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Aliases for PHF20L1 Gene

Aliases for PHF20L1 Gene

  • PHD Finger Protein 20 Like 1 2 3 5
  • Tudor Domain Containing 20B 2 3
  • Tudor Domain-Containing Protein PHF20L1 3
  • PHD Finger Protein 20-Like Protein 1 3
  • Up-Regulated In Lung Cancer 1 3
  • TDRD20B 3
  • CGI-72 3
  • URLC1 3

External Ids for PHF20L1 Gene

Previous GeneCards Identifiers for PHF20L1 Gene

  • GC08P133857
  • GC08P129105
  • GC08P133787

Summaries for PHF20L1 Gene

GeneCards Summary for PHF20L1 Gene

PHF20L1 (PHD Finger Protein 20 Like 1) is a Protein Coding gene. An important paralog of this gene is PHF20.

Additional gene information for PHF20L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF20L1 Gene

Genomics for PHF20L1 Gene

GeneHancer (GH) Regulatory Elements for PHF20L1 Gene

Promoters and enhancers for PHF20L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J132774 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 658.3 +0.2 211 2.1 PKNOX1 ATF1 MLX ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 PHF20L1 ENSG00000223697 TMEM71 GC08P132799
GH08J132758 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.8 -15.2 -15230 4.2 CTCF SP1 JUND PKNOX1 RNF2 POLR2A JUN FOXP2 TMEM71 PHF20L1 LRRC6
GH08J133080 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 33.3 +306.8 306796 3.2 SP1 CTCF RXRA POLR2A CEBPG RAD21 NR2F2 GABPA TMEM71 PHF20L1 WISP1 SLA ST3GAL1 TG GC08P133070
GH08J133147 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 28 +371.9 371883 1.7 ZBTB21 CREB1 ATF7 RUNX3 ATF2 CREM TMEM71 PHF20L1 WISP1 SLA TG ST3GAL1 LOC105375769 GC08M133177
GH08J133149 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 24.9 +375.3 375343 2.2 POLR2A CREB1 ATF2 YY1 GABPA TMEM71 PHF20L1 WISP1 SLA ST3GAL1 LOC105375769 GC08M133177
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PHF20L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PHF20L1 gene promoter:
  • AREB6
  • Sox9
  • c-Jun
  • ATF-2
  • SEF-1 (1)
  • STAT1
  • STAT1alpha
  • STAT1beta
  • POU6F1 (c2)
  • FOXL1

Genomic Locations for PHF20L1 Gene

Genomic Locations for PHF20L1 Gene
73,450 bases
Plus strand
73,449 bases
Plus strand

Genomic View for PHF20L1 Gene

Genes around PHF20L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF20L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF20L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF20L1 Gene

Proteins for PHF20L1 Gene

  • Protein details for PHF20L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PHD finger protein 20-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A8MZC9
    • Q86U89
    • Q86W43
    • Q96BT0
    • Q9H702
    • Q9HBK3
    • Q9NYR3
    • Q9Y381

    Protein attributes for PHF20L1 Gene

    1017 amino acids
    Molecular mass:
    115010 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34067.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP33690.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15098.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW92152.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PHF20L1 Gene

    Alternative splice isoforms for PHF20L1 Gene


neXtProt entry for PHF20L1 Gene

Post-translational modifications for PHF20L1 Gene

  • Ubiquitination at Lys150
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PHF20L1 Gene

Domains & Families for PHF20L1 Gene

Gene Families for PHF20L1 Gene

Protein Domains for PHF20L1 Gene

Suggested Antigen Peptide Sequences for PHF20L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PHF20L1: view

No data available for UniProtKB/Swiss-Prot for PHF20L1 Gene

Function for PHF20L1 Gene

Phenotypes From GWAS Catalog for PHF20L1 Gene

Gene Ontology (GO) - Molecular Function for PHF20L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16415788
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHF20L1: view
genes like me logo Genes that share phenotypes with PHF20L1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHF20L1 Gene

Localization for PHF20L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHF20L1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PHF20L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PHF20L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHF20L1 Gene

Pathways & Interactions for PHF20L1 Gene

SuperPathways for PHF20L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF20L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PHF20L1: view

No data available for Pathways by source and SIGNOR curated interactions for PHF20L1 Gene

Drugs & Compounds for PHF20L1 Gene

No Compound Related Data Available

Transcripts for PHF20L1 Gene

mRNA/cDNA for PHF20L1 Gene

Unigene Clusters for PHF20L1 Gene

PHD finger protein 20-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF20L1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: -
SP9: - - -
SP10: - -
SP11: - - - - - - -
SP12: - - - -
SP13: -
SP14: -
SP15: -

ExUns: 16a · 16b ^ 17a · 17b

Relevant External Links for PHF20L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PHF20L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHF20L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHF20L1 Gene

This gene is overexpressed in Heart (19.4), Frontal cortex (17.8), Fetal Brain (10.0), and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHF20L1 Gene

Protein tissue co-expression partners for PHF20L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PHF20L1 Gene:


SOURCE GeneReport for Unigene cluster for PHF20L1 Gene:


Evidence on tissue expression from TISSUES for PHF20L1 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with PHF20L1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHF20L1 Gene

Orthologs for PHF20L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHF20L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PHF20L1 33
  • 99.66 (n)
(Bos Taurus)
Mammalia PHF20L1 34 33
  • 95.69 (n)
(Canis familiaris)
Mammalia PHF20L1 34 33
  • 93.84 (n)
(Rattus norvegicus)
Mammalia Phf20l1 33
  • 89.06 (n)
(Mus musculus)
Mammalia Phf20l1 16 34 33
  • 88.7 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
-- 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia PHF20L1 34
  • 79 (a)
(Gallus gallus)
Aves PHF20L1 34 33
  • 84.04 (n)
(Anolis carolinensis)
Reptilia PHF20L1 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731476 33
  • 65.13 (n)
Str.20374 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17160 33
(Danio rerio)
Actinopterygii phf20l1 34 33
  • 61.07 (n)
Dr.7293 33
fruit fly
(Drosophila melanogaster)
Insecta MBD-R2 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
-- 34
  • 22 (a)
Species where no ortholog for PHF20L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF20L1 Gene

Gene Tree for PHF20L1 (if available)
Gene Tree for PHF20L1 (if available)
Evolutionary constrained regions (ECRs) for PHF20L1: view image

Paralogs for PHF20L1 Gene

Paralogs for PHF20L1 Gene

(1) SIMAP similar genes for PHF20L1 Gene using alignment to 8 proteins:

  • P20L1_HUMAN
  • E5RK91_HUMAN
  • E9PM57_HUMAN
  • F8W9L8_HUMAN
  • H0YC05_HUMAN
genes like me logo Genes that share paralogs with PHF20L1: view

Variants for PHF20L1 Gene

Sequence variations from dbSNP and Humsavar for PHF20L1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000007249 -- 132,795,461(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000040964 -- 132,841,908(+) G/C/T genic_downstream_transcript_variant, intron_variant
rs1000065723 -- 132,807,484(+) T/A 5_prime_UTR_variant, intron_variant
rs1000120277 -- 132,788,619(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000143051 -- 132,834,888(+) T/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PHF20L1 Gene

Variant ID Type Subtype PubMed ID
dgv7317n100 CNV loss 25217958
dgv7318n100 CNV loss 25217958
dgv7319n100 CNV loss 25217958
dgv7320n100 CNV loss 25217958
dgv7321n100 CNV loss 25217958
esv3370341 CNV insertion 20981092
nsv1015669 CNV loss 25217958
nsv1016348 CNV loss 25217958
nsv831463 CNV gain 17160897

Variation tolerance for PHF20L1 Gene

Residual Variation Intolerance Score: 2.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHF20L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF20L1 Gene

Disorders for PHF20L1 Gene

Additional Disease Information for PHF20L1

No disorders were found for PHF20L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHF20L1 Gene

Publications for PHF20L1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. (PMID: 24492612) Estève PO … Pradhan S (The Journal of biological chemistry 2014) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for PHF20L1 Gene

Sources for PHF20L1 Gene

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