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This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signali... See more...
Aliases for PHLPP1 Gene
Aliases for PHLPP1 Gene
- PH Domain And Leucine Rich Repeat Protein Phosphatase 1 2 3 5
- SCOP 2 3 4
- Pleckstrin Homology Domain Containing, Family E (With Leucine Rich Repeats) Member 1 2 3
- PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 1 3 4
- Suprachiasmatic Nucleus Circadian Oscillatory Protein 3 4
- Protein Phosphatase, Mg2+/Mn2+ Dependent 3A 2 3
- PH Domain-Containing Family E Member 1 3 4
- EC 3.1.3.16 4 51
External Ids for PHLPP1 Gene
- HGNC: 20610
- NCBI Entrez Gene: 23239
- Ensembl: ENSG00000081913
- OMIM®: 609396
- UniProtKB/Swiss-Prot: O60346
Previous HGNC Symbols for PHLPP1 Gene
- PLEKHE1
- PHLPP
Previous GeneCards Identifiers for PHLPP1 Gene
- GC18P058535
- GC18P060382
- GC18P057093
Summaries for PHLPP1 Gene
-
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
GeneCards Summary for PHLPP1 Gene
PHLPP1 (PH Domain And Leucine Rich Repeat Protein Phosphatase 1) is a Protein Coding gene. Diseases associated with PHLPP1 include Colorectal Cancer and Timothy Grass Allergy. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is PHLPP2.
UniProtKB/Swiss-Prot Summary for PHLPP1 Gene
-
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).
Additional gene information for PHLPP1 Gene
- HGNC (20610)
- NCBI Entrez Gene (23239)
- Ensembl (ENSG00000081913)
- OMIM® (609396)
- UniProtKB/Swiss-Prot (O60346)
- Open Targets Platform(ENSG00000081913)
- Monarch Initiative
- Search for PHLPP1 at DataMed
- Search for PHLPP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PHLPP1 Gene
Genomics for PHLPP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PHLPP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PHLPP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PHLPP1
Genomic Locations for PHLPP1 Gene
Latest Assembly
- chr18:62,715,445-62,980,433
- (GRCh38/hg38)
- Size:
- 264,989 bases
- Orientation:
- Plus strand
Previous Assembly
- chr18:60,382,774-60,647,666
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 264,893 bases
- Orientation:
- Plus strand
- chr18:60,382,672-60,647,666
- (GRCh37/hg19 by Ensembl)
- Size:
- 264,995 bases
- Orientation:
- Plus strand
Genomic View for PHLPP1 Gene
Genes around PHLPP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.33 by HGNC
- 18q21.33 by Entrez Gene
- 18q21.33 by Ensembl
PHLPP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PHLPP1 Gene
Proteins for PHLPP1 Gene
-
Protein details for PHLPP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60346-PHLP1_HUMAN
- Recommended name:
- PH domain leucine-rich repeat-containing protein phosphatase 1
- Protein Accession:
- O60346
- A1A4F5
- Q641Q7
- Q6P4C4
- Q6PJI6
- Q86TN6
- Q96FK2
- Q9NUY1
Protein attributes for PHLPP1 Gene
- Size:
- 1717 amino acids
- Molecular mass:
- 184672 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats (By similarity). Interacts with AKT2, AKT3, PRKCB isoform beta-II, STK4, RPS6KB1, RAF1 (PubMed:17386267, PubMed:18162466, PubMed:19732725, PubMed:21986499, PubMed:24530606). Isoform 1 (predominantly) and isoform 2 interact with BRAP (PubMed:25820252). Interacts with FKBP5; FKBP5 acts as a scaffold for PHLPP1 and Akt (PubMed:19732725). Interacts with SCRIB; SCRIB acts as a scaffold for PHLPP1 and Akt (PubMed:21701506). Interacts with SLC9A3R1; SLC9A3R1 scaffolds a heterotrimeric complex with PTEN at the plasma membrane (PubMed:21804599). Interacts with WDR48 and USP12 (PubMed:24145035).
- SequenceCaution:
-
- Sequence=AAH14927.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH82244.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI26278.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91980.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for PHLPP1 Gene
Selected DME Specific Peptides for PHLPP1 Gene
- O60346:
-
- LCGTCLIVSSVKD
- SDNGLDSDD
- IPEVLEKLT
- LAAAKKLCTLAQSYGC
- PPPSPGI
- YNVRKGK
- LHCERNQL
- SSEVGSTASDE
- KAIITED
- VEVEVDIHC
Post-translational modifications for PHLPP1 Gene
Other Protein References for PHLPP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SCOP / PHLPP Antibody
- G Biosciences Immunotag™ SCOP Antibody
-
Custom Antibody ServicesOriGene Antibodies for PHLPP1
- Novus Biologicals Antibodies for PHLPP1
- Invitrogen Antibodies for PHLPP1 (AFLGC-PHLPP1)
-
Custom Antibody ServicesProSci Antibodies for PHLPP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PHLPP1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PHLPP1
- Origene Custom Protein Services for PHLPP1
Assay products for research
Domains & Families for PHLPP1 Gene
Gene Families for PHLPP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PHLPP1 Gene
- InterPro:
- Blocks:
-
- Leucine-rich repeat signature
- Pleckstrin-like
- ProtoNet:
Suggested Antigen Peptide Sequences for PHLPP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Suprachiasmatic nucleus circadian oscillatory protein (PHLP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60346UniProtKB/Swiss-Prot:
PHLP1_HUMAN :- The PH domain is required for interaction with PRKCB and its dephosphorylation.
