Aliases for PIFO Gene
Aliases for PIFO Gene
External Ids for PIFO Gene
- HGNC: 27009
- Entrez Gene: 128344
- Ensembl: ENSG00000173947
- OMIM: 614234
- UniProtKB: Q8TCI5
Previous HGNC Symbols for PIFO Gene
- C1orf88
Previous GeneCards Identifiers for PIFO Gene
- GC01P111889
Summaries for PIFO Gene
GeneCards Summary for PIFO Gene
PIFO (Primary Cilia Formation) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding and beta-tubulin binding.
UniProtKB/Swiss-Prot for PIFO Gene
-
During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIFO Gene
Genomics for PIFO Gene
GeneHancer (GH) Regulatory Elements for PIFO Gene
Promoters and enhancers for PIFO Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PIFO on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PIFO Gene
Genomic Locations for PIFO Gene
- chr1:111,324,515-111,353,017
- (GRCh38/hg38)
- Size:
- 28,503 bases
- Orientation:
- Plus strand
- chr1:111,888,910-111,895,639
- (GRCh37/hg19)
Genomic View for PIFO Gene
Genes around PIFO on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by Ensembl
- 1p13.2 by Entrez Gene
- 1p13.2 by HGNC
PIFO Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIFO Gene
Proteins for PIFO Gene
-
Protein details for PIFO Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TCI5-PIFO_HUMAN
- Recommended name:
- Protein pitchfork
- Protein Accession:
- Q8TCI5
- D9J0A2
- D9J0A3
- Q4G0K4
- Q52LJ6
- Q5T5D5
- Q5T5D6
- Q8N310
Protein attributes for PIFO Gene
- Size:
- 191 amino acids
- Molecular mass:
- 21973 Da
- Quaternary structure:
-
- Interacts with proteins involved in ciliary transport, including ARL13B, CETN1, KIF3A, RAB6A, RAB8A, TUBB1 and TUBG1. Interacts with AURKA.
Post-translational modifications for PIFO Gene
Other Protein References for PIFO Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Invitrogen Antibodies for PIFO
- antibodies-online: Search results for available PIFO related products ranked by validation data
- Search GeneTex for Antibodies for PIFO
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PIFO
- Origene Custom Protein Services for PIFO
- antibodies-online: Search results for 3 available PIFO Proteins ranked by validation data
- Compare Top PIFO Proteins
-
Quality Products:
- Search GeneTex for Proteins for PIFO
Assay Products
- antibodies-online: Search results for available PIFO related products ranked by validation data
No data available for DME Specific Peptides for PIFO Gene
Domains & Families for PIFO Gene
Gene Families for PIFO Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for PIFO Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PIFO Gene
Function for PIFO Gene
Molecular function for PIFO Gene
- UniProtKB/Swiss-Prot Function:
- During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.
Phenotypes From GWAS Catalog for PIFO Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20643351 |
| GO:0017137 | Rab GTPase binding | IPI | 20643351 |
| GO:0019894 | kinesin binding | IPI | 20643351 |
| GO:0019901 | protein kinase binding | IPI | 20643351 |
| GO:0043015 | gamma-tubulin binding | IDA | 20643351 |
Phenotypes for PIFO Gene
- MGI mutant phenotypes for PIFO:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PIFO:
Animal Models for PIFO Gene
- MGI Knock Outs for PIFO:
-
- Pifo tm1.1Heli
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIFO
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PIFO gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIFO gene
- Search ViGene Biosciences for PIFO
CRISPR Products
-
OriGene CRISPR knockouts for PIFO
- genomics-online: gRNA clones - Search results for available PIFO gene related products
- Applied Biological Materials CRISPR for PIFO
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIFO
- GenScript: Design CRISPR guide RNA sequences for PIFO
miRNA for PIFO Gene
- miRTarBase miRNAs that target PIFO
miRNA Products
- Search ViGene Biosciences for PIFO
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PIFO
- Browse OriGene Inhibitory RNA Products For PIFO
- genomics-online: shRNA clones - Search results for available PIFO gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PIFO gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PIFO
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIFO
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PIFO gene related products
- orf clones - Search results for available PIFO gene related products
- Applied Biological Materials Clones for PIFO
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PIFO
-
ViGene Biosciences adenoviral particle packaged cDNA for PIFO gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PIFO gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIFO gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIFO Gene
Localization for PIFO Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIFO Gene
- Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Cytoplasm. Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| golgi apparatus | 4 |
| nucleus | 3 |
| cytosol | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005802 | trans-Golgi network | ISS | -- |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIFO Gene
Pathways & Interactions for PIFO Gene
No Data Available
Interacting Proteins for PIFO Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030030 | cell projection organization | IEA | -- |
| GO:0031344 | regulation of cell projection organization | IBA,ISS | -- |
