Aliases for PIAS3 Gene
Aliases for PIAS3 Gene
External Ids for PIAS3 Gene
- HGNC: 16861
- Entrez Gene: 10401
- Ensembl: ENSG00000131788
- OMIM: 605987
- UniProtKB: Q9Y6X2
Previous GeneCards Identifiers for PIAS3 Gene
- GC01P144096
- GC01P142163
- GC01P143302
- GC01P143324
- GC01P143065
- GC01P144287
- GC01P145575
- GC01P119540
Summaries for PIAS3 Gene
-
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIAS3 Gene
PIAS3 (Protein Inhibitor Of Activated STAT 3) is a Protein Coding gene. Among its related pathways are EGF/EGFR Signaling Pathway and C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ligase activity. An important paralog of this gene is PIAS1.
UniProtKB/Swiss-Prot for PIAS3 Gene
-
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIAS3 Gene
Genomics for PIAS3 Gene
GeneHancer (GH) Regulatory Elements for PIAS3 Gene
Promoters and enhancers for PIAS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PIAS3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PIAS3 gene promoter:
-
- TBP
- TFIID
- YY1
- GATA-2
- HTF
- MAZR
- GATA-1
- E47
Regulatory Element Products
Genomic Locations for PIAS3 Gene
Genomic Locations for PIAS3 Gene
- chr1:145,848,522-145,859,836
- (GRCh38/hg38)
- Size:
- 11,315 bases
- Orientation:
- Minus strand
- chr1:145,575,233-145,586,546
- (GRCh37/hg19)
- Size:
- 11,314 bases
- Orientation:
- Plus strand
Genomic View for PIAS3 Gene
Genes around PIAS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.1 by Entrez Gene
- 1q21.1 by HGNC
- 1q21.1 by Ensembl
PIAS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIAS3 Gene
Proteins for PIAS3 Gene
-
Protein details for PIAS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6X2-PIAS3_HUMAN
- Recommended name:
- E3 SUMO-protein ligase PIAS3
- Protein Accession:
- Q9Y6X2
- Q9UFI3
Protein attributes for PIAS3 Gene
- Size:
- 628 amino acids
- Molecular mass:
- 68017 Da
- Quaternary structure:
-
- Monomer (By similarity). Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity (By similarity). Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. Interacts with MTA1. Interacts with CCAR2 (via N-terminus). Interacts with TRIM8 (PubMed:20516148).
- SequenceCaution:
-
- Sequence=BAA78533.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PIAS3 Gene
Post-translational modifications for PIAS3 Gene
- Sumoylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PIAS3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PIAS3 (PIAS3)
-
Custom Antibody ServicesOriGene Antibodies for PIAS3
- Novus Biologicals Antibodies for PIAS3
-
Abcam antibodies for PIAS3
- Invitrogen Antibodies for PIAS3 (AFLGC-PIAS3)
- GeneTex PIAS3 Antibody for PIAS3
-
Custom Antibody ServicesProSci Antibodies for PIAS3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PIAS3
Protein Products
-
OriGene Purified Proteins for PIAS3
- Search Origene for MassSpec and Protein Over-expression Lysates for PIAS3
- Origene Custom Protein Services for PIAS3
- Search GeneTex for Proteins for PIAS3
-
Abcam proteins for PIAS3
Assay Products
No data available for DME Specific Peptides for PIAS3 Gene
Domains & Families for PIAS3 Gene
Gene Families for PIAS3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PIAS3 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PIAS3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6X2UniProtKB/Swiss-Prot:
PIAS3_HUMAN :- The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.
- Belongs to the PIAS family.
- Domain:
-
- The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.
- The LXXLL motif is a transcriptional coregulator signature.
- Family:
-
- Belongs to the PIAS family.
Function for PIAS3 Gene
Molecular function for PIAS3 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
- UniProtKB/Swiss-Prot Induction:
- By dihydrotestosterone (DHT) in prostate cancer cells.
