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Aliases for PHOSPHO2 Gene

Aliases for PHOSPHO2 Gene

  • Phosphatase, Orphan 2 2 3 5
  • EC 3.1.3.74 4 56

External Ids for PHOSPHO2 Gene

Previous GeneCards Identifiers for PHOSPHO2 Gene

  • GC02P170377
  • GC02U900798
  • GC02P170259
  • GC02P170550
  • GC02P162441

Summaries for PHOSPHO2 Gene

GeneCards Summary for PHOSPHO2 Gene

PHOSPHO2 (Phosphatase, Orphan 2) is a Protein Coding gene. Among its related pathways are Vitamin B6 metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphatase activity and pyridoxal phosphatase activity. An important paralog of this gene is PHOSPHO1.

UniProtKB/Swiss-Prot for PHOSPHO2 Gene

  • Phosphatase that has high activity toward pyridoxal 5-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.

Additional gene information for PHOSPHO2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHOSPHO2 Gene

Genomics for PHOSPHO2 Gene

GeneHancer (GH) Regulatory Elements for PHOSPHO2 Gene

Promoters and enhancers for PHOSPHO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I169693 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 568.8 +0.4 359 2.7 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 PHOSPHO2 CCDC173 KLHL23 PHOSPHO2-KLHL23 FASTKD1 SSB GC02P169728
GH02I169715 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 567.6 +22.1 22106 2.8 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 SP5 MXD4 ZNF592 PHOSPHO2 FASTKD1 CCDC173 ENSG00000229827 GC02P169728 PHOSPHO2-KLHL23 KLHL23
GH02I169583 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.1 -109.3 -109303 2.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D PPIG GC02M169582 PHOSPHO2 FASTKD1 CCDC173 SSB GC02P169639
GH02I169709 Enhancer 0.9 ENCODE 29.6 +17.1 17095 4.1 ATF1 ZNF766 ATF7 CAVIN1 ZNF592 MEF2D ATF4 GMEB1 ZNF184 SMARCA4 PHOSPHO2 PPIG SSB CCDC173 CYB5AP2 METTL5 UBR3 KLHL23 GC02P169728 PHOSPHO2-KLHL23
GH02I168889 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.4 -804.2 -804195 1.7 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF143 SPC25 PPIG PHOSPHO2 G6PC2 GC02P168847
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PHOSPHO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PHOSPHO2 gene promoter:

Genomic Locations for PHOSPHO2 Gene

Genomic Locations for PHOSPHO2 Gene
chr2:169,694,454-169,701,708
(GRCh38/hg38)
Size:
7,255 bases
Orientation:
Plus strand
chr2:170,550,964-170,558,218
(GRCh37/hg19)

Genomic View for PHOSPHO2 Gene

Genes around PHOSPHO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHOSPHO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHOSPHO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHOSPHO2 Gene

Proteins for PHOSPHO2 Gene

  • Protein details for PHOSPHO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCD6-PHOP2_HUMAN
    Recommended name:
    Pyridoxal phosphate phosphatase PHOSPHO2
    Protein Accession:
    Q8TCD6
    Secondary Accessions:
    • B2RC30
    • D3DPC7

    Protein attributes for PHOSPHO2 Gene

    Size:
    241 amino acids
    Molecular mass:
    27769 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for PHOSPHO2 Gene

Selected DME Specific Peptides for PHOSPHO2 Gene

Q8TCD6:
  • FDCIIISDSN
  • IVYIGDGGNDVCPVTFLK
  • DNSDTWIVQC

Post-translational modifications for PHOSPHO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PHOSPHO2 Gene

Gene Families for PHOSPHO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PHOSPHO2 Gene

Suggested Antigen Peptide Sequences for PHOSPHO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCD6

UniProtKB/Swiss-Prot:

PHOP2_HUMAN :
  • Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
Family:
  • Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
genes like me logo Genes that share domains with PHOSPHO2: view

Function for PHOSPHO2 Gene

Molecular function for PHOSPHO2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=45.5 uM for pyridoxal 5-phosphate {ECO:0000269 PubMed:16054448}; Vmax=633 nmol/min/mg enzyme with pyridoxal 5-phosphate as substrate {ECO:0000269 PubMed:16054448};
UniProtKB/Swiss-Prot CatalyticActivity:
Pyridoxal 5-phosphate + H(2)O = pyridoxal + phosphate.
UniProtKB/Swiss-Prot Function:
Phosphatase that has high activity toward pyridoxal 5-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.

