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Aliases for PIGA Gene

Aliases for PIGA Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis Class A 2 3 5
  • EC 2.4.1.198 4 56
  • PIG-A 3 4
  • Phosphatidylinositol Glycan, Class A (Paroxysmal Nocturnal Hemoglobinuria) 2
  • Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A 3
  • Phosphatidylinositol-Glycan Biosynthesis, Class A Protein 3
  • Phosphatidylinositol-Glycan Biosynthesis Class A Protein 4
  • Class A GlcNAc-Inositol Phospholipid Assembly Protein 3
  • Phosphatidylinositol N-Acetylglucosaminyltransferase 2
  • Paroxysmal Nocturnal Hemoglobinuria 2
  • GLCNAC-PI Synthesis Protein 3
  • GlcNAc-PI Synthesis Protein 4
  • GPI Anchor Biosynthesis 3
  • MCAHS2 3
  • GPI3 3
  • PNH1 3

External Ids for PIGA Gene

Previous GeneCards Identifiers for PIGA Gene

  • GC0XM014782
  • GC0XM014163
  • GC0XM014539
  • GC0XM014699
  • GC0XM015097
  • GC0XM015247
  • GC0XM013097
  • GC0XM015337

Summaries for PIGA Gene

Entrez Gene Summary for PIGA Gene

  • This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]

GeneCards Summary for PIGA Gene

PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis Class A) is a Protein Coding gene. Diseases associated with PIGA include Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2 and Paroxysmal Nocturnal Hemoglobinuria 1. Among its related pathways are Metabolism of proteins and Glycosylphosphatidylinositol (GPI)-anchor biosynthesis. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol N-acetylglucosaminyltransferase activity and UDP-glycosyltransferase activity.

UniProtKB/Swiss-Prot for PIGA Gene

  • Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.

Gene Wiki entry for PIGA Gene

Additional gene information for PIGA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGA Gene

Genomics for PIGA Gene

GeneHancer (GH) Regulatory Elements for PIGA Gene

Promoters and enhancers for PIGA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI015333 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 576.1 +0.3 257 2.9 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 BRCA1 YY1 POLR2B PIGA ASB11 ZRSR2 CA5B PIR MOSPD2 GC0XM015327
GH0XI015748 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -416.6 -416586 6.8 PKNOX1 KLF1 ZBTB6 KLF17 FEZF1 GATA3 ZSCAN5C ATF7 PRDM10 KLF7 CA5B ZRSR2 CA5BP1 PIGA CLTRN GC0XP015773 ENSG00000200620
GH0XI015299 Enhancer 0.7 Ensembl ENCODE 12.6 +35.7 35684 0.4 CTCF ZNF654 TAF1 SMC3 RAD21 ATF2 PIGA ASB11 ASB9
GH0XI015301 Enhancer 0.7 Ensembl ENCODE 12.4 +33.4 33387 1.2 HLF ZSCAN5C MAX MYC MGA PIGA ASB11 ASB9
GH0XI015314 Promoter 0.7 EPDnew 12 +21.0 21001 0.1 ATF4 ATF2 ASB11 PIGA ASB9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PIGA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIGA gene promoter:

Genomic Locations for PIGA Gene

Genomic Locations for PIGA Gene
chrX:15,319,451-15,335,580
(GRCh38/hg38)
Size:
16,130 bases
Orientation:
Minus strand
chrX:15,337,573-15,353,676
(GRCh37/hg19)

Genomic View for PIGA Gene

Genes around PIGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGA Gene

Proteins for PIGA Gene

  • Protein details for PIGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37287-PIGA_HUMAN
    Recommended name:
    Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
    Protein Accession:
    P37287
    Secondary Accessions:
    • B4E0V2
    • Q16025
    • Q16250

    Protein attributes for PIGA Gene

    Size:
    484 amino acids
    Molecular mass:
    54127 Da
    Quaternary structure:
    • Associates with PIGC, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity. Interacts directly with PIGY.

