Aliases for PHGDH Gene
Aliases for PHGDH Gene
External Ids for PHGDH Gene
- HGNC: 8923
- Entrez Gene: 26227
- Ensembl: ENSG00000092621
- OMIM: 606879
- UniProtKB: O43175
Previous GeneCards Identifiers for PHGDH Gene
- GC01P120701
- GC01P119092
- GC01P119401
- GC01P119600
- GC01P119966
- GC01P120056
- GC01P120202
- GC01P118112
Summaries for PHGDH Gene
-
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
GeneCards Summary for PHGDH Gene
PHGDH (Phosphoglycerate Dehydrogenase) is a Protein Coding gene. Diseases associated with PHGDH include Neu-Laxova Syndrome 1 and Phosphoglycerate Dehydrogenase Deficiency. Among its related pathways are Metabolism and Amino acid synthesis and interconversion (transamination). Gene Ontology (GO) annotations related to this gene include electron transfer activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is CTBP2.
UniProtKB/Swiss-Prot for PHGDH Gene
-
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
Additional gene information for PHGDH Gene
- Monarch Initiative
- Search for PHGDH at DataMed
- Search for PHGDH at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHGDH Gene
Genomics for PHGDH Gene
GeneHancer (GH) Regulatory Elements for PHGDH Gene
Promoters and enhancers for PHGDH Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PHGDH on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PHGDH gene promoter:
-
- CUTL1
- Max1
- c-Myc
- IRF-1
- PPAR-alpha
- Max
- NRF-2
- GR
- GR-alpha
Regulatory Element Products
Genomic Locations for PHGDH Gene
Genomic Locations for PHGDH Gene
- chr1:119,648,411-119,744,226
- (GRCh38/hg38)
- Size:
- 95,816 bases
- Orientation:
- Plus strand
- chr1:120,202,421-120,286,849
- (GRCh37/hg19)
- Size:
- 84,429 bases
- Orientation:
- Plus strand
Genomic View for PHGDH Gene
Genes around PHGDH on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p12 by Entrez Gene
- 1p12 by HGNC
- 1p12 by Ensembl
PHGDH Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PHGDH Gene
Proteins for PHGDH Gene
-
Protein details for PHGDH Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43175-SERA_HUMAN
- Recommended name:
- D-3-phosphoglycerate dehydrogenase
- Protein Accession:
- O43175
- B2RD08
- Q5SZU3
- Q9BQ01
Protein attributes for PHGDH Gene
- Size:
- 533 amino acids
- Molecular mass:
- 56651 Da
- Quaternary structure:
-
- Homotetramer.
Protein Expression for PHGDH Gene
Post-translational modifications for PHGDH Gene
Other Protein References for PHGDH Gene
- ENSEMBL proteins:
-
- ENSP00000493305
- ENSP00000492955
- ENSP00000358417
- ENSP00000493213
- ENSP00000493415
- ENSP00000493147
- ENSP00000492948
- ENSP00000493446
- ENSP00000492994
- ENSP00000493453
- ENSP00000493382
- ENSP00000493288
- ENSP00000493187
- ENSP00000493089
- ENSP00000493432
- ENSP00000493433
- ENSP00000493264
- ENSP00000493398
- ENSP00000493296
- ENSP00000493175
- ENSP00000493079
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PHGDH
- Novus Biologicals Antibodies for PHGDH
-
Abcam antibodies for PHGDH
- Invitrogen Antibodies for PHGDH (AFLGC-PHGDH)
- antibodies-online: Search results for 125 available PHGDH Antibodies ranked by validation data
- Compare Top PHGDH Antibodies
-
Recommended
- 23 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 97 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 23 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 97 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 23 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 97 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- GeneTex PHGDH Antibody for PHGDH
-
Boster Bio Antibodies for PHGDH
-
Santa Cruz Biotechnology (SCBT) Antibodies for PHGDH
- Sino Biological Antibodies for PHGDH
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PHGDH
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- Sino Biological Recombinant Proteins for PHGDH
- Browse Sino Biological Cell Lysates
- Search GeneTex for Proteins for PHGDH
-
Abcam proteins for PHGDH
Assay Products
- antibodies-online: Search results for 7 available PHGDH Elisa Kits ranked by validation data
- Compare Top PHGDH Elisa Kits
-
Recommended
- 1 Cow (Bovine) ELISA Kit
- 3 Human ELISA Kits
- 1 Mouse (Murine) ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 3 Human ELISA Kits
- 1 Mouse (Murine) ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 3 Human ELISA Kits
- 1 Mouse (Murine) ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
