Aliases for PI3 Gene
External Ids for PI3 Gene
Previous GeneCards Identifiers for PI3 Gene
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
GeneCards Summary for PI3 Gene
PI3 (Peptidase Inhibitor 3) is a Protein Coding gene. Diseases associated with PI3 include Erysipelas and Impetigo Herpetiformis. Among its related pathways are Defensins and Keratinization. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.
UniProtKB/Swiss-Prot for PI3 Gene
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.