Aliases for PI4KB Gene
External Ids for PI4KB Gene
Previous HGNC Symbols for PI4KB Gene
Previous GeneCards Identifiers for PI4KB Gene
GeneCards Summary for PI4KB Gene
PI4KB (Phosphatidylinositol 4-Kinase Beta) is a Protein Coding gene. Diseases associated with PI4KB include Nonparalytic Poliomyelitis and Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease. Among its related pathways are Glycerophospholipid biosynthesis and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and 1-phosphatidylinositol 4-kinase activity. An important paralog of this gene is PI4KA.
UniProtKB/Swiss-Prot Summary for PI4KB Gene
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
(Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).
(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.