No data available for DME Specific Peptides for PHGDH Gene
Domains & Families for PHGDH Gene
Gene Families for PHGDH Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for PHGDH Gene
Suggested Antigen Peptide Sequences for PHGDH Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43175UniProtKB/Swiss-Prot:
SERA_HUMAN :- Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
- Family:
-
- Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Function for PHGDH Gene
Molecular function for PHGDH Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- (R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- (S)-malate + NAD(+) = oxaloacetate + NADH.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=21.6 uM for 3-phosphonooxypyruvate {ECO:0000269 PubMed:19235232}; KM=0.26 mM for 3-phosphoglycerate {ECO:0000269 PubMed:25406093}; KM=6.5 mM for oxaloacetate {ECO:0000269 PubMed:25406093}; KM=10.1 mM for 2-oxoglutarate {ECO:0000269 PubMed:25406093}; KM=22 uM for NAD(+) {ECO:0000269 PubMed:25406093}; KM=4 uM for NADH {ECO:0000269 PubMed:25406093}; Vmax=35 nmol/min/mg enzyme with 3-phosphohydroxypyruvate as substrate (in patient-derived fibroblasts) {ECO:0000269 PubMed:19235232}; Vmax=168 nmol/min/mg enzyme with 3-phosphohydroxypyruvate as substrate (in 3-PGDH overexpressed cells) {ECO:0000269 PubMed:19235232}; Note=kcat is 4.5 min(-1) for 3-phosphoglycerate oxidation. kcat is 10.6 min(-1) for oxaloacetate reduction. kcat is 4.7 min(-1) for 2-oxoglutarate reduction. {ECO:0000269 PubMed:25406093};
- UniProtKB/Swiss-Prot Induction:
- Induced by 17-beta-estradiol (estrogenic ligand) and 4-hydroxytamoxifen (agonist/antagonist ligand). Positively regulated by the transcription factors SP1 and NF-Y.
Enzyme Numbers (IUBMB) for PHGDH Gene
Phenotypes From GWAS Catalog for PHGDH Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004617 | phosphoglycerate dehydrogenase activity | TAS | -- |
| GO:0009055 | electron transfer activity | TAS | 8758134 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | -- |
| GO:0030060 | L-malate dehydrogenase activity | IEA | -- |
Phenotypes for PHGDH Gene
- MGI mutant phenotypes for PHGDH:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PHGDH:
Animal Models for PHGDH Gene
- MGI Knock Outs for PHGDH:
-
- Phgdh Phgdh<tm1.1Shfu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PHGDH
-
CRISPR Products
-
OriGene CRISPR knockouts for PHGDH
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHGDH
- genomics-online: gRNA clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
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- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
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- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
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- pPB-His-GST
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- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
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- pLenti-C-Myc-DDK
- pLenti-C-mGFP
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- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- Applied Biological Materials CRISPR for PHGDH
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHGDH
- GenScript: Design CRISPR guide RNA sequences for PHGDH
miRNA for PHGDH Gene
- miRTarBase miRNAs that target PHGDH
-
- hsa-mir-155-5p (MIRT020945)
- hsa-mir-26b-5p (MIRT030040)
- hsa-mir-1229-3p (MIRT036377)
- hsa-mir-296-3p (MIRT038390)
- hsa-mir-615-3p (MIRT039728)
- hsa-mir-331-3p (MIRT043507)
- hsa-mir-107 (MIRT048300)
- hsa-mir-143-5p (MIRT265755)
- hsa-mir-759 (MIRT265756)
- hsa-mir-4519 (MIRT265758)
- hsa-mir-6499-3p (MIRT265759)
- hsa-mir-6792-5p (MIRT265760)
- hsa-mir-6733-3p (MIRT332444)
- hsa-mir-1178-5p (MIRT367150)
- hsa-mir-6801-5p (MIRT367151)
- hsa-mir-4257 (MIRT571069)
- hsa-mir-6847-5p (MIRT571070)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHGDH
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHGDH
- genomics-online: shRNA clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
Clone Products
- Sino Biological Human cDNA Clone for PHGDH
- Addgene plasmids for PHGDH
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHGDH
- genomics-online: cdna clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- orf clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- Applied Biological Materials Clones for PHGDH
