This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomer...
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Aliases for PI3 Gene
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Peptidase Inhibitor 3
2
3
4
5
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Skin-Derived Antileukoproteinase
2
3
4
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WFDC14
2
3
4
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SKALP
2
3
4
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WAP3
2
3
4
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ESI
2
3
4
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Protease Inhibitor 3, Skin-Derived (SKALP)
2
3
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WAP Four-Disulfide Core Domain Protein 14
3
4
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Peptidase Inhibitor 3, Skin-Derived
2
3
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Elastase-Specific Inhibitor
3
4
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Protease Inhibitor WAP3
3
4
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Trappin-2
2
3
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Cementoin
2
3
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Elafin
3
4
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PI-3
3
4
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WAP Four-Disulfide Core Domain 14
3
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Pre-Elafin
3
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ELAFIN
2
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PI3
5
External Ids for PI3 Gene
Previous GeneCards Identifiers for PI3 Gene
- GC20P043531
- GC20P044441
- GC20P044489
- GC20P044490
- GC20P043236
- GC20P043803
- GC20P040545
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This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
PI3 (Peptidase Inhibitor 3) is a Protein Coding gene.
Diseases associated with PI3 include Pustular Psoriasis and Impetigo Herpetiformis.
Among its related pathways are Keratinization and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.
An important paralog of this gene is SLPI.
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Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).
No data available for
CIViC Summary ,
Tocris Summary ,
PharmGKB "VIP" Summary ,
Rfam classification and
piRNA Summary
for PI3 Gene