Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors ... See more...
Aliases for PIAS3 Gene
Aliases for PIAS3 Gene
External Ids for PIAS3 Gene
- HGNC: 16861
- Entrez Gene: 10401
- Ensembl: ENSG00000131788
- OMIM: 605987
- UniProtKB: Q9Y6X2
Previous GeneCards Identifiers for PIAS3 Gene
- GC01P144096
- GC01P142163
- GC01P143302
- GC01P143324
- GC01P143065
- GC01P144287
- GC01P145575
- GC01P119540
Summaries for PIAS3 Gene
-
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIAS3 Gene
PIAS3 (Protein Inhibitor Of Activated STAT 3) is a Protein Coding gene. Diseases associated with PIAS3 include Prostate Cancer and Microphthalmia. Among its related pathways are Interleukin-11 Signaling Pathway and C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ligase activity. An important paralog of this gene is PIAS1.
UniProtKB/Swiss-Prot Summary for PIAS3 Gene
-
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
Additional gene information for PIAS3 Gene
- HGNC(16861)
- Entrez Gene(10401)
- Ensembl(ENSG00000131788)
- OMIM(605987)
- UniProtKB(Q9Y6X2)
- Open Targets Platform(ENSG00000131788)
- Search for PIAS3 at DataMed
- Search for PIAS3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PIAS3 Gene
Genomics for PIAS3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PIAS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PIAS3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PIAS3
- Top Transcription factor binding sites by QIAGEN in the PIAS3 gene promoter:
-
- E47
- GATA-1
- GATA-2
- HTF
- MAZR
- TBP
- TFIID
- YY1
Genomic Locations for PIAS3 Gene
Genomic Locations for PIAS3 Gene
- chr1:145,848,522-145,859,836
- (GRCh38/hg38)
- Size:
- 11,315 bases
- Orientation:
- Minus strand
- chr1:145,575,233-145,586,546
- (GRCh37/hg19)
- Size:
- 11,314 bases
- Orientation:
- Plus strand
Genomic View for PIAS3 Gene
Genes around PIAS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.1 by HGNC
- 1q21.1 by Entrez Gene
- 1q21.1 by Ensembl
PIAS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIAS3 Gene
Proteins for PIAS3 Gene
-
Protein details for PIAS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6X2-PIAS3_HUMAN
- Recommended name:
- E3 SUMO-protein ligase PIAS3
- Protein Accession:
- Q9Y6X2
- Q9UFI3
Protein attributes for PIAS3 Gene
- Size:
- 628 amino acids
- Molecular mass:
- 68017 Da
- Quaternary structure:
-
- Monomer (By similarity). Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity (By similarity). Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. Interacts with MTA1. Interacts with CCAR2 (via N-terminus). Interacts with TRIM8 (PubMed:20516148).
- SequenceCaution:
-
- Sequence=BAA78533.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PIAS3 Gene
Post-translational modifications for PIAS3 Gene
- Sumoylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PIAS3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PIAS3 Antibody
- Creative Diagnostics Anti-PIAS3 (aa 453-550) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for PIAS3
- Novus Biologicals Antibodies for PIAS3
-
Abcam antibodies for PIAS3
- Invitrogen Antibodies for PIAS3 (AFLGC-PIAS3)
-
Custom Antibody ServicesProSci Antibodies for PIAS3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PIAS3
- Sino Biological Antibodies for PIAS3
Protein Products
-
OriGene Purified Proteins for PIAS3
- Search Origene for MassSpec and Protein Over-expression Lysates for PIAS3
- Origene Custom Protein Services for PIAS3
-
Signalway Proteins for PIAS3
-
Abcam proteins for PIAS3
Assay Products
- G Biosciences Immunotag™ E3 SUMO-protein ligase PIAS3 ELISA Kit
-
Boster Bio ELISA Kits for PIAS3
-
Signalway ELISA kits for PIAS3
No data available for DME Specific Peptides for PIAS3 Gene
Domains & Families for PIAS3 Gene
Gene Families for PIAS3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PIAS3 Gene
- InterPro:
- Blocks:
-
- DNA-binding SAP
- Zn-finger, MIZ type
- ProtoNet:
Suggested Antigen Peptide Sequences for PIAS3 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein inhibitor of activated STAT protein 3 (PIAS3_HUMAN)
- Protein inhibitor of activated STAT3 (Q6IAR4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y6X2UniProtKB/Swiss-Prot:
PIAS3_HUMAN :- The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.
- Belongs to the PIAS family.
- Domain:
-
- The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.
- The LXXLL motif is a transcriptional coregulator signature.
- Family:
-
- Belongs to the PIAS family.
Function for PIAS3 Gene
Molecular function for PIAS3 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
- UniProtKB/Swiss-Prot Induction:
- By dihydrotestosterone (DHT) in prostate cancer cells.