    Alternative splice isoforms for PIGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIGA Gene

Selected DME Specific Peptides for PIGA Gene

P37287:
  • VGGIPEVLP
  • TVFTDHSL

Post-translational modifications for PIGA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PIGA Gene

Gene Families for PIGA Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PIGA Gene

Graphical View of Domain Structure for InterPro Entry

P37287

UniProtKB/Swiss-Prot:

PIGA_HUMAN :
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Family:
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
genes like me logo Genes that share domains with PIGA: view

Function for PIGA Gene

Molecular function for PIGA Gene

GENATLAS Biochemistry:
glycosyl-phosphatidylinositol (GPI),54kDa,anchor synthesis,class A,putatively involved in apoptosis regulation
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.
UniProtKB/Swiss-Prot Function:
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.

Enzyme Numbers (IUBMB) for PIGA Gene

Gene Ontology (GO) - Molecular Function for PIGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16162815
GO:0008194 UDP-glycosyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity TAS 16162815
genes like me logo Genes that share ontologies with PIGA: view
genes like me logo Genes that share phenotypes with PIGA: view

Human Phenotype Ontology for PIGA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PIGA Gene

MGI Knock Outs for PIGA:

Clone Products

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for PIGA Gene

Localization for PIGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGA Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIGA gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
mitochondrion 2
cytosol 2
endosome 2
extracellular 1
peroxisome 1
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PIGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IDA 16162815
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS,IDA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIGA Gene

Pathways & Interactions for PIGA Gene

genes like me logo Genes that share pathways with PIGA: view

UniProtKB/Swiss-Prot P37287-PIGA_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Gene Ontology (GO) - Biological Process for PIGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process TAS,IEA 16162815
GO:0009893 positive regulation of metabolic process TAS 16162815
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with PIGA: view

No data available for SIGNOR curated interactions for PIGA Gene

Drugs & Compounds for PIGA Gene

(7) Drugs for PIGA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Full agonist, Agonist 0

(847) Additional Compounds for PIGA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with PIGA: view

Transcripts for PIGA Gene

Unigene Clusters for PIGA Gene

Phosphatidylinositol glycan anchor biosynthesis, class A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: - - -

Relevant External Links for PIGA Gene

GeneLoc Exon Structure for
PIGA
ECgene alternative splicing isoforms for
PIGA

Expression for PIGA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIGA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIGA Gene

This gene is overexpressed in Serum (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIGA Gene



Protein tissue co-expression partners for PIGA Gene

NURSA nuclear receptor signaling pathways regulating expression of PIGA Gene:

PIGA

SOURCE GeneReport for Unigene cluster for PIGA Gene:

Hs.137154

Evidence on tissue expression from TISSUES for PIGA Gene

  • Nervous system(4.4)
  • Bone marrow(2.8)
  • Blood(2.6)
  • Intestine(2.2)
  • Kidney(2)
  • Liver(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PIGA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • olfactory bulb
  • outer ear
  • pharynx
  • skull
  • tooth
Thorax:
  • chest wall
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
Abdomen:
  • abdominal wall
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • pelvis
  • rectum
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • nail
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with PIGA: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIGA Gene

Orthologs for PIGA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGA 33 34
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia PIGA 33 34
  • 91.8 (n)
dog
(Canis familiaris)
Mammalia PIGA 33 34
  • 91.67 (n)
oppossum
(Monodelphis domestica)
Mammalia PIGA 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Piga 33 16 34
  • 87.81 (n)
rat
(Rattus norvegicus)
Mammalia Piga 33
  • 85.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PIGA 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIGA 33 34
  • 78.68 (n)
lizard
(Anolis carolinensis)
Reptilia PIGA 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia piga 33
  • 74.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16573 33
zebrafish
(Danio rerio)
Actinopterygii piga 33 34
  • 69.88 (n)
zgc56589 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011274 33
  • 60.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6401 35 33 34
  • 56.17 (n)
worm
(Caenorhabditis elegans)
Secernentea piga-1 33 34
  • 56.6 (n)
D2085.6 35
  • 52 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09713g 33
  • 55.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT14 33 34 36
  • 53.38 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL108C 33
  • 51.4 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SETH2 33
  • 57.29 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.4393 33
wheat
(Triticum aestivum)
Liliopsida Ta.10118 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpi3 33
  • 56.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU09757 33
  • 51.93 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5861 33
Species where no ortholog for PIGA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PIGA Gene

ENSEMBL:
Gene Tree for PIGA (if available)
TreeFam:
Gene Tree for PIGA (if available)

Paralogs for PIGA Gene

Pseudogenes.org Pseudogenes for PIGA Gene

genes like me logo Genes that share paralogs with PIGA: view

No data available for Paralogs for PIGA Gene

Variants for PIGA Gene

Sequence variations from dbSNP and Humsavar for PIGA Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1060499625 likely-pathogenic, Multiple congenital anomalies-hypotonia-seizures syndrome 2 15,331,536(-) G/C coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, upstream_transcript_variant
rs1060499666 likely-pathogenic, Multiple congenital anomalies-hypotonia-seizures syndrome 2 15,324,670(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs185874005 benign, not specified, not provided 15,335,488(-) G/A/C genic_upstream_transcript_variant, intron_variant
rs199422232 pathogenic, Paroxysmal nocturnal hemoglobinuria 1 15,331,637(-) G/T coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, stop_gained, upstream_transcript_variant
rs199422233 pathogenic, Paroxysmal nocturnal hemoglobinuria 1 15,331,768(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, stop_gained, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PIGA Gene

Variant ID Type Subtype PubMed ID
esv3573603 CNV loss 25503493
nsv517938 CNV gain 19592680
nsv522729 CNV gain 19592680
nsv528343 CNV gain 19592680

Variation tolerance for PIGA Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIGA Gene

Human Gene Mutation Database (HGMD)
PIGA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIGA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGA Gene

Disorders for PIGA Gene

MalaCards: The human disease database

(14) MalaCards diseases for PIGA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PIGA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PIGA_HUMAN
  • Multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2) [MIM:300868]: An X-linked recessive developmental disorder characterized by dysmorphic features, neonatal hypotonia, myoclonic seizures, and variable congenital anomalies involving the central nervous, cardiac, and urinary systems. Most affected individuals die in infancy. {ECO:0000269 PubMed:22305531, ECO:0000269 PubMed:24259184, ECO:0000269 PubMed:24259288, ECO:0000269 PubMed:24706016, ECO:0000269 PubMed:26993267}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Paroxysmal nocturnal hemoglobinuria 1 (PNH1) [MIM:300818]: A disorder characterized by hemolytic anemia with hemoglobinuria, thromboses in large vessels, and a deficiency in hematopoiesis. Red blood cell breakdown with release of hemoglobin into the urine is manifested most prominently by dark-colored urine in the morning. {ECO:0000269 PubMed:10087994, ECO:0000269 PubMed:12037021, ECO:0000269 PubMed:8167330, ECO:0000269 PubMed:8306954, ECO:0000269 PubMed:8500164}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for PIGA

genes like me logo Genes that share disorders with PIGA: view

No data available for Genatlas for PIGA Gene

Publications for PIGA Gene

  1. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. (PMID: 8500164) Takeda J … Kinoshita T (Cell 1993) 2 3 4 22 58
  2. The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications. (PMID: 10087994) Nafa K … Luzzatto L (Blood cells, molecules & diseases 1998) 3 4 22 58
  3. Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal haemoglobinuria and of a related autosomal pseudogene mapped to 12q21. (PMID: 8081362) Bessler M … Mason PJ (Human molecular genetics 1994) 3 4 22 58
  4. Mutations within the Piga gene in patients with paroxysmal nocturnal hemoglobinuria. (PMID: 8167330) Ware RE … Howard TA (Blood 1994) 3 4 22 58
  5. Characterization of genomic PIG-A gene: a gene for glycosylphosphatidylinositol-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria. (PMID: 8193350) Iida Y … Kinoshita T (Blood 1994) 3 4 22 58

Products for PIGA Gene

Sources for PIGA Gene

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