
- HGNC: 8968
- NCBI Entrez Gene: 5284
- Ensembl: ENSG00000162896
- OMIM®: 173880
- UniProtKB/Swiss-Prot: P01833
Previous GeneCards Identifiers for PIGR Gene
- GC01M205761
- GC01M202813
- GC01M203745
- GC01M204185
- GC01M203335
- GC01M205168
- GC01M207101
- GC01M177799
Summaries for PIGR Gene
-
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
GeneCards Summary for PIGR Gene
PIGR (Polymeric Immunoglobulin Receptor) is a Protein Coding gene. Diseases associated with PIGR include Protein-Energy Malnutrition and Periampullary Adenocarcinoma. Among its related pathways are IL4-mediated signaling events and Allograft rejection. Gene Ontology (GO) annotations related to this gene include polymeric immunoglobulin receptor activity. An important paralog of this gene is FCAMR.
UniProtKB/Swiss-Prot Summary for PIGR Gene
-
[Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
-
[Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).
Additional gene information for PIGR Gene
- HGNC (8968)
- NCBI Entrez Gene (5284)
- Ensembl (ENSG00000162896)
- OMIM® (173880)
- UniProtKB/Swiss-Prot (P01833)
- Open Targets Platform(ENSG00000162896)
- Alliance of Genome Resources
- Search for PIGR at DataMed
- Search for PIGR at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIGR Gene
Genomics for PIGR Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PIGR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PIGR on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIGR
- Top Transcription factor binding sites by QIAGEN in the PIGR gene promoter:
-
- ATF6
- Bach1
- Bach2
- HNF-1
- HNF-1A
- IRF-7A
- USF-1
- USF-1:USF-2
- USF1
- USF2
Genomic Locations for PIGR Gene
Latest Assembly
- chr1:206,928,522-206,946,466
- (GRCh38/hg38)
- Size:
- 17,945 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:207,101,867-207,119,811
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 17,945 bases
- Orientation:
- Minus strand
Genomic View for PIGR Gene
Genes around PIGR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by HGNC
- 1q32.1 by Entrez Gene
- 1q32.1 by Ensembl
PIGR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIGR Gene
Proteins for PIGR Gene
-
Protein details for PIGR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01833-PIGR_HUMAN
- Recommended name:
- Polymeric immunoglobulin receptor
- Protein Accession:
- P01833
- Q68D81
- Q8IZY7
Protein attributes for PIGR Gene
- Size:
- 764 amino acids
- Molecular mass:
- 83284 Da
- Quaternary structure:
-
- Interacts (mainly via CDR1-like domain) with dimeric IgA (PubMed:15530357). Interacts (mainly via CDR2-like domain) with pentameric IgM (PubMed:10229845).
- [Secretory component]: Either free or part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR) (PubMed:8292260, PubMed:19079336, PubMed:32029686, PubMed:16543244). Free secretory component interacts with bacterial antigens toxA of C. difficile and eae of E. coli (PubMed:16543244).
Protein Expression for PIGR Gene
Post-translational modifications for PIGR Gene
- N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding.
-
Glycosylation at Asn83, Asn90, Asn135, Asn186, Asn421, Asn469, Asn499, Thr614, Ser621, Ser624, Ser627, and Ser630
- NX_P01833 (NX_P01833-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- PIGR_HUMAN (550)
Other Protein References for PIGR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PIGR Antibody (LS-A8430) and PIGR Antibody (LS-A8426)
- Novus Biologicals Antibodies for PIGR
- Invitrogen Antibodies for PIGR (AFLGC-Pigr)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PIGR
- Sino Biological Antibodies for PIGR
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PIGR
- Origene Custom Protein Services for PIGR
- Sino Biological Recombinant Proteins for PIGR
- Sino Biological Cell Lysates for PIGR
-
Abcam proteins for PIGR
Assay products for research
- RayBiotech Custom Human pIgR ELISA
- antibodies-online: Show 34 available PIGR Elisa Kits ranked by validation data
- Compare Top PIGR Elisa Kits
-
Quality Products:
- Sino Biological Assays for PIGR
No data available for DME Specific Peptides for PIGR Gene
Domains & Families for PIGR Gene
Gene Families for PIGR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
Protein Domains for PIGR Gene
- InterPro:
- Blocks:
-
- Immunoglobulin V-set
- Immunoglobulin subtype
Suggested Antigen Peptide Sequences for PIGR Gene
- GenScript: Design optimal peptide antigens:
-
- Hepatocellular carcinoma-associated protein TB6 (PIGR_HUMAN)
- Polymeric immunoglobulin receptor (Q8TE27_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01833UniProtKB/Swiss-Prot:
PIGR_HUMAN :- The Ig-like V-type 1/D1 domain contains three complementarity determining region-like loops CDR1-3, which mediate interaction with IgA and IgM.
- Domain:
-
- The Ig-like V-type 1/D1 domain contains three complementarity determining region-like loops CDR1-3, which mediate interaction with IgA and IgM.
