Aliases for PHLPP2 Gene
External Ids for PHLPP2 Gene
Previous HGNC Symbols for PHLPP2 Gene
Previous GeneCards Identifiers for PHLPP2 Gene
GeneCards Summary for PHLPP2 Gene
PHLPP2 (PH Domain And Leucine Rich Repeat Protein Phosphatase 2) is a Protein Coding gene. Diseases associated with PHLPP2 include Colorectal Cancer and Bladder Urothelial Carcinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PHLPP1.
UniProtKB/Swiss-Prot Summary for PHLPP2 Gene
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).