Enzyme Numbers (IUBMB) for PIAS3 Gene
Phenotypes From GWAS Catalog for PIAS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001085 | RNA polymerase II transcription factor binding | IBA | 21873635 |
| GO:0003712 | transcription coregulator activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 11060035 |
| GO:0008022 | protein C-terminus binding | IEA,IPI | 14715251 |
| GO:0008270 | zinc ion binding | IEA | -- |
Phenotypes for PIAS3 Gene
- MGI mutant phenotypes for PIAS3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PIAS3:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Reduced mammosphere formation
- Decreased shRNA abundance
- Increased replication of vaccinia virus (VACV)
- Increased shRNA abundance (Z-score > 2)
Animal Models for PIAS3 Gene
- MGI Knock Outs for PIAS3:
-
- Pias3 Pias3<tm1.2Asw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PIAS3 - Select products 50% OFF >
- * PIAS3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PIAS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIAS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
miRNA for PIAS3 Gene
- miRTarBase miRNAs that target PIAS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIAS3
Clone Products
- Applied Biological Materials (abm): Clones for PIAS3 - Select products 50% OFF >
- * PIAS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209486
- MG220934
- MG220936
- MR209486
- MR209486L3
- MR209486L4
- MR220934
- MR220934L3
- MR220934L4
- MR220936
- MR220936L3
- MR220936L4
- RC207034
- RC207034L1
- RC207034L2
- RC207034L3
- RC207034L4
- RG207034
- RR202737
- RR202737L3
- RR202737L4
- MR209486L3V
- MR209486L4V
- MR220934L3V
- MR220934L4V
- MR220936L3V
- MR220936L4V
- RC207034L1V
- RC207034L2V
- RC207034L3V
- RC207034L4V
- RR202737L3V
- RR202737L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PIAS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIAS3
Cell Line Products
-
Horizon Cell Lines for PIAS3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIAS3 Gene
Localization for PIAS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIAS3 Gene
- Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250 UniProtKB:O54714}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016607 | nuclear speck | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
Pathways & Interactions for PIAS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Jak Stat Signaling Pathway | ||
| 4 | Metabolism of proteins | ||
| 5 | NF-kappaB Signaling | ||
Pathways by source for PIAS3 Gene
2 Sino Biological pathways for PIAS3 Gene
10 BioSystems pathways for PIAS3 Gene
10 Reactome pathways for PIAS3 Gene
2 KEGG pathways for PIAS3 Gene
2 GeneGo (Thomson Reuters) pathways for PIAS3 Gene
- Development_Leptin signaling via JAK/STAT and MAPK cascades
- Development_Thrombopoetin signaling via JAK-STAT pathway
2 Qiagen pathways for PIAS3 Gene
- IL-6 Pathway
- JAK-STAT Pathway
1 Cell Signaling Technology pathway for PIAS3 Gene
UniProtKB/Swiss-Prot Q9Y6X2-PIAS3_HUMAN
- Pathway: Protein modification; protein sumoylation.
Interacting Proteins for PIAS3 Gene
Selected Interacting proteins:
Q9Y6X2-PIAS3_HUMAN
ENSP00000376765
for PIAS3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PIAS3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0009725 | response to hormone | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
| GO:0010629 | negative regulation of gene expression | IEA | -- |
Transcripts for PIAS3 Gene
mRNA/cDNA for PIAS3 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369298 2761 nts (view in UCSC)
- ENST00000369299 1235 nts (view in UCSC)
- ENST00000393045 2902 nts (view in UCSC)
- ENST00000393046 952 nts (view in UCSC)
- ENST00000463514 429 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PIAS3 - Select products 50% OFF >
- * PIAS3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PIAS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIAS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIAS3
Clone Products
- Applied Biological Materials (abm): Clones for PIAS3 - Select products 50% OFF >
- * PIAS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209486
- MG220934
- MG220936
- MR209486
- MR209486L3
- MR209486L4
- MR220934
- MR220934L3
- MR220934L4
- MR220936
- MR220936L3
- MR220936L4
- RC207034
- RC207034L1
- RC207034L2
- RC207034L3
- RC207034L4
- RG207034
- RR202737
- RR202737L3
- RR202737L4
- MR209486L3V
- MR209486L4V
- MR220934L3V
- MR220934L4V
- MR220936L3V
- MR220936L4V
- RC207034L1V
- RC207034L2V
- RC207034L3V
- RC207034L4V
- RR202737L3V
- RR202737L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PIAS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIAS3
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||
| SP2: | |||||||||||||
| SP3: | - | - | - | ||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | - | ||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: |
Relevant External Links for PIAS3 Gene
- GeneLoc Exon Structure for
- PIAS3
Expression for PIAS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Cone Precursor Cells Outer Nuclear Layer
- Rod Precursor Cells Outer Nuclear Layer
-
Neurons
- Cone Precursor Cells Outer Nuclear Layer
- Rod Precursor Cells Outer Nuclear Layer
- Brain (Nervous System)
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
This gene is overexpressed in Serum (55.8) and Heart (13.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIAS3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PIAS3
SOURCE GeneReport for Unigene cluster for PIAS3 Gene:
Hs.435761mRNA Expression by UniProt/SwissProt for PIAS3 Gene:
Q9Y6X2-PIAS3_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for PIAS3 Gene
- Nervous system(4.4)
- Muscle(4.4)
- Blood(4.4)
- Skin(2.6)
- Lung(2.5)
- Kidney(2.4)
- Intestine(2.3)
- Spleen(2.2)
- Lymph node(2.2)
- Heart(2.2)
