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This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
PIAS3 (Protein Inhibitor Of Activated STAT 3) is a Protein Coding gene. Diseases associated with PIAS3 include Prostate Cancer and Microphthalmia. Among its related pathways are Interleukin-11 Signaling Pathway and C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ligase activity. An important paralog of this gene is PIAS1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001085 | RNA polymerase II transcription factor binding | IBA | 21873635 |
GO:0003712 | transcription coregulator activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 11060035 |
GO:0008022 | protein C-terminus binding | IEA,IPI | 14715251 |
GO:0008270 | zinc ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0016607 | nuclear speck | IEA | -- |
GO:0030425 | dendrite | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
2 | SUMOylation |
.95
|
|
3 | Jak Stat Signaling Pathway | ||
4 | Metabolism of proteins | ||
5 | NF-kappaB Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0009725 | response to hormone | IEA | -- |
GO:0010628 | positive regulation of gene expression | IEA | -- |
GO:0010629 | negative regulation of gene expression | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - |
ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||
SP2: | |||||||||||||
SP3: | - | - | - | ||||||||||
SP4: | |||||||||||||
SP5: | |||||||||||||
SP6: | - | ||||||||||||
SP7: | |||||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: | |||||||||||||
SP12: | |||||||||||||
SP13: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PIAS3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PIAS3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PIAS3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pias3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pias3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PIAS3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | PIAS3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PIAS3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pias3 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Su(var)2-10 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | W10D5.3a 32 |
|
|
|
W10D5.3d 32 |
|
|
|||
gei-17 31 32 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NFI1 31 |
|
ManyToMany | |
SIZ1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2754 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
726837 | Likely Benign: not provided | 145,850,884(-) | G/C | SYNONYMOUS_VARIANT | |
728990 | Benign: not provided | 145,856,094(-) | A/G | SYNONYMOUS_VARIANT | |
756016 | Likely Benign: not provided | 145,850,277(-) | G/A | INTRON_VARIANT | |
773151 | Benign: not provided | 145,849,550(-) | T/G | MISSENSE_VARIANT | |
829799 | Uncertain Significance: not provided | 145,856,375(-) | G/A | NONSENSE |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3587420 | CNV | gain | 21293372 |
nsv1005055 | CNV | loss | 25217958 |
nsv1015025 | CNV | gain | 25217958 |
nsv831381 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
prostate cancer |
|
|
microphthalmia |
|
|