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This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomer... See more...
Aliases for PI3 Gene
Aliases for PI3 Gene
External Ids for PI3 Gene
- HGNC: 8947
- NCBI Entrez Gene: 5266
- Ensembl: ENSG00000124102
- OMIM®: 182257
- UniProtKB/Swiss-Prot: P19957
Previous GeneCards Identifiers for PI3 Gene
- GC20P043531
- GC20P044441
- GC20P044489
- GC20P044490
- GC20P043236
- GC20P043803
- GC20P040545
Summaries for PI3 Gene
-
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
GeneCards Summary for PI3 Gene
PI3 (Peptidase Inhibitor 3) is a Protein Coding gene. Diseases associated with PI3 include Pustular Psoriasis and Impetigo Herpetiformis. Among its related pathways are Keratinization and Defensins. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is SLPI.
UniProtKB/Swiss-Prot Summary for PI3 Gene
-
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).
Additional gene information for PI3 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PI3 Gene
Genomics for PI3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PI3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PI3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PI3
- Top Transcription factor binding sites by QIAGEN in the PI3 gene promoter:
-
- C/EBPbeta
- GR
- GR-alpha
- GR-beta
- NF-kappaB
- NF-kappaB1
- p53
Genomic Locations for PI3 Gene
Latest Assembly
- chr20:45,174,902-45,176,544
- (GRCh38/hg38)
- Size:
- 1,643 bases
- Orientation:
- Plus strand
Previous Assembly
- chr20:43,803,543-43,805,185
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 1,643 bases
- Orientation:
- Plus strand
Genomic View for PI3 Gene
Genes around PI3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by HGNC
- 20q13.12 by Entrez Gene
- 20q13.12 by Ensembl
PI3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PI3 Gene
Proteins for PI3 Gene
-
Protein details for PI3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P19957-ELAF_HUMAN
- Recommended name:
- Elafin
- Protein Accession:
- P19957
- E1P618
- Q6FG74
Protein attributes for PI3 Gene
- Size:
- 117 amino acids
- Molecular mass:
- 12270 Da
- Quaternary structure:
- No Data Available
Protein Expression for PI3 Gene
Post-translational modifications for PI3 Gene
Other Protein References for PI3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ ELAF Polyclonal Antibody
- LifeSpan BioSciences PI3 / Elafin Antibody
- NSJ Bioreagents Elafin Antibody
-
Custom Antibody ServicesOriGene Antibodies for PI3
- Novus Biologicals Antibodies for PI3
-
Abcam antibodies for PI3
- Invitrogen Antibodies for PI3 (AFLGC-PI3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PI3
- Sino Biological Antibodies for PI3
Protein products for research
- G Biosciences Human Elafin/Trappin-2, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for PI3
- Origene Custom Protein Services for PI3
- Sino Biological Recombinant Proteins for PI3
- Sino Biological Cell Lysates for PI3
- ProSpec Recombinant Proteins for PI3
- antibodies-online: Show 15 available PI3 Proteins ranked by validation data
- Compare Top PI3 Proteins
-
ProSci Proteins for PI3
-
Abcam proteins for PI3
Assay products for research
- RayBiotech Human Trappin-2 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for PI3
- antibodies-online: Show 41 available PI3 Elisa Kits ranked by validation data
- Compare Top PI3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for PI3 Gene
Domains & Families for PI3 Gene
Gene Families for PI3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for PI3 Gene
- InterPro:
- Blocks:
-
- 4-disulphide core signature
Suggested Antigen Peptide Sequences for PI3 Gene
- GenScript: Design optimal peptide antigens:
-
- WAP four-disulfide core domain protein 14 (ELAF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P19957UniProtKB/Swiss-Prot:
ELAF_HUMAN :- Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins.
- Domain:
-
- Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins.
Function for PI3 Gene
Molecular function for PI3 Gene
- UniProtKB/Swiss-Prot Function:
- Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).
- GENATLAS Biochemistry:
- elafin,serine proteinase inhibitor,epidermal,member of the troppin family,induced in epidermis by cellular stress,involved in the regulation of inflammation and in protection against tissue damage,regulated by neutrophil elastase in type II alveolar epithelial cells
Phenotypes From GWAS Catalog for PI3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004866 | endopeptidase inhibitor activity | TAS | 2394696 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | TAS,IBA | 21873635 |
| GO:0030280 | structural constituent of epidermis | IDA | 7543090 |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
Phenotypes for PI3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PI3 - Starting at $85 >
- * PI3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PI3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PI3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PI3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PI3
- Browse OriGene Inhibitory RNA Products For PI3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PI3
Clone products for research
- Applied Biological Materials (abm): Clones for PI3 - Starting at $45 >
- * PI3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PI3
- Addgene plasmids for PI3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PI3
Cell Lines for research
-
Horizon Cell Lines for PI3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PI3 Gene
Localization for PI3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PI3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 4 |
| cytosol | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | IDA,TAS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0031012 | extracellular matrix | TAS | 8476637 |
Pathways & Interactions for PI3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratinization |
.33
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Defensins | ||
| 4 | Developmental Biology | ||
Pathways by source for PI3 Gene
6 Reactome pathways for PI3 Gene
Interacting Proteins for PI3 Gene
GPS-Prot Interaction Network for PI3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007620 | copulation | IEA | -- |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
| GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
| GO:0018149 | peptide cross-linking | IDA | 7543090 |
| GO:0019730 | antimicrobial humoral response | TAS | -- |
No data available for SIGNOR curated interactions for PI3 Gene
Drugs & Compounds for PI3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Elafin/Trappin-2, Liquid
Transcripts for PI3 Gene
mRNA/cDNA for PI3 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000243924 551 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PI3 - Starting at $85 >
- * PI3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PI3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PI3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PI3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PI3
- Browse OriGene Inhibitory RNA Products For PI3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PI3
Clone products for research
- Applied Biological Materials (abm): Clones for PI3 - Starting at $45 >
- * PI3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PI3
- Addgene plasmids for PI3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PI3
Relevant External Links for PI3 Gene
- GeneLoc Exon Structure for
- PI3
Expression for PI3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
- Epidermis (Integumentary System)
- Hair
-
Colon (Gastrointestinal Tract)
-
Gall Bladder (Hepatobiliary System)
-
Tonsil (Hematopoietic System)
-
Esophagus (Gastrointestinal Tract)
-
Larynx (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for PI3 Gene
This gene is overexpressed in Esophagus - Mucosa (x22.7), Vagina (x12.3), and Whole Blood (x7.6).
