Aliases for PI4K2B Gene
External Ids for PI4K2B Gene
Previous GeneCards Identifiers for PI4K2B Gene
This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]
GeneCards Summary for PI4K2B Gene
PI4K2B (Phosphatidylinositol 4-Kinase Type 2 Beta) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and PI Metabolism. Gene Ontology (GO) annotations related to this gene include kinase activity and 1-phosphatidylinositol 4-kinase activity. An important paralog of this gene is PI4K2A.
UniProtKB/Swiss-Prot Summary for PI4K2B Gene
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.