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Aliases for PHYHIPL Gene

Aliases for PHYHIPL Gene

  • Phytanoyl-CoA 2-Hydroxylase Interacting Protein Like 2 3 5
  • Phytanoyl-CoA 2-Hydroxylase Interacting Protein-Like 2
  • Phytanoyl-CoA Hydroxylase-Interacting Protein-Like 3
  • Phytanoyl-CoA Hydroxylase Interacting Protein-Like 2
  • KIAA1796 4

External Ids for PHYHIPL Gene

Previous GeneCards Identifiers for PHYHIPL Gene

  • GC10P060281
  • GC10P060606
  • GC10P060936
  • GC10P054927

Summaries for PHYHIPL Gene

GeneCards Summary for PHYHIPL Gene

PHYHIPL (Phytanoyl-CoA 2-Hydroxylase Interacting Protein Like) is a Protein Coding gene. An important paralog of this gene is PHYHIP.

UniProtKB/Swiss-Prot for PHYHIPL Gene

  • May play a role in the development of the central system.

Gene Wiki entry for PHYHIPL Gene

Additional gene information for PHYHIPL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHYHIPL Gene

Genomics for PHYHIPL Gene

GeneHancer (GH) Regulatory Elements for PHYHIPL Gene

Promoters and enhancers for PHYHIPL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J059172 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 665.2 +3.4 3417 8 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 FOS PAF1 PHYHIPL GC10M059173 ENSG00000236556
GH10J058998 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 650.1 -173.5 -173533 1.7 TAF1 RXRA MAX REST PPARG RAD21 YY1 SP1 XRCC5 JUND LINC00844 PHYHIPL LOC102724768
GH10J058967 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 13.8 -205.5 -205548 1.2 FOXA2 ARID4B SIN3A ZNF48 ETS1 RXRA SP5 MIER2 KAT8 NFIL3 PHYHIPL FAM13C GC10M058913 GC10P058898
GH10J058963 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.8 -209.1 -209051 2.1 SOX13 CTCF USF1 FOXA2 SAP130 BACH1 SIN3A EBF1 ZIC2 ZNF644 PHYHIPL FAM13C GC10M058913 GC10P058898
GH10J059283 Enhancer 0.9 Ensembl ENCODE dbSUPER 14.6 +111.3 111255 2.4 ZFHX2 ZNF521 ZNF8 HES1 CHD2 ZKSCAN1 EGR2 PHYHIPL ENSG00000236556 GC10P059316 FAM13C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PHYHIPL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PHYHIPL gene promoter:
  • NRSF form 2
  • NRSF form 1
  • RSRFC4
  • POU2F1a
  • POU2F1

Genomic Locations for PHYHIPL Gene

Genomic Locations for PHYHIPL Gene
chr10:59,173,371-59,247,774
(GRCh38/hg38)
Size:
74,404 bases
Orientation:
Plus strand
chr10:60,936,348-61,007,534
(GRCh37/hg19)
Size:
71,187 bases
Orientation:
Plus strand

Genomic View for PHYHIPL Gene

Genes around PHYHIPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHYHIPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHYHIPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHYHIPL Gene

Proteins for PHYHIPL Gene

  • Protein details for PHYHIPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FC7-PHIPL_HUMAN
    Recommended name:
    Phytanoyl-CoA hydroxylase-interacting protein-like
    Protein Accession:
    Q96FC7
    Secondary Accessions:
    • B7WP61
    • Q68DF3
    • Q6UXY3
    • Q8N3W3
    • Q96JM9
    • Q96NP7

    Protein attributes for PHYHIPL Gene

    Size:
    376 amino acids
    Molecular mass:
    42486 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88529.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB97028.1; Type=Frameshift; Positions=350; Evidence={ECO:0000305};

    Alternative splice isoforms for PHYHIPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHYHIPL Gene

Post-translational modifications for PHYHIPL Gene

  • Glycosylation at isoforms=237 and isoforms=323
  • Modification sites at PhosphoSitePlus

Other Protein References for PHYHIPL Gene

No data available for DME Specific Peptides for PHYHIPL Gene

Domains & Families for PHYHIPL Gene

Gene Families for PHYHIPL Gene

Protein Domains for PHYHIPL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PHYHIPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FC7

UniProtKB/Swiss-Prot:

PHIPL_HUMAN :
  • Belongs to the PHYHIP family.
Family:
  • Belongs to the PHYHIP family.
genes like me logo Genes that share domains with PHYHIPL: view

Function for PHYHIPL Gene

Molecular function for PHYHIPL Gene

UniProtKB/Swiss-Prot Function:
May play a role in the development of the central system.
genes like me logo Genes that share phenotypes with PHYHIPL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PHYHIPL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PHYHIPL Gene

Localization for PHYHIPL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHYHIPL gene
Compartment Confidence
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PHYHIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with PHYHIPL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHYHIPL Gene

Pathways & Interactions for PHYHIPL Gene

SuperPathways for PHYHIPL Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHYHIPL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PHYHIPL Gene

Drugs & Compounds for PHYHIPL Gene

No Compound Related Data Available

Transcripts for PHYHIPL Gene

Unigene Clusters for PHYHIPL Gene

Phytanoyl-CoA 2-hydroxylase interacting protein-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHYHIPL Gene

No ASD Table

Relevant External Links for PHYHIPL Gene

GeneLoc Exon Structure for
PHYHIPL
ECgene alternative splicing isoforms for
PHYHIPL

Expression for PHYHIPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHYHIPL Gene

mRNA differential expression in normal tissues according to GTEx for PHYHIPL Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Hypothalamus (x4.4), Brain - Substantia nigra (x4.3), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for PHYHIPL Gene

This gene is overexpressed in Retina (17.1), Spinal cord (14.7), Fetal Brain (12.0), and Frontal cortex (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHYHIPL Gene



Protein tissue co-expression partners for PHYHIPL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHYHIPL Gene:

PHYHIPL

SOURCE GeneReport for Unigene cluster for PHYHIPL Gene:

Hs.499704

Evidence on tissue expression from TISSUES for PHYHIPL Gene

  • Eye(4)
  • Liver(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with PHYHIPL: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHYHIPL Gene

Orthologs for PHYHIPL Gene

This gene was present in the common ancestor of animals.

Orthologs for PHYHIPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHYHIPL 34 33
  • 99.82 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHYHIPL 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHYHIPL 34 33
  • 96.28 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHYHIPL 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phyhipl 16 34 33
  • 91.64 (n)
rat
(Rattus norvegicus)
Mammalia Phyhipl 33
  • 90 (n)
cow
(Bos Taurus)
Mammalia PHYHIPL 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHYHIPL 34 33
  • 86.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHYHIPL 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phyhipl 33
  • 79.61 (n)
Str.15916 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25161 33
zebrafish
(Danio rerio)
Actinopterygii phyhipla 34
  • 76 (a)
ManyToMany
phyhiplb 33
  • 73.94 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_T10H4.4 33
  • 45.89 (n)
T10H4.13 34
  • 27 (a)
ManyToMany
M01B2.10 34
  • 27 (a)
ManyToMany
M01B2.12 34
  • 26 (a)
ManyToMany
M01B2.13 34
  • 26 (a)
ManyToMany
T10H4.4 34
  • 18 (a)
ManyToMany
Y92H12BR.7 34
  • 16 (a)
ManyToMany
Species where no ortholog for PHYHIPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHYHIPL Gene

ENSEMBL:
Gene Tree for PHYHIPL (if available)
TreeFam:
Gene Tree for PHYHIPL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PHYHIPL: view image

Paralogs for PHYHIPL Gene

Paralogs for PHYHIPL Gene

(1) SIMAP similar genes for PHYHIPL Gene using alignment to 2 proteins:

  • PHIPL_HUMAN
  • L8E903_HUMAN
genes like me logo Genes that share paralogs with PHYHIPL: view

Variants for PHYHIPL Gene

Sequence variations from dbSNP and Humsavar for PHYHIPL Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000011126 -- 59,199,593(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000025609 -- 59,182,178(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000038081 -- 59,218,411(+) T/C intron_variant
rs1000046302 -- 59,216,003(+) T/C intron_variant
rs1000123463 -- 59,175,473(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PHYHIPL Gene

Variant ID Type Subtype PubMed ID
esv1646035 CNV insertion 17803354
esv2460033 CNV insertion 19546169
esv2676927 CNV deletion 23128226
esv2737418 CNV deletion 23290073
esv2759761 CNV gain 17122850
esv3305207 CNV mobile element insertion 20981092
esv3307924 CNV mobile element insertion 20981092
esv3342305 CNV insertion 20981092
esv3370688 CNV insertion 20981092
esv34715 CNV gain 17911159
nsv475294 CNV novel sequence insertion 20440878
nsv831888 CNV gain 17160897
nsv950966 CNV duplication 24416366

Variation tolerance for PHYHIPL Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHYHIPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHYHIPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHYHIPL Gene

Disorders for PHYHIPL Gene

Additional Disease Information for PHYHIPL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PHYHIPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHYHIPL Gene

Publications for PHYHIPL Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PHYHIPL Gene

Sources for PHYHIPL Gene

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