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Aliases for PHYHIP Gene

Aliases for PHYHIP Gene

  • Phytanoyl-CoA 2-Hydroxylase Interacting Protein 2 3 5
  • Phytanoyl-CoA Hydroxylase-Associated Protein 1 3 4
  • DYRK1A Interacting Protein 3 2 3
  • DYRK1AP3 3 4
  • PAHX-AP1 3 4
  • PAHXAP1 3 4
  • Phytanoyl-CoA Alpha-Hydroxylase Associated Protein 3
  • Phytanoyl-CoA Hydroxylase Interacting Protein 2
  • Phytanoyl-CoA Hydroxylase-Interacting Protein 3
  • KIAA0273 4
  • PAHX-AP 3

External Ids for PHYHIP Gene

Previous HGNC Symbols for PHYHIP Gene

  • DYRK1AP3

Previous GeneCards Identifiers for PHYHIP Gene

  • GC08M021835
  • GC08M022429
  • GC08M022099
  • GC08M022133
  • GC08M022077
  • GC08M020619

Summaries for PHYHIP Gene

GeneCards Summary for PHYHIP Gene

PHYHIP (Phytanoyl-CoA 2-Hydroxylase Interacting Protein) is a Protein Coding gene. An important paralog of this gene is PHYHIPL.

UniProtKB/Swiss-Prot for PHYHIP Gene

  • Its interaction with PHYH suggests a role in the development of the central system.

Additional gene information for PHYHIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHYHIP Gene

Genomics for PHYHIP Gene

GeneHancer (GH) Regulatory Elements for PHYHIP Gene

Promoters and enhancers for PHYHIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I022231 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 179 1.3 MXI1 USF1 NRF1 SIN3A USF2 ZFHX2 POLR2A EGR1 PHYHIP PIWIL2 LOC105379319
GH08I022232 Promoter/Enhancer 0.9 EPDnew dbSUPER 550.8 +1.1 1125 0.1 ZFHX2 EGR1 EGR2 PHYHIP LOC105379319
GH08I022243 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16.7 -12.8 -12833 3.8 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC GLIS1 POLR3D GC08P022245 GC08P022247 MIR320A ENSG00000253200 PIWIL2 FAM160B2 PHYHIP BIN3 LOC107986927
GH08I023067 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 -836.6 -836564 3.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 TNFRSF10B LOC286059 ENSG00000253616 PHYHIP FAM160B2 ENSG00000253200 BMP1 TNFRSF10C PEBP4 PPP3CC
GH08I022603 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.1 -372.7 -372667 3.6 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC CCAR2 GC08P022605 PIR54985 PIR42411 PIR62346 C8orf58 ENSG00000253200 FAM160B2 ENTPD4 BIN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PHYHIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PHYHIP gene promoter:

Genomic Locations for PHYHIP Gene

Genomic Locations for PHYHIP Gene
chr8:22,219,703-22,232,341
(GRCh38/hg38)
Size:
12,639 bases
Orientation:
Minus strand
chr8:22,077,216-22,089,854
(GRCh37/hg19)

Genomic View for PHYHIP Gene

Genes around PHYHIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHYHIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHYHIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHYHIP Gene

Proteins for PHYHIP Gene

  • Protein details for PHYHIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92561-PHYIP_HUMAN
    Recommended name:
    Phytanoyl-CoA hydroxylase-interacting protein
    Protein Accession:
    Q92561
    Secondary Accessions:
    • D3DSR1
    • Q8N4I9

    Protein attributes for PHYHIP Gene

    Size:
    330 amino acids
    Molecular mass:
    37573 Da
    Quaternary structure:
    • Interacts with PHYH and ADGRB1.
    SequenceCaution:
    • Sequence=BAA13402.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PHYHIP Gene

Post-translational modifications for PHYHIP Gene

No Post-translational modifications

Other Protein References for PHYHIP Gene

No data available for DME Specific Peptides for PHYHIP Gene

Domains & Families for PHYHIP Gene

Gene Families for PHYHIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PHYHIP Gene

Graphical View of Domain Structure for InterPro Entry

Q92561

UniProtKB/Swiss-Prot:

PHYIP_HUMAN :
  • Belongs to the PHYHIP family.
Family:
  • Belongs to the PHYHIP family.
genes like me logo Genes that share domains with PHYHIP: view

Function for PHYHIP Gene

Molecular function for PHYHIP Gene

UniProtKB/Swiss-Prot Function:
Its interaction with PHYH suggests a role in the development of the central system.