| GO:0033674 | positive regulation of kinase activity | IMP | 20643351 |
No data available for Pathways by source and SIGNOR curated interactions for PIFO Gene
Transcripts for PIFO Gene
mRNA/cDNA for PIFO Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (84) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PIFO Gene
CRISPR Products
-
OriGene CRISPR knockouts for PIFO
- genomics-online: gRNA clones - Search results for available PIFO gene related products
- Applied Biological Materials CRISPR for PIFO
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIFO
- GenScript: Design CRISPR guide RNA sequences for PIFO
miRNA Products
- Search ViGene Biosciences for PIFO
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PIFO
- Browse OriGene Inhibitory RNA Products For PIFO
- genomics-online: shRNA clones - Search results for available PIFO gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PIFO gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PIFO
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIFO
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PIFO gene related products
- orf clones - Search results for available PIFO gene related products
- Applied Biological Materials Clones for PIFO
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: |
Expression for PIFO Gene
mRNA differential expression in normal tissues according to GTEx for PIFO Gene
This gene is overexpressed in Testis (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of PIFO Gene:
PIFOSOURCE GeneReport for Unigene cluster for PIFO Gene:
Hs.172510Evidence on tissue expression from TISSUES for PIFO Gene
- Nervous system(4.4)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for PIFO
- genomics-online: primer clones - Search results for available PIFO gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIFO Gene
Orthologs for PIFO Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PIFO 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC611691 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | C3H1orf88 33 |
|
||
| PIFO 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pifo 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pifo 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PIFO 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PIFO 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PIFO 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PIFO 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | PIFO 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3194 34 |
|
OneToOne |
- Species where no ortholog for PIFO was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PIFO Gene
No data available for Paralogs for PIFO Gene
Variants for PIFO Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000160193 | -- | 111,331,516(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000194599 | -- | 111,331,894(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000197153 | -- | 111,329,624(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000274730 | -- | 111,350,803(+) | G/A | intron_variant | |
| rs1000556042 | -- | 111,333,051(+) | A/T | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.63;
56.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIFO Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIFO
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIFO Gene
Disorders for PIFO Gene
Additional Disease Information for PIFO
No disorders were found for PIFO Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIFO Gene
Publications for PIFO Gene
- Pitchfork regulates primary cilia disassembly and left-right asymmetry. (PMID: 20643351) Kinzel D … Lickert H (Developmental cell 2010) 2 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
Products for PIFO Gene
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- Browse R&D Systems for biochemical assays
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PIFO
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- OriGene qPCR primer pairs for PIFO
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIFO
- VectorBuilder custom plasmid, inducible vectors for PIFO
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIFO
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available PIFO related products ranked by validation data
- antibodies-online: Search results for available PIFO related products ranked by validation data
- antibodies-online: Search results for 3 available PIFO Proteins ranked by validation data
- Compare Top PIFO Proteins
- Quality Products:
- Search GeneTex for Antibodies for PIFO
- Search GeneTex for Proteins for PIFO
- ViGene Biosciences adenoviral particle packaged cDNA for PIFO gene
- ViGene Biosciences lentiviral particle packaged cDNA for PIFO gene
- ViGene Biosciences ready-to-package AAV shRNAs for PIFO gene
- Search ViGene Biosciences for PIFO
- Horizon Cell Lines for PIFO
- genomics-online: cdna clones - Search results for available PIFO gene related products
- orf clones - Search results for available PIFO gene related products
- genomics-online: gRNA clones - Search results for available PIFO gene related products
- genomics-online: primer clones - Search results for available PIFO gene related products
- genomics-online: shRNA clones - Search results for available PIFO gene related products
Sources for PIFO Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
