Aliases for PHF20 Gene
External Ids for PHF20 Gene
Previous HGNC Symbols for PHF20 Gene
Previous GeneCards Identifiers for PHF20 Gene
GeneCards Summary for PHF20 Gene
PHF20 (PHD Finger Protein 20) is a Protein Coding gene. Diseases associated with PHF20 include Hepatocellular Carcinoma. Among its related pathways are Regulation of TP53 Activity and Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific). An important paralog of this gene is PHF20L1.
UniProtKB/Swiss-Prot Summary for PHF20 Gene
Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.