Enzyme Numbers (IUBMB) for PIAS3 Gene
Phenotypes From GWAS Catalog for PIAS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11060035 |
| GO:0008022 | protein C-terminus binding | IEA,IPI | 14715251 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0015459 | potassium channel regulator activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for PIAS3 Gene
- MGI mutant phenotypes for PIAS3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PIAS3:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for PIAS3 Gene
- MGI Knock Outs for PIAS3:
-
- Pias3 Pias3<tm1.2Asw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIAS3
-
CRISPR Products
-
OriGene CRISPR knockouts for PIAS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIAS3
- genomics-online: gRNA clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
- Applied Biological Materials CRISPR for PIAS3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
- GenScript: Design CRISPR guide RNA sequences for PIAS3
miRNA for PIAS3 Gene
- miRTarBase miRNAs that target PIAS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIAS3
- genomics-online: shRNA clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PIAS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIAS3
- Applied Biological Materials Clones for PIAS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PIAS3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIAS3 Gene
Localization for PIAS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIAS3 Gene
- Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250 UniProtKB:O54714}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016607 | nuclear speck | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
Pathways & Interactions for PIAS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Jak-STAT signaling pathway (KEGG) | ||
| 5 | Ubiquitin mediated proteolysis | ||
Pathways by source for PIAS3 Gene
1 Sino Biological pathway for PIAS3 Gene
10 BioSystems pathways for PIAS3 Gene
10 Reactome pathways for PIAS3 Gene
2 KEGG pathways for PIAS3 Gene
2 GeneGo (Thomson Reuters) pathways for PIAS3 Gene
1 R&D Systems pathway for PIAS3 Gene
2 Qiagen pathways for PIAS3 Gene
1 Cell Signaling Technology pathway for PIAS3 Gene
UniProtKB/Swiss-Prot Q9Y6X2-PIAS3_HUMAN
- Pathway: Protein modification; protein sumoylation.
Interacting Proteins for PIAS3 Gene
Selected Interacting proteins:
Q9Y6X2-PIAS3_HUMAN
ENSP00000376765
for PIAS3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PIAS3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0009725 | response to hormone | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
Transcripts for PIAS3 Gene
mRNA/cDNA for PIAS3 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (208) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000472114 2386 bps (uc057kba.1)
- ENST00000475261 2679 bps (uc001eod.2)
- ENST00000369298 2761 bps (uc057kbb.1)
- ENST00000393045 2901 bps (uc001eoc.2)
- ENST00000369299 1235 bps (uc010oyy.2)
Unigene Clusters for PIAS3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PIAS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIAS3
- genomics-online: gRNA clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
- Applied Biological Materials CRISPR for PIAS3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
- GenScript: Design CRISPR guide RNA sequences for PIAS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIAS3
- genomics-online: shRNA clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PIAS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIAS3
- Applied Biological Materials Clones for PIAS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||
| SP2: | |||||||||||||
| SP3: | - | - | - | ||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | - | ||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: |
Expression for PIAS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Cone Precursor Cells Outer Nuclear Layer
- Rod Precursor Cells Outer Nuclear Layer
-
Neurons
- Cone Precursor Cells Outer Nuclear Layer
- Rod Precursor Cells Outer Nuclear Layer
- Brain (Nervous System)
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
This gene is overexpressed in Serum (55.8) and Heart (13.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIAS3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PIAS3 Gene:
PIAS3SOURCE GeneReport for Unigene cluster for PIAS3 Gene:
Hs.435761mRNA Expression by UniProt/SwissProt for PIAS3 Gene:
Q9Y6X2-PIAS3_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for PIAS3 Gene
- Nervous system(4.3)
- Blood(4.2)
- Muscle(4.2)
- Lung(2.3)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for PIAS3
-
OriGene qPCR primer pairs and template standards for PIAS3
- genomics-online: primer clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIAS3 Gene
Orthologs for PIAS3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PIAS3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PIAS3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PIAS3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pias3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pias3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PIAS3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | PIAS3 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PIAS3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pias3 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Su(var)2-10 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | W10D5.3d 35 |
