Aliases for PIGR Gene
External Ids for PIGR Gene
Previous GeneCards Identifiers for PIGR Gene
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
GeneCards Summary for PIGR Gene
PIGR (Polymeric Immunoglobulin Receptor) is a Protein Coding gene. Diseases associated with PIGR include Periampullary Adenocarcinoma and Protein-Energy Malnutrition. Among its related pathways are Integrated Breast Cancer Pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include polymeric immunoglobulin receptor activity. An important paralog of this gene is FCAMR.
UniProtKB/Swiss-Prot for PIGR Gene
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.