Aliases for PIDD1 Gene
External Ids for PIDD1 Gene
Previous HGNC Symbols for PIDD1 Gene
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
GeneCards Summary for PIDD1 Gene
PIDD1 (P53-Induced Death Domain Protein 1) is a Protein Coding gene. Diseases associated with PIDD1 include Poikiloderma With Neutropenia. Among its related pathways are Apoptosis Modulation and Signaling and Gene Expression. Gene Ontology (GO) annotations related to this gene include death receptor binding.
UniProtKB/Swiss-Prot for PIDD1 Gene
Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.