|
|
|
| W10D5.3a 35 |
|
|
|||
| gei-17 34 35 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NFI1 34 |
|
ManyToMany | |
| SIZ1 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.2754 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2754 33 |
|
- Species where no ortholog for PIAS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Evolution for PIAS3 Gene
- ENSEMBL:
- Gene Tree for PIAS3 (if available)
- TreeFam:
- Gene Tree for PIAS3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PIAS3: view image
Paralogs for PIAS3 Gene
Variants for PIAS3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000988439 | -- | 145,859,234(-) | G/T | upstream_transcript_variant | |
| rs1001131319 | -- | 145,852,874(-) | A/T | intron_variant | |
| rs1001518764 | -- | 145,853,116(-) | A/T | intron_variant | |
| rs1001578931 | -- | 145,854,257(-) | A/G | intron_variant | |
| rs1001917674 | -- | 145,852,247(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3587420 | CNV | gain | 21293372 |
| nsv1005055 | CNV | loss | 25217958 |
| nsv1015025 | CNV | gain | 25217958 |
| nsv831381 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.03;
60.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PIAS3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIAS3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIAS3 Gene
Disorders for PIAS3 Gene
Additional Disease Information for PIAS3
No disorders were found for PIAS3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIAS3 Gene
Publications for PIAS3 Gene
- Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. (PMID: 11071847) Junicho A … Muraguchi A (Biochemical and biophysical research communications 2000) 3 4 22 58
- Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3). (PMID: 10319586) Ueki N … Muramatsu M (Journal of human genetics 1999) 2 3 4 58
- Specific inhibition of Stat3 signal transduction by PIAS3. (PMID: 9388184) Chung CD … Shuai K (Science (New York, N.Y.) 1997) 3 4 22 58
- Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. (PMID: 24651376) Sun X … Dong JT (PloS one 2014) 3 4 58
- SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. (PMID: 21965678) Cong L … Kumar R (The Journal of biological chemistry 2011) 3 4 58
Products for PIAS3 Gene
- R&D Systems Antibodies for PIAS3 (PIAS3)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PIAS3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PIAS3
- Search Origene for MassSpec and Protein Over-expression Lysates for PIAS3
- Origene Custom Protein Services for PIAS3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
- OriGene qPCR primer pairs for PIAS3
- OriGene qPCR primer pairs and template standards for PIAS3
- OriGene CRISPR knockouts for PIAS3
- OriGene ORF clones in human for PIAS3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PIAS3
- GenScript: Next-day shipping of latest version cDNA ORF clones for PIAS3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PIAS3
- GenScript Custom Assay Services for PIAS3
- GenScript Custom overexpressing Cell Line Services for PIAS3
- GenScript: Design CRISPR guide RNA sequences for PIAS3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PIAS3
- Sino Biological Human cDNA Clone for PIAS3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PIAS3
- Novus Biologicals proteins and lysates for PIAS3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PIAS3
- Abcam proteins for PIAS3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for PIAS3 (AFLGC-PIAS3)
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIAS3
- antibodies-online: Search results for 67 available PIAS3 Antibodies ranked by validation data
- Compare Top PIAS3 Antibodies
- antibodies-online: Search results for 14 available PIAS3 Elisa Kits ranked by validation data
- Compare Top PIAS3 Elisa Kits
- antibodies-online: Search results for 6 available PIAS3 Proteins ranked by validation data
- Compare Top PIAS3 Proteins
- GeneTex PIAS3 Antibody for PIAS3
- Search GeneTex for Proteins for PIAS3
- Santa Cruz Biotechnology (SCBT) Antibodies for PIAS3
- Search Santa Cruz Biotechnology (SCBT) for PIAS3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
- Custom Antibody ServicesProSci Antibodies for PIAS3
- Search for PIAS3 Proteins at ProSci
- Horizon Cell Lines for PIAS3
- genomics-online: cdna clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
- orf clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
- genomics-online: gRNA clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
- genomics-online: primer clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
- genomics-online: shRNA clones - Search results for 115 available PIAS3 gene related products
- Overview of 115 available PIAS3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PIAS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PIAS3
- GeneCopoeia miRNA 3'UTR Target clone products for PIAS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PIAS3
Sources for PIAS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt