This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016] See more...

Aliases for PI4K2B Gene

Aliases for PI4K2B Gene

  • Phosphatidylinositol 4-Kinase Type 2 Beta 2 3 5
  • Phosphatidylinositol 4-Kinase Type 2-Beta 3 4
  • PI4KII-BETA 3 4
  • EC 2.7.1.67 4 52
  • Phosphatidylinositol 4-Kinase Type-II Beta 3
  • Phosphatidylinositol 4-Kinase Type II-Beta 4
  • PI4KIIB 3
  • PIK42B 3

External Ids for PI4K2B Gene

Previous GeneCards Identifiers for PI4K2B Gene

  • GC04U990105
  • GC04P025319
  • GC04P024924
  • GC04P024986
  • GC04P024911
  • GC04P024844
  • GC04P025236
  • GC04P024575
  • GC04P025163
  • GC04P025233

Summaries for PI4K2B Gene

Entrez Gene Summary for PI4K2B Gene

  • This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]

GeneCards Summary for PI4K2B Gene

PI4K2B (Phosphatidylinositol 4-Kinase Type 2 Beta) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and PI Metabolism. Gene Ontology (GO) annotations related to this gene include kinase activity and 1-phosphatidylinositol 4-kinase activity. An important paralog of this gene is PI4K2A.

UniProtKB/Swiss-Prot Summary for PI4K2B Gene

  • Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.

Gene Wiki entry for PI4K2B Gene

Additional gene information for PI4K2B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PI4K2B Gene

Genomics for PI4K2B Gene

GeneHancer (GH) Regulatory Elements for PI4K2B Gene

Promoters and enhancers for PI4K2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J025158 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 509.9 0.0 -25 3.9 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 POLR2G USF1 SP1 NCOR1 PHF8 PI4K2B SEPSECS SEPSECS-AS1 ANAPC4 DHX15 ZCCHC4
GH04J025233 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 505.5 +74.2 74247 3.8 HNRNPK CTCF SIN3A NRF1 USF1 POLR2G NCOR1 PHF8 ZFX ZIC2 PI4K2B LOC105374535 lnc-SEPSECS-4 ANAPC4 ZCCHC4 DHX15 piR-39098-167
GH04J025276 Promoter 0.3 EPDnew 500.1 +116.3 116327 0.1 PI4K2B ZCCHC4 ANAPC4 lnc-PI4K2B-2 piR-42491-163
GH04J025312 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 4.6 +152.5 152487 2.1 RXRA EP300 ZNF217 CTCF MYC TCF12 POLR2G SP1 GTF2E2 SIX5 ZCCHC4 ANAPC4 DHX15 PI4K2B piR-35277
GH04J025178 Enhancer 1 Ensembl ENCODE 8 +18.1 18138 1.6 FOXK2 NCOR1 KDM6A SKI TEAD1 FOXA2 MAFF USF1 SAP130 MIER3 ANAPC4 PI4K2B SEPSECS-AS1 piR-42491-162
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PI4K2B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PI4K2B

Top Transcription factor binding sites by QIAGEN in the PI4K2B gene promoter:
  • ATF-2
  • ATF6
  • CRE-BP1
  • Egr-1
  • Egr-2
  • HNF-1
  • HNF-1A
  • Pax-2
  • Pax-2a
  • Pbx1a

Genomic Locations for PI4K2B Gene

Genomic Locations for PI4K2B Gene
chr4:25,160,663-25,279,209
(GRCh38/hg38)
Size:
118,547 bases
Orientation:
Plus strand
chr4:25,162,263-25,280,831
(GRCh37/hg19)
Size:
118,569 bases
Orientation:
Plus strand

Genomic View for PI4K2B Gene

Genes around PI4K2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PI4K2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PI4K2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI4K2B Gene

Proteins for PI4K2B Gene

  • Protein details for PI4K2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCG2-P4K2B_HUMAN
    Recommended name:
    Phosphatidylinositol 4-kinase type 2-beta
    Protein Accession:
    Q8TCG2
    Secondary Accessions:
    • Q9NUW2

    Protein attributes for PI4K2B Gene

    Size:
    481 amino acids
    Molecular mass:
    54744 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PI4K2B Gene

neXtProt entry for PI4K2B Gene

Selected DME Specific Peptides for PI4K2B Gene

Q8TCG2:
  • VMRGQILNL
  • KHPDEWR
  • RIGLPPK
  • IRNTDRGNDNWL
  • AAIDNGL
  • CCPCCFGR
  • GSSGSYFV
  • PNQGYLSEAGAYLVD
  • EDLYELFK
  • LNPKWTK
  • WAWLPQAK
  • ALEKVPKV

Post-translational modifications for PI4K2B Gene

  • Ubiquitination at Lys137, Lys161, Lys272, Lys352, and Lys411
  • Modification sites at PhosphoSitePlus

Other Protein References for PI4K2B Gene

Domains & Families for PI4K2B Gene

Gene Families for PI4K2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PI4K2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PI4K2B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ46781 fis, clone TRACH3027701, highly similar to Homo sapiens phosphatidylinositol 4-kinase type 2 beta (PI4K2B), mRNA (B3KY39_HUMAN)
  • Phosphatidylinositol 4-kinase type II-beta (P4K2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TCG2

UniProtKB/Swiss-Prot:

P4K2B_HUMAN :
  • Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
Family:
  • Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
genes like me logo Genes that share domains with PI4K2B: view

Function for PI4K2B Gene

Molecular function for PI4K2B Gene

UniProtKB/Swiss-Prot Function:
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216; EC=2.7.1.67;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Recruited and activated by membrane association. Binding to the microsomal membrane has been shown to enhance its activity.

Enzyme Numbers (IUBMB) for PI4K2B Gene

Phenotypes From GWAS Catalog for PI4K2B Gene

Gene Ontology (GO) - Molecular Function for PI4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004430 1-phosphatidylinositol 4-kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PI4K2B: view
genes like me logo Genes that share phenotypes with PI4K2B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PI4K2B

CRISPR Products

miRNA for PI4K2B Gene

miRTarBase miRNAs that target PI4K2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PI4K2B

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PI4K2B Gene

Localization for PI4K2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI4K2B Gene

Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PI4K2B gene
Compartment Confidence
cytosol 5
endosome 4
plasma membrane 3
golgi apparatus 3
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PI4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IBA 21873635
GO:0005802 trans-Golgi network IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with PI4K2B: view

Pathways & Interactions for PI4K2B Gene

genes like me logo Genes that share pathways with PI4K2B: view

Gene Ontology (GO) - Biological Process for PI4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007030 Golgi organization IBA 21873635
GO:0007032 endosome organization IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0046854 phosphatidylinositol phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with PI4K2B: view

No data available for SIGNOR curated interactions for PI4K2B Gene

Drugs & Compounds for PI4K2B Gene

(4) Drugs for PI4K2B Gene - From: DrugBank, ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Resveratrol Approved, Experimental, Investigational Pharma Target Cyclooxygenase inhibitor 150
Adenosine Approved, Investigational Pharma Agonist, Channel blocker, agonist 642
Guanosine triphosphate Experimental Pharma 0
PI4KIII beta inhibitor 3 Pharma PI4KIII beta inhibitor 0

(1) ApexBio Compounds for PI4K2B Gene

Compound Action Cas Number
PI4KIII beta inhibitor 3 PI4KIII beta inhibitor 1245319-54-3
genes like me logo Genes that share compounds with PI4K2B: view

Drug Products

Transcripts for PI4K2B Gene

mRNA/cDNA for PI4K2B Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PI4K2B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PI4K2B Gene

No ASD Table

Relevant External Links for PI4K2B Gene

GeneLoc Exon Structure for
PI4K2B

Expression for PI4K2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PI4K2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PI4K2B Gene

This gene is overexpressed in Cervix (33.5) and Breast (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PI4K2B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PI4K2B

SOURCE GeneReport for Unigene cluster for PI4K2B Gene:

Hs.191701

mRNA Expression by UniProt/SwissProt for PI4K2B Gene:

Q8TCG2-P4K2B_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PI4K2B Gene

  • Liver(4.3)
  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PI4K2B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PI4K2B Gene

Orthologs for PI4K2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PI4K2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PI4K2B 31 30
  • 98.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PI4K2B 31 30
  • 91.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PI4K2B 31 30
  • 88.09 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PI4K2B 31
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pi4k2b 17 31 30
  • 84.23 (n)
rat
(Rattus norvegicus)
Mammalia Pi4k2b 30
  • 83.3 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 75 (a)
OneToMany
-- 31
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves PI4K2B 31 30
  • 76.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PI4K2B 31
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pi4k2b 30
  • 72.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11769 30
zebrafish
(Danio rerio)
Actinopterygii pi4k2b 31 30
  • 73.39 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pi4KIIalpha 31
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC8.6 31
  • 37 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14080g 30
  • 53.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSB6 33 31 30
  • 52.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR087W 30
  • 50.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2475 31
  • 60 (a)
OneToMany
Cin.4109 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lsb6 30
  • 52.55 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04355 30
  • 51.08 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4109 30
Species where no ortholog for PI4K2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PI4K2B Gene

ENSEMBL:
Gene Tree for PI4K2B (if available)
TreeFam:
Gene Tree for PI4K2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PI4K2B: view image

Paralogs for PI4K2B Gene

Paralogs for PI4K2B Gene

(1) SIMAP similar genes for PI4K2B Gene using alignment to 2 proteins:

  • P4K2B_HUMAN
  • G5E9Z4_HUMAN
genes like me logo Genes that share paralogs with PI4K2B: view

Variants for PI4K2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PI4K2B Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs143048917 Benign: Abnormality of neuronal migration 25,259,141(+) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs863223383 Benign: Abnormality of neuronal migration 25,234,173(+) C/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs313549 - p.Ser78Pro

Additional dbSNP identifiers (rs#s) for PI4K2B Gene

Structural Variations from Database of Genomic Variants (DGV) for PI4K2B Gene

Variant ID Type Subtype PubMed ID
esv2662257 CNV deletion 23128226
esv2727308 CNV deletion 23290073
esv3599959 CNV loss 21293372
esv3599960 CNV gain 21293372
nsv1073314 CNV deletion 25765185
nsv1123759 CNV deletion 24896259
nsv518834 CNV loss 19592680
nsv524925 CNV loss 19592680

Variation tolerance for PI4K2B Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PI4K2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PI4K2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PI4K2B Gene

Disorders for PI4K2B Gene

Additional Disease Information for PI4K2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PI4K2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PI4K2B Gene

Publications for PI4K2B Gene

  1. A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B. (PMID: 19539307) Houlihan LM … Evans KL (Journal of psychiatric research 2009) 3 23 41 54
  2. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. (PMID: 11923287) Balla A … Balla T (The Journal of biological chemistry 2002) 2 3 4 54
  3. Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity. (PMID: 18316730) Griffioen M … Falkenburg JH (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 23 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP. (PMID: 12324459) Wei YJ … Yin HL (The Journal of biological chemistry 2002) 3 4 54

Products for PI4K2B Gene

Sources for PI4K2B Gene