- Domain:
-
- The PH domain is required for interaction with PRKCB and its dephosphorylation.
Function for PHLPP1 Gene
Molecular function for PHLPP1 Gene
- UniProtKB/Swiss-Prot Function:
- Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:24892992};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:24892992};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1.5 mM for p-nitrophenyl phosphate {ECO:0000269|PubMed:24892992};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Insensitive to okadaic acid (PubMed:15808505). Deubiquitination by WDR48-USP12 complex positively regulates PHLPP1 stability (PubMed:24145035).
Enzyme Numbers (IUBMB) for PHLPP1 Gene
Phenotypes From GWAS Catalog for PHLPP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IEA,IPI | 18162466 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PHLPP1 Gene
- MGI mutant phenotypes for PHLPP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PHLPP1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased viability (cell death)
- Increased shRNA abundance (Z-score > 2)
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for PHLPP1 Gene
- MGI Knock Outs for PHLPP1:
-
- Phlpp1 Phlpp1<tm1.1Saco>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PHLPP1 - Starting at $85 >
- * PHLPP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PHLPP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHLPP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHLPP1
miRNA for PHLPP1 Gene
- miRTarBase miRNAs that target PHLPP1
-
- mmu-miR-219a-5p (MIRT005076)
- mmu-miR-17-5p (MIRT010108)
- hsa-miR-331-3p (MIRT019235)
- hsa-miR-190a-5p (MIRT021082)
- hsa-miR-1307-3p (MIRT035820)
- hsa-miR-877-5p (MIRT037351)
- hsa-miR-484 (MIRT041846)
- hsa-miR-17-5p (MIRT052967)
- hsa-miR-18a-5p (MIRT052968)
- hsa-miR-19a-3p (MIRT052969)
- hsa-miR-92a-3p (MIRT052970)
- hsa-miR-224-5p (MIRT053250)
- hsa-miR-141-3p (MIRT054811)
- hsa-miR-1279 (MIRT199172)
- hsa-miR-4495 (MIRT199173)
- hsa-miR-15a-5p (MIRT438163)
- hsa-miR-375 (MIRT438164)
- hsa-miR-200b-3p (MIRT438165)
- hsa-miR-7112-3p (MIRT535287)
- hsa-miR-7-2-3p (MIRT535288)
- hsa-miR-7-1-3p (MIRT535289)
- hsa-miR-5688 (MIRT535290)
- hsa-miR-495-3p (MIRT535291)
- hsa-miR-4422 (MIRT535292)
- hsa-miR-6835-3p (MIRT535293)
- hsa-miR-4446-5p (MIRT644105)
- hsa-miR-3679-3p (MIRT644106)
- hsa-miR-3127-5p (MIRT735178)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHLPP1
- Browse OriGene Inhibitory RNA Products For PHLPP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHLPP1
Clone products for research
- Applied Biological Materials (abm): Clones for PHLPP1 - Starting at $45 >
- * PHLPP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for PHLPP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHLPP1
Cell Lines for research
-
Horizon Cell Lines for PHLPP1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHLPP1 Gene
Localization for PHLPP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PHLPP1 Gene
- Cytoplasm. Membrane. Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.
- [Isoform 2]: Cell membrane.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PHLPP1 Gene
Pathways & Interactions for PHLPP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | GAB1 signalosome |
.89
|
|
| 3 | Downstream signaling events of B Cell Receptor (BCR) | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for PHLPP1 Gene
1 Sino Biological pathway for PHLPP1 Gene
1 BioSystems pathway for PHLPP1 Gene
20 Reactome pathways for PHLPP1 Gene
1 KEGG pathway for PHLPP1 Gene
Interacting Proteins for PHLPP1 Gene
Selected Interacting proteins:
O60346-PHLP1_HUMAN
ENSP00000262719
for PHLPP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PHLPP1
SIGNOR curated interactions for PHLPP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002667 | regulation of T cell anergy | IEA | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007165 | signal transduction | IBA | 21873635 |
| GO:0009649 | entrainment of circadian clock | IEA | -- |
Transcripts for PHLPP1 Gene
mRNA/cDNA for PHLPP1 Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262719 6299 nts (view in UCSC)
- ENST00000487409 665 nts (view in UCSC)
- ENST00000497351 572 nts (view in UCSC)
- ENST00000588452 559 nts (view in UCSC)
- ENST00000588953 2198 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PHLPP1 - Starting at $85 >
- * PHLPP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PHLPP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHLPP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHLPP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHLPP1
- Browse OriGene Inhibitory RNA Products For PHLPP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHLPP1
Clone products for research
- Applied Biological Materials (abm): Clones for PHLPP1 - Starting at $45 >
- * PHLPP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for PHLPP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHLPP1
Relevant External Links for PHLPP1 Gene
- GeneLoc Exon Structure for
- PHLPP1
Expression for PHLPP1 Gene
This gene is overexpressed in Monocytes (30.0), Heart (10.8), and Neutrophil (10.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHLPP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PHLPP1
SOURCE GeneReport for Unigene cluster for PHLPP1 Gene:
Hs.465337mRNA Expression by UniProt/SwissProt for PHLPP1 Gene:
O60346-PHLP1_HUMAN
Tissue specificity:
In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 78% of tested tumors (at protein level). Ubiquitously expressed in non-cancerous tissues.