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PHGDH
No data available for Transcription Factor Targets and HOMER Transcription for PHGDH Gene
Localization for PHGDH Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0043209 | myelin sheath | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHGDH Gene
Pathways & Interactions for PHGDH Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Carbon metabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Amino acid synthesis and interconversion (transamination) | ||
| 4 | Glycine, serine and threonine metabolism | ||
| 5 | Glucose / Energy Metabolism | ||
Pathways by source for PHGDH Gene
1 BioSystems pathway for PHGDH Gene
4 Reactome pathways for PHGDH Gene
4 KEGG pathways for PHGDH Gene
1 Cell Signaling Technology pathway for PHGDH Gene
UniProtKB/Swiss-Prot O43175-SERA_HUMAN
- Pathway: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.
Interacting Proteins for PHGDH Gene
GPS-Prot Interaction Network for PHGDH
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006541 | glutamine metabolic process | IEA | -- |
| GO:0006544 | glycine metabolic process | IEA | -- |
| GO:0006563 | L-serine metabolic process | IEA | -- |
| GO:0006564 | L-serine biosynthetic process | IEA,TAS | -- |
| GO:0006566 | threonine metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for PHGDH Gene
Drugs & Compounds for PHGDH Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-hydroxyglutarate |
|
|
||||
| D-2-Hydroxyglutaric acid |
|
13095-47-1 |
|
|||
| Hydrogen Ion |
|
|
||||
| Phosphohydroxypyruvic acid |
|
3913-50-6 |
|
Drug Products
Transcripts for PHGDH Gene
mRNA/cDNA for PHGDH Gene
- (6) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (1066) Selected AceView cDNA sequences:
- (34) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000641597 2585 bps
- ENST00000493622 742 bps (uc057jvr.1)
- ENST00000641720 548 bps
- ENST00000641023 2096 bps
- ENST00000642041 943 bps
Unigene Clusters for PHGDH Gene
CRISPR Products
-
OriGene CRISPR knockouts for PHGDH
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHGDH
- genomics-online: gRNA clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- Applied Biological Materials CRISPR for PHGDH
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHGDH
- GenScript: Design CRISPR guide RNA sequences for PHGDH
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHGDH
- Browse OriGene Inhibitory RNA Products For PHGDH
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHGDH
- genomics-online: shRNA clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
Clone Products
- Sino Biological Human cDNA Clone for PHGDH
- Addgene plasmids for PHGDH
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHGDH
- genomics-online: cdna clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- orf clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- Applied Biological Materials Clones for PHGDH
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | - | |||||||||||||
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| SP9: | |||||||||||||||
| SP10: | - | ||||||||||||||
| SP11: | - | - | - | - | - | ||||||||||
| SP12: | |||||||||||||||
| SP13: | - | ||||||||||||||
| SP14: | |||||||||||||||
| SP15: |
Expression for PHGDH Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Bergmann Glia Purkinje Cell Layer
- Protoplasmic Astrocyte Cells Neocortex
- Hypothalamus
- Pituitary Gland
- Thalamus
- Neural Tube (Nervous System)
-
Glial Cells
- Bergmann Glia Purkinje Cell Layer
- Protoplasmic Astrocyte Cells Neocortex
- NULL (Uncategorized)
-
Eye (Sensory Organs)
- Lens Vesicle Cells Lens Vesicle
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Adipose (Muscoskeletal System)
-
Prostate (Endocrine System)
-
Lymph (Hematopoietic System)
This gene is overexpressed in Bone (14.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHGDH Gene
NURSA nuclear receptor signaling pathways regulating expression of PHGDH Gene:
PHGDHSOURCE GeneReport for Unigene cluster for PHGDH Gene:
Hs.487296Evidence on tissue expression from TISSUES for PHGDH Gene
- Nervous system(5)
- Lung(4.8)
- Liver(4.7)
- Muscle(4.6)
- Kidney(4.2)
- Eye(4)
- Skin(3.8)
- Intestine(2.9)
- Blood(2.6)
- Heart(2.5)
- Pancreas(2.3)
- Urine(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PHGDH Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- chin