Function for PIGR Gene
Molecular function for PIGR Gene
- UniProtKB/Swiss-Prot Function:
- [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
- UniProtKB/Swiss-Prot Function:
- [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).
- GENATLAS Biochemistry:
- immunoglobulin polymeric (poly-Ig) receptor,transmembrane secretory complement
Phenotypes From GWAS Catalog for PIGR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001792 | polymeric immunoglobulin receptor activity | IDA | 22022593 |
| GO:0004888 | transmembrane signaling receptor activity | IBA | 21873635 |
Phenotypes for PIGR Gene
- MGI mutant phenotypes for PIGR:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PIGR:
-
- Strongly decreased CFP-tsO45G cell surface transport
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- no effect
- Decreased viability ratio
- Decreased viability
- Dynamic nuclei (hole, folded or small irregular)
- Decreased hepcidin::fluc mRNA expression
- Increased IL-8 secretion
- Decreased shRNA abundance (Z-score < -2)
- Effect on mitosis
- Increased shRNA abundance (Z-score > 2)
Animal Models for PIGR Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PIGR - Starting at $85 >
- * PIGR CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PIGR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIGR
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIGR
miRNA for PIGR Gene
- miRTarBase miRNAs that target PIGR
-
- hsa-miR-6720-5p (MIRT540313)
- hsa-miR-7703 (MIRT540314)
- hsa-miR-6512-3p (MIRT540315)
- hsa-miR-6729-5p (MIRT540316)
- hsa-miR-4649-5p (MIRT540317)
- hsa-miR-1273a (MIRT540318)
- hsa-miR-661 (MIRT540319)
- hsa-miR-4793-3p (MIRT540320)
- hsa-miR-4486 (MIRT540321)
- hsa-miR-766-3p (MIRT540322)
- hsa-miR-939-3p (MIRT540323)
- hsa-miR-6849-3p (MIRT540324)
- hsa-miR-508-5p (MIRT540325)
- mmu-miR-1953 (MIRT592484)
- mmu-miR-471-3p (MIRT592485)
- mmu-miR-712-5p (MIRT592486)
- mmu-miR-1903 (MIRT592487)
- mmu-miR-3102-3p (MIRT592488)
- mmu-miR-207 (MIRT592489)
- mmu-miR-1958 (MIRT592490)
- mmu-miR-542-3p (MIRT592491)
- hsa-miR-24-3p (MIRT629570)
- hsa-miR-4284 (MIRT629571)
- hsa-miR-4743-5p (MIRT629572)
- hsa-miR-6089 (MIRT629573)
- hsa-miR-583 (MIRT629574)
- hsa-miR-6513-5p (MIRT693551)
- hsa-miR-887-5p (MIRT693552)
- hsa-miR-3913-5p (MIRT693553)
- hsa-miR-3122 (MIRT693554)
- hsa-miR-450a-1-3p (MIRT693555)
- hsa-miR-6780a-5p (MIRT693556)
- hsa-miR-6779-5p (MIRT693557)
- hsa-miR-3689c (MIRT693558)
- hsa-miR-3689b-3p (MIRT693559)
- hsa-miR-3689a-3p (MIRT693560)
- hsa-miR-30b-3p (MIRT693561)
- hsa-miR-1273h-5p (MIRT693562)
- hsa-miR-6788-5p (MIRT693563)
- hsa-miR-30c-2-3p (MIRT693564)
- hsa-miR-30c-1-3p (MIRT693565)
- hsa-miR-6799-5p (MIRT693566)
- hsa-miR-6883-5p (MIRT693567)
- hsa-miR-6785-5p (MIRT693568)
- hsa-miR-4728-5p (MIRT693569)
- hsa-miR-149-3p (MIRT693570)
- hsa-miR-7106-5p (MIRT693571)
- hsa-miR-650 (MIRT693572)
- hsa-miR-3612 (MIRT693573)
- hsa-miR-2467-3p (MIRT693574)
- hsa-miR-1827 (MIRT693575)
- hsa-miR-3937 (MIRT693576)
- hsa-miR-940 (MIRT693577)
- hsa-miR-6893-5p (MIRT693578)
- hsa-miR-6808-5p (MIRT693579)
- hsa-miR-6511a-5p (MIRT693580)
- hsa-miR-1910-3p (MIRT693581)
- hsa-miR-133a-3p (MIRT713925)
- hsa-miR-4713-5p (MIRT713926)
- hsa-miR-642a-5p (MIRT713927)
- hsa-miR-1260b (MIRT713928)
- hsa-miR-1260a (MIRT713929)
- hsa-miR-4281 (MIRT713930)
- hsa-miR-7152-3p (MIRT713931)
- hsa-miR-1236-3p (MIRT713932)
- hsa-miR-2116-3p (MIRT713933)
- hsa-miR-532-3p (MIRT713934)
- hsa-miR-150-5p (MIRT713935)
- hsa-miR-877-3p (MIRT713936)
- hsa-miR-2276-5p (MIRT713937)
- hsa-miR-6892-3p (MIRT713938)
- hsa-miR-1224-3p (MIRT713939)
- hsa-miR-3620-3p (MIRT713940)
- hsa-miR-504-5p (MIRT713941)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIGR
- Browse OriGene Inhibitory RNA Products For PIGR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIGR
Clone products for research
- Applied Biological Materials (abm): Clones for PIGR - Starting at $45 >
- * PIGR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PIGR
- Addgene plasmids for PIGR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIGR
Cell Lines for research
-
Horizon Cell Lines for PIGR
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIGR Gene
Localization for PIGR Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIGR Gene
- [Polymeric immunoglobulin receptor]: Cell membrane. Single-pass type I membrane protein.