Evidence on tissue expression from TISSUES for PHLPP1 Gene
- Nervous system(4.8)
- Liver(2.3)
- Intestine(2.2)
- Skin(2)
Primer products for research
-
OriGene qPCR primer pairs for PHLPP1
-
OriGene qPCR primer pairs and template standards for PHLPP1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHLPP1 Gene
Orthologs for PHLPP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PHLPP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PHLPP1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Phlpp1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Phlpp1 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | PHLPP1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PHLPP1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PHLPP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PHLPP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PHLPP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100497530 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | PHLPP1 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Phlpp 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F43C1.1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CYR1 31 33 |
|
OneToMany |
- Species where no ortholog for PHLPP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PHLPP1 Gene
- ENSEMBL:
- Gene Tree for PHLPP1 (if available)
- TreeFam:
- Gene Tree for PHLPP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PHLPP1: view image
Paralogs for PHLPP1 Gene
Paralogs for PHLPP1 Gene
(4) SIMAP similar genes for PHLPP1 Gene using alignment to 2 proteins:
- PHLP1_HUMAN
- K7EP91_HUMAN
Variants for PHLPP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PHLPP1 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 983333 | Uncertain Significance: Intellectual disability | 62,903,146(+) |
C/T NM_194449.4(PHLPP1):c.2627C>T (p.Ala876Val) |
MISSENSE | |
| rs1038320366 | Benign: not provided | 62,716,274(+) |
C/T NM_194449.4(PHLPP1):c.591C>T (p.His197=) |
SYNONYMOUS | |
| rs140161294 | Benign: not provided | 62,979,347(+) |
G/T NM_194449.4(PHLPP1):c.5070G>T (p.Pro1690=) |
SYNONYMOUS | |
| rs144520623 | Benign: not provided | 62,979,014(+) |
ACAG/A NM_194449.4(PHLPP1):c.4740_4742GCA[1] (p.Gln1581del) |
INFRAME_DELETION | |
| rs1555686556 | Uncertain Significance: not provided | 62,978,814(+) |
G/A NM_194449.4(PHLPP1):c.4537G>A (p.Glu1513Lys) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv620e214 | CNV | gain | 21293372 |
| esv2384564 | CNV | deletion | 18987734 |
| esv2659096 | CNV | deletion | 23128226 |
| esv2665321 | CNV | deletion | 23128226 |
| esv2717197 | CNV | deletion | 23290073 |
| esv3339270 | CNV | duplication | 20981092 |
| esv3447821 | CNV | insertion | 20981092 |
| esv7829 | CNV | gain | 19470904 |
| nsv1072808 | CNV | deletion | 25765185 |
| nsv1133429 | CNV | deletion | 24896259 |
| nsv1146696 | CNV | insertion | 26484159 |
| nsv525821 | CNV | loss | 19592680 |
| nsv953555 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
6.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.82;
67.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PHLPP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PHLPP1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHLPP1 Gene
Disorders for PHLPP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| timothy grass allergy |
|
|
| cowden syndrome 1 |
|
|
Search PHLPP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PHLPP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PHLPP1 Gene
Publications for PHLPP1 Gene
- PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (PMID: 15808505) Gao T … Newton AC (Molecular cell 2005) 2 3 4 23
- Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. (PMID: 19079341) Liu J … Gao T (Oncogene 2009) 3 4 23
- The phosphatase PHLPP controls the cellular levels of protein kinase C. (PMID: 18162466) Gao T … Newton AC (The Journal of biological chemistry 2008) 3 4 23
- PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. (PMID: 17386267) Brognard J … Newton AC (Molecular cell 2007) 3 4 23
- Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. (PMID: 25820252) Fatima S … Jans DA (Scientific reports 2015) 3 4
ExternalLinks
Products for PHLPP1 Gene
- Custom Antibody ServicesOriGene Antibodies for PHLPP1
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- Novus Biologicals proteins and lysates for PHLPP1
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- Invitrogen Antibodies for PHLPP1 (AFLGC-PHLPP1)
- VectorBuilder Custom and pre-made DNA vectors for PHLPP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PHLPP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PHLPP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
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- Addgene plasmids for PHLPP1
- antibodies-online: Show 10 available PHLPP1 Antibodies ranked by validation data
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- Search for PHLPP1 Proteins at ProSci
- Horizon Cell Lines for PHLPP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHLPP1
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Sources for PHLPP1 Gene
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