Phenotypes From GWAS Catalog for PHYHIP Gene

genes like me logo Genes that share phenotypes with PHYHIP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHYHIP Gene

Localization for PHYHIP Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PHYHIP Gene

Pathways & Interactions for PHYHIP Gene

SuperPathways for PHYHIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHYHIP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PHYHIP Gene

Drugs & Compounds for PHYHIP Gene

No Compound Related Data Available

Transcripts for PHYHIP Gene

Unigene Clusters for PHYHIP Gene

Phytanoyl-CoA 2-hydroxylase interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHYHIP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for PHYHIP Gene

GeneLoc Exon Structure for
PHYHIP
ECgene alternative splicing isoforms for
PHYHIP

Expression for PHYHIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHYHIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHYHIP Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Cerebellum (x4.9), Brain - Frontal Cortex (BA9) (x4.8), Brain - Putamen (basal ganglia) (x4.6), and Brain - Cerebellar Hemisphere (x4.6).

Protein differential expression in normal tissues from HIPED for PHYHIP Gene

This gene is overexpressed in Frontal cortex (44.9) and Brain (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHYHIP Gene



Protein tissue co-expression partners for PHYHIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHYHIP Gene:

PHYHIP

SOURCE GeneReport for Unigene cluster for PHYHIP Gene:

Hs.334688

mRNA Expression by UniProt/SwissProt for PHYHIP Gene:

Q92561-PHYIP_HUMAN
Tissue specificity: Highly expressed in the brain.

Evidence on tissue expression from TISSUES for PHYHIP Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PHYHIP: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PHYHIP Gene

Orthologs for PHYHIP Gene

This gene was present in the common ancestor of animals.

Orthologs for PHYHIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHYHIP 33 34
  • 99.7 (n)
oppossum
(Monodelphis domestica)
Mammalia PHYHIP 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHYHIP 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHYHIP 33 34
  • 93.74 (n)
dog
(Canis familiaris)
Mammalia PHYHIP 33 34
  • 93.43 (n)
mouse
(Mus musculus)
Mammalia Phyhip 33 16 34
  • 92.83 (n)
rat
(Rattus norvegicus)
Mammalia Phyhip 33
  • 92.32 (n)
lizard
(Anolis carolinensis)
Reptilia PHYHIP 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phyhip 33
  • 70.27 (n)
zebrafish
(Danio rerio)
Actinopterygii PHYHIP 34
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10516 33
worm
(Caenorhabditis elegans)
Secernentea M01B2.12 34
  • 27 (a)
ManyToMany
T10H4.13 34
  • 26 (a)
ManyToMany
M01B2.13 34
  • 25 (a)
ManyToMany
M01B2.10 34
  • 24 (a)
ManyToMany
T10H4.4 34
  • 17 (a)
ManyToMany
Y92H12BR.7 34
  • 15 (a)
ManyToMany
Species where no ortholog for PHYHIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHYHIP Gene

ENSEMBL:
Gene Tree for PHYHIP (if available)
TreeFam:
Gene Tree for PHYHIP (if available)

Paralogs for PHYHIP Gene

Paralogs for PHYHIP Gene

(1) SIMAP similar genes for PHYHIP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PHYHIP: view

Variants for PHYHIP Gene

Sequence variations from dbSNP and Humsavar for PHYHIP Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000245474 -- 22,220,401(-) A/G 3_prime_UTR_variant, intron_variant
rs1000560317 -- 22,230,613(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000586732 -- 22,230,343(-) T/G genic_upstream_transcript_variant, intron_variant
rs1001018355 -- 22,233,908(-) C/G upstream_transcript_variant
rs1001131738 -- 22,228,930(-) T/C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PHYHIP Gene

Variant ID Type Subtype PubMed ID
nsv831265 CNV loss 17160897
nsv831264 CNV gain+loss 17160897
nsv470205 CNV loss 18288195
esv2759604 CNV loss 17122850
dgv12054n54 CNV loss 21841781

Variation tolerance for PHYHIP Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHYHIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHYHIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHYHIP Gene

Disorders for PHYHIP Gene

Additional Disease Information for PHYHIP

No disorders were found for PHYHIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHYHIP Gene

Publications for PHYHIP Gene

  1. Identification of a brain specific protein that associates with a refsum disease gene product, phytanoyl-CoA alpha-hydroxylase. (PMID: 10686344) Lee ZH … Kim KK (Brain research. Molecular brain research 2000) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 58
  3. Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein. (PMID: 15694837) Bescond M … Rahmani Z (The international journal of biochemistry & cell biology 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PHYHIP Gene

Sources for PHYHIP Gene

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