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- skull
Thorax:
- heart
- lung
- rib
- rib cage
Abdomen:
- kidney
Pelvis:
- pelvis
- penis
- placenta
- testicle
- ureter
- uterus
- vagina
- vulva
Limb:
- ankle
- arm
- digit
- femur
- fibula
- finger
- foot
- forearm
- hand
- humerus
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
General:
- blood
- blood vessel
- coagulation system
- hair
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for PHGDH
-
OriGene qPCR primer pairs and template standards for PHGDH
- genomics-online: primer clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PHGDH Gene
Orthologs for PHGDH Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PHGDH 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| LOC607890 33 |
|
||||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Phgdh 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PHGDH 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Phgdh 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PHGDH 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PHGDH 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PHGDH 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PHGDH 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | phgdh 33 |
|
||
| Str.20062 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | phgdh 34 33 |
|
OneToOne | |
| wufb38f06 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008849 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6287 34 35 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | CELE_C31C9.2 33 |
|
||
| C31C9.2 34 35 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SER33 36 34 |
|
||
| SER3 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | EDA9 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0650800 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6094 34 |
|
OneToOne | |
| Cin.4899 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4899 33 |
|
- Species where no ortholog for PHGDH was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PHGDH Gene
- ENSEMBL:
- Gene Tree for PHGDH (if available)
- TreeFam:
- Gene Tree for PHGDH (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PHGDH: view image
Paralogs for PHGDH Gene
Variants for PHGDH Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1021309146 | uncertain-significance, Phosphoglycerate dehydrogenase deficiency | 119,711,840(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs115747918 | likely-benign, Phosphoglycerate dehydrogenase deficiency | 119,723,403(+) | C/T | 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant | |
| rs121907987 | pathogenic, Phosphoglycerate dehydrogenase deficiency, Phosphoglycerate dehydrogenase deficiency (PHGDHD) [MIM:601815] | 119,743,906(+) | G/A | coding_sequence_variant, missense_variant | |
| rs121907988 | pathogenic, Phosphoglycerate dehydrogenase deficiency, Phosphoglycerate dehydrogenase deficiency (PHGDHD) [MIM:601815] | 119,742,870(+) | G/A | coding_sequence_variant, missense_variant | |
| rs140037378 | uncertain-significance, Phosphoglycerate dehydrogenase deficiency | 119,744,206(+) | /GTAG | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.98;
36.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PHGDH Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHGDH Gene
Disorders for PHGDH Gene
(11) MalaCards diseases for PHGDH Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neu-laxova syndrome 1 |
|
|
| phosphoglycerate dehydrogenase deficiency |
|
|
| serine deficiency |
|
|
| phosphoserine phosphatase deficiency |
|
|
| cerebral folate deficiency |
|
|
Search PHGDH in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SERA_HUMAN- Phosphoglycerate dehydrogenase deficiency (PHGDHD) [MIM:601815]: An autosomal recessive inborn error of L-serine biosynthesis, clinically characterized by congenital microcephaly, psychomotor retardation, and seizures. {ECO:0000269 PubMed:11055895, ECO:0000269 PubMed:19235232}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Neu-Laxova syndrome 1 (NLS1) [MIM:256520]: A lethal, autosomal recessive multiple malformation syndrome characterized by ichthyosis, marked intrauterine growth restriction, microcephaly, short neck, limb deformities, hypoplastic lungs, edema, and central nervous system anomalies including lissencephaly, cerebellar hypoplasia and/or abnormal/agenesis of the corpus callosum. Abnormal facial features include severe proptosis with ectropion, hypertelorism, micrognathia, flattened nose, and malformed ears. {ECO:0000269 PubMed:24836451}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PHGDH
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PHGDH Gene
Publications for PHGDH Gene
- Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics. (PMID: 19235232) Tabatabaie L … Klomp LW (Human mutation 2009) 3 4 22 58
- V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme. (PMID: 11751922) Pind S … Natowicz MR (The Journal of biological chemistry 2002) 3 4 22 58
- Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene. (PMID: 10713460) Cho HM … Kim YH (Gene 2000) 3 4 22 58
- Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis. (PMID: 11055895) Klomp LW … Berger R (American journal of human genetics 2000) 3 4 22 58
- Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH. (PMID: 24836451) Shaheen R … Alkuraya FS (American journal of human genetics 2014) 3 4 58
Products for PHGDH Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PHGDH
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PHGDH
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHGDH
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- OriGene qPCR primer pairs for PHGDH
- OriGene qPCR primer pairs and template standards for PHGDH
- OriGene CRISPR knockouts for PHGDH
- OriGene ORF clones in human for PHGDH
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PHGDH
- GenScript: Next-day shipping of latest version cDNA ORF clones for PHGDH in any vector
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- GenScript: Design CRISPR guide RNA sequences for PHGDH
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- CloneReady with Over 120,000 Genes
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- Sino Biological Human cDNA Clone for PHGDH
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PHGDH
- Novus Biologicals lysates and proteins for PHGDH
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PHGDH
- Abcam proteins for PHGDH
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for PHGDH (AFLGC-PHGDH)
- Cyagen custom Knockout/knockin (KOKI) mouse models for PHGDH
- Addgene plasmids for PHGDH
- antibodies-online: Search results for 125 available PHGDH Antibodies ranked by validation data
- Compare Top PHGDH Antibodies
- Recommended
- 23 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 97 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 23 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 97 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 23 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 97 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 7 available PHGDH Elisa Kits ranked by validation data
- Compare Top PHGDH Elisa Kits
- Recommended
- 1 Cow (Bovine) ELISA Kit
- 3 Human ELISA Kits
- 1 Mouse (Murine) ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 3 Human ELISA Kits
- 1 Mouse (Murine) ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 3 Human ELISA Kits
- 1 Mouse (Murine) ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- antibodies-online: Search results for 11 available PHGDH Proteins ranked by validation data
- Compare Top PHGDH Proteins
- GeneTex PHGDH Antibody for PHGDH
- Search GeneTex for Proteins for PHGDH
- Santa Cruz Biotechnology (SCBT) Antibodies for PHGDH
- Search Santa Cruz Biotechnology (SCBT) for PHGDH siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PHGDH
- Horizon Cell Lines for PHGDH
- genomics-online: cdna clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- orf clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- genomics-online: gRNA clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- genomics-online: primer clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- genomics-online: shRNA clones - Search results for 132 available PHGDH gene related products
- Overview of 132 available PHGDH gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pCMV6-XL5
- pCMV6-Entry
- pCMV6-AC
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHGDH
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHGDH
- GeneCopoeia miRNA 3'UTR Target clone products for PHGDH
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHGDH
- Boster Bio Antibodies for PHGDH
- Browse Boster Bio ELISA Kits
Sources for PHGDH Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131)