This gene is overexpressed in Cervix (33.8) and Oral epithelium (20.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PI3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PI3
SOURCE GeneReport for Unigene cluster for PI3 Gene:
Hs.112341Evidence on tissue expression from TISSUES for PI3 Gene
- Skin(4.6)
- Nervous system(4.4)
- Intestine(3.4)
- Blood(2.7)
- Lung(2.6)
- Muscle(2.2)
- Spleen(2)
- Liver(2)
Primer products for research
-
OriGene qPCR primer pairs for PI3
-
OriGene qPCR primer pairs and template standards for PI3
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PI3 Gene
Orthologs for PI3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PI3 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PI3 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| PI3 30 |
|
OneToMany |
- Species where no ortholog for PI3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for PI3 Gene
- ENSEMBL:
- Gene Tree for PI3 (if available)
- TreeFam:
- Gene Tree for PI3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PI3: view image
- Alliance of Genome Resources:
- Additional Orthologs for PI3
Paralogs for PI3 Gene
Variants for PI3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PI3 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs761507163 | Uncertain Significance: not provided | 45,174,923(+) |
A/G NM_002638.4(PI3):c.1A>G (p.Met1Val) |
INITIATIOR_CODON_VARIANT,MISSENSE | |
| rs17333103 | -- |
p.Thr17Met |
|||
| rs2664581 | -- |
p.Thr34Pro |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1056102 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.03;
60.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PI3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PI3 Gene
Disorders for PI3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pustular psoriasis |
|
|
| impetigo herpetiformis |
|
|
| erysipelas |
|
|
| farmer's lung |
|
|
| extrinsic allergic alveolitis |
|
|
Search PI3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PI3
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PI3 Gene
Publications for PI3 Gene
- Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome. (PMID: 19251943) Tejera P … Christiani DC (American journal of respiratory cell and molecular biology 2009) 3 22 40
- SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis. (PMID: 9727750) Kuijpers AL … Schalkwijk J (Clinical genetics 1998) 3 22 40
- Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13. (PMID: 8287685) Molhuizen HO … Schalkwijk J (Cytogenetics and cell genetics 1994) 2 3 22
- SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking. (PMID: 7685029) Molhuizen HO … Schalkwijk J (The Journal of biological chemistry 1993) 3 4 22
- Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions. (PMID: 8476637) Sallenave JM … Silva A (American journal of respiratory cell and molecular biology 1993) 3 4 22
ExternalLinks
Products for PI3 Gene
- View all 8 R&D Systems PI3 (Trappin-2/Elafin) Products
- View all R&D Systems PI3 (Trappin-2/Elafin) Proteins and Enzymes
- View all 3 R&D Systems PI3 (Trappin-2/Elafin) Primary Antibodies
- View all R&D Systems PI3 (Trappin-2/Elafin) ELISAs
- View all R&D Systems PI3 (Trappin-2/Elafin) Simple Plex Assays
- View all 2 R&D Systems PI3 (Trappin-2/Elafin) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom PI3 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for PI3
- Custom Assay ServicesOriGene ELISA Kits for PI3
- Search Origene for MassSpec and Protein Over-expression Lysates for PI3
- Origene Custom Protein Services for PI3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PI3
- Browse OriGene Inhibitory RNA Products For PI3
- OriGene qPCR primer pairs for PI3
- OriGene qPCR primer pairs and template standards for PI3
- OriGene CRISPR knockouts for PI3
- OriGene ORF clones in human for PI3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PI3
- Sino Biological Human cDNA Clone for PI3
- Sino Biological Recombinant Proteins for PI3
- Sino Biological Cell Lysates for PI3
- Sino Biological Antibodies for PI3
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PI3
- Novus Biologicals proteins and lysates for PI3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PI3
- Abcam proteins for PI3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for PI3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PI3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PI3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PI3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PI3
- Addgene plasmids for PI3
- antibodies-online: Show 169 available PI3 Antibodies ranked by validation data
- Compare Top PI3 Antibodies
- antibodies-online: Show 41 available PI3 Elisa Kits ranked by validation data
- Compare Top PI3 Elisa Kits
- Quality Products:
- antibodies-online: Show 15 available PI3 Proteins ranked by validation data
- Compare Top PI3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PI3
- Search Santa Cruz Biotechnology (SCBT) for PI3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PI3
- Custom Antibody ServicesProSci Antibodies for PI3
- ProSci Proteins for PI3
- Horizon Cell Lines for PI3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PI3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PI3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PI3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PI3
Sources for PI3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
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