- Thyroid gland(2.1)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for PIAS3
-
OriGene qPCR primer pairs and template standards for PIAS3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIAS3 Gene
Orthologs for PIAS3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PIAS3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PIAS3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PIAS3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pias3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pias3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PIAS3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | PIAS3 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PIAS3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pias3 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Su(var)2-10 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | W10D5.3a 32 |
|
|
|
| W10D5.3d 32 |
|
|
|||
| gei-17 31 32 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NFI1 31 |
|
ManyToMany | |
| SIZ1 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2754 30 |
|
- Species where no ortholog for PIAS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for PIAS3 Gene
- ENSEMBL:
- Gene Tree for PIAS3 (if available)
- TreeFam:
- Gene Tree for PIAS3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PIAS3: view image
Paralogs for PIAS3 Gene
Variants for PIAS3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PIAS3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 726837 | Likely Benign: not provided | 145,850,884(-) | G/C | SYNONYMOUS_VARIANT | |
| 728990 | Benign: not provided | 145,856,094(-) | A/G | SYNONYMOUS_VARIANT | |
| 756016 | Likely Benign: not provided | 145,850,277(-) | G/A | INTRON_VARIANT | |
| 773151 | Benign: not provided | 145,849,550(-) | T/G | MISSENSE_VARIANT | |
| 829799 | Uncertain Significance: not provided | 145,856,375(-) | G/A | NONSENSE |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3587420 | CNV | gain | 21293372 |
| nsv1005055 | CNV | loss | 25217958 |
| nsv1015025 | CNV | gain | 25217958 |
| nsv831381 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.03;
60.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIAS3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIAS3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIAS3 Gene
Disorders for PIAS3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer |
|
|
| microphthalmia |
|
|
Search PIAS3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PIAS3
No data available for UniProtKB/Swiss-Prot and Genatlas for PIAS3 Gene
Publications for PIAS3 Gene
- Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. (PMID: 11071847) Junicho A … Muraguchi A (Biochemical and biophysical research communications 2000) 3 4 23
- Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3). (PMID: 10319586) Ueki N … Muramatsu M (Journal of human genetics 1999) 2 3 4
- Specific inhibition of Stat3 signal transduction by PIAS3. (PMID: 9388184) Chung CD … Shuai K (Science (New York, N.Y.) 1997) 3 4 23
- Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. (PMID: 24651376) Sun X … Dong JT (PloS one 2014) 3 4
- SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. (PMID: 21965678) Cong L … Kumar R (The Journal of biological chemistry 2011) 3 4
ExternalLinks
Products for PIAS3 Gene
- Custom Antibody ServicesOriGene Antibodies for PIAS3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PIAS3
- Search Origene for MassSpec and Protein Over-expression Lysates for PIAS3
- Origene Custom Protein Services for PIAS3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
- OriGene qPCR primer pairs for PIAS3
- OriGene qPCR primer pairs and template standards for PIAS3
- OriGene CRISPR knockouts for PIAS3
- MG209486
- MG220934
- MG220936
- MR209486
- MR209486L3
- MR209486L4
- MR220934
- MR220934L3
- MR220934L4
- MR220936
- MR220936L3
- MR220936L4
- RC207034
- RC207034L1
- RC207034L2
- RC207034L3
- RC207034L4
- RG207034
- RR202737
- RR202737L3
- RR202737L4
- MR209486L3V
- MR209486L4V
- MR220934L3V
- MR220934L4V
- MR220936L3V
- MR220936L4V
- RC207034L1V
- RC207034L2V
- RC207034L3V
- RC207034L4V
- RR202737L3V
- RR202737L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PIAS3
- Sino Biological Human cDNA Clone for PIAS3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PIAS3
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PIAS3
- Novus Biologicals proteins and lysates for PIAS3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PIAS3
- Abcam proteins for PIAS3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for PIAS3 (AFLGC-PIAS3)
- VectorBuilder Custom and pre-made DNA vectors for PIAS3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PIAS3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PIAS3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PIAS3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PIAS3
- antibodies-online: Show 17 available PIAS3 Antibodies ranked by validation data
- Compare Top PIAS3 Antibodies
- antibodies-online: Show 23 available PIAS3 Elisa Kits ranked by validation data
- Compare Top PIAS3 Elisa Kits
- antibodies-online: Show 6 available PIAS3 Proteins ranked by validation data
- Compare Top PIAS3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PIAS3
- Search Santa Cruz Biotechnology (SCBT) for PIAS3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
- Custom Antibody ServicesProSci Antibodies for PIAS3
- Search for PIAS3 Proteins at ProSci
- Horizon Cell Lines for PIAS3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIAS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIAS3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PIAS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIAS3
Sources for PIAS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151)