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Aliases for PI15 Gene

Aliases for PI15 Gene

  • Peptidase Inhibitor 15 2 3 3 5
  • P25TI 3 4 4
  • Cysteine-Rich Secretory Protein 8 3 4
  • 25 KDa Trypsin Inhibitor 3 4
  • Protease Inhibitor 15 2 3
  • SugarCrisp 3 4
  • CRISP-8 3 4
  • CRISP8 3 4
  • PI-15 3 4
  • P24TI 3

External Ids for PI15 Gene

Previous GeneCards Identifiers for PI15 Gene

  • GC08P075724
  • GC08P075460
  • GC08P075786
  • GC08P075773
  • GC08P075899
  • GC08P071227

Summaries for PI15 Gene

Entrez Gene Summary for PI15 Gene

  • This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for PI15 Gene

PI15 (Peptidase Inhibitor 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is R3HDML.

UniProtKB/Swiss-Prot for PI15 Gene

  • Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity).

Additional gene information for PI15 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PI15 Gene

Genomics for PI15 Gene

GeneHancer (GH) Regulatory Elements for PI15 Gene

Promoters and enhancers for PI15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J074823 Promoter/Enhancer 0.9 EPDnew ENCODE 650.7 -0.7 -667 1.6 FOXP2 REST PI15 ENSG00000253777 ENSG00000253706 MIR2052HG
GH08J074599 Promoter 0.5 EPDnew 650.1 -224.7 -224726 0.1 MIR2052HG PI15 LOC105375904 MIR5681B
GH08J074836 Enhancer 0.2 FANTOM5 0.4 +12.3 12281 0.2 PI15 ENSG00000253706
GH08J074807 Enhancer 0.2 ENCODE 0.4 -16.8 -16828 0.2 ENSG00000253777 PI15 ENSG00000253706 MIR2052HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PI15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PI15 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • HOXA5
  • Ik-1
  • FOXL1
  • SRF
  • SRF (504 AA)
  • FOXJ2
  • FOXJ2 (long isoform)
  • c-Rel

Genomic Locations for PI15 Gene

Genomic Locations for PI15 Gene
30,576 bases
Plus strand
30,493 bases
Plus strand

Genomic View for PI15 Gene

Genes around PI15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PI15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PI15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI15 Gene

Proteins for PI15 Gene

  • Protein details for PI15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidase inhibitor 15
    Protein Accession:
    Secondary Accessions:
    • Q68CY1

    Protein attributes for PI15 Gene

    258 amino acids
    Molecular mass:
    29065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PI15 Gene

Post-translational modifications for PI15 Gene

Other Protein References for PI15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PI15 Gene

Domains & Families for PI15 Gene

Gene Families for PI15 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PI15 Gene

Suggested Antigen Peptide Sequences for PI15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CRISP family.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with PI15: view

Function for PI15 Gene

Molecular function for PI15 Gene

UniProtKB/Swiss-Prot Function:
Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity).

Gene Ontology (GO) - Molecular Function for PI15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PI15: view
genes like me logo Genes that share phenotypes with PI15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PI15

Clone Products

  • Addgene plasmids for PI15

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PI15 Gene

Localization for PI15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI15 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PI15 gene
Compartment Confidence
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PI15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PI15: view

Pathways & Interactions for PI15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PI15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with PI15: view

No data available for Pathways by source and SIGNOR curated interactions for PI15 Gene

Drugs & Compounds for PI15 Gene

No Compound Related Data Available

Transcripts for PI15 Gene

mRNA/cDNA for PI15 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PI15 Gene

Peptidase inhibitor 15:
Representative Sequences:

Clone Products

  • Addgene plasmids for PI15

Alternative Splicing Database (ASD) splice patterns (SP) for PI15 Gene

No ASD Table

Relevant External Links for PI15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PI15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PI15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PI15 Gene

This gene is overexpressed in Fallopian Tube (x7.9), Breast - Mammary Tissue (x5.9), and Prostate (x5.8).

Protein differential expression in normal tissues from HIPED for PI15 Gene

This gene is overexpressed in Prostate (43.5) and Fetal heart (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PI15 Gene

Protein tissue co-expression partners for PI15 Gene

NURSA nuclear receptor signaling pathways regulating expression of PI15 Gene:


SOURCE GeneReport for Unigene cluster for PI15 Gene:


mRNA Expression by UniProt/SwissProt for PI15 Gene:

Tissue specificity: Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.

Evidence on tissue expression from TISSUES for PI15 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with PI15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PI15 Gene

Orthologs for PI15 Gene

This gene was present in the common ancestor of animals.

Orthologs for PI15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PI15 34 33
  • 99.61 (n)
(Canis familiaris)
Mammalia PI15 34 33
  • 95.09 (n)
(Bos Taurus)
Mammalia PI15 34 33
  • 93.67 (n)
(Monodelphis domestica)
Mammalia PI15 34
  • 89 (a)
(Mus musculus)
Mammalia Pi15 16 34 33
  • 87.6 (n)
(Rattus norvegicus)
Mammalia Pi15 33
  • 87.34 (n)
(Ornithorhynchus anatinus)
Mammalia PI15 34
  • 75 (a)
(Gallus gallus)
Aves PI15 34 33
  • 84.63 (n)
(Anolis carolinensis)
Reptilia PI15 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pi15 33
  • 75.06 (n)
(Danio rerio)
Actinopterygii pi15a 34 33
  • 73.12 (n)
pi15b 34
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8483 34
  • 17 (a)
(Caenorhabditis elegans)
Secernentea scl-23 34
  • 17 (a)
scl-22 34
  • 12 (a)
vap-1 34
  • 11 (a)
Species where no ortholog for PI15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PI15 Gene

Gene Tree for PI15 (if available)
Gene Tree for PI15 (if available)
Evolutionary constrained regions (ECRs) for PI15: view image

Paralogs for PI15 Gene

(5) SIMAP similar genes for PI15 Gene using alignment to 1 proteins:

  • PI15_HUMAN
genes like me logo Genes that share paralogs with PI15: view

Variants for PI15 Gene

Sequence variations from dbSNP and Humsavar for PI15 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000109332 -- 74,846,726(+) A/T intron_variant
rs1000198713 -- 74,849,013(+) C/T intron_variant
rs1000272812 -- 74,843,374(+) A/G intron_variant
rs1000375017 -- 74,849,902(+) A/G 3_prime_UTR_variant
rs1000501422 -- 74,855,073(+) A/G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PI15 Gene

Variant ID Type Subtype PubMed ID
dgv7241n100 CNV loss 25217958
esv28358 CNV gain+loss 19812545
esv3891410 CNV gain 25118596
nsv519265 CNV loss 19592680
nsv524736 CNV loss 19592680

Variation tolerance for PI15 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PI15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PI15 Gene

Disorders for PI15 Gene

Additional Disease Information for PI15

No disorders were found for PI15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PI15 Gene

Publications for PI15 Gene

  1. cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. (PMID: 9473672) Yamakawa T … Miyazaki K (Biochimica et biophysica acta 1998) 2 3 4 58
  2. Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells. (PMID: 8882727) Koshikawa N … Miyazaki K (Journal of biochemistry 1996) 2 3 4 58
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 44 58
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for PI15 Gene

Sources for PI15 Gene

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