- [Secretory component]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| lysosome | 4 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 24248522 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 2920039 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIGR Gene
Pathways & Interactions for PIGR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Allograft rejection | ||
| 3 | IL4-mediated signaling events | ||
| 4 | Integrated Breast Cancer Pathway | ||
Pathways by source for PIGR Gene
2 BioSystems pathways for PIGR Gene
3 Reactome pathways for PIGR Gene
1 KEGG pathway for PIGR Gene
Interacting Proteins for PIGR Gene
GPS-Prot Interaction Network for PIGR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IDA | 24248522 |
| GO:0001895 | retina homeostasis | HEP | 23580065 |
| GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor | IBA,IDA | 9379029 |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IDA | 22022593 |
| GO:0038093 | Fc receptor signaling pathway | IDA | 22022593 |
No data available for SIGNOR curated interactions for PIGR Gene
Transcripts for PIGR Gene
mRNA/cDNA for PIGR Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356495 4275 nts (view in UCSC)
- ENST00000487208 285 nts (view in UCSC)
- ENST00000491503 263 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PIGR - Starting at $85 >
- * PIGR CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PIGR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIGR
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIGR
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIGR
- Browse OriGene Inhibitory RNA Products For PIGR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIGR
Clone products for research
- Applied Biological Materials (abm): Clones for PIGR - Starting at $45 >
- * PIGR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PIGR
- Addgene plasmids for PIGR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIGR
Relevant External Links for PIGR Gene
- GeneLoc Exon Structure for
- PIGR
Expression for PIGR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for PIGR Gene
This gene is overexpressed in Colon - Transverse (x26.3), Minor Salivary Gland (x10.5), and Small Intestine - Terminal Ileum (x5.5).
This gene is overexpressed in Milk (25.3), Pancreatic juice (15.6), and Lavage (14.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIGR Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIGR
SOURCE GeneReport for Unigene cluster for PIGR Gene:
Hs.497589Evidence on tissue expression from TISSUES for PIGR Gene
- Intestine(5)
- Liver(4.5)
- Bone marrow(4.4)
- Saliva(4.4)
- Lung(4.3)
- Stomach(3.4)
- Kidney(3.3)
- Muscle(2.5)
- Gall bladder(2.5)
- Blood(2.4)
- Spleen(2)
Primer products for research
-
OriGene qPCR primer pairs for PIGR
Gene Expression Assays for research
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIGR Gene
Orthologs for PIGR Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PIGR 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PIGR 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PIGR 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pigr 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pigr 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PIGR 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PIGR 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PIGR 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PIGR 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100495453 29 |
|
- Species where no ortholog for PIGR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for PIGR Gene
- ENSEMBL:
- Gene Tree for PIGR (if available)
- TreeFam:
- Gene Tree for PIGR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PIGR: view image
- Alliance of Genome Resources:
- Additional Orthologs for PIGR
Paralogs for PIGR Gene
Variants for PIGR Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3375038 | CNV | insertion | 20981092 |
| nsv1010486 | CNV | gain | 25217958 |
| nsv468049 | CNV | loss | 19166990 |
| nsv549071 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.31;
88.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIGR Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGR Gene
Disorders for PIGR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| protein-energy malnutrition |
|
|
| periampullary adenocarcinoma |
|
|
| iga glomerulonephritis |
|
|
| immunoglobulin alpha deficiency |
|
|
| nasopharyngeal carcinoma |
|
|
Search PIGR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PIGR
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PIGR Gene
Publications for PIGR Gene
- [Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]. (PMID: 16086865) Fan Q … Zeng YX (Ai zheng = Aizheng = Chinese journal of cancer 2005) 3 22 40
- Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. (PMID: 15530357) Hamburger AE … Bjorkman PJ (Structure (London, England : 1993) 2004) 3 4 22
- Association of gene polymorphism of polymeric immunoglobulin receptor and IgA nephropathy. (PMID: 11579946) Narita I … Gejyo F (Internal medicine (Tokyo, Japan) 2001) 3 22 40
- Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interaction. (PMID: 10229845) Røe M … Johansen FE (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4 22
- Mechanism for enhanced external transfer of dimeric IgA over pentameric IgM: studies of diffusion, binding to the human polymeric Ig receptor, and epithelial transcytosis. (PMID: 9379029) Natvig IB … Brandtzaeg P (Journal of immunology (Baltimore, Md. : 1950) 1997) 3 4 22
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Products for PIGR Gene
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