The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non... See more...

Aliases for PICK1 Gene

Aliases for PICK1 Gene

  • Protein Interacting With PRKCA 1 2 3 5
  • Protein Kinase C-Alpha-Binding Protein 3 4
  • Protein Interacting With C Kinase 1 3 4
  • PRKCA-Binding Protein 3 4
  • PRKCABP 3 4
  • Protein Kinase C, Alpha Binding Protein 2
  • Protein Interacting With PRKCA 2
  • PICK 3

External Ids for PICK1 Gene

Previous HGNC Symbols for PICK1 Gene

  • PRKCABP

Previous GeneCards Identifiers for PICK1 Gene

  • GC22P036783
  • GC22P038452
  • GC22P021417

Summaries for PICK1 Gene

Entrez Gene Summary for PICK1 Gene

  • The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PICK1 Gene

PICK1 (Protein Interacting With PRKCA 1) is a Protein Coding gene. Diseases associated with PICK1 include Spermatogenic Failure 6 and Depression. Among its related pathways are Cell surface interactions at the vascular wall and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include identical protein binding and enzyme binding. An important paralog of this gene is ARFIP2.

UniProtKB/Swiss-Prot Summary for PICK1 Gene

  • Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Gene Wiki entry for PICK1 Gene

Additional gene information for PICK1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PICK1 Gene

Genomics for PICK1 Gene

GeneHancer (GH) Regulatory Elements for PICK1 Gene

Promoters and enhancers for PICK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PICK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PICK1

Top Transcription factor binding sites by QIAGEN in the PICK1 gene promoter:
  • ATF-2
  • CRE-BP1
  • GR
  • GR-alpha
  • GR-beta
  • LCR-F1
  • MyoD
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1

Genomic Locations for PICK1 Gene

Genomic Locations for PICK1 Gene
chr22:38,056,311-38,075,701
(GRCh38/hg38)
Size:
19,391 bases
Orientation:
Plus strand
chr22:38,452,318-38,471,708
(GRCh37/hg19)
Size:
19,391 bases
Orientation:
Plus strand

Genomic View for PICK1 Gene

Genes around PICK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PICK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PICK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PICK1 Gene

Proteins for PICK1 Gene

  • Protein details for PICK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD5-PICK1_HUMAN
    Recommended name:
    PRKCA-binding protein
    Protein Accession:
    Q9NRD5
    Secondary Accessions:
    • B3KS52
    • O95906

    Protein attributes for PICK1 Gene

    Size:
    415 amino acids
    Molecular mass:
    46600 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition.

    Three dimensional structures from OCA and Proteopedia for PICK1 Gene

    Alternative splice isoforms for PICK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PICK1 Gene

Post-translational modifications for PICK1 Gene

  • Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
  • Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).
  • Ubiquitination at Lys209
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PICK1 Gene

Domains & Families for PICK1 Gene

Gene Families for PICK1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PICK1 Gene

Blocks:
  • PDZ/DHR/GLGF domain
  • Arfaptin-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PICK1 Gene

GenScript: Design optimal peptide antigens:
  • Protein interacting with PRKCA 1 (B0QYK9_HUMAN)
  • Protein interacting with PRKCA 1 (B0QYL0_HUMAN)
  • Protein interacting with PRKCA 1 (B0QYL1_HUMAN)
  • Protein interacting with PRKCA 1 (B0QYL2_HUMAN)
  • Protein interacting with PRKCA 1 (B0QYL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRD5

UniProtKB/Swiss-Prot:

PICK1_HUMAN :
  • The AH domain mediates binding to F-actin.
Domain:
  • The AH domain mediates binding to F-actin.
  • The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular bridge with the AH domain leading to a 'closed' formation. Binding of a PDZ ligand, such as GRIA2, allows enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization (By similarity).
genes like me logo Genes that share domains with PICK1: view

Function for PICK1 Gene

Molecular function for PICK1 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Phenotypes From GWAS Catalog for PICK1 Gene

Gene Ontology (GO) - Molecular Function for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding ISS --
GO:0003779 actin binding IEA --
GO:0005080 protein kinase C binding IBA,ISS --
GO:0005102 signaling receptor binding ISS --
GO:0005515 protein binding IEA,IPI 11802773
genes like me logo Genes that share ontologies with PICK1: view
genes like me logo Genes that share phenotypes with PICK1: view

Animal Models for PICK1 Gene

MGI Knock Outs for PICK1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PICK1 Gene

Localization for PICK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PICK1 Gene

Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PICK1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
mitochondrion 4
endosome 4
golgi apparatus 4
nucleus 3
extracellular 2
endoplasmic reticulum 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 11343649
GO:0005739 mitochondrion IDA --
GO:0005794 Golgi apparatus ISS --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PICK1: view

Pathways & Interactions for PICK1 Gene

genes like me logo Genes that share pathways with PICK1: view

SIGNOR curated interactions for PICK1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IBA,ISS --
GO:0006468 protein phosphorylation ISS --
GO:0006886 intracellular protein transport IBA 21873635
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS 10623590
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway IDA 10623590
genes like me logo Genes that share ontologies with PICK1: view

Drugs & Compounds for PICK1 Gene

(8) Drugs for PICK1 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methamphetamine Approved, Illicit Pharma 427
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for PICK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PICK1: view

Transcripts for PICK1 Gene

mRNA/cDNA for PICK1 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PICK1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: - - - - -
SP9: - -
SP10: - - - - -
SP11: - -
SP12: -

Relevant External Links for PICK1 Gene

GeneLoc Exon Structure for
PICK1

Expression for PICK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PICK1 Gene

Protein differential expression in normal tissues from HIPED for PICK1 Gene

This gene is overexpressed in Frontal cortex (22.5), Fetal Brain (12.3), and Pancreatic juice (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PICK1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PICK1

SOURCE GeneReport for Unigene cluster for PICK1 Gene:

Hs.180871

mRNA Expression by UniProt/SwissProt for PICK1 Gene:

Q9NRD5-PICK1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PICK1 Gene

  • Nervous system(4.7)
  • Skin(4.4)
  • Intestine(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PICK1 Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Regions:
Pelvis:
  • ovary
  • testicle
genes like me logo Genes that share expression patterns with PICK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PICK1 Gene

Orthologs for PICK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PICK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PICK1 31 30
  • 99.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCABP 31
  • 97 (a)
OneToOne
PICK1 30
  • 92.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PICK1 31
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PICK1 31 30
  • 91.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pick1 17 31 30
  • 89.16 (n)
rat
(Rattus norvegicus)
Mammalia Pick1 30
  • 89 (n)
oppossum
(Monodelphis domestica)
Mammalia PICK1 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PICK1 31 30
  • 80.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PICK1 31
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pick1 30
  • 75.88 (n)
Str.5642 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19162 30
zebrafish
(Danio rerio)
Actinopterygii pick1 31 30
  • 78.08 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007832 30
  • 62.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta PICK1 31 30
  • 60.84 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.22 30
  • 51.23 (n)
Y57G11C.22 31
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 67 (a)
OneToOne
Cin.14348 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14348 30
Species where no ortholog for PICK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PICK1 Gene

ENSEMBL:
Gene Tree for PICK1 (if available)
TreeFam:
Gene Tree for PICK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PICK1: view image

Paralogs for PICK1 Gene

Paralogs for PICK1 Gene

genes like me logo Genes that share paralogs with PICK1: view

Variants for PICK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PICK1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
712400 Benign: not provided 38,074,931(+) C/T SYNONYMOUS_VARIANT
715752 Benign: not provided 38,069,027(+) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for PICK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PICK1 Gene

Variant ID Type Subtype PubMed ID
nsv471198 CNV loss 18288195
nsv834193 CNV loss 17160897
nsv834194 CNV loss 17160897

Variation tolerance for PICK1 Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PICK1 Gene

Human Gene Mutation Database (HGMD)
PICK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PICK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PICK1 Gene

Disorders for PICK1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PICK1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 6
  • spgf6
depression
  • major depressive disorder
spermatogenic failure 9
  • globozoospermia
spermatogenic failure 5
  • spgf5
substance dependence
- elite association - COSMIC cancer census association via MalaCards
Search PICK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PICK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PICK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PICK1 Gene

Publications for PICK1 Gene

  1. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PMID: 19219857) Bousman CA … Tsuang MT (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 23 41 54
  2. Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis. (PMID: 17606663) Matsuzawa D … Iyo M (The American journal of psychiatry 2007) 3 23 41 54
  3. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: association study in a large case-control population. (PMID: 17367885) Ishiguro H … Arinami T (Neuroscience research 2007) 3 23 41 54
  4. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PMID: 15304526) Excoffon KJ … Zabner J (Journal of cell science 2004) 3 4 23 54
  5. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin SH … Civelli O (Molecular pharmacology 2001) 3 4 23 54

Products for PICK1 Gene

Sources for PICK1 Gene