Enzyme Numbers (IUBMB) for PHOSPHO2 Gene

Gene Ontology (GO) - Molecular Function for PHOSPHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IBA --
GO:0033883 pyridoxal phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHOSPHO2: view

Phenotypes for PHOSPHO2 Gene

genes like me logo Genes that share phenotypes with PHOSPHO2: view

Animal Model Products

CRISPR Products

miRNA for PHOSPHO2 Gene

miRTarBase miRNAs that target PHOSPHO2

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHOSPHO2 Gene

Localization for PHOSPHO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHOSPHO2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PHOSPHO2 Gene

Pathways & Interactions for PHOSPHO2 Gene

SuperPathways for PHOSPHO2 Gene

SuperPathway Contained pathways
1 Metabolism
2 Vitamin B6 metabolism
genes like me logo Genes that share pathways with PHOSPHO2: view

Pathways by source for PHOSPHO2 Gene

2 KEGG pathways for PHOSPHO2 Gene

Gene Ontology (GO) - Biological Process for PHOSPHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with PHOSPHO2: view

No data available for SIGNOR curated interactions for PHOSPHO2 Gene

Drugs & Compounds for PHOSPHO2 Gene

(9) Drugs for PHOSPHO2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Magnesium Approved Nutra 0
Pyridoxal Approved Nutra 197
Pyridoxal Phosphate Approved, Investigational Nutra 17

(1) Additional Compounds for PHOSPHO2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PHOSPHO2: view

Transcripts for PHOSPHO2 Gene

mRNA/cDNA for PHOSPHO2 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PHOSPHO2 Gene

Phosphatase, orphan 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHOSPHO2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for PHOSPHO2 Gene

GeneLoc Exon Structure for
PHOSPHO2
ECgene alternative splicing isoforms for
PHOSPHO2

Expression for PHOSPHO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHOSPHO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHOSPHO2 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for PHOSPHO2 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PHOSPHO2 Gene



Protein tissue co-expression partners for PHOSPHO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHOSPHO2 Gene:

PHOSPHO2

SOURCE GeneReport for Unigene cluster for PHOSPHO2 Gene:

Hs.745233

Evidence on tissue expression from TISSUES for PHOSPHO2 Gene

  • Lung(4.2)
  • Nervous system(4.2)
  • Bone(4)
genes like me logo Genes that share expression patterns with PHOSPHO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHOSPHO2 Gene

Orthologs for PHOSPHO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHOSPHO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHOSPHO2 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia PHOSPHO2 33 34
  • 91.56 (n)
cow
(Bos Taurus)
Mammalia PHOSPHO2 33 34
  • 89.21 (n)
mouse
(Mus musculus)
Mammalia Phospho2 33 16 34
  • 85.56 (n)
rat
(Rattus norvegicus)
Mammalia Phospho2 33
  • 82.78 (n)
oppossum
(Monodelphis domestica)
Mammalia PHOSPHO2 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHOSPHO2 33 34
  • 70.82 (n)
lizard
(Anolis carolinensis)
Reptilia PHOSPHO2 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phospho2 33
  • 61.6 (n)
zebrafish
(Danio rerio)
Actinopterygii phospho2 33 34
  • 53.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12237 33 34
  • 42.27 (n)
CG14212 34
  • 28 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002841 33
  • 40.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G29530 33
  • 49.07 (n)
Species where no ortholog for PHOSPHO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHOSPHO2 Gene

ENSEMBL:
Gene Tree for PHOSPHO2 (if available)
TreeFam:
Gene Tree for PHOSPHO2 (if available)

Paralogs for PHOSPHO2 Gene

Paralogs for PHOSPHO2 Gene

(1) SIMAP similar genes for PHOSPHO2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PHOSPHO2 Gene

genes like me logo Genes that share paralogs with PHOSPHO2: view

Variants for PHOSPHO2 Gene

Sequence variations from dbSNP and Humsavar for PHOSPHO2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000145909 -- 169,696,623(+) A/G intron_variant
rs1000178995 -- 169,696,172(+) C/T intron_variant
rs1000426311 -- 169,694,624(+) T/C 5_prime_UTR_variant, intron_variant, splice_donor_variant
rs1000864554 -- 169,700,789(+) A/C intron_variant
rs1000895554 -- 169,700,317(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PHOSPHO2 Gene

Variant ID Type Subtype PubMed ID
nsv1007492 CNV gain 25217958
nsv1008726 CNV loss 25217958
nsv1011368 CNV loss 25217958
nsv10201 CNV loss 18304495
nsv834454 CNV loss 17160897

Variation tolerance for PHOSPHO2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHOSPHO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHOSPHO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHOSPHO2 Gene

Disorders for PHOSPHO2 Gene

Additional Disease Information for PHOSPHO2

No disorders were found for PHOSPHO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHOSPHO2 Gene

Publications for PHOSPHO2 Gene

  1. Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. (PMID: 16054448) Roberts SJ … Farquharson C (Biochimica et biophysica acta 2005) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for PHOSPHO2 Gene

Sources for PHOSPHO2 Gene

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